The potential of protein-nanomaterial interaction for advanced drug delivery

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The potential of protein-nanomaterial interaction for advanced drug delivery. / Peng, Qiang; Mu, Huiling.

In: Journal of Controlled Release, Vol. 225, 23.01.2016, p. 121-132.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Peng, Q & Mu, H 2016, 'The potential of protein-nanomaterial interaction for advanced drug delivery', Journal of Controlled Release, vol. 225, pp. 121-132. https://doi.org/10.1016/j.jconrel.2016.01.041

APA

Peng, Q., & Mu, H. (2016). The potential of protein-nanomaterial interaction for advanced drug delivery. Journal of Controlled Release, 225, 121-132. https://doi.org/10.1016/j.jconrel.2016.01.041

Vancouver

Peng Q, Mu H. The potential of protein-nanomaterial interaction for advanced drug delivery. Journal of Controlled Release. 2016 Jan 23;225:121-132. https://doi.org/10.1016/j.jconrel.2016.01.041

Author

Peng, Qiang ; Mu, Huiling. / The potential of protein-nanomaterial interaction for advanced drug delivery. In: Journal of Controlled Release. 2016 ; Vol. 225. pp. 121-132.

Bibtex

@article{f38670f946114558bb5e109fe90934e1,
title = "The potential of protein-nanomaterial interaction for advanced drug delivery",
abstract = "Nanomaterials, like nanoparticles, micelles, nano-sheets, nanotubes and quantum dots, have great potentials in biomedical fields. However, their delivery is highly limited by the formation of protein corona upon interaction with endogenous proteins. This new identity, instead of nanomaterial itself, would be the real substance the organs and cells firstly encounter. Consequently, the behavior of nanomaterials in vivo is uncontrollable and some undesired effects may occur, like rapid clearance from blood stream; risk of capillary blockage; loss of targeting capacity; and potential toxicity. Therefore, protein-nanomaterial interaction is a great challenge for nanomaterial systems and should be inhibited. However, this interaction can also be used to functionalize nanomaterials by forming a selected protein corona. Unlike other decoration using exogenous molecules, nanomaterials functionalized by selected protein corona using endogenous proteins would have greater promise for clinical use. In this review, we aim to provide a comprehensive understanding of protein-nanomaterial interaction. Importantly, a discussion about how to use such interaction is launched and some possible applications of such interaction for advanced drug delivery are presented.",
keywords = "The Faculty of Pharmaceutical Sciences",
author = "Qiang Peng and Huiling Mu",
note = "Copyright {\circledC} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
month = "1",
day = "23",
doi = "10.1016/j.jconrel.2016.01.041",
language = "English",
volume = "225",
pages = "121--132",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The potential of protein-nanomaterial interaction for advanced drug delivery

AU - Peng, Qiang

AU - Mu, Huiling

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016/1/23

Y1 - 2016/1/23

N2 - Nanomaterials, like nanoparticles, micelles, nano-sheets, nanotubes and quantum dots, have great potentials in biomedical fields. However, their delivery is highly limited by the formation of protein corona upon interaction with endogenous proteins. This new identity, instead of nanomaterial itself, would be the real substance the organs and cells firstly encounter. Consequently, the behavior of nanomaterials in vivo is uncontrollable and some undesired effects may occur, like rapid clearance from blood stream; risk of capillary blockage; loss of targeting capacity; and potential toxicity. Therefore, protein-nanomaterial interaction is a great challenge for nanomaterial systems and should be inhibited. However, this interaction can also be used to functionalize nanomaterials by forming a selected protein corona. Unlike other decoration using exogenous molecules, nanomaterials functionalized by selected protein corona using endogenous proteins would have greater promise for clinical use. In this review, we aim to provide a comprehensive understanding of protein-nanomaterial interaction. Importantly, a discussion about how to use such interaction is launched and some possible applications of such interaction for advanced drug delivery are presented.

AB - Nanomaterials, like nanoparticles, micelles, nano-sheets, nanotubes and quantum dots, have great potentials in biomedical fields. However, their delivery is highly limited by the formation of protein corona upon interaction with endogenous proteins. This new identity, instead of nanomaterial itself, would be the real substance the organs and cells firstly encounter. Consequently, the behavior of nanomaterials in vivo is uncontrollable and some undesired effects may occur, like rapid clearance from blood stream; risk of capillary blockage; loss of targeting capacity; and potential toxicity. Therefore, protein-nanomaterial interaction is a great challenge for nanomaterial systems and should be inhibited. However, this interaction can also be used to functionalize nanomaterials by forming a selected protein corona. Unlike other decoration using exogenous molecules, nanomaterials functionalized by selected protein corona using endogenous proteins would have greater promise for clinical use. In this review, we aim to provide a comprehensive understanding of protein-nanomaterial interaction. Importantly, a discussion about how to use such interaction is launched and some possible applications of such interaction for advanced drug delivery are presented.

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.jconrel.2016.01.041

DO - 10.1016/j.jconrel.2016.01.041

M3 - Journal article

VL - 225

SP - 121

EP - 132

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

ER -

ID: 154402110