Topoisomerase 1(TOP1) gene copy number in stage III colorectal cancer patients and its relation to prognosis

Research output: Contribution to journalJournal articleResearchpeer-review

Maria Unni Koefoed Rømer, Sune Boris Nygård, Ib Jarle Christensen, Signe Lykke Nielsen, Kirsten Vang Nielsen, Sven Müller, David Hersi Smith, Ben Vainer, Hans Jørgen Nielsen, Nils Brünner

A Topoisomerase 1 (Top1) poison is frequently included in the treatment regimens for metastatic colorectal cancer (mCRC). However, no predictive biomarkers for Top1 poisons are available. We here report a study on the TOP1 gene copy number in CRC patients and its association with patient prognosis and tumor cell proliferation.
Original languageEnglish
JournalMolecular Oncology
Volume7
Issue number1
Pages (from-to)101-111
Number of pages11
ISSN1574-7891
DOIs
Publication statusPublished - 2013

ID: 40707423