Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Trimethoprim use in early pregnancy and the risk of miscarriage : a register-based nationwide cohort study. / Andersen, J T; Petersen, M; Jimenez-Solem, E; Broedbaek, K; Andersen, Elisabeth Anne Wreford; Andersen, N L; Afzal, Shoaib; Torp-Pedersen, C; Keiding, Niels; Poulsen, H E.

In: Epidemiology and Infection, Vol. 141, No. 8, 08.2013, p. 1749-1755.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Andersen, JT, Petersen, M, Jimenez-Solem, E, Broedbaek, K, Andersen, EAW, Andersen, NL, Afzal, S, Torp-Pedersen, C, Keiding, N & Poulsen, HE 2013, 'Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study', Epidemiology and Infection, vol. 141, no. 8, pp. 1749-1755. https://doi.org/10.1017/S0950268812002178

APA

Andersen, J. T., Petersen, M., Jimenez-Solem, E., Broedbaek, K., Andersen, E. A. W., Andersen, N. L., ... Poulsen, H. E. (2013). Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. Epidemiology and Infection, 141(8), 1749-1755. https://doi.org/10.1017/S0950268812002178

Vancouver

Andersen JT, Petersen M, Jimenez-Solem E, Broedbaek K, Andersen EAW, Andersen NL et al. Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. Epidemiology and Infection. 2013 Aug;141(8):1749-1755. https://doi.org/10.1017/S0950268812002178

Author

Andersen, J T ; Petersen, M ; Jimenez-Solem, E ; Broedbaek, K ; Andersen, Elisabeth Anne Wreford ; Andersen, N L ; Afzal, Shoaib ; Torp-Pedersen, C ; Keiding, Niels ; Poulsen, H E. / Trimethoprim use in early pregnancy and the risk of miscarriage : a register-based nationwide cohort study. In: Epidemiology and Infection. 2013 ; Vol. 141, No. 8. pp. 1749-1755.

Bibtex

@article{2168450b06e841fd88a0f32ca64720fa,
title = "Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study",
abstract = "SUMMARY The antibiotic trimethoprim acts as a folate antagonist. Since trophoblasts are very sensitive to drugs that interfere with the folic acid cycle and thereby inhibit DNA synthesis, use of trimethoprim during the first trimester could be associated with miscarriage. A nationwide cohort study including all women in Denmark with a registered pregnancy between 1997 and 2005 was conducted. We used nationwide registers to identify all women giving birth, having a record of miscarriage or induced abortion. Data on exposure to trimethoprim were obtained from the National Prescription Register. Cox proportional hazard regression analysis with exposure to trimethoprim as a time-dependent variable was used to estimate the risk of miscarriage. The adjusted hazard ratio of having a miscarriage after exposure to trimethoprim in the first trimester compared to non-exposure was 2·04 (95{\%} confidence interval 1·43-2·91). Our results indicate that trimethoprim exposure in the first trimester is associated with a doubling of the hazard of miscarriage.",
keywords = "Faculty of Health and Medical Sciences, Antibiotics, birth defects, epidemiology, pregnancy",
author = "Andersen, {J T} and M Petersen and E Jimenez-Solem and K Broedbaek and Andersen, {Elisabeth Anne Wreford} and Andersen, {N L} and Shoaib Afzal and C Torp-Pedersen and Niels Keiding and Poulsen, {H E}",
year = "2013",
month = "8",
doi = "10.1017/S0950268812002178",
language = "English",
volume = "141",
pages = "1749--1755",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Trimethoprim use in early pregnancy and the risk of miscarriage

T2 - a register-based nationwide cohort study

AU - Andersen, J T

AU - Petersen, M

AU - Jimenez-Solem, E

AU - Broedbaek, K

AU - Andersen, Elisabeth Anne Wreford

AU - Andersen, N L

AU - Afzal, Shoaib

AU - Torp-Pedersen, C

AU - Keiding, Niels

AU - Poulsen, H E

PY - 2013/8

Y1 - 2013/8

N2 - SUMMARY The antibiotic trimethoprim acts as a folate antagonist. Since trophoblasts are very sensitive to drugs that interfere with the folic acid cycle and thereby inhibit DNA synthesis, use of trimethoprim during the first trimester could be associated with miscarriage. A nationwide cohort study including all women in Denmark with a registered pregnancy between 1997 and 2005 was conducted. We used nationwide registers to identify all women giving birth, having a record of miscarriage or induced abortion. Data on exposure to trimethoprim were obtained from the National Prescription Register. Cox proportional hazard regression analysis with exposure to trimethoprim as a time-dependent variable was used to estimate the risk of miscarriage. The adjusted hazard ratio of having a miscarriage after exposure to trimethoprim in the first trimester compared to non-exposure was 2·04 (95% confidence interval 1·43-2·91). Our results indicate that trimethoprim exposure in the first trimester is associated with a doubling of the hazard of miscarriage.

AB - SUMMARY The antibiotic trimethoprim acts as a folate antagonist. Since trophoblasts are very sensitive to drugs that interfere with the folic acid cycle and thereby inhibit DNA synthesis, use of trimethoprim during the first trimester could be associated with miscarriage. A nationwide cohort study including all women in Denmark with a registered pregnancy between 1997 and 2005 was conducted. We used nationwide registers to identify all women giving birth, having a record of miscarriage or induced abortion. Data on exposure to trimethoprim were obtained from the National Prescription Register. Cox proportional hazard regression analysis with exposure to trimethoprim as a time-dependent variable was used to estimate the risk of miscarriage. The adjusted hazard ratio of having a miscarriage after exposure to trimethoprim in the first trimester compared to non-exposure was 2·04 (95% confidence interval 1·43-2·91). Our results indicate that trimethoprim exposure in the first trimester is associated with a doubling of the hazard of miscarriage.

KW - Faculty of Health and Medical Sciences

KW - Antibiotics

KW - birth defects

KW - epidemiology

KW - pregnancy

U2 - 10.1017/S0950268812002178

DO - 10.1017/S0950268812002178

M3 - Journal article

C2 - 23010291

VL - 141

SP - 1749

EP - 1755

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 8

ER -

ID: 122545779