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Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors

Research output: Contribution to journalJournal articleResearchpeer-review

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Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. / Petersen, Ida Nymann; Crestey, François; Jensen, Anders A; Indurthi, Dinesh C; Pedersen, Henrik; Andreasen, Jesper T; Balle, Thomas; Kristensen, Jesper L.

In: A C S Medicinal Chemistry Letters, Vol. 6, No. 4, 09.04.2015, p. 472-475.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Petersen, IN, Crestey, F, Jensen, AA, Indurthi, DC, Pedersen, H, Andreasen, JT, Balle, T & Kristensen, JL 2015, 'Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors' A C S Medicinal Chemistry Letters, vol. 6, no. 4, pp. 472-475. https://doi.org/10.1021/acsmedchemlett.5b00028

APA

Petersen, I. N., Crestey, F., Jensen, A. A., Indurthi, D. C., Pedersen, H., Andreasen, J. T., ... Kristensen, J. L. (2015). Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. A C S Medicinal Chemistry Letters, 6(4), 472-475. https://doi.org/10.1021/acsmedchemlett.5b00028

Vancouver

Petersen IN, Crestey F, Jensen AA, Indurthi DC, Pedersen H, Andreasen JT et al. Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. A C S Medicinal Chemistry Letters. 2015 Apr 9;6(4):472-475. https://doi.org/10.1021/acsmedchemlett.5b00028

Author

Petersen, Ida Nymann ; Crestey, François ; Jensen, Anders A ; Indurthi, Dinesh C ; Pedersen, Henrik ; Andreasen, Jesper T ; Balle, Thomas ; Kristensen, Jesper L. / Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. In: A C S Medicinal Chemistry Letters. 2015 ; Vol. 6, No. 4. pp. 472-475.

Bibtex

@article{bef5945517a04734adf71576ccd8dfe2,
title = "Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors",
abstract = "Conformational restriction of the pyrrolidine nitrogen in nicotine by the introduction of an ethylene bridge provided a potent and selective antagonist of the α4β2-subtype of the nicotinic acetylcholine receptors. Resolution by chiral SFC, pharmacological characterization of the two enantiomers, and determination of absolute configuration via enantioselective synthesis showed that the pharmacological activity resided almost exclusively in the (R)-enantiomer.",
author = "Petersen, {Ida Nymann} and Fran{\cc}ois Crestey and Jensen, {Anders A} and Indurthi, {Dinesh C} and Henrik Pedersen and Andreasen, {Jesper T} and Thomas Balle and Kristensen, {Jesper L}",
year = "2015",
month = "4",
day = "9",
doi = "10.1021/acsmedchemlett.5b00028",
language = "English",
volume = "6",
pages = "472--475",
journal = "A C S Medicinal Chemistry Letters",
issn = "1948-5875",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors

AU - Petersen, Ida Nymann

AU - Crestey, François

AU - Jensen, Anders A

AU - Indurthi, Dinesh C

AU - Pedersen, Henrik

AU - Andreasen, Jesper T

AU - Balle, Thomas

AU - Kristensen, Jesper L

PY - 2015/4/9

Y1 - 2015/4/9

N2 - Conformational restriction of the pyrrolidine nitrogen in nicotine by the introduction of an ethylene bridge provided a potent and selective antagonist of the α4β2-subtype of the nicotinic acetylcholine receptors. Resolution by chiral SFC, pharmacological characterization of the two enantiomers, and determination of absolute configuration via enantioselective synthesis showed that the pharmacological activity resided almost exclusively in the (R)-enantiomer.

AB - Conformational restriction of the pyrrolidine nitrogen in nicotine by the introduction of an ethylene bridge provided a potent and selective antagonist of the α4β2-subtype of the nicotinic acetylcholine receptors. Resolution by chiral SFC, pharmacological characterization of the two enantiomers, and determination of absolute configuration via enantioselective synthesis showed that the pharmacological activity resided almost exclusively in the (R)-enantiomer.

U2 - 10.1021/acsmedchemlett.5b00028

DO - 10.1021/acsmedchemlett.5b00028

M3 - Journal article

VL - 6

SP - 472

EP - 475

JO - A C S Medicinal Chemistry Letters

JF - A C S Medicinal Chemistry Letters

SN - 1948-5875

IS - 4

ER -

ID: 140626663