VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in Glioblastoma Multiforme tumor

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

M. Grodzik, E. Sawosz, M. Wierzbicki, Anna Malgorzata Hotowy, M. Prasek, J. Jaworski, André Chwalibog

Malignant gliomas are highly lethal cancers dependent on angiogenesis. The concept of treating tumors by inhibiting tumor angiogenesis was first articulated almost 30 years ago. Inhibition of tumor angiogenesis suppresses both tumor growth and metastasis. We determined the inhibition effect of diamond nanoparticles on the growth of brain tumor (cultured on CAM membrane) and the development of its blood vessels. We hypothesize that diamond nanoparticles can bind VEGF or their receptors and this way influence of signal transduction between cells. The aim of our study was to evaluate the influence of diamond nanoparticle on VEGF level and inhibition of the brain tumor angiogenesis. We evaluated interaction of VEGF-A and VEGF-receptor proteins with diamond nanoparticles (TEM), visualized lower the permeability of blood vessels after diamond nanoparticles treatment and determined localization in the cell and expression on protein level VEGF-A and VEGF-A-receptor.
Original languageEnglish
Title of host publicationNanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy
Number of pages4
Volume3
PublisherNSTI Nano Science and Technology Institute
Publication date2012
Pages218-221
ISBN (Print)978-.1-4665-6276-9
Publication statusPublished - 2012

ID: 44560673