Lona Louring Christrup

Lona Louring Christrup

Professor Emerita

Education & Degrees:

  • M.Sc. (Pharm): The Royal Danish School of Pharmacy, 1978-1986           
  • Ph.D.  The Royal Danish School of Pharmacy 1983-1986.

Former employment: (Current PharmaSchool)

  • Assistant professor 1986-1990
  • Associate professor 1990-2010

Research Abroad:

Dept. of Clinical Pharmacolo­gy, University of Adelaide, Australia. 1994 -1997

Dept. of Pharmaceuti­cal Sci­ence, Univer­sity of Notting­ham, Eng­land. 1988

Current Affiliations/Memberships

  • EFIC (European Federation of IASP (International Association for the Study of Pain) Chapters) Task for Appropriate use of Opioids: 2014-
  • Nordic OIC&OIBD (opioid induced constipation & opioid induced bowel dysfunction) Consensus Working Group: 2014-
  • EFIC Task for Reimbursement Policies of Opioid Analgesics: 2011- (Chair)
  • Steering committee for the MULTIPAIN research consort: 2011-
  • Editorial board of European Journal of Hospital Pharmacy 2008- 

Scientific Work

Publications: 131 research papers, 26 dissemination papers (popular scientific, debate, etc.), 2 patent applications (1 patent granted) and 1 thesis, 1 expert report and editor of 1 book. Reviewer for more than 20 scientific journals Participation in more than 160 scientific meetings and conferences, presentation of more than 90 poster or free oral presentations and more than 40 invited lectures. 
Current research activities are focused on: 

  • Influence of administration routes and delivery systems on the pharmacokinetic and pharmacodynamic behaviour of opioids with special focus on the dose-response of both wanted and unwanted effects. 
  • PK/PD modeling of the effects of opioids. 
  • Optimization of the pharmacological treatment of chronic pain disorders; with focus on the individual patient needs.
  • MULTIPAIN; individualization of pharmacological pain treatment, by elucidation of the reasons for the differentiated effects of analgesics in human experimental pain models.
  • Optimization of the pharmacological treatment of chronic pain disorders; with focus on the individual patient needs. 
  • MULTIPAIN; individualization of pharmacological pain treatment, by elucidation of the reasons for the differentiated effects of analgesics in human experimental pain models. 

Supervisor Responsibilities and Teaching

Supervisor for a total of 26 Ph.D. students (currently 4), 8 pre graduate scholar students and more than 200 master students.  Member of the assessment committees for 13 PhD. theses.

Educational activities have included a broad spectrum of pharmaceutical disciplines, such a pharmaceutical technology, biopharmaceutics, drug delivery/formulation, pharmacotherapy, clinical pharmacy, social pharmacy, and pharmacology at both pre graduate and post-graduate level.

Activities have included lectures, laboratory exercises, work-shops, tutorials, supervision as well as  examnination, evaluation and course planning and managing.

Selected publications

  1. Published

    Pain characteristics and management of inpatients admitted to a comprehensive cancer centre: a cross-sectional study

    Kurita, G. P., Tange, U. B., Farholt, H., Sonne, N. M., Strömgren, A. S., Ankersen, L., Kristensen, L., Bendixen, L., Grønvold, M., Petersen, M. A., Nordly, M., Christrup, L., Niemann, C. & Sjøgren, P., 22 Jan 2013, In : Acta Anaesthesiologica Scandinavica. 57, p. 518-525

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Pharmacokinetic/pharmacodynamic relationships of tranddermal buprenorphine and fentanyl in experimental human pain models

    Andresen, T., Upton, R. N., Foster, D. J. R., Christrup, L. L., Arendt-Nielsen, L. & Drewes, A. M., Apr 2011, In : Basic & Clinical Pharmacology & Toxicology. 108, 4, p. 274-284

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Symptoms and side effects in chronic non-cancer pain:patient report vs. systematic assessment

    Jonsson, T., Christrup, L. L., Højsted, J., Villlesen, H. H., Albjerg, T., Ravn-Nielsen, L. V. & Sjøgren, P., 2011, In : Acta Anaesthesiologica Scandinavica. 55

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Rationales behind the choice of administration form with fentanyl: Delphi survey among Danish general practitioners

    Jacobsen, R., Møldrup, C. & Christrup, L., 2010, In : Journal of Opioid Management. 6, 4, p. 259-68 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy:  a randomized controlled trial

    Christensen, A., Christrup, L. L., Fabricius, P. E., Chrostowska, M., Wronka, M., Narkiewicz, K. & Hansen, E. H., 2010, In : Journal of Hypertension. 28, 1, p. 194-200

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia

    Olesen, A. E., Upton, R., Staahl, C., Christrup, L. L., Arendt-Nielsen, L. & Drewes, A. M., 2010, In : Clinical Pharmacokinetics. 49, 12, p. 817-827

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The importance of the proper procedures in the implementation process of new guidelines

    Villesen, H. H., Faber, T., Skov, B., Bonde, J. & Christrup, L. L., 2010, In : E J H P Practice. 16, 3

    Research output: Contribution to journalJournal articleResearch

  8. Published

    The Danish Barriers Questionnaire-II: preliminary validation in cancer pain patients

    Jacobsen, R., Møldrup, C., Christrup, L. L., Sjøgren, P. & Hansen, O. B., 2009, In : Pain Practice. 9, 4, p. 266-74 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Barries to cancer management: a review of empirical research

    Jacobsen, R., Liubarskiene, Z., Møldrup, C., Christrup, L. L., Sjøgren, P. & Samsanaviciene, J., 2009, In : Medicina. 45, 6, p. 427-432

    Research output: Contribution to journalReviewResearch

  10. Published

    Translational pain research: evaluating analgesic effect in experimental visceral pain models

    Olesen, A. E., Andresen, T., Christrup, L. L. & Upton, R. N., 2009, In : World Journal of Gastroenterology. 15, 2, p. 177-81

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Survey of patient and physician assessment of a compliance reminder device in the treatment of hypertension

    Christensen, A., Christrup, L. L., Fabricius, P. E., Chrostowska, M., Wronka, M., Narkiewicz, K. & Hansen, E. H., 2009, In : Blood Pressure. 18, 5, p. 280-285

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Danish pain specialists' rationales behind the choice of fentanyl transdermal patches and oral transmucosal systems-A Delphi study

    Jacobsen, R., Møldrup, C. & Christrup, L., 2009, In : Pain Medicine. 10, 8, p. 1442-1451

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The Danish version of the questionnaire on pain communication: preliminary validation in cancer patients: preliminary validation in cancer patients

    Jacobsen, R., Møldrup, C., Christrup, L. L., Sjøgren, P. & Hansen, O. B., 2009, In : Acta Anaesthesiologica Scandinavica. 53, 6, p. 807-15 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The Danish version of the Medication Adherence Report Scale: preliminary validation in cancer pain patients: preliminary validation in cancer pain patients

    Jacobsen, R., Møldrup, C., Christrup, L. L., Sjøgren, P. & Hansen, O. B., 2009, In : Pain Practice. 9, 1, p. 1-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Role of active metabolites in the use of opioids

    Coller, J. K., Christrup, L. L. & Somogyi, A. A., 2009, In : European Journal of Clinical Pharmacology. 65, 2, p. 121-139

    Research output: Contribution to journalReviewResearch

  16. Published

    Patient-related barriers to cancer pain management: a systematic exploratory review: a systematic exploratory review

    Jacobsen, R., Møldrup, C., Christrup, L. L. & Sjøgren, P., 2009, In : Scandinavian Journal of Caring Sciences. 23, 1, p. 190-208 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Novel formulations and routes of administration fro opioids in the treatment of breakthrough pain

    Christrup, L. L., Lundorff, L. & Werner, M., 2009, In : Therapy. 6, 5

    Research output: Contribution to journalJournal articleResearch

  18. Published

    Generisk substitution af depotpraeparater indeholdende opioider

    Christrup, L. L., Jensen, N-H., Jonsson, T., Kristensen, H. G., Sjøgren, P. & Steffansen, B., 4 May 2009, In : Ugeskrift for læger. 171, 19, p. 1624; author reply 1624

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Laegemiddelstyrelsen bør genoverveje tilladelsen til generisk substitution mellem fentanyldepotplastre

    Christrup, L. L., Jensen, N-H., Jonsson, T., Sjøgren, P. & Steffansen, B., 2009, In : Ugeskrift for læger. 171, 44, p. 3215

    Research output: Contribution to journalComment/debateResearch

  20. Published

    Duplik til debatoplæg

    Christrup, L. L., Jørgensen, N-H., Jonsson, T. & Sjøgren, P., 2009, In : Ugeskrift for læger. 171, 49, p. 3637

    Research output: Contribution to journalComment/debateResearch

  21. Published

    Pharmacokinetic-Pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model

    Staahl, C., Upton, R., Foster, D. J. R., Christrup, L. L., Kristensen, K., Hansen, S. H., Arendt-Nielsen, L. & Drewes, A. M., 2008, In : Journal of Clinical Pharmacology. 48, 5, p. 619-631

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Pharmacokinetic-Pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers

    Jensen, M. L., Sjøgren, P., Upton, R. N., Foster, D. J. R., Bonde, P., Graae, C., Skram, U., Stevner, L. L. S. & Christrup, L. L., 2008, In : Basic & Clinical Pharmacology & Toxicology. 103, 1, p. 94-101

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery

    Foster, D., Upton, R., Christrup, L. L. & Popper, L., 2008, In : Annals of Pharmacotherapy. 42, 10, p. 1380-1387

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Clinical rationale for administering fentanyl to cancer pain patients: two Delphi surveys of pain management experts in Denmark

    Jacobsen, R., Møldrup, C. & Christrup, L. L., 2008, In : Journal of Opioid Management. 4, 6, p. 383-391

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: A randomized, double-blind, double-dummy, two-way, crossover study

    Christrup, L. L., Foster, D., Popper, L. D., Troen, T. & Upton, R., 2008, In : Clinical Therapeutics. 30, 3, p. 469-481

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Pharmakonetics of morphine and oxycodone following intravenous administration in elderly patients

    Villesen, H. H., Banning, A-M., Petersen, R. H., Weinelt, S., Poulsen, J. B., Hansen, S. H. & Christrup, L. L., 2007, In : Therapeutics and Clinical Risk Management. 3, 5

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

    Villesen, H. H., Kristensen, K., Hansen, S. H., Jensen, N-H., Skram, U. & Christrup, L. L., 2007, In : European Journal of Clinical Pharmacology. 63, 8, p. 761-767

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Patient acceptance of a tablet reminder device

    Christensen, A., Christrup, L. L., Fabricius, P. E. & Hansen, E. H., 2007, In : Journal of Medical Marketing (Print Edition). 7, 2, p. 152-161

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    A new intelligent tablet reminder device - do health professionals find it of therapeutic value?

    Christensen, A., Christrup, L. L., Fabricius, P. E. & Hansen, E. H., 2007, In : Journal of Medical Marketing (Print Edition). 7, 3, p. 235-243

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Forskelle på ordinationsmønstret af analgetika ved behandling af cancersmerter på seks danske smertebehandlingsenheder

    Olesen, A. E., Jarvig, L., Hansen, O. B., Højsted, J., Jensen, N-H., Jonsson, T., Sjøgren, P., Sonne, N. M., Sørensen, J. T. & Christrup, L. L., 2007, In : Ugeskrift for læger. 169, 21, p. 2024-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study

    Staahl, C., Dimcevski, G., Andersen, S. D., Thorsgaard, N., Christrup, L. L., Arendt-Nielsen, L. & Drewes, A. M., 2007, In : Scandinavian Journal of Gastroenterology. 42, 3, p. 383-90

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers

    Jensen, M. L., Foster, D. J. R., Upton, R. N., Kristensen, K., Hansen, S. H., Jensen, N-H., Nielsen, B. N., Skram, U., Villesen, H. H. & Christrup, L. L., 2007, In : European Journal of Clinical Pharmacology. 63, 12, p. 1153-1159

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.

    Coller, J. K., Joergensen, C., Foster, D. J. R., James, H., Gillis, D., Christrup, L. & Somogyi, A. A., 2007, In : International Journal of Clinical Pharmacology and Therapeutics. 45, 7, p. 410-7

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Physician-related barriers to cancer pain management with opioid analgesics: a systematic review

    Jacobsen, R., Sjøgren, P., Møldrup, C. & Christrup, L., 2007, In : Journal of Opioid Management. 3, 4, p. 207-14

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

    Sunesen, V. H., Vedelsdal, R., Kristensen, H. G., Christrup, L. & Müllertz, A., 2005, In : European Journal of Pharmaceutical Sciences. 24, 4, p. 297-303 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1301280