Employees – University of Copenhagen

Thor Christian Møller

Thor Christian Møller

Assistant professor

My research is focused on the fundamental, molecular mechanisms of signaling, trafficking and oligomerization of G protein-coupled receptors (GPCRs), the largest family of membrane proteins and the target of approximately a third of all drugs. My approach is to develop or apply innovative tools and methods, such as CRISPR/Cas9 genome edited cell lines, nanobodies, advanced fluorescence microscopy and real-time biosensors, to push the boundaries of what we already know. GPCRs are involved in most physiological and pathological processes, so insights into their basic functions has broad perspectives for basic research and for drug discovery.

Current research

  • Dissection of GPCR internalization pathways with CRISPR/Cas9 genome edited cell lines
  • β-arrestin independent internalization mechanisms of GPCRs
  • Inhibitors for intracellular protein-protein interactions involved in receptor trafficking
  • Second messenger generation from internalized GPCRs
  • Real-time assay for studying forward trafficking of GPCRs to the cell membrane

Teaching

  • Endocrinology, Pharmacology: From Physiology to Therapy (MSc level, Pharmaceutical Sciences)
  • CURIS and ORCiD workshop (PhD level, Drug Research Academy)

Selected publications

  1. Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics

    Møller, T. C., Hottin, J., Clerté, C., Zwier, J. M., Durroux, T., Rondard, P., Prézeau, L., Royer, C. A., Pin, J-P., Margeat, E. & Kniazeff, J., 10 Jul 2018, In : Scientific Reports. 8, 1, p. 10414

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

    Scholler, P., Nevoltris, D., de Bundel, D., Bossi, S., Moreno-Delgado, D., Rovira, X., Møller, T. C., El Moustaine, D., Mathieu, M., Blanc, E., McLean, H., Dupuis, E., Mathis, G., Trinquet, E., Daniel, H., Valjent, E., Baty, D., Chames, P., Rondard, P. & Pin, J-P., 6 Dec 2017, In : Nature Communications. 8, 1, p. 1967

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

    Moreno Delgado, D., Møller, T. C., Ster, J., Giraldo, J., Maurel, D., Rovira, X., Scholler, P., Zwier, J. M., Perroy, J., Durroux, T., Trinquet, E., Prezeau, L., Rondard, P. & Pin, J-P., 29 Jun 2017, In : eLife. 6

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 11225093