Employees – University of Copenhagen

Kasper Skytte Harpsøe

Kasper Skytte Harpsøe

Academic staff

Primary fields of research

Computational chemistry and molecular modeling in drug design - especially within the target areas of GPCRs, G proteins and ligand-gated ion channels.

Selected publications

  1. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

    Zhang, H., Nielsen, A. L., Boesgaard, M. W., Harpsøe, K., Daly, N. L., Xiong, X., Underwood, C. R., Haugaard-kedström, L. M., Bräuner-osborne, H., Gloriam, D. E. & Strømgaard, K. 5 Aug 2018 In : European Journal of Medicinal Chemistry. 156, p. 847-860

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

    Peng, Y., Mccorvy, J. D., Harpsøe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L. F., Huang, X., Wu, Y., Shen, L., Bjørn-Yoshimoto, W. E., Ding, K., Wacker, D., Han, G. W., Cheng, J., Katritch, V., Jensen, A. A., Hanson, M. A., Zhao, S., Gloriam, D. E., Roth, B. L., Stevens, R. C. & Liu, Z. 2018 In : Cell. 172, 4, p. 719-730 P719-730.E14

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    GPCRdb in 2018: adding GPCR structure models and ligands

    Pándy-Szekeres, G., Munk, C., Tsonkov, T. M., Mordalski, S., Harpsøe, K., Hauser, A. S., Bojarski, A. J. & Gloriam, D. E. 2018 In : Nucleic acids research. 46, D1, 7 p., gkx1109

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

    Harpsøe, K., Boesgaard, M. W., Munk, C., Bräuner-Osborne, H. & Gloriam, D. E. 2017 In : Bioinformatics (Oxford, England). 33, 8, p. 1116-1120 5 p., btw784

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

    Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, K., Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, D. E., Bräuner-osborne, H. & Strømgaard, K. Nov 2016 In : Nature Chemistry. 8, 11, p. 1035-1041 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Integrating structural and mutagenesis data to elucidate GPCR ligand binding

    Munk, C., Harpsøe, K., Hauser, A. S., Isberg, V. & Gloriam, D. E. Oct 2016 In : Current Opinion in Pharmacology. 30, p. 51-58 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    GPCRdb: an information system for G protein-coupled receptors

    Isberg, V., Mordalski, S., Munk, C., Rataj, K., Harpsøe, K., Hauser, A. S., Vroling, B., Bojarski, A. J., Vriend, G. & Gloriam, D. E. 4 Jan 2016 In : Nucleic acids research. 44, D1, p. D356-64

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants

    Harpsøe, K., Isberg, V., Tehan, B. G., Weiss, D., Arsova, A., Marshall, F. H., Bräuner-Osborne, H. & Gloriam, D. E. 11 Sep 2015 In : Scientific Reports. 5, p. 1-11 11 p., 13869

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A robust force field based method for calculating conformational energies of charged drug-like molecules

    Pøhlsgaard, J., Harpsøe, K., Jørgensen, F. S. & Olsen, L. 2012 In : Journal of Chemical Information and Modeling. 52, 2, p. 409-419

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors

    Harpsøe, K., Ahring, P. K., Christensen, J. K., Jensen, M. L., Peters, D. & Balle, T. 27 Jul 2011 In : Journal of Neuroscience. 31, 30, p. 10759-10766

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1428429