Employees – University of Copenhagen

Timothy Peter Lynagh

Timothy Peter Lynagh

Assistant professor

Research focus

Ligand-gated ion channels (LGICs) are membrane proteins that couple chemical signals with electrical excitation of cells like neurons. I study LGIC evolution, function and pharmacology, using molecular biology and electrophysiology. I am also interested in engineering LGICs for chemogenetic tools in dissecting neuronal circuitry.

Education/training

  • 2014-2018, Postdoc/Assistant Professor, University of Copenhagen, Denmark
  • 2011-2013, Postdoc, Technical University of Darmstadt, Germany
  • 2007-2011, PhD, University of Queensland, Australia
  • 2006, BSc (Hons), University of Queensland, Australia

Selected publications

Lynagh, T., Mikhaleva, Y., Colding, J.M., Glover, J.C., and Pless, S.A. (2018). Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes. Proceedings of the National Academy of Sciences of the USA. In press. https://doi.org/10.1073/pnas.1806614115.

Todd, W.D., Fenselau, H., Wang, J.L., Zhang, R., Machado, N.L., Venner, A., Broadhurst, R.Y., Kaur, S., Lynagh, T., Olson, D.P., Lowell, B.B., Fuller, P.M., and Saper, C.B. (2018). A hypothalamic circuit for the circadian control of aggression. Nature Neuroscience 21, 717-724. DOI: 10.1038/s41593-018-0126-0

Lynagh, T., Flood, E., Boiteux, C., Wulf, M., Komnatnyy, V.V., Colding, J.M., Allen, T.W., and Pless, S.A. (2017). A selectivity filter at the intracellular end of the acid-sensing ion channel pore. eLife 6. DOI: 10.7554/eLife.24630

Lynagh, T., Romero-Rojo, J.L., Lund, C., and Pless, S.A. (2017). Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen. Journal of Medicinal Chemistry 60, 8192-8200. DOI: 10.1021/acs.jmedchem.7b01072

Lynagh, T., Beech, R.N., Lalande, M.J., Keller, K., Cromer, B.A., Wolstenholme, A.J., and Laube, B. (2015). Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels. Scientific Reports 5, 8558. DOI: 10.1038/srep08558

Lynagh, T., and Laube, B. (2014). Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site. The Journal of Neuroscience 34, 2155-2159. DOI: 10.1523/JNEUROSCI.4307-13.2014

Lynagh, T., and Lynch, J.W. (2012). Ivermectin binding sites in human and invertebrate Cys-loop receptors. Trends in Pharmacological Sciences 33, 432-441. DOI: 10.1016/j.tips.2012.05.002

ID: 96013904