Department of Drug Design and Pharmacology

  1. 2022
  2. Accepted/In press

    C-locked analogs of the antimicrobial peptide BP214

    Andersen, I. K. L., Thomsen, T. T., Rashid, J., Bobak, T. R., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 7 Aug 2022, (Accepted/In press) In: Antibiotics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

    Dos Santos, A. B., Skaanning, L. K., Thaneshwaran, S., Mikkelsen, E., Romero-Leguizamón, C. R., Skamris, T., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 26 Jul 2022, In: Cellular and Molecular Life Sciences. 79, 8, p. 450

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria.

    Christensen, Søren Brøgger, 25 Jul 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). Amsterdam: Elsever, p. 389-407 18 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  5. E-pub ahead of print

    Hypothermic oxygenated perfusion in extended criteria donor liver transplantation-A randomized clinical trial

    Ravaioli, M., Germinario, G., Dajti, G., Sessa, Maurizio, Vasuri, F., Siniscalchi, A., Morelli, M. C., Serenari, M., Del Gaudio, M., Zanfi, C., Odaldi, F., Bertuzzo, V. R., Maroni, L., Laurenzi, A. & Cescon, M., 7 Jun 2022, (E-pub ahead of print) In: American Journal of Transplantation.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

    Brito dos Santos, Altair, Skaanning, L. K., Thaneskwaran, S., Mikkelsen, E., Leguizamon, Cesar Ramon Romero, Skamris, T., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 9 May 2022, Research Square-Preprint, 46 p.

    Research output: Working paperPreprintResearch

  7. Submitted

    Cyclic N-Locked Indolicidin Analogues with Antimicrobial Activity: Effect of Ring Size and Fatty Acid Acylation

    Lone, A., Nielsen, J. E., Thulstrup, Peter Waaben, Lund, R., Hansen, Paul Robert & Jenssen, H., 1 Feb 2022, (Submitted) In: European Journal of Medicinal Chemistry.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    (S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist

    Poulie, Christian Bernard Matthijs, Larsen, Y., Leteneur, C., Barthet, G., Bjørn-Yoshimoto, Walden, Malhaire, F., Nielsen, B., Pin, J. P., Mulle, C., Pickering, Darryl S & Bunch, Lennart, 2022, In: ACS Chemical Neuroscience. 13, 10, p. 1580–1587

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    In Vivo Neutralization of Myotoxin II, a Phospholipase A2Homologue from Bothrops asper Venom, Using Peptides Discovered via Phage Display Technology

    Laustsen, A. H., Gless, Bengt, Jenkins, T. P., Meyhoff-Madsen, M., Bjärtun, J., Munk, A. S., Oscoz, S., Fernández, J., Gutiérrez, J. M., Lomonte, B. & Lohse, B., 2022, In: ACS Omega. 7, 18, p. 15561–15569

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    popsicleR: A R Package for Pre-processing and Quality Control Analysis of Single Cell RNA-seq Data

    Grandi, F., Caroli, J., Romano, O., Marchionni, M., Forcato, M. & Bicciato, S., 2022, In: Journal of Molecular Biology. 434, 11, 11 p., 167560.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

    Miettinen, Karel, Leelahakorn, Nattawat, Almeida Robles, A. R., Zhao, Yong, Hansen, L. R., Nikolajsen, I. E., Andersen, Jens Bo, Givskov, Michael, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 3664.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    A Nationwide Observational Study of Chlamydia trachomatis Infections in Denmark during the COVID-19 Pandemic

    Hedley, P. L., Hoffmann, S., Lausten-Thomsen, U., Voldstedlund, M., Bjerre, K. D., Hviid, Anders Peter, Krebs, Lone, Jensen, J. S. & Christiansen, M., 2022, In: Acta Dermato-Venereologica. 102, 5 p., adv00704.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark

    Sørensen, Anna Irene Vedel, Spiliopoulos, L., Bager, P., Nielsen, N. M., Hansen, J. V., Koch, A., Meder, I. K., Ethelberg, Steen & Hviid, Anders Peter, 2022, In: Nature Communications. 13, 1, 8 p., 4213.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A systematic review of blood eosinophils and continued treatment with inhaled corticosteroids in patients with COPD

    Dalin, D. A., Løkke, A., Kristiansen, P., Jensen, C., Birkefoss, K., Christensen, H. R., Godtfredsen, Nina, Hilberg, O., Rohde, J. F., Ussing, A., Vermehren, Charlotte & Händel, M. N., 2022, In: Respiratory Medicine. 198, 11 p., 106880.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Adverse Effects and Safety in Glaucoma Patients: Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD)—A Delphi Consensus Statement

    Thein, A. S., Hedengran, A., Azuara-Blanco, A., Arita, R., Cvenkel, B., Gazzard, G., Heegaard, Steffen, de Paiva, C. S., Petrovski, G., Prokosch-Willing, V., Utheim, T. P., Virgili, G. & Kolko, Miriam, 2022, In: American Journal of Ophthalmology. 241, p. 190-197

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    An Evaluation of the Physicochemical Properties of Preservative-Free 0.005% (w/v) Latanoprost Ophthalmic Solutions, and the Impact on In Vitro Human Conjunctival Goblet Cell Survival

    Freiberg, Josefine Clement, Hedengran, A., Heegaard, Steffen, Petrovski, G., Jacobsen, Jette, Cvenkel, B. & Kolko, Miriam, 2022, In: Journal of Clinical Medicine. 11, 11, 3137.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method

    Nordin, E., Steffensen, S. K., Laursen, B. B., Andersson, S., Johansson, J., Åman, P., Hallmans, G., Borre, M., Stærk, Dan, Hanhineva, K., Fomsgaard, I. S. & Landberg, R., 2022, In: Scientific Reports. 12, 14 p., 5260.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Analysis of Thromboembolic and Thrombocytopenic Events After the AZD1222, BNT162b2, and MRNA-1273 COVID-19 Vaccines in 3 Nordic Countries

    Dag Berild, J., Bergstad Larsen, V., Myrup Thiesson, E., Lehtonen, T., Grøsland, M., Helgeland, J., Wolhlfahrt, J., Vinsløv Hansen, J., Palmu, A. A. & Hviid, Anders Peter, 2022, In: JAMA network open. 5, 6, 12 p., E2217375.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Ancient biosynthesis in an oil crop: Glucosinulate profiles in Limnanthes alba and its relatives (Limnanthaceae, Brassicales)

    Agerbirk, Niels, Pattison, David, Mandáková, T., Lysak, M. A., Montaut, S. & Stærk, Dan, 2022, In: Journal of Agricultural and Food Chemistry. 70, p. 1134-1147

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Artificial neural network vs pharmacometric model for population prediction of plasma concentration in real-world data: a case study on valproic acid

    Soeorg, H., Sverrisdóttir, Eva, Andersen, Morten, Lund, Trine Meldgaard & Sessa, Maurizio, 2022, In: Clinical Pharmacology and Therapeutics. 111, 6, p. 1278-1285

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Assessment of Seasonality and Extremely Preterm Birth in Denmark

    Hviid, Anders Peter, Laksafoss, A., Hedley, P., Lausten-Thomsen, U., Hjalgrim, Henrik, Christiansen, M. & Olsen, Sjurdur F., 2022, In: JAMA Network Open. 5, 2, 13 p., e2145800.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Astrocytic abnormalities in schizophrenia

    Saleki, K., Banazadeh, M., Abadi, B., Pirmoradi, Z., Esmaili, Z., Pourahmad, R., Kohlmeier, Kristi Anne & M, S., 2022, Astrocytes in Brain Communication and Disease. Larrivee, D. (ed.). In Tech Open Access

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  23. Published

    Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners

    Christensen, N. R., Pedersen, Christian Parsbæk, Sereikaité, Vita, Pedersen, J. N., Vistrup-Parry, Maria, Sørensen, Andreas Toft, Otzen, D., Teilum, Kaare, Madsen, Kenneth Lindegaard & Strømgaard, Kristian, 2022, In: iScience. 25, 2, 26 p., 103808.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. E-pub ahead of print

    Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

    Semple, S., Stærk, Dan, Buirchell, B., Fowler, R., Gericke, Oliver, Kjaerulff, Louise, Zhao, Yong, Pedersen, H. A., Petersen, M. J., Rasmussen, Line Fentz, Bredahl, E. K., Pedersen, Gustav Blichfeldt, McNair, Laura M., Ndi, C., Hansen, Nikolaj Lervad, Heskes, A., Bayly, M., Loland, Claus Juul, Heinz, Nanna & Møller, Birger Lindberg, 2022, (E-pub ahead of print) In: Plant Journal. 15866.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Biological and small molecule strategies in migraine therapy with relation to the CGRP family of peptides

    Edvinsson, L., Edvinsson, Jacob Carl Alexander & Haanes, Kristian Agmund, 2022, In: British Journal of Pharmacology. 179, 3, p. 371-380

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061

    Vit, Gianmatteo, Duro, Joana Maria, Rajendraprasad, G., Hertz, Emil Peter Thrane, Holland, Lya Katrine Kauffeldt, Weisser, Melanie, McEwan, B. C., Lopez-Mendez, B., Sotelo-Parrilla, P., Jeyaprakash, A. A., Montoya, Guillermo, Mailand, Niels, Maeda, K., Kettenbach, A., Barisic, Marin & Nilsson, Jakob, 2022, In: EMBO Journal. 41, 14, e110611.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

    Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, Trond, Hudson, B. D., Ulven, Elisabeth Rexen, Dekker, N., Tobin, A. B. & Milligan, G., 2022, In: eLife. 11, 23 p., e73777.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Class I histone deacetylases (HDAC1-3) are histone lysine delactylases

    Moreno Yruela, Carlos, Zhang, D., Wei, W., Bæk, M., Liu, W., Gao, J., Dankova, Daniela, Nielsen, A. L., Bolding, Julie Eilskov, Yang, L., Jameson, S. T., Wong, J., Olsen, Christian Adam & Zhao, Y., 2022, In: Science Advances. 8, 3, eabi6696.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Co-treatment with letrozole during ovarian stimulation for IVF/ICSI: a systematic review and meta-analysis

    Bülow, N. S., Dreyer Holt, M., Skouby, Sven O., Petersen, Kathrine Birch, Englund, A. L. M., Pinborg, Anja & Macklon, N. S., 2022, In: Reproductive BioMedicine Online. 44, 4, p. 717-736

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Comment on Delanaye et al: Future perspectives regarding kidney function estimates and dose adjustments

    Iversen, E., Hornum, M., Lund, Trine Meldgaard & Houlind, Morten Baltzer, 2022, In: British Journal of Clinical Pharmacology. 88, 6, p. 2998-2999

    Research output: Contribution to journalLetterResearchpeer-review

  31. Published

    Common coupling map advances GPCR-G protein selectivity

    Hauser, Alexander Sebastian, Avet, C., Normand, C., Mancini, A., Inoue, A., Bouvier, M. & Gloriam, David E., 2022, In: eLife. 11, 22 p., e74107.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Community guidelines for GPCR ligand bias: IUPHAR review 32

    Kolb, P., Kenakin, T., Alexander, S. P. H., Bermudez, M., Bohn, L. M., Breinholt, C. S., Bouvier, M., Hill, S. J., Kostenis, E., Martemyanov, K. A., Neubig, R. R., Onaran, H. O., Rajagopal, S., Roth, B. L., Selent, J., Shukla, A. K., Sommer, M. E. & Gloriam, David E., 2022, In: British Journal of Pharmacology. 179, 14, p. 3651-3674

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    Comparative efficacy and safety of preserved versus preservative-free beta-blockers in patients with glaucoma or ocular hypertension: a systematic review

    Skov, A. G., Rives, A. S., Freiberg, Josefine Clement, Virgili, G., Azuara-Blanco, A. & Kolko, Miriam, 2022, In: Acta Ophthalmologica. 100, 3, p. 253-261

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    Conformational decoupling in acidsensing ion channels uncovers mechanism and stoichiometry of PcTx1mediated inhibition

    Heusser, Stephanie, Borg, C. B., Colding, J. M. & Pless, Stephan, 2022, In: eLife. 11, 20 p., e73384.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Data-dependent acquisition-mass spectrometry guided isolation of new benzoxazinoids from the roots of Acanthus mollis L.

    Bhattarai, B., Steffensen, S. K., Stærk, Dan, Laursen, B. B. & Fomsgaard, I. S., 2022, In: International Journal of Mass Spectrometry. 474, 10 p., 116815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer's Disease

    Tams, A. L. M., Sanz-Morello, B., Westi, E. W., Mouhammad, Zaynab Ahmad, Andersen, Jens Velde, Freude, Kristine, Vohra, Rupali, Hannibal, Jens, Aldana, Blanca & Kolko, Miriam, 2022, In: Cellular and Molecular Neurobiology. 42, p. 291–303

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Delineation of the GPR15 receptor-mediated Gα protein signalling profile in recombinant mammalian cells

    Deng, Y., Moo, Ee Von, Almería, C. V. P., Gentry, P. R., Vedel, L., Mathiesen, Jesper M. & Bräuner-Osborne, Hans, 2022, In: Basic and Clinical Pharmacology and Toxicology. 131, 2, p. 104-113

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

    Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Rouzbeh, N., Liu, N., Bunch, Lennart, Hansen, K. B. & Clausen, Rasmus Prætorius, 2022, In: Journal of Medicinal Chemistry. 65, 1, p. 734-746

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Development of18F-Labeled Bispyridyl Tetrazines for In Vivo Pretargeted PET Imaging

    García Vázquez, Rocío, Jørgensen, Jesper Tranekjær, Bratteby, K. E., Shalgunov, Vladimir, Hvass, Lars, Herth, Matthias Manfred, Kjær, Andreas & Battisti, Umberto Maria, 2022, In: Pharmaceuticals. 15, 2, 28 p., 245.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain

    Tian, Yongsong, Shehata, Mohamed A., Gauger, Stine Juul, Ng, C. K. L., Solbak, Sara Marie Øie, Thiesen, L., Bruus-Jensen, J., Krall, J., Bundgaard, C., Gibson, K. M., Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 9, p. 6656-6676

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Drug-induced optic neuropathy

    Horwitz, Anna & Horwitz, Henrik, 2022, In: Adverse Drug Reaction Bulletin. 334, 1, p. 1295-1298

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Dual action of the cannabinoid receptor 1 ligand arachidonyl-2′-chloroethylamide on calcitonin gene-related peptide release

    Christiansen, I. M., Edvinsson, Jacob Carl Alexander, Reducha, Philip Victor, Edvinsson, L. & Haanes, Kristian Agmund, 2022, In: Journal of Headache and Pain. 23, 11 p., 30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Editorial: Amyloid-Membrane Interactions in Protein Misfolding Disorders: From Basic Mechanisms to Therapy

    Vassallo, N., Galvagnion-Büll, Céline & Chi, E. Y., 2022, In: Frontiers in Cell and Developmental Biology. 10, 870791.

    Research output: Contribution to journalEditorialResearchpeer-review

  44. Published

    Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

    Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, Alexander Sebastian, Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., St-Onge, S., Carrier, M., Héroux, M., Morissette, S., Fauman, E. B., Fortin, J. P., Schann, S., Leroy, X., Gloriam, David E. & Bouvier, M., 2022, In: eLife. 11, 34 p., e74101.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Electromembrane extraction of polar substances – Status and perspectives

    Eie, L. V., Pedersen-Bjergaard, Stig & Hansen, F. A., 2022, In: Journal of Pharmaceutical and Biomedical Analysis. 207, 17 p., 114407.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Elucidating Pathway and Anesthetic Mechanism of Action of Clove Oil Nanoformulations in Fish

    Kheawfu, K., Pikulkaew, S., Wellendorph, Petrine, Jørgensen, Louise von Gersdorff, Rades, Thomas, Mullertz, Anette & Okonogi, S., 2022, In: Pharmaceutics. 14, 5, 13 p., 919.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Enhanced depth imaging optical coherence tomography of the optic nerve head improves correct diagnosis in glaucoma suspects without glaucomatous optic disc morphology

    Ahmadi, H., Kolko, Miriam & Hamann, Steffen, 2022, In: BMJ Case Reports. 15, 2, e248109.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Erythropoietin attenuates locomotor and cognitive impairments in male rats subjected to physical and psychological stress

    Fathi, M., Tahamtan, M., Kohlmeier, Kristi Anne & Shabani, M., 2022, In: IBRO Neuroscience Reports. 12, p. 303-308

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Establishing a metabolic model of osteoarthritis in rats

    Mohamed, K. E., Iken, M. S., Katri, A., Karsdal, M. & Henriksen, K., 2022, In: Osteoarthritis and Cartilage. 30, Suppl. 1, p. S329-S329 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  50. Published

    Estimating Renal Function Following Lung Transplantation

    nsx114, nsx114, Houlind, Morten Baltzer, Iversen, E., Porrini, E., Luis-Lima, S., Oturai, P., Iversen, M., Bredahl, P., Carlsen, Jørn, Møller, Christian H., Andersen, M. J., Feldt-Rasmussen, Bo & Perch, Michael, 2022, In: Journal of Clinical Medicine. 11, 6, 13 p., 1496.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Exploration of Symptom Scale as an Outcome for Deprescribing: A Medication Review Study in Nursing Homes

    Dalin, D. A., Frandsen, S., Madsen, G. K. & Vermehren, Charlotte, 2022, In: Pharmaceuticals. 15, 5, 13 p., 505.

    Research output: Contribution to journalJournal articleResearchpeer-review

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