Cell Signalling Pharmacology – University of Copenhagen

Group photo from the CSP lab retreat at Store Færgedal near Frederikssund, May 2018 

In the Cell Signalling Pharmacology (CSP) Lab, we aim to better understand receptor- and non receptor-mediated intracellular signals, how parallel signalling trains interact laterally, and which cellular functions are under the control of these signals.

A major interest in CSP is 3’,5’-cyclic adenosine monophosphate (cAMP) signals, how these interact with concurrent Ca2+ signals, and how such intersecting signals control cellular metabolism - we call that signalling-metabolism coupling, and this is a major focus in CSP.  

We believe that knowledge about these intersecting signals is necessary for developing novel strategies to treat a range of diseases with an unmet need for novel pharmacology.

Research interests & disease themes

Treatment-resistant epilepsy Some epilepsy patients are not responding to the currently available anti-epileptic drugs. We aim to understand the underlying mechanisms and provide clues to novel drug targets.

Alzheimer's disease Alzheimer's disease is a common form of dementia for which no effective treatment exist. We are looking into novel targets in brain energy metabolism.