Albert Jelke Kooistra

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Albert is an associate professor in Data Science for Drug Design (DSDD) at the University of Copenhagen (DK), where he also heads the Pharmaceutical Data Science team and the Data and Computing Facility. His DSDD research group focuses on developing and applying cutting-edge and data-driven technologies to ultimately advance the development of new therapeutics. With expertise in structural bioinformatics, cheminformatics, computer-aided drug discovery & design, research tool/database development and applying machine learning/AI approaches. He is also the founder and developer of KLIFS (https://klifs.net), a structural kinase database that is widely used by >1500 researchers every month for kinase and kinase inhibitor research. In addition, he serves as senior scientific expert at the quantum software company Kvantify.

After a masters in bioinformatics, he obtained his PhD degree in computational medicinal chemistry at the Vrije Universiteit Amsterdam (NL), and subsequently did postdoctoral work in molecular dynamics, structural bioinformatics, and cheminformatics. For his continued work enabling research via scientific databases, he received the 2021 MGMS Frank Blaney award from the Molecular Graphics and Modelling Society.

 

Selected publications

1. Published

   GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources

   Pándy-Szekeres, Gáspár, Caroli, J., Mamyrbekov, A., Kermani, A. A., Keserű, G. M., Kooistra, Albert Jelke & Gloriam, David E., 2023, In: Nucleic Acids Research. 51, D1, p. D395–D402

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Published

   KLIFS: an overhaul after the first 5 years of supporting kinase research

   Kanev, G. K., de Graaf, C., Westerman, B. A., de Esch, I. J. P. & Kooistra, Albert Jelke, 2021, In: Nucleic Acids Research. 49, D1, p. D562-D569

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   Structure of the class D GPCR Ste2 dimer coupled to two G proteins

   Velazhahan, V., Ma, N., Pándy-Szekeres, Gáspár, Kooistra, Albert Jelke, Lee, Y., Gloriam, David E., Vaidehi, N. & Tate, C. G., 2021, In: Nature. 589, p. 148-153 +app 24 pp

   Research output: Contribution to journal › Journal article › Research › peer-review

4. The Landscape of Atypical and Eukaryotic Protein Kinases

   Kanev, G. K., de Graaf, C., de Esch, I. J. P., Leurs, R., Würdinger, T., Westerman, B. A. & Kooistra, Albert Jelke, Nov 2019, In: Trends in Pharmacological Sciences. 40, 11, p. 818-832 15 p.

   Research output: Contribution to journal › Review › Research › peer-review

5. Chemical Diversity in the G Protein-Coupled Receptor Superfamily

   Vass, M., Kooistra, Albert Jelke, Yang, D., Stevens, R. C., Wang, M. W. & de Graaf, C., 1 May 2018, In: Trends in Pharmacological Sciences. 39, 5, p. 494-512 19 p.

   Research output: Contribution to journal › Review › Research › peer-review