Annette Eva Langkilde

Annette Eva Langkilde

Associate Professor


  1. 2023
  2. Published

    Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils

    Skamris, T., Vestergaard, Bente, Madsen, Kenneth Lindegaard, Langkilde, Annette Eva & Foderà, Vito, 2023, In: Methods in molecular biology (Clifton, N.J.). 2551, p. 321-344 24 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching

    Skriver, K., Sjørup, S. A., Langkilde, A. E., Balouka, E., Christensen, C. S., Carbel, K., Decker, J. N. V., Essenbæk, D. N., Gräf, J. F., Jessen, C. H., Kristensen, P., Merrild, C., Mortensen, T. S., Nalepa, I. F., Nordsteen, B. W., Svoren, S. K., van Hall, M., Weicher, J., Wind, M. L., Zhang, D. & 8 others, Saar, Daniel, Blæsild, H., Stahlhut, M., Andersen, K. V., Dagil, Robert, Vestergaard, Bente, Ryberg, Marie L. & Kragelund, Birthe Brandt, 2023, In: The Biophysicist. 4 , 2, p. 1-7 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Monomeric α-synuclein activates the plasma membrane calcium pump

    Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, Estella Anne, Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, Annette Eva, Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, Birthe Brandt, Jensen, P. H. & Nissen, Poul, 2023, In: EMBO Journal. 42, 23, 21 p., e111122.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Protein fibrillation from another small angle—SAXS data analysis of developing systems

    Langkilde, Annette Eva & Vestergaard, Bente, 2023, Methods in Enzymology. Elsevier, Vol. 678. p. 377-409

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  6. Published

    Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons

    Brito dos Santos, Altair, Thaneshwaran, S., Ali, L. K., Leguizamon, Cesar Ramon Romero, Wang, Y., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2023, In: Cell & Bioscience. 13, 1, 16 p., 172.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published
  8. Published

    Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors

    Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, Stig, Tuelung, P. S., Narayanan, Dilip, Langkilde, Annette Eva, Gajhede, Michael, Pagano, P. J., Jaquet, V., Vilhardt, Frederik & Bach, Anders, 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005

    Research output: Contribution to journalJournal articlepeer-review

  9. 2022
  10. Published

    Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

    Brito dos Santos, Altair, Skaanning, L. K., Thaneskwaran, S., Mikkelsen, E., Leguizamon, Cesar Ramon Romero, Skamris, T., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 9 May 2022, Research Square-Preprint, 46 p.

    Research output: Working paperPreprintResearch

  11. Published

    Protein fibrillation from another small angle: Sample preparation and SAXS data collection

    Vestergaard, Bente & Langkilde, Annette Eva, 2022, Methods in Enzymology. Academic Press, Vol. 677. p. 291-321 (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  12. Published

    Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases

    Solomon, M., Foderà, Vito, Langkilde, Annette Eva, Elliott, P., Tagliavini, F., Forsyth, V. T., Klementieva, O. & Bellotti, V., 2022, In: Journal of Translational Medicine. 20, 1, 7 p., 213.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

    Brito dos Santos, Altair, Skaanning, L. K., Thaneshwaran, S., Mikkelsen, E., Romero-Leguizamón, C. R., Skamris, T., Kristensen, M. P., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2022, In: Cellular and Molecular Life Sciences. 79, 8, 450.

    Research output: Contribution to journalJournal articlepeer-review

  14. 2021
  15. Published

    The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme

    Ramos, J., Laux, V., Haertlein, M., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 1 Dec 2021, In: Acta crystallographica Section D: Structural biology . 77, 12, p. 1579-1590 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

    Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

    Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme

    Ramos, J. C. M., Laux, V., Haertlein, M., Boeri Erba, E., McAuley , K., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 2021, In: IUCrJ. 8, 3, 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets

    Sagar, A., Herranz-Trillo, F., Langkilde, Annette Eva, Vestergaard, Bente & Bernadó, P., 2021, In: Structure. 29, 9, p. 1074-1090

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease

    Brito dos Santos, Altair, Skaanning, L. K., Mikkelsen, E., Leguizamon, Cesar Ramon Romero, Kristensen, M. P., Klein, A. B., Thaneshwaran, S. S., Langkilde, Annette Eva & Kohlmeier, Kristi Anne, 2021, In: Journal of Parkinson's Disease. 11, 4, p. 1773-1790

    Research output: Contribution to journalJournal articlepeer-review

  21. 2020
  22. Published

    Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4

    Juul-madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, Annette Eva, Vestergaard, Bente, Howard, K. A., Dehesa-etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-ramos, M. & Vorup-jensen, T., 22 Jan 2020, In: The Journal of Immunology. 204, 5, p. 1345-1361

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

    Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery

    Solbak, Sara Marie Øie, Zang, J., Narayanan, Dilip, Høj, L. J., Bucciarelli, S., Softley, C., Meier, S., Langkilde, Annette Eva, Gotfredsen, C. H., Sattler, M. & Bach, Anders, 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1156-1177

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

    Skaanning, L. K., Santoro, A., Skamris, T., Martinsen, J. H., D’Ursi, A. M., Bucciarelli, S., Vestergaard, Bente, Bugge, K., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: Biomolecules. 10, 8, 23 p., 1192.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    The structural basis of fungal glucuronoyl esterase activity on natural substrates

    Ernst, H. A., Mosbech, C., Langkilde, Annette Eva, Westh, P., Meyer, A. S., Wittrup Agger, J. & Larsen, Sine, 2020, In: Nature Communications. 11, 1026, p. 1-12

    Research output: Contribution to journalJournal articlepeer-review

  27. 2019
  28. Published

    Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

    Cholak, E., Bucciarelli, S., Bugge, K., Johansen, Nicolai Tidemand, Vestergaard, Bente, Arleth, Lise, Kragelund, Birthe Brandt & Langkilde, Annette Eva, Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065

    Research output: Contribution to journalJournal articlepeer-review

  29. 2018
  30. Published

    Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering

    Langkilde, Annette Eva, Herranz-Trillo, F., Bernadó, P. & Vestergaard, Bente, 8 Jun 2018, Amyloid Proteins: methods and protocols. Sigurdsson, E., Calero, M. & Gasset, M. (eds.). Humana Press, Vol. 1779. p. 209-239 31 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  31. Published

    Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

    Seuring, C., Ayyer, K., Filippaki, E., Barthelmess, M., Longchamp, J-N., Ringler, P., Pardini, T., Wojtas, D. H., Coleman, M. A., Dörner, K., Fuglerud, S., Hammarin, G., Habenstein, B., Langkilde, A. E., Loquet, A., Meents, A., Riek, R., Stahlberg, H., Boutet, S., Hunter, M. S. & 7 others, Koglin, J., Liang, M., Ginn, H. M., Millane, R. P., Frank, M., Barty, A. & Chapman, H. N., 9 May 2018, In: Nature Communications. 9, 1, 10 p., 1836.

    Research output: Contribution to journalJournal articlepeer-review

  32. 2016
  33. Published

    Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

    Pedersen, T. S., Tian, X., Thorolfsson, M., Karkov, H. S., Rasmussen, H. B., Langkilde, Annette Eva & Vestergaard, Bente, Mar 2016, In: Pharmaceutical Research. 33, 3, p. 716-28 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. 2015
  35. Published

    Formation of covalent di-tyrosine dimers in recombinant α-synuclein

    van Maarschalkerweerd, A., Pedersen, M., Peterson, H., Nilsson, M., Nguyen, T., Skamris, T., Rand, Kasper Dyrberg, Vetri, V., Langkilde, Annette Eva & Vestergaard, Bente, 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

    Langkilde, Annette Eva, Morris, K. L., Serpell, L. C., Svergun, D. I. & Vestergaard, Bente, Apr 2015, In: Acta crystallographica. Section D, Biological crystallography. 71, Pt 4, p. 882-95 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    In-depth analysis of subclass-specific conformational preferences of IgG antibodies

    Tian, X., Vestergaard, Bente, Thorolfsson, M., Yang, Z., Rasmussen, H. B. & Langkilde, Annette Eva, 1 Jan 2015, In: IUCrJ. 2, 1, p. 9-18 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. 2014
  39. Published

    Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers

    van Maarschalkerweerd, A., Vetri, V., Langkilde, Annette Eva, Foderà, Vito & Vestergaard, Bente, 13 Oct 2014, In: Biomacromolecules. 15, 10, p. 3643-54 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    Small-Angle X-ray Scattering Screening Complements Conventional Biophysical Analysis: Comparative Structural and Biophysical Analysis of Monoclonal Antibodies IgG1, IgG2, and IgG4

    Tian, X., Langkilde, Annette Eva, Thorolfsson, M., Rasmussen, H. B. & Vestergaard, Bente, Jun 2014, In: Journal of Pharmaceutical Sciences. 103, 6, p. 1701-10 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. 2013
  42. Published

    Wildtype and A30P mutant alpha-synuclein form different fibril structures

    Nielsen, S. B., Macchi, F., Raccosta , S., Langkilde, Annette Eva, Giehm, L., Kyrsting, A. H., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L. B., Vestergaard, Bente & Otzen, D., 2013, In: PLOS ONE. 8, 7, e67713.

    Research output: Contribution to journalJournal articlepeer-review

  43. 2012
  44. Published

    Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

    Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering

    Langkilde, Annette Eva & Vestergaard, Bente, 2012, Amyloid proteins: methods and protocols. Sigurdsson, E. M., Calero, M. & Gasset, M. (eds.). 2 ed. New York: Springer Science+Business Media, Vol. 849. p. 137-155 18 p. (Methods in Molecular Biology, Vol. 849).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  46. 2011
  47. Published

    The first lesson in the classroom - getting students engaged in active learning process

    Langkilde, Annette Eva, 2011, Improving University Science Teaching and Learning: Pedagogical Projects 2010. Ulriksen, L., Rump, C. & Hansen, H. W. (eds.). Department of Science Education, University of Copenhagen, Vol. 3. p. 3-17

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  48. 2009
  49. Published

    Methods for structural characterization of prefibrillar intermediates and amyloid fibrils

    Langkilde, Annette Eva & Vestergaard, Bente, 2009, In: FEBS Letters. 583, 16, p. 2600-2609

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Sparing the ortho-position in nucleophilic aromatic substitution-specific displacement of the 4-SePh group in 2,4-bis(phenylseleno)nitrobenzene

    Stuhr-Hansen, N., Götze, T. F., Henriksen, L., Sølling, Theis Ivan, Langkilde, Annette Eva & Sørensen, H. O., 2009, In: Heteroatom Chemistry. 20, 2, p. 101-108

    Research output: Contribution to journalJournal articlepeer-review

  51. 2008
  52. Published
  53. Published

    Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

    Langkilde, Annette Eva, Kristensen, S. M., Lo Leggio, Leila, Mølgaard, A., Jensen, Jan Halborg, Houk, A. R., Poulsen, Jens-Christian Navarro, Larsen, Sine & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

    Research output: Contribution to journalJournal articlepeer-review

  54. 2005
  55. Published

    Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

    Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, Anders, Jacobsen, T. A., Langkilde, Annette Eva, Larsen, Sine, Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. 2004
  57. Published

    Structures of three salts of phthalic acid; variation in crystal packing and geometry of the hydrogen phthalate ion

    Langkilde, Annette Eva, Madsen, D. & Larsen, Sine, 2004, In: Acta Crystallographica. B60, p. 502-511

    Research output: Contribution to journalJournal articlepeer-review

  58. 2002
  59. Published

    Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities

    Langkilde, Annette Eva, Oddershede, J. & Larsen, Sine, 2002, In: Acta Crystallographica B. 58, p. 1044-1050

    Research output: Contribution to journalJournal articlepeer-review

ID: 11736