Department of Drug Design and Pharmacology

Dan Stærk

Head of Department, Visiting professor

Administration and Operations
Jagtvej 160
2100 København Ø
- ds@sund.ku.dk
- https://drug.ku.dk/
Phone: +4535336177Mobile: +4523648836
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- ds@sund.ku.dk
Phone: +4535336177Mobile: +4523648836

ORCID: 0000-0003-0074-298X

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2024
Published
Eremane, viscidane and isozizaene diterpenoids from the leaves of Eremophila rigida and their absolute configurations
Liang, Chao, Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2024, In: Phytochemistry. 219, 16 p., 113972.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme
Zhao, Yong, zpm303, zpm303, Xie, Yuman, Duan, Y. T., Andeadelli, A., Pateraki, Irini, Makris, A. M., Pomorski, Thomas Guenther, Stærk, Dan & Kampranis, Sotirios, 2024, In: Journal of the American Chemical Society. 146, p. 801-810
Research output: Contribution to journal › Journal article › Research › peer-review
2023
Published
Biosynthesis and biotechnological production of the anti-obesity agent celastrol
Zhao, Yong, Hansen, N. L., Duan, Yaotao, Prasad, M., Motawie, Mohammed Saddik, Møller, Birger Lindberg, Pateraki, Irini, Stærk, Dan, Bak, Søren, Miettinen, Karel & Kampranis, Sotirios, 2023, In: Nature Chemistry. 15, p. 1236–1246
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Characterization of serrulatane diterpenoids in Eremophila phyllopoda subsp. phyllopoda by triple high-resolution α-glucosidase/PTP1B/radical scavenging profiling, NMR spectroscopy, DFT-GIAO NMR, and electronic circular dichroism calculations
Liang, Chao, Ndi, C., Kjaerulff, Louise, Semple, S., Buirchell, B., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2023, In: Journal of Natural Products. 86, 4, p. 694–709
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification of new PTP1B-inhibiting decipiene diterpenoid esters from Eremophila clarkei by high-resolution PTP1B inhibition profiling, enzyme kinetics analysis, and molecular docking
Liang, Chao, Zang, J., Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2023, In: Bioorganic Chemistry. 139, 15 p., 106744.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Orthogonal reversed-phase C₁₈ and pentafluorophenyl HPLC separation for phytochemical profiling of serrulatanes in Eremophila denticulata
Zhao, Yong, Li, T., Kjaerulff, Louise, Venter, H., Coriani, S., Møller, Birger Lindberg, Semple, S. & Stærk, Dan, 2023, In: Journal of Natural Products. 86, 12, p. 2638-2650
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Polypharmacology-labeled molecular networking: An analytical technology workflow for accelerated identification of multiple bioactive constituents in complex extracts
Zhao, Yong, Gericke, Oliver, Li, T., Kjaerulff, Louise, Kongstad, Kenneth Thermann, Heskes, A. M., Møller, Birger Lindberg, Jørgensen, Flemming Steen, Venter, H., Coriani, S., Semple, S. J. & Stærk, Dan, 2023, In: Analytical Chemistry. 95, 9, p. 4381-4389 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Semi-synthesis of novel thebaine derivatives with low cytotoxicity and their antibacterial and antihemolytic properties
Hasanpour, Z., Salehi, P., Aliahmadi, A., Hoseinpour, M., Behboodi, H., Stærk, Dan & Bararjanian, M., 2023, In: Medicinal Chemistry Research. 32, p. 1713–1725
Research output: Contribution to journal › Journal article › Research › peer-review
Published
The causal mutation leading to sweetness in modern white lupin cultivars
Mancinotti, Davide, Czepiel, K., Taylor, J. L., Galehshahi, H. G., Møller, L. A., Jensen, M. K., Motawie, Mohammed Saddik, Hufnagel, B., Soriano, A., Yeheyis, L., Kjaerulff, Louise, Péret, B., Stærk, Dan, Wendt, T., Nelson, M. N., Kroc, M. & Geu-Flores, Fernando, 2023, In: Science Advances. 9, 31, 10 p., eadg8866.
Research output: Contribution to journal › Journal article › Research › peer-review
2022
Published
Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide
Hansen, N. L., Kjaerulff, Louise, Heck, Q. K., Forman, Victor, Stærk, Dan, Møller, Birger Lindberg & Andersen-Ranberg, Johan, 2022, In: Nature Communications. 13, 5011.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination
Miettinen, Karel, Leelahakorn, Nattawat, Almeida Robles, A. R., Zhao, Yong, Hansen, L. R., Nikolajsen, I. E., Andersen, Jens Bo, Givskov, Michael, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 3664.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A gene cluster in Ginkgo biloba encodes unique multifunctional cytochrome P450s that initiate ginkgolide biosynthesis
Forman, Victor, Luo, Dan, Geu-Flores, Fernando, Lemcke, René, Nelson, D., Kampranis, Sotirios, Stærk, Dan, Møller, Birger Lindberg & Pateraki, Irini, 2022, In: Nature Communications. 13, 14 p., 5143.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method
Nordin, E., Steffensen, S. K., Laursen, B. B., Andersson, S., Johansson, J., Åman, P., Hallmans, G., Borre, M., Stærk, Dan, Hanhineva, K., Fomsgaard, I. S. & Landberg, R., 2022, In: Scientific Reports. 12, 14 p., 5260.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Ancient biosynthesis in an oil crop: Glucosinulate profiles in Limnanthes alba and its relatives (Limnanthaceae, Brassicales)
Agerbirk, Niels, Pattison, David, Mandáková, T., Lysak, M. A., Montaut, S. & Stærk, Dan, 2022, In: Journal of Agricultural and Food Chemistry. 70, p. 1134-1147
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas
Semple, S., Stærk, Dan, Buirchell, B., Fowler, R., Gericke, Oliver, Kjaerulff, Louise, Zhao, Yong, Pedersen, H. A., Petersen, M. J., Rasmussen, L. F., Bredahl, E. K., Pedersen, Gustav Blichfeldt, McNair, Laura M., Ndi, C., Hansen, N. L., Heskes, A., Bayly, M., Loland, Claus Juul, Heinz, Nanna & Møller, Birger Lindberg, 2022, In: Plant Journal. 111, 4, p. 936-953 15866.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Data-dependent acquisition-mass spectrometry guided isolation of new benzoxazinoids from the roots of Acanthus mollis L.
Bhattarai, B., Steffensen, S. K., Stærk, Dan, Laursen, B. B. & Fomsgaard, I. S., 2022, In: International Journal of Mass Spectrometry. 474, 10 p., 116815.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks
Ignea, C., Raadam, Morten Hessellund, Koutsaviti, A., Zhao, Yong, Duan, Yaotao, Harizani, M., Miettinen, Karel, Georgantea, P., Rosenfeldt, M., Viejo-Ledesma, S. E., Petersen, Mikael Agerlin, Bredie, Wender, Stærk, Dan, Roussis, V., Ioannou, E. & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 5188.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Fremtidens bæredygtige medicin fra naturen: Nye teknologier hjælper med at finde nålen i høstakken
Stærk, Dan, 2022, In: Pharma. 2022, 2, p. 20-22
Research output: Contribution to journal › Contribution to newspaper - Newspaper article › Communication
Published
Investigation of the mechanism and chemistry underlying Staphylococcus aureus' ability to inhibit Pseudomonas aeruginosa growth in vitro
Kvich, Lasse Andersson, Crone, S. G., Christensen, M. H., Lima, R. D. C. L., Alhede, M., Alhede, M., Stærk, Dan & Bjarnsholt, Thomas, 2022, In: Journal of Bacteriology. 204, 11, 16 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Isolation and structure elucidation of caryophyllane sesquiterpenoids from leaves of Eremophila spathulata
Bredahl, E. K., Kjaerulff, Louise, Ndi, C., Semple, S., Buirchell, B., Møller, Birger Lindberg & Stærk, Dan, 2022, In: Phytochemistry Letters. 47, p. 156-163
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads
Petersen, M. J., Liang, Chao, Kjaerulff, Louise, Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2022, In: Phytochemistry. 196, 11 p., 113072.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Serrulatane diterpenoids with unusual side chain modifications from root bark of Eremophila longifolia
Rasmussen, L. F., Anton, Jennifer, Kjaerulff, Louise, Zhao, Yong, Semple, S. J., Ndi, C., Buirchell, B., Møller, Birger Lindberg & Stærk, Dan, 2022, In: Phytochemistry. 203, 14 p., 113408.
Research output: Contribution to journal › Journal article › Research › peer-review
2021
Published
Insects as sources for sustainable peptide drugs against type 2 diabetes
Didriksen, A. H., Petersen, M. J. & Stærk, Dan, 8 Jun 2021. 1 p.
Research output: Contribution to conference › Poster › Research
Published
α-Glucosidase inhibitory activity of plant extracts from the Danish Medicinal Plant Biobank
Madsen, A. T., Soelberg, Jens & Stærk, Dan, 8 Jun 2021. 1 p.
Research output: Contribution to conference › Poster › Research
Published
A systematic review of possible interactions for herbal medicines and dietary supplements used concomitantly with disease-modifying or symptom-alleviating multiple sclerosis drugs
Petersen, M. J., Bergien, Sofie Olsgaard & Stærk, Dan, 2021, In: Phytotherapy Research. 35, 7, p. 3610-3631
Research output: Contribution to journal › Journal article › Research › peer-review
Published
An independent evolutionary origin for insect deterrent cucurbitacins in Iberis amara
Dong, L., Almeida Robles, A. R., Pollier, J., Khakimov, Bekzod, Bassard, J. A., Miettinen, K., Stærk, Dan, Mehran, R., Olsen, C. E., Motawie, Mohammed Saddik, Goossens, A. & Bak, Søren, 2021, In: Molecular Biology and Evolution. 38, 11, p. 4659-4673 15 p., msab213.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Characterization of antidiabetic serrulatane diterpenoids from Eremophila phyllopoda by triple high-resolution α-glucosidase / PTP1B / radical scavenging profiling
Liang, Chao, Ndi, C., Semple, S., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2021. 1 p.
Research output: Contribution to conference › Poster › Research
Published
Coupling microplate-based antibacterial assay with liquid chromatography for high-resolution growth inhibition profiling of crude extracts: Validation and proof-of-concept study with Staphylococcus aureus
Ardalani, H., Anam, S., Kromphardt, K. J. K., Stærk, Dan & Kongstad, Kenneth Thermann, 2021, In: Molecules. 26, 6, 12 p., 1550.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Dual high-resolution α-glucosidase and PTP1B profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic chromene meroterpenoids in Rhododendron capitatum
Liang, Chao, Kjaerulff, Louise, Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 2021, In: Journal of Natural Products. 84, p. 2454-2467
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Furolabdane diterpenoids from Pseudodictamnus aucheri (Boiss.) Salmaki & Siadati (Lamiaceae) as chemophenetic markers
Sadani, S., Sarrafi, Y. & Stærk, Dan, 2021, In: Biochemical Systematics and Ecology. 98, 4 p., 104304.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Isolation and structure elucidation of serrulatane diterpenoids from the roots of Eremophila longifolia
Rasmussen, L. F., Anton, J., Kjaerulff, Louise & Stærk, Dan, 2021, p. 1.
Research output: Contribution to conference › Poster › Research
Published
Jagten på bioaktive naturstoffer: Sammenkoblet HPLC-PDA-HRMS-SPE-NMR til hurtig identifikation af bioaktive naturstoffer i komplekse blandinger
Stærk, Dan, 2021, In: Dansk Kemi. 102, 4, p. 40-44
Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
Published
Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila
Gericke, Oliver, Fowler, R., Heskes, A., Bayly, M., Semple, S., Ndi, C. P., Stærk, Dan, Loland, Claus Juul, Murphy, D. J., Buirchell, B. & Møller, Birger Lindberg, 2021, In: Plant Journal. 108, 2, p. 555-578
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Phytochemical investigation of Eremophila spp.
Bredahl, E. K., Ergin, Y., Kjaerulff, Louise & Stærk, Dan, 2021, p. 1.
Research output: Contribution to conference › Poster › Research
Published
Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock
Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, Henrik, Gajhede, Michael, Kongstad, Kenneth Thermann, Stenvang, Jan & Stærk, Dan, 2021, In: Biomolecules. 11, 10, 19 p., 1534.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Semi-synthesis of novel buprenorphine derivatives and their anti-nociceptive properties and dependency potential
Hasanpour, Z., Salehi, P., Bunch, Lennart, Khoramjouy, M., Bararjanian, M., Stærk, Dan & Faizi, M., 2021, In: Canadian Journal of Chemistry. 99, 11, p. 910-919
Research output: Contribution to journal › Journal article › Research › peer-review
2020
Published
Evaluation of the antidiabetic potential of Psidium guajava L. (Myrtaceae) using assays for α-glucosidase, α-amylase, muscle glucose uptake, liver glucose production and triglyceride accumulation in adipocytes
Beidokhti, M. N., Eid, H. M., Villavicencio, M. L. S., Jäger, A. K., Lobbens, E. S., Rasoanaivo, P. R., McNair, Laura M., Haddad, P. S. & Stærk, Dan, 17 Apr 2020, In: Journal of Ethnopharmacology. 257, 8 p., 112877.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Structure elucidation of prenyl- and geranyl substituted coumarins in Gerbera piloselloides by NMR spectroscopy, electronic circular dichroism calculations, and single crystal X-ray crystallography
Li, T., Ma, X., Fedotov, D., Kjaerulff, Louise, Frydenvang, Karla Andrea, Coriani, S., Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 8 Apr 2020, In: Molecules. 25, 25 p., 1706.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
PTP1B-inhibiting branched-chain fatty acid dimers from Eremophila oppositifolia subsp. angustifolia identified by high-resolution PTP1B inhibition profiling and HPLC-PDA-HRMS-SPE-NMR analysis
Pedersen, H. A., Ndi, C., Semple, S. J., Buirchell, B., Møller, Birger Lindberg & Stærk, Dan, 7 Apr 2020, In: Journal of Natural Products. 83, p. 1598-1610
Research output: Contribution to journal › Journal article › Research › peer-review
Published
4-Benzyloxylonchocarpin and muracatanes A-C from Ranunculus muricatus L. and their biological effects
Hussain, H., Ali, I., Wang, D., Mamadalieva, N. Z., Hussain, W., Csuk, R., Loesche, A., Fischer, L., Stærk, Dan, Anam, S., AlZain, M. N., Mushtaq, M., Ul-Haq, Z., Ullah, R., Noman, O. M., Abbas, G. & Green, I. R., 2020, In: Biomolecules. 10, 11, 15 p., 1562.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens
Malik, A., Ardalani, H., Anam, S., McNair, Laura M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, Henrik, Stærk, Dan & Kongstad, Kenneth Thermann, 2020, In: Fitoterapia. 142, 8 p., 104522.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification of Amaryllidaceae alkaloids in larvae of the ‘lily borer’ moth Brithys crini
Nair, J. J., Andresen, A. L., Papenfus, H., Stærk, Dan & van Staden, J., 2020, In: South African Journal of Botany. 131, p. 351-359
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol
Hansen, N. L., Miettinen, Karel, Zhao, Yong, Ignea, C., Andreadeli, A., Raadam, Morten Hessellund, Makris, A. M., Møller, Birger Lindberg, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2020, In: Microbial Cell Factories. 19, 17 p., 15.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Isolation, structure elucidation and PTP1B inhibitory activity of serrulatane diterpenoids from the roots of Myoporum insulare
Kjaerulff, Louise, Jensen, A. B. J., Ndi, C., Semple, S. J., Møller, Birger Lindberg & Stærk, Dan, 2020, In: Phytochemistry Letters. 39, p. 49-56
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Nerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species
Gericke, Oliver, Hansen, N. L., Pedersen, G. B., Kjaerulff, Louise, Luo, Dan, Stærk, Dan, Møller, Birger Lindberg, Pateraki, Irini & Heskes, A., 2020, In: B M C Plant Biology. 20, 15 p., 91.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives
Liang, Chao, Stærk, Dan & Kongstad, Kenneth Thermann, 2020, In: Journal of Functional Foods. 64, 10 p., 103623.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Structure elucidation and absolute configuration determination of nortriterpenoids from Picramnia glazioviana
Gimenes, L., Luna-Dulcey, L., Batista Junior, J. M., dos Santos Junior, F. M., Popolin, C. P., Cominetti, M. R., Fernandes, J. B. & Stærk, Dan, 2020, In: Journal of Natural Products. 83, p. 1859-1876
Research output: Contribution to journal › Journal article › Research › peer-review
2019
Published
High resolution techniques: General discussion
Adair, E., Afonso, C., Bell, N. G. A., Davies, A. N., Delsuc, M. A., Godfrey, R., Goodacre, R., Hawkes, J. A., Hertkorn, N., Jones, D., Lameiras, P., Le Guennec, A., Lubben, A., Nilsson, M., Paša-Tolić, L., Richards, J., Rodgers, R. P., Rüger, C. P., Schmitt-Kopplin, P., Schoenmakers, P. J. & 8 others, Sidebottom, P., Stærk, Dan, Summerfield, S., Uhrín, D., Van Delft, P., Van Der Hooft, J. J. J., Van Zelst, F. H. M. & Zherebker, A., 1 Jan 2019, In: Faraday Discussions. 218, p. 247-267 21 p.
Research output: Contribution to journal › Comment/debate › Research › peer-review
Published
2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity
Zhao, Yong, Kjaerulff, Louise, Kongstad, Kenneth Thermann, Heskes, A. M., Møller, Birger Lindberg & Stærk, Dan, 2019, In: Phytochemistry. 166, p. 1-8 112054.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
¹⁹F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by ¹⁹F NMR
Christensen, M. V., Kongstad, Kenneth Thermann, Sondergaard, T. E., Stærk, Dan, Nielsen, Hanne Mørck, Franzyk, Henrik & Wimmer, R., 2019, In: Journal of Biomolecular N M R. 73, p. 167-182
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis.
Chu, C., Li, T., Pedersen, H. A., Kongstad, Kenneth Thermann, Yan, J. & Stærk, Dan, 2019, In: Phytochemistry Letters. 31, p. 47-52
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia L.
Ernst, M., Nothias, L., van der Hooft, J. J. J., da Silva, R. R., Saslis-Lagoudakis, C. H., Grace, O. M., Martinez-Swatson, K. A., Hassemer, G., Funez, L. A., Simonsen, H. T., Medema, M. H., Stærk, Dan, Nilsson, N., Lovato, P., Dorrestein, P. C. & Rønsted, Nina, 2019, In: Frontiers in Plant Science. 10, 15 p., 846.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Combined magnetic ligand fishing and high-resolution inhibition profiling for identification of α-glucosidase inhibitory ligands: A new screening approach based on complementary inhibition and affinity profiles.
Wubshet, S. G., Liu, B., Kongstad, Kenneth Thermann, Böcker, U., Petersen, M. J., Li, T., Wang, J. & Stærk, Dan, 2019, In: Talanta. 200, p. 279-287
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Detection of Seasonal Variation in Aloe Polysaccharides Using Carbohydrate Detecting Microarrays
Isager Ahl, Louise, Al-Husseini, N., Al-Helle, S., Stærk, Dan, Grace, O. M., Willats, W. G. T., Mravec, Jozef, Jørgensen, Bodil & Rønsted, Nina, 2019, In: Frontiers in Plant Science. 10, p. 1-14 512.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.
Papathanasiou, T., Springborg, A., Kongstad, Kenneth Thermann, Stærk, Dan, Møller, Kirsten, Taylor, B. K., Lund, Trine Meldgaard & Werner, M. U., 2019, In: British Journal of Anaesthesia. 123, 2, p. e204-e214
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification of α-glucosidase inhibitors in Machilus litseifolia by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-PDA-HRMS-SPE-NMR
Li, T., Kongstad, Kenneth Thermann & Stærk, Dan, 2019, In: Journal of Natural Products. 82, p. 249-258
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Immobilized α-amylase magnetic beads for ligand fishing: Proof of concept and identification of α-amylase inhibitors in Ginkgo biloba
Petersen, M. J., Lima, R. D. C. L., Kjaerulff, Louise & Stærk, Dan, 2019, In: Phytochemistry. 164, p. 94-101
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin
Zaharudin, N. B., Stærk, Dan & Dragsted, Lars Ove, 2019, In: Food Chemistry. 270, p. 481-486 6 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Peptides from chicken processing by-product inhibit DPP-IV and promote cellular glucose uptake: potential ingredients for T2D management
Lima, R. D. C. L., Berg, R. S., Rønning, S. B., Afseth, N. K., Knutsen, S. H., Stærk, Dan & Wubshet, S. G., 2019, In: Food & Function. 10, p. 1619-1628
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana
Gimenes, L., Batista Junior, J. M., dos Santos Junior, F. M., Souza, M. D. S., Luna-Dulcey, L., Ellena, J., Cominetti, M. R., da Silva, M. F. D. G. F., Vieira, P. C., Fernandes, J. B. & Stærk, Dan, 2019, In: Phytochemistry. 163, p. 38-45
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Potential of Sorbus berry extracts for management of type 2 diabetes: metabolomics investigation of ¹H NMR spectra, α-amylase and α-glucosidase inhibitory activities, and in vivo anti-hyperglycaemic activity of S. norvegica
Broholm, S. L., Gramsbergen, S., Nyberg, N., Jäger, A. K. & Stærk, Dan, 2019, In: Journal of Ethnopharmacology. 242, 10 p., 112061.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Simultaneous quantification of high-dose naloxone and naloxone-3-β-D-glucuronide in human plasma by UHPLC-MS/MS
Kongstad, Kenneth Thermann, Papathanasiou, T., Springborg, A., Lund, Trine Meldgaard, Werner, M. U. & Stærk, Dan, 2019, In: Bioanalysis. 11, 03, p. 165-173
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Unraveling the complexity of complex mixtures by combining high-resolution pharmacological, analytical and spectroscopic techniques: Antidiabetic constituents in Chinese medicinal plants
Zhao, Yong, Kongstad, Kenneth Thermann, Liu, Y., He, C. & Stærk, Dan, 2019, In: Faraday Discussions. 218, p. 202-218
Research output: Contribution to journal › Journal article › Research › peer-review
2018
Published
Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Investigation of medicinal plants from Madagascar against DPP-IV linked to type 2 diabetes
Beidokhti, M. N., Lobbens, E. S. B., Rasoavaivo, P., Jäger, A. K. & Stærk, Dan, Mar 2018, In: South African Journal of Botany. 115, p. 113-119
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Athenolide A, a new steroidal lactone from the leaves of Athenaea martiana (Solanacea) determined by means of HPLC-HRMS-SPE-NMR analysis
Silva, E. L., Almeida-Lafetá, R. C., Borges, R. M. & Stærk, Dan, Jan 2018, In: Chemistry & Biodiversity. 15, 1, 8 p., e1700455.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus
Heskes, A., Sundram, T. C. M., Boughton, B. A., Bjerg Jensen, N., Hansen, N. L., Crocoll, C., Cozzi, F., Rasmussen, Simon, Hamberger, B., Hamberger, B. R., Stærk, Dan, Møller, Birger Lindberg & Pateraki, Irini, 2018, In: Plant Journal. 93, p. 943-958 16 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Brazilian insulin plant as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antidiabetic compounds in Myrcia rubella Cambess
Lima, R. D. C. L., Kato, L., Kongstad, Kenneth Thermann & Stærk, Dan, 2018, In: Journal of Functional Foods. 45, p. 444-451
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2018.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans
Frandsen, R. J. N., Khorsand-Jamal, P., Kongstad, Kenneth Thermann, Nafisi, M., Kannangara, R. M., Stærk, Dan, Okkels, F. T., Binderup, K., Madsen, B., Møller, Birger Lindberg, Thrane, U. & Mortensen, U. H., 2018, In: Scientific Reports. 8, p. 1-10 10 p., 12853.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans
Lima, R. D. C. L., Kongstad, Kenneth Thermann, Kato, L., José das Silva, M., Franzyk, Henrik & Stærk, Dan, 2018, In: Molecules. 23, 7, 13 p., 1755.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures
McNair, Laura M., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Jäger, A. K., Franzyk, Henrik & Stærk, Dan, 2018, In: F E M S Yeast Research. 18, 9 p., foy094.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
On the biosynthetic origin of carminic acid
Rasmussen, S. A., Kongstad, Kenneth Thermann, Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F. T., Gotfredsen, C. H., Stærk, Dan, Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In: Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Quadruple high-resolution α-glucosidase/α-amylase/PTP1B/radical scavenging profiling combined with high-performance liquid chromatography – high-resolution mass spectrometry – solid-phase extraction – nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude root bark of Morus alba L.
Zhao, Yong, Kongstad, Kenneth Thermann, Jäger, A. K., Nielsen, J. & Stærk, Dan, 2018, In: Journal of Chromatography A. 1556, p. 55-63
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Recreational drug use at a major music festival: trend analysis of anonymised pooled urine
Hoegberg, L., Christiansen, C., Søe, J. L., Telving, R., Andreasen, M. F., Stærk, Dan, Christrup, Lona Louring & Kongstad, Kenneth Thermann, 2018, In: Clinical Toxicology. 56, p. 245-255 1360496.
Research output: Contribution to journal › Journal article › Research › peer-review
2017
Published
Advancing HPLC-PDA-HRMS-SPE-NMR analysis of coumarins in Coleonema album by use of orthogonal reversed-phase C₁₈ and pentafluorophenyl separations
Lima, R. D. C. L., Gramsbergen, S., Van Staden, J., Jäger, A. K., Kongstad, Kenneth Thermann & Stærk, Dan, 2017, In: Journal of Natural Products. 80, 4, p. 1020-1027
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa
Kannangara, R. M., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, Kenneth Thermann, Stærk, Dan, Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, Birger Lindberg, 2017, In: Nature Communications. 8, 12 p., 1987.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Characterization of antileishmanial compounds from Lawsonia inermis leaves using semi-high resolution antileishmanial profiling combined with HPLC-HRMS-SPE-NMR
Iqbal, K., Iqbal, J., Stærk, Dan & Kongstad, Kenneth Thermann, 2017, In: Frontiers in Pharmacology. 8, 7 p., 337.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Dual high-resolution inhibition profiling and HPLC-HRMS-SPE-NMR analysis for identification of α-glucosidase and radical scavenging inhibitors in Solanum americanum Mill.
Silva, E. L. E., Almeida-Lafetá, R. C., Borges, R. M. & Stærk, Dan, 2017, In: Fitoterapia. 118, p. 42-48
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Facilitated visual interpretation of scores in principal component analysis by bioactivity-labeling of ¹H NMR spectra - metabolomics investigation and identification of a new α-glucosidase inhibitor in Radix Astragali
Liu, Y., Nyberg, N., Jäger, A. K. & Stærk, Dan, 2017, In: Molecules. 22, 3, 12 p., 411.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2017, In: B B A - Biomembranes. 1859, 12, p. 2483-2494
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Vietnamese plants
Trinh, T. D. B., Jäger, A. K. & Stærk, Dan, 2017, In: Molecules. 22, 7, 12 p., 1228.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Investigation of antidiabetic potential of Phyllanthus niruri L. using assays for α-glucosidase, muscle glucose transport, liver glucose production, and adipogenesis
Beidokhti, M. N., Andersen, M. V., Eid, H. M., Villavicencio, M. L. S., Stærk, Dan, Haddad, P. S. & Jäger, A. K., 2017, In: Biochemical and Biophysical Research Communications. 493, 1, p. 869-874
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Isolation and structure elucidation of cyclopeptide alkaloids from Ziziphus nummularia and Ziziphus spina-christi by HPLC-DAD-MS and HPLC-PDA-HRMS-SPE-NMR
Tuenter, E., Foubert, K., Stærk, Dan, Apers, S. & Pieters, L., 2017, In: Phytochemistry. 138, p. 163-169
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Potential of Polygonum cuspidatum root as an antidiabetic food: Dual high-resolution α-glucosidase and PTP1B inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic constituents
Zhao, Yong, Chen, M. X., Kongstad, Kenneth Thermann, Jäger, A. K. & Stærk, Dan, 2017, In: Journal of Agricultural and Food Chemistry. 65, p. 4421-4427
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Synthesis of C-glucosylated octaketide anthraquinones in Nicotiana benthamiana using a multispecies-based biosynthetic pathway
Andersen-Ranberg, Johan, Kongstad, Kenneth Thermann, Nafisi, M., Stærk, Dan, Okkels, F. T., Mortensen, U. H., Møller, Birger Lindberg, Frandsen, R. J. N. & Kannangara, R. M., 2017, In: ChemBioChem. 18, 19, p. 1893-1897 5 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii
Pateraki, Irini, Andersen-Ranberg, Johan, Jensen, N. B., Wubshet, S. G., Heskes, A. M., Forman, Victor, Hallström, B., Hamberger, B., Motawie, Mohammed Saddik, Olsen, C. E., Stærk, Dan, Hansen, J., Møller, Birger Lindberg & Hamberger, B. R., 2017, In: eLife. 6, 28 p., e23001.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity
Trinh, T. D. B., Quach, T. T. T., Bui, D. N., Stærk, Dan, Nguyen, L. D. & Jäger, A. K., 2017, In: Fitoterapia. 118, p. 126-131
Research output: Contribution to journal › Journal article › Research › peer-review
2016
Published
Accelerating drug lead discovery from nature by high-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR
Kongstad, Kenneth Thermann, Nyberg, N. T., Wubshet, S. G. & Stærk, Dan, Dec 2016, In: Planta Medica. 81, S 01
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
Assessment of the antidiabetic potential of selected medicinal plants using in vitro bioassays of muscle glucose transport and liver glucose production
Beidokhti, M. N., Sanchez Villavicencio, M. L., Eid, H. M., Stærk, Dan, Jäger, A. K. & Haddad, P. S., Dec 2016, In: Planta Medica. 81, S 01
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
HPLC-HRMS-SPE-NMR combined with high resolution in vitro screening for natural fungicides
Kongstad, Kenneth Thermann, Wubshet, S. G., Kjellerup, L., Winther, A. & Stærk, Dan, Dec 2016, In: Planta Medica. 82, S 01
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
HPLC-HRMS-SPE-NMR for accelerated identification of compounds in complex plant extracts: New coumarine derivatives from Coleonema album (Thunb.) Bartl. & Wendl
de Cássia Lemos Lima, R., Gramsbergen, S. M., Van Staden, J., Jäger, A. K., Kongstad, Kenneth Thermann & Stærk, Dan, Dec 2016, In: Planta Medica. 82, S 01
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
High-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-diabetic compounds in Eremanthus crotonoides (Asteraceae)
Silva, E. L., Lobo, J., Vinther, J. M., Borges, R. M. & Stærk, Dan, Dec 2016, In: Planta Medica. 82, S 01
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
Ligand-fishing and bioactivity-correlated metabolomics for accelerated discovery of antidiabetic drug leads
Nyberg, N. T., Wubshet, S. G., Kongstad, Kenneth Thermann & Stærk, Dan, Dec 2016, In: Planta Medica. 82, S 01
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
Screening selected Vietnamese plants used to treat diabetes for PTP1B inhibitory activity
Trinh, T. D. B., Stærk, Dan & Jäger, A. K., Dec 2016, In: Planta Medica. 81, S 01, p. 1 1 p.
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
The α-glucosidase and PTP1B inhibitory effect of 45 medicinal plants extracts
Liu, B., Kongstad, Kenneth Thermann, Jäger, A. K. & Stærk, Dan, Dec 2016, In: Planta Medica. 81, S 01, p. 1 1 p.
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
α-Glucosidase inhibitors from Phyllanthus amarus and Phyllanthus urinaria
Trinh, T. D. B., Stærk, Dan & Jäger, A. K., Dec 2016, In: Planta Medica. 81, S 01, p. 1 1 p.
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
Hemolymph metabolites and osmolality are tightly linked to cold tolerance of Drosophila species: a comparative study
Olsson, T., MacMillan, H. A., Nyberg, N., Stærk, Dan, Malmendal, A. & Overgaard, J., 15 Aug 2016, In: The Journal of Experimental Biology. 219, 16, p. 2504-2513 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Edible seaweed as future functional food: Identification of α-glucosidase inhibitors by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR
Liu, B., Kongstad, Kenneth Thermann, Wiese, S., Jäger, A. K. & Stærk, Dan, 2016, In: Food Chemistry. 203, p. 16-22 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis
Andersen-Ranberg, Johan, Kongstad, Kenneth Thermann, Nielsen, M. T., Bjerg Jensen, N., Pateraki, Irini, Bach, S. S., Hamberger, B., Zerbe, P., Stærk, Dan, Bohlmann, J., Møller, Birger Lindberg & Hamberger, B. R., 2016, In: Angewandte Chemie International Edition. 55, 6, p. 2142-2146 5 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
HPLC-SPE-NMR for combinatorial biosynthetic investigations – expanding the landscape of diterpene structural diversity
Kongstad, Kenneth Thermann, Andersen-Ranberg, Johan, Hamberger, B. R. & Stærk, Dan, 2016. 1 p.
Research output: Contribution to conference › Poster › Research
Published
High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy: Proof-of-concept and antidiabetic constituents in crude extract of Eremophila lucida
Tahtah, Y., Wubshet, S. G., Kongstad, Kenneth Thermann, Heskes, A. M., Pateraki, Irini, Møller, Birger Lindberg, Jäger, A. & Stærk, Dan, 2016, In: Fitoterapia. 110, p. 52-58 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-diabetic compounds in Eremanthus crotonoides (Asteraceae)
Lana e Silva, E., Felipe Revoredo Lobo, J., Vinther, J. M., Moreira Borges, R. & Stærk, Dan, 2016, In: Molecules. 21, 6, 19 p., 782.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification of PTP1B and α-glucosidase inhibitory serrulatanes from Eremophila spp. by combined use of dual high-resolution PTP1B and α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR
Wubshet, S. G., Tahtah, Y., Heskes, A. M., Kongstad, Kenneth Thermann, Pateraki, Irini, Hamberger, B. R., Møller, Birger Lindberg & Stærk, Dan, 2016, In: Journal of Natural Products. 79, 4, p. 1063-1072 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Molecular phylogenetics as a predictive tool in plant-based drug discovery in the genus Euphorbia L.
Ernst, M., Saslis Lagoudakis, H., Grace, O. M., Nilsson, N., Simonsen, H. T., Horn, J. W., Stærk, Dan & Rønsted, Nina, 2016, In: Planta Medica. 82, S 01
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
Oxidation and cyclization of Casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L
Luo, Dan, Callari, R., Hamberger, B., Wubshet, S. G., Nielsen, M. T., Andersen-Ranberg, Johan, Hallström, B. M., Cozzi, F., Heider, H., Møller, Birger Lindberg, Stærk, Dan & Hamberger, B. R., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 34, p. E5082-E5089 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Screening for potential α-glucosidase and α-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes
Trinh, T. D. B., Stærk, Dan & Jäger, A. K., 2016, In: Journal of Ethnopharmacology. 186, p. 189-195 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Spektroskopi – Strukturopklaring vha NMR og IR: Kompendium med forelæsningsslides, tabeller og opgavesamling til en undervisningsdag i spektroskopi ved Institut for Lægemiddeldesign og Farmakologi på Det Sundhedsvidenskabelige Fakultet, Københavns Universitet.
Stærk, Dan, 2016, 74 p.
Research output: Book/Report › Compendium/lecture notes › Education
2015
Published
High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Clausena excavata
Liu, Y., Stærk, Dan, Nyberg, N. & Jager, A. K., Nov 2015, In: Planta Medica. 81, 16, p. 1432-1432
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
High-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of bioactive constituents in crude extract of Pueraria lobata
Liu, B., Kongstad, Kenneth Thermann, Nyberg, N. T., Sun, Q., Jager, A. K. & Stærk, Dan, Nov 2015, In: Planta Medica. 81, 16, p. 1437-1437
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Published
High-resolution assays combined with HPLC for identification of antidiabetic constituents in Vietnamese plants
Trinh, T. D. B., Stærk, Dan & Jäger, A. K., 26 Aug 2015.
Research output: Contribution to conference › Poster › Research
Published
High-resolution snake venom inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antivenomous constituents in Clausena excavata
Liu, Y., Nyberg, N., Stærk, Dan & Jäger, A. K., 26 Aug 2015.
Research output: Contribution to conference › Poster › Research
Published
High-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of bioactive constituents in crude extract of Pueraria lobata
Liu, B., Kongstad, Kenneth Thermann, Nyberg, N., Qinglei, S., Jäger, A. K. & Stærk, Dan, 26 Aug 2015.
Research output: Contribution to conference › Poster › Research
Published
Inhibitory potential of 40 medicinal plant extracts from Madagascar against enzymes linked to type 2 diabetes
Beidokhti, M. N., Lobbens, E. S., Rasoavaivo, P., Stærk, Dan & Jäger, A. K., 26 Aug 2015.
Research output: Contribution to conference › Poster › Research
Published
NMR-based metabolomics and hyphenated NMR techniques – a perfect match in natural products research
Vinther, J. M., Wubshet, S. G. & Stærk, Dan, Aug 2015, Ethnopharmacology - a Reader. Heinrich, M. & Jäger, A. K. (eds.). Chichester: Wiley, p. 63-74
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Published
Fungal plasma membrane H⁺-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv
Kongstad, Kenneth Thermann, Wubshet, S. G., Kjellerup, L., winther, A. L. & Stærk, Dan, 20 Jun 2015, In: Fitoterapia. 105, p. 102-106 5 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Dual High-Resolution α-Glucosidase and Radical Scavenging Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of Minor and Major Constituents Directly from the Crude Extract of Pueraria lobata
Liu, B., Kongstad, Kenneth Thermann, Qinglei, S., Nyberg, N., Jäger, A. & Stærk, Dan, 13 Feb 2015, In: Journal of Natural Products. 78, 2, p. 294–300 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR for investigation of antidiabetic principles in crude plant extracts
Kongstad, Kenneth Thermann, Özdemir, C., Barzak, A., Wubshet, S. G. & Stærk, Dan, 5 Feb 2015, In: Journal of Agricultural and Food Chemistry. 63, 8, p. 2257-2263 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR: accelerated identification of bioactive constituents in food and medicinal plants
Stærk, Dan, 2015.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
High-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR: α-glucosidase inhibitors and acetylated ellagic acid rhamnosides from Myrcia palustris DC. (Myrtaceae)
Wubshet, S. G., Moresco, H. H., Tahtah, Y., Brighente, I. M. C. & Stærk, Dan, 2015, In: Phytochemistry. 116, p. 246-252 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Chinese plants used to treat snakebite
Liu, Y., Stærk, Dan, Nielsen, M. N., Nyberg, N. & Jäger, A. K., 2015, In: Phytochemistry. 119, p. 62-69 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution snake venom inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antivenomous constituents in Clausena excavata
Liu, Y., Nyberg, N., Stærk, Dan & Jäger, A., 2015.
Research output: Contribution to conference › Poster › Research
Published
High-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of bioactive constituents in crude extract of Pueraria lobata
Liu, B., Kongstad, Kenneth Thermann, Nyberg, N., Qinglei, S., Jäger, A. & Stærk, Dan, 2015.
Research output: Contribution to conference › Poster › Research
Published
Identification of Fungal Plasma Membrane H⁺-ATPase Inhibitors in Lecaniodiscus cupanioides by HPLC-HRMS-SPE-NMR
Straadt, I. K., Kongstad, Kenneth Thermann & Stærk, Dan, 2015.
Research output: Contribution to conference › Poster › Research
Published
Intact penetratin metabolite permeates across Caco-2 monolayers
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2015.
Research output: Contribution to conference › Poster › Research
Published
Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites
Schmidt, M. M., Stærk, Dan, Nielsen, Hanne Mørck, Brandner, J. M., Diallo, D., Kusamba Zacharie, C., Van Staden, J. & Jäger, A., 2015, In: Journal of Ethnopharmacology. 165, p. 1-8
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Magnetic ligand fishing as a targeting tool for HPLC-HRMS-SPE-NMR: α-glucosidase inhibitory ligands and alkylresorcinol glycosides from Eugenia catharinae.
Wubshet, S. G., Brighente, I. M. C., Moaddel, R. & Stærk, Dan, 2015, In: Journal of Natural Products. 78, 11, p. 2657-2665 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)
Broholm, S. L., Gramsbergen, S., Nyberg, N., Jäger, A. & Stærk, Dan, 2015. 1 p.
Research output: Contribution to conference › Poster › Research
Published
Triple aldose reductase/α-glucosidase/radical scavenging high-resolution profiling combined with high-performance liquid chromatography – high-resolution mass spectrometry – solid-phase extraction – nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude extract of Radix Scutellariae
Tahtah, Y., Kongstad, Kenneth Thermann, Wubshet, S. G., Nyberg, N., Jønsson, L. H., Jäger, A. K., Qinglei, S. & Stærk, Dan, 2015, In: Journal of Chromatography A. 1408, p. 125-132 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2014
Published
African plants for inhibition of necrotic enzymes from snake venom
Schmidt, M. M., Nielsen, L., Søgaard, S., Stærk, Dan, Rønsted, Nina, Diallo, D., Kusamba Zacharie, C., Van Staden, J. & Jäger, A. K., 2014.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
Analogues of the natural product Sinefungin as inhibitors of EHMT1 and EHMT2
Devkota, K., Lohse, B., Liu, Q., Wang, M., Stærk, Dan, Berthelsen, J. & Clausen, Rasmus Prætorius, 2014, In: A C S Medicinal Chemistry Letters. 5, 4, p. 293-297
Research output: Contribution to journal › Letter › Research › peer-review
Published
Assessment of constituents in Allium by multivariate data analysis, high-resolution α-glucosidase inhibition assay and HPLC-SPE-NMR
Schmidt, J. S., Nyberg, N. & Stærk, Dan, 2014, In: Food Chemistry. 161, p. 192-198 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution Assays Combined with HPLC-HRMS-SPE-ttNMR for Identification of Antidiabetic Compounds in root of Scutellaria Baicalensis
Tahtah, Y., Jønsson, L. H., Nyberg, N., Jäger, A. & Stærk, Dan, 2014.
Research output: Contribution to conference › Poster › Research
Published
High-resolution bacterial growth inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antibacterial constituents in Chinese plants used to treat snakebites
Liu, Y., Nielsen, M., Stærk, Dan & Jäger, A., 2014, In: Journal of Ethnopharmacology. 155, 2, p. 1276-1283 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution bioactivity profiling combined with hyphenated HPLC-SPE-NMR – Investigation of functional food and plants with antifungal constituents
Stærk, Dan, 2014.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
High-resolution screening combined with HPLC–HRMS–SPE–NMR for identification of fungal plasma membrane H⁺-ATPase inhibitors from plants
Kongstad, Kenneth Thermann, Wubshet, S. G., Johannesen, A., Kjellerup, L., winther, A. L., Jäger, A. & Stærk, Dan, 2014, In: Journal of Agricultural and Food Chemistry. 62, 24, p. 5595-5602 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution α-amylase assay combined with high-performance liquid chromatography−solid-phase extraction−nuclear magnetic resonance spectroscopy for expedited identification of α-amylase inhibitors – proof of concept and α-amylase inhibitor in cinnamon.
Okutan, L., Kongstad, Kenneth Thermann, Jäger, A. & Stærk, Dan, 2014, In: Journal of Agricultural and Food Chemistry. 62, 47, p. 11465-11471 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Hyaluronidase, phospholipase A₂ and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa
Schmidt, M. M., Nielsen, L. H., Søgaard, S. V., Stærk, Dan, Rønsted, Nina, Diallo, D., Kusamba Zacharie, C., van Staden, J. & Jäger, A., 2014, In: Journal of Ethnopharmacology. 157, p. 171-180 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification of Fungal H⁺-ATPase Inhibitors by Microfractionation and HPLC-HRMS-SPE-NMR
Wubshet, S. G., Kongstad, Kenneth Thermann, Johannesen, A., Nyberg, N., Jäger, A., Kjellerup, L., Vinther, A. & Stærk, Dan, 2014.
Research output: Contribution to conference › Poster › Research
Published
Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics
Vinther, J. M., Garrigues, C., Nyberg, N., Jäger, A., Franzyk, Henrik & Stærk, Dan, 2014.
Research output: Contribution to conference › Poster › Research
Published
Secondary metabolite comparison of the species within the Heterobasidion annosum s.l. complex
Hansson, D., Wubshet, S. G., Olson, Å., Karlsson, M., Stærk, Dan & Broberg, A., 2014, In: Phytochemistry. 108, p. 243-251 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2013
Published
Coupling HPLC-SPE-NMR with a microplate-based high-resolution antioxidant assay for efficient analysis of antioxidants in food – Validation and proof-of-concept study with caper buds
Wiese, S., Wubshet, S. G., Nielsen, J. & Stærk, Dan, 2013, In: Food Chemistry. 141, 4, p. 4010-4018
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC-SPE-NMR for advanced bioactivity-profiling of plant extracts
Grosso, C., Jäger, A. & Stærk, Dan, 2013, In: Phytochemical Analysis. 24, 2, p. 141-147
Research output: Contribution to journal › Journal article › Research › peer-review
Published
High-resolution screening combined with HPLC–HRMS–SPE–NMR for identification of potential health-promoting constituents in sea aster and searocket - New nordic food ingredients
Wubshet, S. G., Schmidt, J. S., Wiese, S. & Stærk, Dan, 2013, In: Journal of Agricultural and Food Chemistry. 61, 36, p. 8616-8623
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Targeting high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance analysis with high-resolution radical scavenging profiles - bioactive secondary metabolites from the endophytic fungus Penicillium namyslowskii
Wubshet, S. G., Nyberg, N., Tejesvi, M. V., Pirttilä, A. M., Kajula, M., Mattila, S. & Stærk, Dan, 2013, In: Journal of Chromatography A. 1302, p. 34-39
Research output: Contribution to journal › Journal article › Research › peer-review
2012
Published
Comprehensive analysis of commercial willow bark extracts by new technology platform: combined use of metabolomics, high-perfomance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy and high-resolution radical scavenging assay
Agnolet, S., Wiese, S., Verpoorte, R. & Stærk, Dan, 2012, In: Journal of Chromatography A. 1262, p. 130-137 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Development of a bioassay-coupled HPLC-SPE-ttNMR platform for identification of α-glucosidase inhibitors in apple peel (Malus × domestica Borkh.)
Schmidt, J. S., Lauridsen, M. B., Dragsted, Lars Ove, Nielsen, J. & Stærk, Dan, 2012, In: Food Chemistry. 135, 3, p. 1692-1699 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Effect of residual water and microwave heating on half-lifes of reagents and reactive intermediates in peptide synthesis
Shelton, A. P. T., Pedersen, S. L., Stærk, Dan & Jensen, Knud Jørgen, 2012, In: Chemistry: A European Journal. 18, 29, p. 9024-9031 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Fremtidens funktionelle fødevarer - et vigtigt middel i kampen mod livsstilssygdomme
Stærk, Dan, 2012, Profil/Fødevarer & Sundhed. København: Københavns Universitet, Kommunikation, p. 18-19 2 p.
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
Published
High resolution antioxidant assay guided HPLC-HRMS-SPE-NMR analysis of Penicillium namyslowskii extract
Wubshet, S. G., Nyberg, N. & Stærk, Dan, 2012.
Research output: Contribution to conference › Poster › Research
Published
Identification of α-glucosidase inhibitors in apple peel - a chemometric approach
Schmidt, J. S., Daykin, C. A. & Stærk, Dan, 2012. 1 p.
Research output: Contribution to conference › Poster › Research
Published
Improved solid-phase synthesis and study of arylopeptoids with conformation-directing side chains
Hjelmgaard, T., Faure, S., De Santis, E., Stærk, Dan, Alexander, B. D., Edwards, A. A., Taillefumier, C. & Nielsen, J., 2012, In: Tetrahedron. 68, 23, p. 4444-4454 11 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum
Sørensen, J. L., Hansen, F. T., Søndergaard, T. E., Stærk, Dan, Lee, T. V., Wimmer, R., Klitgaard, L. G., Purup, S., Giese, H. & Frandsen, R. J. N., 2012, In: Environmental Microbiology. 14, 5, p. 1159-1170 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives
Hansen, A. N., Bendiksen, C. D., Sylvest, L., Friis, T., Stærk, Dan, Jørgensen, Flemming Steen, Olsen, Christian Adam & Houen, G., 2012, In: P L o S One. 7, 9, 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Vejledning til laboratorieøvelser i 'Organisk Kemi for Biovidenskab'
Stærk, Dan, 2012, Institut for Grundvidenskab og Miljø, Københavns Universitet. 74 p.
Research output: Book/Report › Compendium/lecture notes › Education
2011
Published
Production of unusual dispiro metabolites in Pestalotiopsis virgatula endophyte cultures: HPLC-SPE-NMR, electronic circular dichroism, and time-dependent density-functional computation study
Kesting, J. R., Olsen, L., Stærk, Dan, Tejesvi, M. V., Kini, K. R., Prakash, H. S. & Jaroszewski, J. W., 26 Sep 2011, In: Journal of Natural Products. 74, 10, p. 2206-2215
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Efficient and versatile COMU-mediated solid-phase submonomer synthesis of arylopeptoids (oligomeric N-substituted aminomethyl benzamides)
Hjelmgaard, T., Faure, S., Stærk, Dan, Taillefumier, C. & Nielsen, J., 2011, In: Organic & Biomolecular Chemistry. 9, p. 6832-6843 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Expedient solution-phase synthesis and NMR studies of arylopeptoids
Hjelmgaard, T., Faure, S., Stærk, Dan, Taillefumier, C. & Nielsen, J., 2011, In: European Journal of Organic Chemistry. 2011, 22, p. 4121-4132 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Two novel classes of enzymes are required for the biosynthesis of aurofusarin in Fusarium graminearum
Frandsen, R. J. N., Schütt, C. W. H., Lund, B. L. W., Stærk, Dan, Nielsen, J., Olsson, S. & Giese, H., 2011, In: Journal of Biological Chemistry. 286, 12, p. 10419-10428 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2010
Published
¹H NMR-based metabolomics combined with HPLC-PDA-MS-SPE-NMR for investigation of standardized Ginkgo biloba preparations
Agnolet, S., Jaroszewski, J. W., Verpoorte, R. & Stærk, Dan, 2010, In: Metabolomics. 6, 2, p. 292-302 11 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Bisbenzylisoquinoline alkaloids as markers of Atherospermataceae: tetrandrine and fangchinoline from Laureliopsis philippiana
Stanstrup, Jan, Schmidt, J. S., Rasmussen, H. B., Mølgaard, Per, Guzmán, A. & Stærk, Dan, 2010, In: Biochemical Systematics and Ecology. 38, 3, p. 450-453 4 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Butenolides from plant-derived smoke: natural plant-growth regulators with antagonistic actions on seed germination
Light, M. E., Burger, B. V., Stærk, Dan, Kohout, L. & Van Staden, J., 2010, In: Journal of Natural Products. 73, 2, p. 267-269 3 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Itoside A and 4-hydroxytremulacin from Dovyalis caffra and Dovyalis zeyheri
Stanstrup, Jan, Rusch, A., Agnolet, S., Rasmussen, H. B., Mølgaard, Per, Van Staden, J., Stafford, G. I. & Stærk, Dan, 2010, In: Biochemical Systematics and Ecology. 38, 3, p. 346-348 3 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
NMR for gymnasieelever: forelæsningsslides, tabeller og opgavesamling til en NMR undervisningssession for gymnasieelever
Stærk, Dan, 2010, Institut for Grundvidenskab og Miljø, Københavns Universitet. 39 p.
Research output: Book/Report › Compendium/lecture notes › Education
Published
New resistance-correlated saponins from the insect-resistant crucifer Barbarea vulgaris
Nielsen, Nikoline Juul, Nielsen, J. & Stærk, Dan, 2010, In: Journal of Agricultural and Food Chemistry. 58, 9, p. 5509-5514 6 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2009
Published
¹H NMR-based metabolomics applied to study of complex pharmaceutical extracts of Ginkgo biloba
Agnolet, S., Jaroszewski, J. W. & Stærk, Dan, 2009.
Research output: Contribution to conference › Conference abstract for conference › Research
Published
¹H-NMR based metabolomics applied to standardized Ginkgo biloba preparations
Agnolet, S., Jaroszewski, J. W., Verpoorte, R. & Stærk, Dan, 2009.
Research output: Contribution to conference › Conference abstract for conference › Research
Published
¹H-NMR based metabolomics applied to standardized Ginkgo biloba preparations
Agnolet, S., Jaroszewski, J. W., Verpoorte, R. & Stærk, Dan, 2009.
Research output: Contribution to conference › Conference abstract for conference › Research
Published
Accelerated dereplication of crude extracts using HPLC-PDA-MS-SPE-NMR
Stærk, Dan, Kesting, J. R., Sairafianpour, M., Witt, M., Asili, J., Emami, S. A. & Jaroszewski, J. W., 2009, In: Phytochemistry. 70, 8, p. 1055-1061 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Antimalarial sesquiterpene lactones from Distephanus angulifolius
Pedersen, M. M., Chukwujekwu, J. C., Lategan, C. A., van Staden, J., Smith, P. J. & Stærk, Dan, 2009, In: Phytochemistry. 70, 5, p. 601-607 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Application of Rotated PCA Models to Facilitate Interpretation of Metabolite Profiles: Commercial Preparations of St. John's Wort
Lawaetz, A. J., Schmidt, B., Stærk, Dan, Jaroszewski, J. W. & Bro, Rasmus, 2009, In: Planta Medica.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Application of rotated PCA models to facilitate interpretation of metabolite profiles: commercial preparations of St. John's wort
Lawaetz, A. J., Schmidt, B., Stærk, Dan, Jaroszewski, J. W. & Bro, Rasmus, 2009, In: Planta Medica. 75, 3, p. 271-279 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
HPLC-SPE-NMR identification of a novel metabolite containing the benzo[c]oxepin skeleton from the endophytic fungus Pestalotiopsis virgatula culture
Kesting, J. R., Stærk, Dan, Tejesvi, M. V., Kini, K. R., Prakash, H. S. & Jaroszewski, J. W., 2009, In: Planta Medica. 75, 10, p. 1104-1106 3 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Hyphenation of HPLC, SPE and NMR for analysis of complex mixtures
Stærk, Dan, 2009.
Research output: Contribution to conference › Conference abstract for conference › Research
Published
Identification of reaction products between drug substances and excipients by HPLC-SPE-NMR: Ester and amide formation between citric acid and 5-aminosalicylic acid
Larsen, J. T., Stærk, Dan, Cornett, Claus, Hansen, S. H. & Jaroszewski, J. W., 2009, In: Journal of Pharmaceutical and Biomedical Analysis. 49, p. 839-842
Research output: Contribution to journal › Journal article › Research › peer-review
Published
New bisbenzylisoquinoline alkaloid from Laureliopsis philippiana
Stærk, Dan, Thi, L. P., Rasmussen, H. B., Guzmán, A. & Mølgaard, Per, 2009, In: Fitoterapia. 80, 2, p. 112-114 3 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Non-biased investigation of standardized Ginkgo biloba preparations by ¹H NMR-based metabolomics and HPLC-PDA-MS-SPE-NMR
Agnolet, S., Jaroszewski, J. W., Verpoorte, R. & Stærk, Dan, 2009.
Research output: Contribution to conference › Poster › Research
Published
Non-biased investigation of standardized Ginkgo biloba preparations by ¹H NMR-based metabolomics and HPLC-PDA-MS-SPE-NMR
Agnolet, S., Jaroszewski, J. W., Verpoorte, R. & Stærk, Dan, 2009. 1 p.
Research output: Contribution to conference › Poster › Research
Published
Piperidine and tetrahydropyridine alkaloids from Lobelia siphilitica and Hippobroma longiflora:
Kesting, J. R., Tolderlund, I., Pedersen, A. F., Witt, M., Jaroszewski, J. W. & Stærk, Dan, 2009, In: Journal of Natural Products. 72, 2, p. 312-315 4 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2008
Published
HPLC-NMR Techniques for Plant Extract Analysis
Stærk, Dan, Lambert, M. & Jaroszewski, J. W., 20 Mar 2008, Medicinal Plant Biotechnology: From Basic Research to Industrial Applications. Wiley-VCH, p. 29-48 20 p.
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Published
Combining HPLC-PDA-MS-SPE-NMR with circular dichroism for complete natural product characterization in crude extracts: Levorotatory gossypol in Thespesia danis
Sprogøe, K., Stærk, Dan, Ziegler, H. L., Jensen, T. H., Holm-Møller, S. B. & Jaroszewski, J. W., 2008, In: Journal of Natural Products. 71, 4, p. 516-519
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Combining PARAFAC analysis of HPLC-PDA profiles and structural characterization using HPLC-PDA-SPE-NMR-MS experiments: commercial preparations of St. John's Wort
Schmidt, B., Jaroszewski, J. W., Bro, Rasmus, Witt, M. & Stærk, Dan, 2008, In: Analytical Chemistry. 80, 6, p. 1978-1987 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Lægemidler fra naturstoffer: fortid eller fremtid?
Jaroszewski, J. W., Christensen, Søren Brøgger, Franzyk, Henrik, Stærk, Dan & Ziegler, H., 2008, In: Lægemiddelforskning. p. 4-6
Research output: Contribution to journal › Journal article › Communication
Published
Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines
Franzyk, Henrik, Crestey, F., Witt, M., Frydenvang, Karla Andrea, Stærk, Dan & Jaroszewski, J., 2008, In: Synfacts. 7, p. 769
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Microwave-assisted ring-opening of activated aziridines with resin-bound amines
Crestey, F., Witt, M., Frydenvang, Karla Andrea, Stærk, Dan, Jaroszewski, J. W. & Franzyk, Henrik, 2008, In: Journal of Organic Chemistry. 73, 9, p. 3566-3569 4 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2007
Published
Identification of natural products using HPLC-SPE combined with CapNMR
Lambert, M., Wolfender, J., Stærk, Dan, Christensen, Søren Brøgger, Hostettmann, K. & Jaroszewski, J. W., 2007, In: Analytical Chemistry. 79, 2, p. 727-735
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Noter til M25-1 spektroskopi
Stærk, Dan & Jaroszewski, J. W., 2007, København: Københavns Universitet, Det Farmaceutiske Fakultet, Institut for Medicinalkemi. 49 p.
Research output: Book/Report › Compendium/lecture notes › Education
Published
Targeted natural product isolation guided by HPLC-SPE-NMR: constituents of Hubertia species
Sprogøe, K., Stærk, Dan, Jäger, A. K., Adsersen, A., Hansen, S. H., Witt, M., Landbo, A. R., Meyer, A. S. & Jaroszewski, J. W., 2007, In: Journal of Natural Products. 70, 9, p. 1472-1477
Research output: Contribution to journal › Journal article › Research › peer-review
2006
Published
Discovering new natural products directly from crude extracts by HPLC-SPE-NMR: chinane diterpenes in Harpagophytum procumbens
Clarkson, C., Stærk, Dan, Hansen, S. H., Smith, P. J. & Jaroszewski, J. W., 2006, In: Journal of Natural Products. 69, p. 527-530
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Dovyalicin-type spermidine alkaloids from Dovyalis species
Rasmussen, B., Nkurunziza, A., Witt, M., Oketch-Rabah, H. A., Jaroszewski, J. W. & Stærk, Dan, 2006, In: Journal of Natural Products. 69, p. 1300-1304
Research output: Contribution to journal › Journal article › Research › peer-review
Published
HPLC-NMR techniques for plant extract analysis
Stærk, Dan, Lambert, M. & Jaroszewski, J. W., 2006, Medicinal Plant Biotechnology. From Basic Research to Applications. Kayser, O. & Quax, W. J. (eds.). Weinheim: Wiley-VCH, p. 29-48
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Published
Identification of major and minor constituents of Harpagophytum procumbens (Devil's Claw) using HPLC-SPE-NMR and HPLC-ESIMS/APCIMS
Clarkson, C., Stærk, Dan, Hansen, S. H., Smith, P. J. & Jaroszewski, J. W., 2006, In: Journal of Natural Products. 69, p. 1280-1288
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Multivariate analysis of integrated and full-resolution ¹H-NMR spectral data from complex pharmaceutical preparations: St. John's wort
Rasmussen, B., Cloarec, O., Tang, H., Stærk, Dan & Jaroszewski, J. W., 2006, In: Planta Medica. 72, p. 556-563
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Plantemetabolomer in action
Schmidt, B., Stærk, Dan, Bro, Rasmus & Jaroszewski, J. W., 2006, In: Lægemiddelforskning. 2006, p. 4-5 2 p.
Research output: Contribution to journal › Journal article › Research
Published
Structural analysis of complex saponins of Balanites aegyptiaca by 800 MHz ¹H NMR spectroscopy
Stærk, Dan, Chapagain, B. P., lindin, T., Wiesman, Z. & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, p. 923-928
Research output: Contribution to journal › Journal article › Research › peer-review
2005
Published
Erratum: "Naravelia zeylanica: Occurrence of primary benzamides in flowering plants" (Natural Product Research vol. 19 (3) (291-294))
Jaroszewski, J. W., Stærk, Dan, Holm-Møller, S. B., Jensen, T. H., Franzyk, Henrik & Somanadhan, B., 1 Jun 2005, In: Natural Product Research. 19, 4, 1 p.
Research output: Contribution to journal › Comment/debate › Research › peer-review
Published
Naravelia zeyanica: occurrence of primary benzamides in flowering plants
Jaroszewski, J. W., Stærk, Dan, Holm-Møller, S. B., Jensen, T. H. & Franzyk, Henrik, 2005, In: Natural Product Research. 19, 3, p. 291-294
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Food preference and performance of the larvae of a specialist herbivore: variation among and within host-plant populations
Leimu, R., Riipi, M. & Stærk, Dan, 2005, In: Acta Oecologica. 28, p. 325-330
Research output: Contribution to journal › Journal article › Research › peer-review
Published
HPLC-SPE-NMR hyphenation in natural products research: optimization of analysis of Croton membranaceus extract
Lambert, M., Stærk, Dan, Hansen, S. H. & Jaroszewski, J. W., 2005, In: Magnetic Resonance in Chemistry. 43, p. 771-775
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Hyphenation of solid-phase extraction with liquid chromatography and nuclear magnetic resonance: application of HPLC-DAD-SPE-NMR to identification of constituents of Kanahia laniflora
Clarkson, C., Stærk, Dan, Hansen, S. H. & Jaroszewski, J. W., 2005, In: Analytical Chemistry. 77, p. 3547-3553
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Phenanthroindolizidine alkaloids from Vincetoxicum pumilum
Stærk, Dan, Nezhad, K. B., Asili, J., Emami, S. A., Ahi, A., Sairafianpour, M. & Jaroszewski, J. W., 2005, In: Biochemical Systematics and Ecology. 33, p. 957-960
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Rapid extract dereplication using HPLC-SPE-NMR: analysis of isoflavonoids from Smirnowia iranica
Lambert, M., Stærk, Dan, Hansen, S. H., Sairafianpour, M. & Jaroszewski, J. W., 2005, In: Journal of Natural Products. 68, p. 1500-1509
Research output: Contribution to journal › Journal article › Research › peer-review
2004
Published
^4N-alkyloxycarbonyl derivatives of cytosine: physicochemical characterisation, and cytosine regeneration rates and release from alginic acid gels
Petersson, K. P., Pedersen, B. T., Stærk, Dan, Krogfelt, K. A. & Larsen, C. S., 2004, In: European Journal of Pharmaceutical Sciences. 23, 4-5, p. 337-345
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Ancistrotanzanine C and related 5,1’- and 7,3’- coupled naphtylisoquinoline alkaloids from Ancistrocladus tanzaniensis
Bringmann, G., Dreyer, M., Faber, J. H., Dalsgaard, P. W., Stærk, Dan, Jaroszewski, J. W., Ndangalasi, H., Mbago, F., Brun, R. & Christensen, Søren Brøgger, 2004, In: Journal of Natural Products. 67, p. 743-748
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues
Ziegler, H. L., Franzyk, Henrik, Sairafianpour, M., Tabatabai, M., Tehrani, M. D., Bagherzadeh, K., Hägerstrand, H., Stærk, Dan & Jaroszewski, J. W., 2004, In: Bioorganic & Medicinal Chemistry. 12, p. 119-127
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Isolation of a library of aromadendranes from Landolphia dulcis and its characterization using the VolSurf approach
Stærk, Dan, Skole, B., Jørgensen, Flemming Steen, Budnik, B. A., Ekpe, P. & Jaroszewski, J. W., 2004, In: Journal of Natural Products. 67, 5, p. 799-805 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Labdanes and isopimaranes from Platycladus orientalis and their effects on erythrocyte membrane and on Plasmodium falciparum growth in the erythrocyte host cells
Asili, J., Lambert, M., Ziegler, H. L., Stærk, Dan, Sairafianpour, M., Witt, M., Asghari, G., Ibrahimi, I. & Jaroszewski, J. W., 2004, In: Journal of Natural Products. 67, p. 631-637
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Når filmens fiktion bliver virkelighed
Stærk, Dan, Lambert, M., Sairafianpour, M., Clarkson, C. & Jaroszewski, J. W., 2004, In: Lægemiddelforskning. p. 12-13
Research output: Contribution to journal › Journal article › Communication
Published
Selagoline, a new alkaloid from Huperzia selago
Stærk, Dan, Larsen, J., Larsen, L. A., Olafsdottir, E. S., Witt, M. & Jaroszewski, J. W., 2004, In: Natural Product Research. 18, p. 197-203
Research output: Contribution to journal › Journal article › Research › peer-review
Published
The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed
Ziegler, H. L., Hansen, Harald S., Stærk, Dan, Christensen, Søren Brøgger, Hägerstrand, H. & Jaroszewski, J. W., 2004, In: Antimicrobial Agents and Chemotherapy. 48, p. 4067-4071
Research output: Contribution to journal › Journal article › Research › peer-review
2003
Published
A 5-deoxyflavonol derivative in Mimosa pudica
Kirk, L. F., Møller, M. V., Christensen, J., Stærk, Dan, Ekpe, P. & Jaroszewski, J. W., 2003, In: Biochemical Systematics and Ecology. 31, 1, p. 103-105
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A new class of spermidine-derived alkaloids
Stærk, Dan, Witt, M., Oketch-Rabah, H. A. & Jaroszewski, J. W., 2003, In: Organic Letters. 5, p. 2793-2796
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Ancistrotanzanine A, the first 5,3’-coupled naphtylisoquinoline alkaloid, and two further, 5,8’-linked related compounds from the newly described species Ancistrocladus tanzaniensis
Bringmann, G., Dreyer, M., Faber, J. H., Dalsgaard, P. W., Stærk, Dan, Jaroszewski, J. W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M., Maksimenka, K. & Christensen, Søren Brøgger, 2003, In: Journal of Natural Products. 66, p. 1159-1165
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Leishmanicidal and antiplasmodial activity of constituents of Smirnowia iranica
Sairafianpour, M., Kayser, O., Christensen, J., Asfa, M., Witt, M., Stærk, Dan & Jaroszewski, J. W., 2003, In: Journal of Natural Products. 65, p. 1754-1768
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Terpenoids of Salvia hydrangea: two new, rearranged 20-norabietanes and the effect of oleanolic acid on erythrocyte membrane
Sairafianpour, M., Bahreininejad, B., Witt, M., Ziegler, H. L., Jaroszewski, J. W. & Stærk, Dan, 2003, In: Planta Medica. 69, p. 846-850
Research output: Contribution to journal › Journal article › Research › peer-review
2002
Published
Incorporation of the crossfire Beilstein database into the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 1 Jun 2002, In: Journal of Chemical Education. 79, 6, 1 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
In vitro Plasmodium falciparum drug sensitivity assay: inhibition of parasite growth by incorporation of stomatocytogenic amphiphiles into the erythrocyte membrane
Ziegler, H. L., Stærk, Dan, Christensen, J., Hviid, Lars, Hägerstrand, H. & Jaroszewski, J. W., 2002, In: Antimicrobial Agents and Chemotherapy. 46, 5, p. 1441-6 5 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells
Stærk, Dan, Lykkeberg, A. K., Christensen, J., Budnik, B. A., Abe, F. & Jaroszewski, J. W., 2002, In: Journal of Natural Products. 65, p. 1299-1302
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Incorporation of the Cross Fire Beilstein database in the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 2002, In: Journal of Chemical Education. 79, p. 765-768
Research output: Contribution to journal › Journal article › Research
Published
New dammarane and malabaricane triterpenes from Caloncoba echinata
Ziegler, H. L., Stærk, Dan, Christensen, J., Olsen, C. E., Sittie, A. A. & Jaroszewski, J. W., 2002, In: Journal of Natural Products. 65, p. 1764-1768
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Possible artefacts in the in vitro determination of antimalarial activity of natural products that incorporate into lipid bilayer: apparent antiplasmodial activity of dehydroabietinol, a constituent of Hyptis suaveolens
Ziegler, H. L., Jensen, T. H., Christensen, J., Stærk, Dan, Hägerstrand, H., Sittie, A. A., Olsen, C. E., Staalsø, Trine, Ekpe, P. & Jaroszewski, J. W., 2002, In: Planta Medica. 68, p. 547-549 3 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2001
Published
Conformational studies of indole alkaloids corynantheine and dihydrocorynantheine by dynamic ¹H NMR spectroscopy and computational methods: steric effects of ethyl vs. vinyl group
Stærk, Dan, Norrby, P. & Jaroszewski, J. W., 2001, In: Journal of Organic Chemistry. 66, p. 2217-2221
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Forbedret test af nye lægemidler mod malaria
Christensen, J., Stærk, Dan, Ziegler, H. L., Sairafianpour, M. & Jaroszewski, J. W., 2001, In: Lægemiddelforskning. p. 8-9
Research output: Contribution to journal › Journal article › Communication
Published
Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones
Sairafianpour, M., Christensen, J., Stærk, Dan, Budnik, B. A., Kharazmi, A., Bagherzadeh, K. & Jaroszewski, J. W., 2001, In: Journal of Natural Products. 64, 11, p. 1398-1403 5 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2000
Published
Cytotoxic activity of some phenanthroindolizidine N-Oxide alkaloids from Cynanchum vincetoxicum
Stærk, Dan, Christensen, J., Lemmich, E., Duus, J. Ø., Olsen, C. E. & Jaroszewski, J. W., 2000, In: Journal of Natural Products. 63, 11, p. 1584-1586
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Leishmanicidal, antiplasmodial and cytotoxic activity of indole alkaloids from Corynanthe pachyceras
Stærk, Dan, Lemmich, E., Christensen, J., Kharazmi, A., Olsen, C. E. & Jaroszewski, J. W., 2000, In: Planta Medica. 66, p. 531-536
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Moderne naturstofkemi: effektiv analyse af naturens stofbiblioteker
Stærk, Dan, Lemmich, E., Franzyk, Henrik, Lemmich, J. & Jaroszewski, J. W., 2000, In: Lægemiddelforskning. p. 6-7
Research output: Contribution to journal › Journal article › Communication
Published
NMR-spectroscopic studies, and pharmacological evaluation of alkaloids from some medicinal plants
Stærk, Dan, 2000, Royal Danish school of Pharmacy.
Research output: Book/Report › Ph.D. thesis › Research
1997
Published
Bis-intercalation of homodimeric thiazole orange dyes in DNA: effect of modifying the linker
Stærk, Dan, Hamed, A. A., Pedersen, E. B. & Jacobsen, J. P., 1997, In: Bioconjugate Chemistry. 8, p. 869-877
Research output: Contribution to journal › Journal article › Research › peer-review

ID: 1299056

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Identification of α-glucosidase inhibitors in apple peel - a chemometric approach
Research output: Contribution to conference › Poster › Research
Published
4026 downloads
Itoside A and 4-hydroxytremulacin from Dovyalis caffra and Dovyalis zeyheri
Research output: Contribution to journal › Journal article › Research › peer-review
Published
2998 downloads
Identification of reaction products between drug substances and excipients by HPLC-SPE-NMR: Ester and amide formation between citric acid and 5-aminosalicylic acid
Research output: Contribution to journal › Journal article › Research › peer-review
Published

Dan Stærk

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