Fredrik Björkling
Emeritus
Medicinal Chemistry
Jagtvej 162
2100 København Ø
- 2024
- Published
Polymyxins with Potent Antibacterial Activity against Colistin-Resistant Pathogens: Fine-Tuning Hydrophobicity with Unnatural Amino Acids
Jørgensen, Johan Storm, Harifi Mood, Elnaz, Knap, A. S. H., Nielsen, S. E., Nielsen, Peter E., Żabicka, D., Matias, C., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2024, In: Journal of Medicinal Chemistry. 67, 2, p. 1370–1383Research output: Contribution to journal › Journal article › peer-review
- Published
Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs)
Couturier, C., Ronzon, Q., Lattanzi, G., Lingard, I., Coyne, S., Cazals, V., Dubarry, N., Yvon, S., Leroi-Geissler, C., Gracia, O. R., Teague, J., Sordello, S., Corbett, D., Bauch, C., Monlong, C., Payne, L., Taillier, T., Fuchs, H., Broenstrup, M., Harrison, P. H. & 10 others, , 2024, In: European Journal of Medicinal Chemistry. 265, 20 p., 116097.Research output: Contribution to journal › Journal article › peer-review
- 2023
- Published
Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents
Craig, A. J., Ermolovich, Y., Cameron, A., Rodler, A., Wang, H., Hawkes, J. A., Hubert, M., Björkling, Fredrik, Molchanova, N., Brimble, M. A., Moodie, L. W. K. & Svenson, J., 2023, In: ACS Medicinal Chemistry Letters. 14, 6, p. 802–809 8 p.Research output: Contribution to journal › Letter › peer-review
- Published
Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
Wróbel, T. M., Sharma, K., Mannella, I., Oliaro-Bosso, S., Nieckarz, P., Du Toit, T., Voegel, C. D., Rojas Velazquez, M. N., Yakubu, J., Matveeva, A., Therkelsen, S., Jørgensen, Flemming Steen, Pandey, A. V., Pippione, A. C., Lolli, M. L., Boschi, D. & Björkling, Fredrik, 2023, In: Biomolecules. 13, 9, 18 p., 1349.Research output: Contribution to journal › Journal article › peer-review
- Published
Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment
Wróbel, T. M., Jørgensen, Flemming Steen, Pandey, A. V., Grudzińska, A., Sharma, K., Yakubu, J. & Björkling, Fredrik, 2023, In: Journal of Medicinal Chemistry. 66, 10, p. 6542–6566Research output: Contribution to journal › Review › peer-review
- Published
Selected strategies to fight pathogenic bacteria
Plotniece, A., Sobolev, A., Supuran, C. T., Carta, F., Björkling, Fredrik, Franzyk, Henrik, Yli-Kauhaluoma, J., Augustyns, K., Cos, P., De Vooght, L., Govaerts, M., Aizawa, J., Tammela, P. & Žalubovskis, R., 2023, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 27 p., 2155816.Research output: Contribution to journal › Review › peer-review
- Published
Structure-activity study of oncocin: On-resin guanidinylation and incorporation of homoarginine, 4-hydroxyproline or 4,4-difluoroproline residues
Shaikh, Ashif Yasin, Björkling, Fredrik, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Kreicberga, A. & Franzyk, Henrik, 2023, In: Bioorganic Chemistry. 141, 11 p., 106876.Research output: Contribution to journal › Journal article › peer-review
- 2022
- Published
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Brem, J., Panduwawala, T., Hansen, J. U., Hewitt, J., Liepins, E., Donets, P., Espina, L., Farley, A. J. M., Shubin, K., Campillos, G. G., Kiuru, P., Shishodia, S., Krahn, D., Leśniak, R. K., Schmidt (Adrian), J., Calvopiña, K., Turrientes, M. C., Kavanagh, M. E., Lubriks, D., Hinchliffe, P. & 41 others, , 2022, In: Nature Chemistry. 14, p. 15–24Research output: Contribution to journal › Journal article › peer-review
- Published
Synthesis and Structure–Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents
Wróbel, T. M., Rogova, O., Sharma, K., Velazquez, M. N. R., Pandey, A. V., Jørgensen, Flemming Steen, Arendrup, Frederic Schrøder, Andersen, Kasper Langebjerg & Björkling, Fredrik, 2022, In: Biomolecules. 12, 2, 165.Research output: Contribution to journal › Journal article › peer-review
- 2021
- Published
Evaluation of 1H-Triazole-1-[N,N'-Bis(tert-butoxycarbonyl)]carboxamidine in Solution-Phase and On-Resin Guanidinylation
Wester, A., Björkling, Fredrik & Franzyk, Henrik, 2021, In: The Journal of Organic Chemistry. 86, 21, p. 14371–14380Research output: Contribution to journal › Journal article › peer-review
- Published
Optimized Synthesis of Fmoc/Boc-Protected PNA Monomers and their Assembly into PNA Oligomers.
Shaikh, Ashif Yasin, Björkling, Fredrik, Nielsen, Peter E. & Franzyk, Henrik, 2021, In: European Journal of Organic Chemistry. 2021, 19, p. 2792-2801 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties
Frederiksen, N., Louka, S., Mudaliar, C., Domraceva, I., Kreicberga, A., Pugovics, O., Żabicka, D., Tomczak, M., Wygoda, W., Björkling, Fredrik & Franzyk, Henrik, 2021, In: International Journal of Molecular Sciences. 22, 13, 17 p., 7041.Research output: Contribution to journal › Journal article › peer-review
- Published
Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates
Farley, A. J. M., Ermolovich, Y., Calvopiña, K., Rabe, P., Panduwawala, T., Brem, J., Björkling, Fredrik & Schofield, C. J., 2021, In: ACS Infectious Diseases. 7, 6, p. 1809–1817Research output: Contribution to journal › Journal article › peer-review
- Published
Synthesis of thiazole linked chalcones and their pyrimidine analogues as anticancer agents
Kesari, C., Rama, K. R., Sedighi, K., Stenvang, Jan, Björkling, Fredrik, Kankala, S. & Thota, N., 2021, In: Synthetic Communications. 51, 9, p. 1406-1416 11 p.Research output: Contribution to journal › Journal article › peer-review
- 2020
- Published
Alternating Cationic-Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity
Frederiksen, N., Hansen, Paul Robert, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2020, In: ChemMedChem. 15, 24, p. 2544-2561Research output: Contribution to journal › Journal article › peer-review
- Published
Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents
Wróbel, T. M., Rogova, O., Andersen, Kasper Langebjerg, Yadav, R., Brixius-Anderko, S., Scott, E. E., Olsen, L., Jørgensen, Flemming Steen & Björkling, Fredrik, 2020, In: International Journal of Molecular Sciences . 21, 14, p. 1-11 4868.Research output: Contribution to journal › Journal article › peer-review
- Published
Synthesis of novel fluorophenylpyrazole-picolinamide derivatives and determination of their anticancer activity
Kankala, S., Rama, K. R., Kesari, C., Björkling, Fredrik, Nerella, S., Gundepaka, P., Guguloth, H. & Thota, N., 2020, In: Synthetic Communications. 50, 19, p. 2997-3006 10 p.Research output: Contribution to journal › Journal article › peer-review
- 2019
- Published
Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity
Frederiksen, N., Hansen, Paul Robert, Björkling, Fredrik & Franzyk, Henrik, 4 Dec 2019, In: Molecules (Print Archive Edition). 24, 18 p., 4429.Research output: Contribution to journal › Journal article › peer-review
- Published
Silver carbene complexes: An emerging class of anticancer agents
Kankala, S., Thota, N., Björkling, Fredrik, Taylor, M. K., Vadde, R. & Balusu, R., Mar 2019, In: Drug Development Research. 80, 2, p. 188-199Research output: Contribution to journal › Journal article › peer-review
- Published
Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae
Hansen, A. M., Bonke, G., Hogendorf, W. F. J., Björkling, Fredrik, Nielsen, J., Kongstad, Kenneth Thermann, Zabicka, D., Tomczak, M., Urbas, M., Nielsen, Peter E. & Franzyk, Henrik, 2019, In: European Journal of Medicinal Chemistry. 168, p. 134-145 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Triphenylcarbenium Tetrafluoroborate as an Efficient Catalyst in the Regioselective Reductive Ring Opening of Benzylidene Acetals of Carbohydrates
Thota, N., Björkling, Fredrik & Kankala, S., 2019, In: ChemistrySelect. 4, 27, p. 7976-7980Research output: Contribution to journal › Journal article › peer-review
- 2018
- Published
Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Wester, A., Björkling, Fredrik, Nieslen, P. & Franzyk, Henrik, Sep 2018, In: Journal of Peptide Science. 24, p. S94-S94Research output: Contribution to journal › Conference abstract in journal › peer-review
- 2017
- Published
Antisense PNA antibiotics against multiresistant Gram-negative bacteria
Nielsen, Peter E., Björkling, Fredrik & Franzyk, Henrik, 2017, In: International Journal of Molecular Medicine. 40, Suppl. 1, p. S22 1 p., Abstract 169.Research output: Contribution to journal › Conference abstract in journal
- 2016
- Published
Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139
Shehata, M. A., Jensen, A. C. N., Lissa, D., Bisig, C., Isberg, V., Andersen, K. B., Harpsøe, Kasper, Björkling, Fredrik, Bräuner, Hans & Gloriam, David E., 10 Nov 2016, In: Scientific Reports. 6, p. 1-13 13 p., 36681.Research output: Contribution to journal › Journal article › peer-review
- 2015
- Published
Jagten på kongens efterfølger
Franzyk, Henrik, Björkling, Fredrik, Nielsen, J. & Nielsen, Peter E., 2015, In: Lægemiddelforskning. 2015, p. 24-27 4 p.Research output: Contribution to journal › Journal article
ID: 8863737
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2309
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Imaging of treatment response to the combination of carboplatin and paclitaxel in human ovarian cancer xenograft tumors in mice using FDG and FLT PET
Research output: Contribution to journal › Journal article › peer-review
Published -
1276
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Research output: Contribution to journal › Conference abstract in journal › peer-review
Published -
275
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Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139
Research output: Contribution to journal › Journal article › peer-review
Published