Søren Brøgger Christensen

Søren Brøgger Christensen

Professor emeritus, Professor, emeritus

Member of:

    ORCID: 0000-0002-5773-6874

    Publication year:
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    1 - 100 out of 182Page size: 100
    1. 2022
    2. Published

      Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides

      Christensen, Søren Brøgger, 2022, In: Molecules. 27, 17, 29 p., 5648.

      Research output: Contribution to journal › Review › Research › peer-review

    3. Published

      Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria

      Christensen, Søren Brøgger, 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    4. 2021
    5. Published

      Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams

      Christensen, Søren Brøgger, 2021, In: Molecules. 26, 19, 31 p., 6057.

      Research output: Contribution to journal › Review › Research › peer-review

    6. Published

      From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development

      Christensen, Søren Brøgger, Simonsen, H. T., Engedal, N., Nissen, P., Møller, J. V., Denmeade, S. R. & Isaacs, J. T., 2021, In: Progress in the chemistry of organic natural products. 115, p. 59-114

      Research output: Contribution to journal › Review › Research › peer-review

    7. Published

      Mipsagargin: The Beginning—Not the End—of Thapsigargin Prodrug-Based Cancer Therapeutics

      Isaacs, J. T., Brennen, W. N., Christensen, Søren Brøgger & Denmeade, S. R., 2021, In: Molecules. 26, 24, 7469.

      Research output: Contribution to journal › Review › Research › peer-review

    8. Published

      Natural Products that Changed Society

      Christensen, Søren Brøgger, 2021, In: Biomedicines. 9, 5, 31 p., 472.

      Research output: Contribution to journal › Review › Research › peer-review

    9. Published

      Targeting Toxins toward Tumors

      Franzyk, Henrik & Christensen, Søren Brøgger, 2021, In: Molecules. 26, 5, 23 p., 1292.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2020
    11. Published

      Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

      Lindner, P., Christensen, Søren Brøgger, Nissen, Poul, Moller, J. V. & Engedal, N., 2020, In: Cell Communication and Signaling. 18, 23 p., 12.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)- 8-O-Debutanoylthapsigargin

      Zimmermann, T., Drasar, P., Rempelova, S., Christensen, Søren Brøgger, Khripach, V. & Jurasek, M., 2020, In: Biomolecules. 10, 11 p., 1640.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

      Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, Henrik, Tuominen, R. K. & Christensen, Søren Brøgger, 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. 2019
    15. Published

      Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

      Andersen, T. B., Rasmussen, S. A., Christensen, Søren Brøgger & Simonsen, H. T., Jan 2019, In: Phytochemistry. 157, https://doi.org/10.1016/j.phytochem.2018.10.027, p. 168-174 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca

      Hassan, A. R., Amer, K. F., El-Toumy, S. A., Nielsen, J. & Christensen, Søren Brøgger, 2019, In: Natural Product Research. 33, 8, p. 1135-1139

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. 2018
    18. Published

      Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds - Scope, Limitations and Perspectives

      Nielsen, J., Christensen, Søren Brøgger & Tung, T. T., Dec 2018, In: Synthesis. 50, 23, p. A193-A196 4 p.

      Research output: Contribution to journal › Conference article › Research › peer-review

    19. Published

      Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death

      Szalai, P., Parys, J. B., Bultynckb, G., Christensen, Søren Brøgger, Nissen, P., Møller, J. V. & Engedal, N., Dec 2018, In: Cell Calcium. 76, p. 48-61 14 p., https://doi.org/10.1016/j.ceca.2018.09.005.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Phorbol Rearrangements

      Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Direct difluoromethylation of heterocycles using difluoroacetic acid

      Nielsen, J., Truong Thanh Tung & Christensen, Søren Brøgger, 19 Aug 2018.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    22. Published

      Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

      Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Cover Feature: LEGO-Inspired Drug Design: Unveiling a Class of Benzo[d ]thiazoles Containing a 3,4-Dihydroxyphenyl Moiety as Plasma Membrane H+ -ATPase Inhibitors (ChemMedChem 1/2018)

      Tung, T., Dao, T. T., Junyent, M. G., Palmgren, Michael, Pomorski, Thomas Guenther, Fuglsang, Anja Thoe, Christensen, Søren Brøgger & Nielsen, J., 8 Jan 2018, In: ChemMedChem. 13, 1, 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      LEGO-inspired drug design: unveiling a class of Benzo[d]thiazoles containing a 3,4-Dihydroxyphenyl moiety as plasma membrane H+-ATPase inhibitors

      Thanh Tung, T., Dao, T. T., Grifell Junyent, M., Palmgren, Michael, Pomorski, Thomas Guenther, Fuglsang, Anja Thoe, Christensen, Søren Brøgger & Nielsen, J., 2018, In: ChemMedChem. 13, 1, 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. 2017
    26. Published

      Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

      Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, Karla Andrea, Tung, T. T., Olsen, J., Nielsen, J. & Christensen, Søren Brøgger, 27 Oct 2017, In: Journal of Natural Products. 80, p. 2830-2834 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Cover picture: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds

      Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 25 Oct 2017, In: Chemistry - A European Journal. 2 p.

      Research output: Contribution to journal › Journal article › Communication

    28. Published

      Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

      Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 11 Oct 2017, In: Chemistry: A European Journal. 23, p. 18125-18128

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response

      Sehgal, P., Szalai, P., Praetorius, H. A., Nissen, Poul, Christensen, Søren Brøgger, Engedal, N. & Møller, J. V., 2 Oct 2017, In: Journal of Biological Chemistry. 292, 48, p. 19656-19673

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection

      Jensen, H. D., Struve, C., Christensen, Søren Brøgger & Krogfelt, K. A., 4 Apr 2017, In: Frontiers in Microbiology. 8, 6 p., 542.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      LEGO-inspired drug design: Discovery of novel fungal Plasma membrane H+-ATPase (Pma1) inhibitors from small molecule libraries: An introduction of HFSA-SBS_DOS-RD strategy in drug discovery.

      Tung, T. T., Dao, T. T., Palmgren, M. B., Fuglsang, A. T., Christensen, Søren Brøgger & Nielsen, J., 2 Apr 2017.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    32. Published

      Perturbing dissimilar biomolecular targets from natural product scaffolds and focused chemical decoration.

      Nielsen, J., Tung, T. T., Tim, H. J., Trong Tuan, D., Anja T., F., Michael, G. & Christensen, Søren Brøgger, 2 Apr 2017. 1 p.

      Research output: Contribution to conference › Poster › Research › peer-review

    33. Published

      Accelerating the domestication of new crops: feasibility and approaches

      Østerberg, J. T., Xiang, Wen, Olsen, L. I., Edenbrandt, A. K., Vedel, S. E., Christiansen, Andreas, Landes, X., Andersen, M. M., Pagh-Rasmussen, Peter, Sandøe, Peter, Nielsen, J., Christensen, Søren Brøgger, Thorsen, Bo Jellesmark, Kappel, Klemens, Gamborg, Christian & Palmgren, Michael, 2017, In: Trends in Plant Science. 22, 5, p. 373-384 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

      Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Localization and in-vivo characterization of Thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

      Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, Kirsten, Andersen-Ranberg, Johan, Nyberg, N., Christensen, Søren Brøgger & Simonsen, H. T., 2017, In: Plant Physiology. 174, 1, p. 56-72 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+-Transport ATPase (SPCA1a)

      Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, Søren Brøgger & Vangheluwe, P., 2017, In: Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. 2016
    38. Published

      Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life

      Dao, T. T., Sehgal, P., Thanh Tung, T., Møller, J. V., Nielsen, J., Palmgren, Michael, Christensen, Søren Brøgger & Fuglsang, Anja Thoe, 2016, In: P L o S One. 11, 9, 19 p., e0163260.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

      Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Neglected diseases

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 347-368 22 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    41. 2015
    42. Published

      Novel thapsigargin analogues and methods of preparing them

      Doan, T. Q. N., Christensen, Søren Brøgger & Crestey, F. L. J., 30 Dec 2015, Patent No. WO2015197860 A2, Priority date 27 Jun 2014, Priority No. DK20140070395 20140627

      Research output: Patent

    43. Published

      Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.

      Doan, T. Q. N. & Christensen, Søren Brøgger, Oct 2015, In: Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    44. Published

      Concise Synthesis of Thapsigargin from Nortrilobolide

      Crestey, F., Toma, M. & Christensen, Søren Brøgger, 8 Sep 2015, In: Tetrahedron Letters. 56, 43, p. 5896-5898 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Drugs and drug leads based on natural products for treatment and prophylaxis of malaria

      Christensen, Søren Brøgger, 25 Feb 2015, Evidence-based validation of herbal medicine: Elsevier. Amsterdam, p. 307-319

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    46. Published

      Are we ready for back-to-nature crop breeding?

      Palmgren, Michael, Edenbrandt, A. K., Vedel, S. E., Andersen, M. M., Landes, X., Østerberg, J. T., Falhof, J., Olsen, L. I., Christensen, Søren Brøgger, Sandøe, Peter, Gamborg, Christian, Kappel, Klemens, Thorsen, Bo Jellesmark & Pagh-Rasmussen, Peter, 2015, In: Trends in Plant Science. 20, 3, p. 155-164 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Chemo- and regioselective functionalization of nortrilobolide: application for semi-synthesis of the natural product 2-acetoxytrilobolide

      Doan, T. Q. N., Crestey, F., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In: Journal of Natural Products. 78, 6, p. 1406-1414

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Iminolactones from Schizophyllum commune

      Liu, X., Frydenvang, Karla Andrea, Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In: Journal of Natural Products. 78, 5, p. 1165-1168 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Targeting thapsigargin towards tumors

      Christensen, Søren Brøgger, Doan, T. Q. N., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T. & Dionne, C. A., 2015, In: Steroids. 97, p. 2-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. 2013
    51. Published

      Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

      Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase

      Paulsen, E. S., Villadsen, J., Tenori, E., Liu, Huizhen, Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, Henriette Elisabeth, Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, Søren Brøgger, 9 May 2013, In: Journal of Medicinal Chemistry. 56, 9, p. 3609-19 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium

      Christensen, Søren Brøgger, Dubois, C., Abeele, F. V., Sehgal, P., Olesen, C., Junker, S., Prevarskaya, N. & Møller, J. V., 2013, In: F E B S Journal. 280, 21, p. 5430-5440 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

      Simonsen, H. T., Weitzel, C. & Christensen, Søren Brøgger, 2013, Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Ramawat, K. G. & Mérillon, J-M. (eds.). Springer, p. 3069-3098 30 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    55. 2012
    56. Published

      Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: New strategies going beyond the standard

      Kongstad, Kenneth Thermann, Ebild, S. J., Christensen, Søren Brøgger, Godejohann, M. & Jaroszewski, J. W., 28 Dec 2012, In: Journal of Chromatography A. 1270, p. 171-177 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae

      Rønsted, Nina, Symonds, M. R. E., Birkholm, T., Christensen, Søren Brøgger, Meerow, A. W., Schmidt, M. M., Mølgaard, Per, Petersen, G., Rasmussen, N., van Staden, J., Stafford, G. I. & Jäger, A., 14 Sep 2012, In: BMC Evolutionary Biology. 12, 12 p., 182.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy (Science Translational Medicine)

      Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, Poul, Christensen, Søren Brøgger & Isaacs, J. T., 18 Jul 2012, In: Science Translational Medicine. 4, 143, 143er4.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    59. Published

      Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy

      Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, P., Christensen, Søren Brøgger & Isaacs, J. T., 27 Jun 2012, In: Science Translational Medicine. 4, 140, p. 140ra86

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      6-O-Methylkrigeine, a new Amaryllidaceae alkaloid from Nerine huttoniae Schönland

      Molander, M., Christensen, Søren Brøgger, Jaeger, A. K., Olsen, C. E. & Rønsted, Nina, 2012, In: Natural Product Research. 26, 1, p. 56-60 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles

      Holler, J. G., Slotved, H., Mølgaard, Per, Olsen, C. E. & Christensen, Søren Brøgger, 2012, In: Bioorganic & Medicinal Chemistry. 20, 14, p. 4514 - 4521 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Drugs for the neglected disease malaria based on natural products

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2012, Bioactive compounds from natural sources: natural products as lead compounds in drug discovery. Tringali, C. (ed.). 2 ed. Boca Raton: CRC Press, p. 525-550

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    63. Published

      Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees

      Holler, J. G., Christensen, Søren Brøgger, Slotved, H., Rasmussen, H. B., Guzman, A., Olsen, C. E., Petersen, B. & Mølgaard, Per, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1138 - 1144 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. 2011
    65. Published

      Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump

      Mahmmoud, Y. A. & Christensen, Søren Brøgger, Oct 2011, In: BBA General Subjects. 1808, 10, p. 2413-2420

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      Amaryllidaceae alkaloids from Rauhia multiflora (Kunth) Ravenna

      Birkholm, T., Rasmussen, N., Christensen, Søren Brøgger, Jäger, A. & Rønsted, Nina, Aug 2011, In: Planta Medica. 77, 12, PG12.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    67. Published

      Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases

      Vandecaetsbeek, I., Christensen, Søren Brøgger, Liu, Huizhen, van Veldhoven, P. P., Waelkens, E., Eggermont, J., Raeymaekers, L., Møller, J. V., Nissen, P., Wuytack, F. & Vangheluwe, P., 1 May 2011, In: BBA General Subjects. 1813, 5, p. 1118-1127

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Amaryllidaceae alkaloids from the Australasian tribe Calostemmateae with acetylcholinesterase inhibitory activity

      Søvsø Jensen, B., Christensen, Søren Brøgger, Jäger, A. K. & Rønsted, Nina, Apr 2011, In: Biochemical Systematics and Ecology. 39, 2, p. 153-155

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

      Saaby, Lasse, Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In: Phytotherapy Research. 25, 2, p. 195-201

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Drugs for the neglected disease malaria based on natural products

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 1 Jan 2011, Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery, Second Edition. CRC Press, p. 525-550 26 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    71. 2010
    72. Published

      Planternes slægtskab som skattekort til nye lægemidler

      Rønsted, Nina, Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H. & Jäger, A. K., Dec 2010, In: Lægemiddelforskning. 2010, p. 19-21

      Research output: Contribution to journal › Journal article › Communication

    73. Published

      Characterization of anti-inflammatory triterpene acids from rose hip powder (Rosa canina L.)

      Saaby, Lasse, Jäger, A., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Aug 2010, In: Planta Medica. 76, 12, p. 1171

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    74. Published

      The pharmacophore of thapsigargin

      Christensen, Søren Brøgger, Skytte, D. M., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M. & Møller, J. V., Aug 2010, In: Planta Medica. 76, 12, p. 1187

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    75. Published

      A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa

      Rubal, J. J., Moreno-Dorado, F. J., Guerra, F. M., Jorge, Z. D., Galán, M. D. C., Salido, G. M., Christensen, Søren Brøgger, Søhoel, H. & Massanet, G. M., 2010, In: Planta Medica. 76, 3, p. 284-290

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs

      Winther, A. L., Liu, Huizhen, Sonntag, Y., Olesen, C., le Maire, M., Søhoel, H., Olsen, C. E., Christensen, Søren Brøgger, Nissen, P. & Møller, J. V., 2010, In: Journal of Biological Chemistry. 285, 37, p. 28883-28892

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase

      Skytte, D. M., Møller, J. V., Liu, Huizhen, Nielsen, H. Ø., Svenningsen, L. E., Jensen, C. M., Olsen, C. E. & Christensen, Søren Brøgger, 2010, In: Bioorganic & Medicinal Chemistry. 18, 15, p. 5634-5646 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      Neglected diseases

      Christensen, Søren Brøgger, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 341-358

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

    79. Published

      Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

      Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. 2009
    81. Published

      19a-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum

      Traore, M., Ziegler, H. L., Olsen, C. E., Hassanata, M., Pierre, G. I., Nacoulma, O. G., Guiguemdé, T. R. & Christensen, Søren Brøgger, 2009, In: Natural Product Research. 23, 12, p. 1108-1111 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells

      Christensen, Søren Brøgger, Skytte, D. M., Denmeade, S. R., Dionne, C., Møller, J. V., Nissen, P. & Isaacs, J. T., 2009, In: Anti-Cancer Agents in Medicinal Chemistry. 9, 3, p. 276-294

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells

      Griend, D. J. V., Antony, L., Dalrymple, S. L., Xu, Y., Christensen, Søren Brøgger, Denmeade, S. R. & Isaacs, J. T., 2009, In: Molecular Cancer Therapeutics. 8, 5, p. 1340-1349

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. 2008
    85. Published

      S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis

      Sheykhzade, Majid, Smajilovic, S., Issa, A., Haunsø, Stig, Christensen, Søren Brøgger & Tfelt-Hansen, J., 28 Sep 2008, In: European Journal of Pharmacology. 593, 1-3, p. 79-86

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      A configurational and conformational study of aframodial and its diasteriomers via experimental and theoretical VA and VCD spectroscopies

      Jalkanen, K. J., Gale, J. D., Lassen, P. R., Hemmingsen, Lars Bo Stegeager, Rodarte, A., Degtyarenko, I. M., Nieminen, R. M., Knapp-Mohammady, M., Suhai, S. & Christensen, Søren Brøgger, 2008, In: Theoretical Chemistry Accounts. 119, 1-3, p. 177-190 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Published

      A new oxygenated ursane derivative from Canthium multiflorum

      Traore, M., Jaroszewski, J. W., Olsen, C. E., Ouédraogo, J. B., Pierre, G. I., Nacoulma, O. G., Guiguemdé, T. R. & Christensen, Søren Brøgger, 2008, In: Planta Medica. 74, 5, p. 560-562 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Bioassay-guided identification and isolation of anticancer components in Hypholoma fasciculare extract

      Pang, W. S. K., Chen, M., Zhai, L. & Christensen, Søren Brøgger, 2008.

      Research output: Contribution to conference › Poster › Research

    89. Published

      Carroll rearrangement to construct the norneolignan skeleton

      Skytte, D. M., Rasmussen, H. B. & Christensen, Søren Brøgger, 2008, In: Natural Product Research. 22, 2, p. 116-123

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      Evaluation of Medicinal Plants from Chile

      Simonsen, H. T., Guzman, A., Adsersen, A., Christensen, Søren Brøgger & Mølgaard, Per, 2008.

      Research output: Contribution to conference › Conference abstract for conference › Research

    91. Published

      Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip

      Jäger, A., Petersen, K. N., Thomasen, G. & Christensen, Søren Brøgger, 2008, In: Phytotherapy Research. 22, 7, p. 982-984 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Isolation of the MAO-inhibitor naringenin from Mentha aquatica L

      Olsen, H. T., Stafford, G. I., van Staden, J., Christensen, Søren Brøgger & Jäger, A. K., 2008, In: Journal of Ethnopharmacology. 117, 3, p. 500-502

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Lægemidler fra naturstoffer: fortid eller fremtid?

      Jaroszewski, J. W., Christensen, Søren Brøgger, Franzyk, Henrik, Stærk, Dan & Ziegler, H., 2008, In: Lægemiddelforskning. p. 4-6

      Research output: Contribution to journal › Journal article › Communication

    94. Published

      Mild psychoactive constituents of Mentha aquatica L.

      Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A., Jäger, A. K. & van Staden, J., 2008, In: South African Journal of Botany. 2, p. 389

      Research output: Contribution to journal › Conference abstract in journal › Research

    95. 2007
    96. Published

      Psychotropic constituents of Mentha aquatica L.

      Van Staden, J., Stafford, G. ,. I., Almqvist, J. P., Vangsoe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A., Aug 2007, In: Planta Medica. 73, 9, p. 928-929

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell.

      Khalid, S. A., Friedrichsen, G. M., Christensen, Søren Brøgger, El Tahir, A. & Satti, G. M., 29 Jan 2007, In: ARKIVOC. 2007, 9, p. 129-134 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Cytotoxic kurubasch aldehyde from Trichilia emetica

      Traore, M., Zhai, L., Chen, M., Olsen, C. E., Odile, N., Pierres, G. I., Bosco, O. J., Robert, G. T. & Christensen, Søren Brøgger, 2007, In: Natural Product Reports. 21, 1, p. 13-17

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Identification of natural products using HPLC-SPE combined with CapNMR

      Lambert, M., Wolfender, J., Stærk, Dan, Christensen, Søren Brøgger, Hostettmann, K. & Jaroszewski, J. W., 2007, In: Analytical Chemistry. 79, 2, p. 727-735

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Published

      Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell.

      Khalid, S. A., Friedrichsen, G. M., Christensen, Søren Brøgger, El Tahir, A. & Satti, G. M., 2007, In: Arkivoc. ix, p. 129-134

      Research output: Contribution to journal › Journal article › Research › peer-review

    101. Published

      Noter til bioorganisk kemi M23-1

      Franzyk, Henrik, Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, København: Københavns Universitet, Det Farmaceutiske Fakultet, Institut for Medicinalkemi.

      Research output: Book/Report › Compendium/lecture notes › Education

    102. Published

      Prenylated acetophenones from Melicope obscura and Melicope obtusifolia ssp. obtusifolia var. arborea and their distribution in Rutaceae

      Adsersen, A., Smitt, U. W., Simonsen, H. T., Christensen, Søren Brøgger & Jaroszewski, J. W., 2007, In: Biochemical Systematics and Ecology. 35, 7, p. 447-453

      Research output: Contribution to journal › Journal article › Research › peer-review

    103. Published

      Psychotropic constituents of Mentha aquatica L.

      van Staden, J., Stafford, G. I., Almqvist, J. P., Vangsøe, S. A. K., Olsen, H. T., Christensen, Søren Brøgger, Adsersen, A. & Jäger, A. K., 2007.

      Research output: Contribution to conference › Poster › Research

    104. 2006
    105. Published

      Ancistrocladinium A and B, the first N,C-coupled naphthyldihydroisoquinoline alkaloids, from a Congolese Ancistrocladus species

      Bringmann, G., Kajahn, I., Reichert, M., Pedersen, S. E. H., Faber, J. H., Gulder, T., Brun, R., Christensen, Søren Brøgger, Ponte-Sucre, A., Moll, H., Heubl, G. & Mudogo, V., 8 Dec 2006, In: Journal of Organic Chemistry. 71, 25, p. 9348-9356 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Published

      Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis

      Kvist, L. P., Christensen, Søren Brøgger, Rasmussen, H. B., Mejia, K. & Gonzalez, Ana Valeria, 19 Jul 2006, In: Journal of Ethnopharmacology. 106, 3, p. 390-402 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. Published

      Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug

      Janssen, S., Rosen, D. M., Ricklis, R. M., Dionne, C. A., Lilja, H., Christensen, Søren Brøgger, Isaacs, J. T. & Denmeade, S. R., 1 Mar 2006, In: Prostate. 66, 4, p. 358-368 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    108. Published

      Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

      Liu, Huizhen, Jensen, K. G., Tran, L. M., Chen, M., Zhai, L., Olsen, C. E., Søhoel, H., Denmeade, S. R., Issacs, J. T. & Christensen, Søren Brøgger, 2006, In: Phytochemistry. 67, 24, p. 2651-2658 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    109. Published

      Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida

      Rubal, J. J., Guerra, F. M., Moreno-Dorado, F. J., Jorge, Z. D., Massanet, G. M., Søhoel, H., Smitt, U. W., Frydenvang, Karla Andrea, Christensen, Søren Brøgger, Nielsen, C. & Eriksson, M., 2006, In: Journal of Natural Products. 69, 11, p. 1566-71 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    110. 2005
    111. Published

      Applying linear interaction energy method for rational design of noncompetitive allosteric inhibitors of the sarco- and endoplasmic reticulum calcium-ATPase

      Singh, P., Mhaka, A. M., Christensen, Søren Brøgger, Gray, J. J., Denmeade, S. R. & Isaacs, J. T., 21 Apr 2005, In: Journal of Medicinal Chemistry. 48, 8, p. 3005-3014 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    112. 2004
    113. Published

      Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer

      Janssen, S., Jakobsen, C. M., Rosen, D. M., Ricklis, R. M., Reineke, U., Christensen, Søren Brøgger, Lilja, H. & Denmeade, S. R., 1 Nov 2004, In: Molecular Cancer Therapeutics. 3, 11, p. 1439-1450 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    114. Published

      Synthesis of the thapsigargins

      Ley, S. V., Antonello, A., Balskus, E. P., Booth, D. T., Christensen, Søren Brøgger, Cleator, E., Gold, H., Högenauer, K., Hünger, U., Myers, R. M., Oliver, S. F., Simic, O., Smith, M. D., Søhoel, H. & Woolford, A. J. A., 17 Aug 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 33, p. 12073-12078 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    115. Published

      Antiplasmodial Constituents of Cajanus cajan

      Duker-Eshun, G., Jaroszewski, J. W., Asomaning, W. A., Oppong-Boachie, F. & Christensen, Søren Brøgger, 1 Feb 2004, In: Phytotherapy Research. 18, 2, p. 128-130 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    116. Published

      Ancistrotanzanine C and related 5,1’- and 7,3’- coupled naphtylisoquinoline alkaloids from Ancistrocladus tanzaniensis

      Bringmann, G., Dreyer, M., Faber, J. H., Dalsgaard, P. W., Stærk, Dan, Jaroszewski, J. W., Ndangalasi, H., Mbago, F., Brun, R. & Christensen, Søren Brøgger, 2004, In: Journal of Natural Products. 67, p. 743-748

      Research output: Contribution to journal › Journal article › Research › peer-review

    117. Published

      The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed

      Ziegler, H. L., Hansen, Harald S., Stærk, Dan, Christensen, Søren Brøgger, Hägerstrand, H. & Jaroszewski, J. W., 2004, In: Antimicrobial Agents and Chemotherapy. 48, p. 4067-4071

      Research output: Contribution to journal › Journal article › Research › peer-review

    118. 2003
    119. Published

      Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

      Denmeade, S. R., Jakobsen, C. M., Janssen, S., Khan, S. R., Garrett, E. S., Lilja, H., Christensen, Søren Brøgger & Isaacs, J. T., 2 Jul 2003, In: National Cancer Institute. Journal (Online). 95, 13, p. 990-1000 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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