Søren Brøgger Christensen

Søren Brøgger Christensen

Professor emeritus, Professor, emeritus

Member of:


    1. 2022
    2. Published

      Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides

      Christensen, Søren Brøgger, 2022, In: Molecules. 27, 17, 29 p., 5648.

      Research output: Contribution to journalReviewpeer-review

    3. Published

      Validation of anti-malarial leads from natural products and traditional medicine for treatment of malaria

      Christensen, Søren Brøgger, 2022, In Evidence-Based validation of herbal medicine. Mukherjee, P. K. (ed.). 2 ed. Amsterdam: Elsevier, p. 389-407

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    4. 2021
    5. Published

      Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams

      Christensen, Søren Brøgger, 2021, In: Molecules. 26, 19, 31 p., 6057.

      Research output: Contribution to journalReviewpeer-review

    6. Published

      From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development

      Christensen, Søren Brøgger, Simonsen, H. T., Engedal, N., Nissen, P., Møller, J. V., Denmeade, S. R. & Isaacs, J. T., 2021, In: Progress in the chemistry of organic natural products. 115, p. 59-114

      Research output: Contribution to journalReviewpeer-review

    7. Published

      Mipsagargin: The Beginning—Not the End—of Thapsigargin Prodrug-Based Cancer Therapeutics

      Isaacs, J. T., Brennen, W. N., Christensen, Søren Brøgger & Denmeade, S. R., 2021, In: Molecules. 26, 24, 7469.

      Research output: Contribution to journalReviewpeer-review

    8. Published

      Natural Products that Changed Society

      Christensen, Søren Brøgger, 2021, In: Biomedicines. 9, 5, 31 p., 472.

      Research output: Contribution to journalReviewpeer-review

    9. Published

      Targeting Toxins toward Tumors

      Franzyk, Henrik & Christensen, Søren Brøgger, 2021, In: Molecules. 26, 5, 23 p., 1292.

      Research output: Contribution to journalJournal articlepeer-review

    10. 2020
    11. Published

      Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

      Lindner, P., Christensen, Søren Brøgger, Nissen, Poul, Moller, J. V. & Engedal, N., 2020, In: Cell Communication and Signaling. 18, 23 p., 12.

      Research output: Contribution to journalJournal articlepeer-review

    12. Published

      Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)- 8-O-Debutanoylthapsigargin

      Zimmermann, T., Drasar, P., Rempelova, S., Christensen, Søren Brøgger, Khripach, V. & Jurasek, M., 2020, In: Biomolecules. 10, 11 p., 1640.

      Research output: Contribution to journalJournal articlepeer-review

    13. Published

      Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

      Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, Henrik, Tuominen, R. K. & Christensen, Søren Brøgger, 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    14. 2019
    15. Published

      Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

      Andersen, T. B., Rasmussen, S. A., Christensen, Søren Brøgger & Simonsen, H. T., Jan 2019, In: Phytochemistry. 157, https://doi.org/10.1016/j.phytochem.2018.10.027, p. 168-174 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    16. Published

      A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca

      Hassan, A. R., Amer, K. F., El-Toumy, S. A., Nielsen, J. & Christensen, Søren Brøgger, 2019, In: Natural Product Research. 33, 8, p. 1135-1139

      Research output: Contribution to journalJournal articlepeer-review

    17. 2018
    18. Published

      Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds - Scope, Limitations and Perspectives

      Nielsen, J., Christensen, Søren Brøgger & Tung, T. T., Dec 2018, In: Synthesis. 50, 23, p. A193-A196 4 p.

      Research output: Contribution to journalConference articlepeer-review

    19. Published

      Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death

      Szalai, P., Parys, J. B., Bultynckb, G., Christensen, Søren Brøgger, Nissen, P., Møller, J. V. & Engedal, N., Dec 2018, In: Cell Calcium. 76, p. 48-61 14 p., https://doi.org/10.1016/j.ceca.2018.09.005.

      Research output: Contribution to journalJournal articlepeer-review

    20. Published

      Phorbol Rearrangements

      Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    21. Published

      Direct difluoromethylation of heterocycles using difluoroacetic acid

      Nielsen, J., Truong Thanh Tung & Christensen, Søren Brøgger, 19 Aug 2018.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    22. Published

      Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

      Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

      Research output: Contribution to journalJournal articlepeer-review

    23. Published
    24. Published

      LEGO-inspired drug design: unveiling a class of Benzo[d]thiazoles containing a 3,4-Dihydroxyphenyl moiety as plasma membrane H+-ATPase inhibitors

      Thanh Tung, T., Dao, T. T., Grifell Junyent, M., Palmgren, Michael, Pomorski, Thomas Guenther, Fuglsang, Anja Thoe, Christensen, Søren Brøgger & Nielsen, J., 2018, In: ChemMedChem. 13, 1, 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    25. 2017
    26. Published

      Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

      Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, Karla Andrea, Tung, T. T., Olsen, J., Nielsen, J. & Christensen, Søren Brøgger, 27 Oct 2017, In: Journal of Natural Products. 80, p. 2830-2834 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    27. Published

      Cover picture: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds

      Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 25 Oct 2017, In: Chemistry - A European Journal. 2 p.

      Research output: Contribution to journalJournal article

    28. Published

      Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds

      Thanh Tung, T., Christensen, Søren Brøgger & Nielsen, J., 11 Oct 2017, In: Chemistry: A European Journal. 23, p. 18125-18128

      Research output: Contribution to journalJournal articlepeer-review

    29. Published

      Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response

      Sehgal, P., Szalai, P., Praetorius, H. A., Nissen, Poul, Christensen, Søren Brøgger, Engedal, N. & Møller, J. V., 2 Oct 2017, In: Journal of Biological Chemistry. 292, 48, p. 19656-19673

      Research output: Contribution to journalJournal articlepeer-review

    30. Published

      Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection

      Jensen, H. D., Struve, C., Christensen, Søren Brøgger & Krogfelt, K. A., 4 Apr 2017, In: Frontiers in Microbiology. 8, 6 p., 542.

      Research output: Contribution to journalJournal articlepeer-review

    31. Published

      LEGO-inspired drug design: Discovery of novel fungal Plasma membrane H+-ATPase (Pma1) inhibitors from small molecule libraries: An introduction of HFSA-SBS_DOS-RD strategy in drug discovery.

      Tung, T. T., Dao, T. T., Palmgren, M. B., Fuglsang, A. T., Christensen, Søren Brøgger & Nielsen, J., 2 Apr 2017.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    32. Published

      Perturbing dissimilar biomolecular targets from natural product scaffolds and focused chemical decoration.

      Nielsen, J., Tung, T. T., Tim, H. J., Trong Tuan, D., Anja T., F., Michael, G. & Christensen, Søren Brøgger, 2 Apr 2017. 1 p.

      Research output: Contribution to conferencePosterResearchpeer-review

    33. Published

      Accelerating the domestication of new crops: feasibility and approaches

      Østerberg, J. T., Xiang, Wen, Olsen, L. I., Edenbrandt, A. K., Vedel, S. E., Christiansen, Andreas, Landes, X., Andersen, M. M., Pagh-Rasmussen, Peter, Sandøe, Peter, Nielsen, J., Christensen, Søren Brøgger, Thorsen, Bo Jellesmark, Kappel, Klemens, Gamborg, Christian & Palmgren, Michael, 2017, In: Trends in Plant Science. 22, 5, p. 373-384 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    34. Published

      Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

      Thanh Tung, T., Jakobsen, Tim Holm, Dao, T. T., Fuglsang, Anja Thoe, Givskov, Michael, Christensen, Søren Brøgger & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    35. Published

      Localization and in-vivo characterization of Thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

      Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, Kirsten, Andersen-Ranberg, Johan, Nyberg, N., Christensen, Søren Brøgger & Simonsen, H. T., 2017, In: Plant Physiology. 174, 1, p. 56-72 17 p.

      Research output: Contribution to journalJournal articlepeer-review

    36. Published

      Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+-Transport ATPase (SPCA1a)

      Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, Søren Brøgger & Vangheluwe, P., 2017, In: Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.

      Research output: Contribution to journalJournal articlepeer-review

    37. 2016
    38. Published

      Demethoxycurcumin is a potent inhibitor of P-type ATPases from diverse kingdoms of life

      Dao, T. T., Sehgal, P., Thanh Tung, T., Møller, J. V., Nielsen, J., Palmgren, Michael, Christensen, Søren Brøgger & Fuglsang, Anja Thoe, 2016, In: P L o S One. 11, 9, 19 p., e0163260.

      Research output: Contribution to journalJournal articlepeer-review

    39. Published

      Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

      Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

      Research output: Contribution to journalJournal articlepeer-review

    40. Published

      Neglected diseases

      Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 347-368 22 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    41. 2015
    42. Published

      Novel thapsigargin analogues and methods of preparing them

      Doan, T. Q. N., Christensen, Søren Brøgger & Crestey, F. L. J., 30 Dec 2015, Patent No. WO2015197860 A2, Priority date 27 Jun 2014, Priority No. DK20140070395 20140627

      Research output: Patent

    43. Published

      Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.

      Doan, T. Q. N. & Christensen, Søren Brøgger, Oct 2015, In: Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.

      Research output: Contribution to journalReviewpeer-review

    44. Published

      Concise Synthesis of Thapsigargin from Nortrilobolide

      Crestey, F., Toma, M. & Christensen, Søren Brøgger, 8 Sep 2015, In: Tetrahedron Letters. 56, 43, p. 5896-5898 3 p.

      Research output: Contribution to journalJournal articlepeer-review

    45. Published

      Drugs and drug leads based on natural products for treatment and prophylaxis of malaria

      Christensen, Søren Brøgger, 25 Feb 2015, Evidence-based validation of herbal medicine: Elsevier. Amsterdam, p. 307-319

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    46. Published

      Are we ready for back-to-nature crop breeding?

      Palmgren, Michael, Edenbrandt, A. K., Vedel, S. E., Andersen, M. M., Landes, X., Østerberg, J. T., Falhof, J., Olsen, L. I., Christensen, Søren Brøgger, Sandøe, Peter, Gamborg, Christian, Kappel, Klemens, Thorsen, Bo Jellesmark & Pagh-Rasmussen, Peter, 2015, In: Trends in Plant Science. 20, 3, p. 155-164 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    47. Published

      Chemo- and regioselective functionalization of nortrilobolide: application for semi-synthesis of the natural product 2-acetoxytrilobolide

      Doan, T. Q. N., Crestey, F., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In: Journal of Natural Products. 78, 6, p. 1406-1414

      Research output: Contribution to journalJournal articlepeer-review

    48. Published

      Iminolactones from Schizophyllum commune

      Liu, X., Frydenvang, Karla Andrea, Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In: Journal of Natural Products. 78, 5, p. 1165-1168 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    49. Published

      Targeting thapsigargin towards tumors

      Christensen, Søren Brøgger, Doan, T. Q. N., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T. & Dionne, C. A., 2015, In: Steroids. 97, p. 2-7 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    50. 2013
    51. Published

      Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

      Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    52. Published

      Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase

      Paulsen, E. S., Villadsen, J., Tenori, E., Liu, H., Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C. L., Autzen, Henriette Elisabeth, Dach, I., Sehgal, P., Nissen, P., Møller, J., Schiøtt, B. & Christensen, Søren Brøgger, 9 May 2013, In: Journal of Medicinal Chemistry. 56, 9, p. 3609-19 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    53. Published

      Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium

      Christensen, Søren Brøgger, Dubois, C., Abeele, F. V., Sehgal, P., Olesen, C., Junker, S., Prevarskaya, N. & Møller, J. V., 2013, In: F E B S Journal. 280, 21, p. 5430-5440 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    54. Published

      Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

      Simonsen, H. T., Weitzel, C. & Christensen, Søren Brøgger, 2013, Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Ramawat, K. G. & Mérillon, J-M. (eds.). Springer, p. 3069-3098 30 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    55. 2012
    56. Published

      Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: New strategies going beyond the standard

      Kongstad, Kenneth Thermann, Ebild, S. J., Christensen, Søren Brøgger, Godejohann, M. & Jaroszewski, J. W., 28 Dec 2012, In: Journal of Chromatography A. 1270, p. 171-177 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    57. Published

      Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae

      Rønsted, Nina, Symonds, M. R. E., Birkholm, T., Christensen, Søren Brøgger, Meerow, A. W., Schmidt, M. M., Mølgaard, Per, Petersen, G., Rasmussen, N., van Staden, J., Stafford, G. I. & Jäger, A., 14 Sep 2012, In: BMC Evolutionary Biology. 12, 12 p., 182.

      Research output: Contribution to journalJournal articlepeer-review

    58. Published

      Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy (Science Translational Medicine)

      Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, Poul, Christensen, Søren Brøgger & Isaacs, J. T., 18 Jul 2012, In: Science Translational Medicine. 4, 143, 143er4.

      Research output: Contribution to journalComment/debatepeer-review

    59. Published

      Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy

      Denmeade, S. R., Mhaka, A. M., Rosen, D. M., Brennen, W. N., Dalrymple, S., Dach, I., Olesen, C., Gurel, B., DeMarzo, A. M., Wilding, G., Carducci, M. A., Dionne, C. A., Møller, J. V., Nissen, P., Christensen, Søren Brøgger & Isaacs, J. T., 27 Jun 2012, In: Science Translational Medicine. 4, 140, p. 140ra86

      Research output: Contribution to journalJournal articlepeer-review

    60. Published

      6-O-Methylkrigeine, a new Amaryllidaceae alkaloid from Nerine huttoniae Schönland

      Molander, M., Christensen, Søren Brøgger, Jaeger, A. K., Olsen, C. E. & Rønsted, Nina, 2012, In: Natural Product Research. 26, 1, p. 56-60 5 p.

      Research output: Contribution to journalJournal articlepeer-review

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