Stephan Pless

Stephan Pless

Professor


  1. 2024
  2. Accepted/In press

    Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels

    Sarkar, Debayan, Galleano, I., Heusser, Stephanie, Ou, S. Y., Uzun, G. R., Khoo, K. K., van der Heden van Noort, G. J., Harrison, J. S. & Pless, Stephan, 2024, (Accepted/In press) In: Cell Chemical Biology.

    Research output: Contribution to journalJournal articlepeer-review

  3. 2023
  4. Published

    Functional modulation of a pH-sensitive ion channel by a transporter family

    Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249a

    Research output: Contribution to journalConference abstract in journalpeer-review

  5. Published

    Unravelling the functional regulation of the NALCN sodium leak channel complex by G protein-coupled receptors

    Harms, Hendrik & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 163a

    Research output: Contribution to journalConference abstract in journal

  6. 2022
  7. Published

    ATP signaling in pancreatic cancer: the P2X7 receptor

    Magni, Lara, Bouazzi, R., Christensen, Nynne, Tozzi, M., Poulsen, M., Johansen, J., Pless, Stephan & Novak, Ivana, 2022, In: Acta Physiologica. 236, S725, p. 661-661

    Research output: Contribution to journalConference abstract in journalpeer-review

  8. Published

    Conformational decoupling in acidsensing ion channels uncovers mechanism and stoichiometry of PcTx1mediated inhibition

    Heusser, Stephanie, Borg, C. B., Colding, J. M. & Pless, Stephan, 2022, In: eLife. 11, 20 p., e73384.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity

    Gasparri, F., Sarkar, Debayan, Bielickaite, S., Poulsen, Mette Homann, Hauser, Alexander Sebastian & Pless, Stephan, 2022, In: British Journal of Pharmacology. 179, 14, p. 3859-3874

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Structural architecture of the human NALCN channelosome

    Kschonsak, M., Chua, H. C., wbv551, wbv551, Chakouri, N., Noland, C. L., Schott, K., Chang, T., Tam, C., Patel, N., Arthur, C. P., Leitner, A., Ben-Johny, M., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature. 603, p. 180–186

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

    Noland, C. L., Chua, H. C., Kschonsak, M., Heusser, Stephanie, Braun, N., Chang, T., Tam, C., Tang, J., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature Communications. 13, 1, 10 p., 1416.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    The suitability of high throughput automated patch clamp for physiological applications

    Obergrussberger, A., Rinke-Weiß, I., Goetze, T. A., Rapedius, M., Brinkwirth, N., Becker, N., Rotordam, M. G., Hutchison, L., Madau, P., Pau, D., Dalrymple, D., Braun, N., Friis, S., Pless, Stephan & Fertig, N., 2022, In: Journal of Physiology. 600, 2, p. 277-297

    Research output: Contribution to journalJournal articlepeer-review

  13. 2021
  14. Published

    Acid-sensing ion channels as potential therapeutic targets

    Heusser, Stephanie & Pless, Stephan, 2021, In: Trends in Pharmacological Sciences. 42, 12, p. 1035-1050

    Research output: Contribution to journalReviewpeer-review

  15. Published

    Characterizing Conformational Changes of ASIC1a During Gating and Peptide Modulation

    Heusser, Stephanie, Sheikh, Zeshan Pervez, Borg, C. B., Galleano, I. & Pless, Stephan, 2021, p. 337A-337A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  16. Published

    Functional Characterization of Disease-Causing Mutations in the Sodium Leak Channel NALCN

    wbv551, wbv551, Ameen, A. O., Chua, H. C. & Pless, Stephan, 2021, p. 10A-11A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  17. Published

    Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5

    Galleano, I., Harms, Hendrik, Choudhury, K., Khoo, K., Delemotte, L. & Pless, Stephan, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 33, 10 p., e2025320118.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology

    Braun, N., Friis, S., Ihling, C., Sinz, A., Andersen, J. & Pless, Stephan, 2021, In: PLOS Biology. 19, 9, 30 p., e3001321.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Interplay of Nav1.5 Disease-Causing Mutations and Phosphorylation Revealed by Protein Semi-Synthesis and Molecular Dynamics Simulations

    Galleano, I., Harms, Hendrik, Choudhury, K., Khoo, K. K., Delemotte, L. & Pless, Stephan, 2021, p. 288A-288A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  20. Published

    Ion channel engineering using protein trans-splicing

    Sarkar, Debayan, Harms, Hendrik, Galleano, I., Sheikh, Zeshan Pervez & Pless, Stephan, 2021, Methods in Enzymology. Elsevier, p. 19-48 30 p. (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  21. Published

    The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs

    Sheikh, Zeshan Pervez, Wulf, M., Friis, S., Althaus, M., Lynagh, T. & Pless, Stephan, 2021, In: Journal of General Physiology. 153, 10, 23 p., e202112899.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons

    Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, Stephan, Engel, D., Liégeois, J. F., Lakaye, B., Roeper, J. & Seutin, V., 2021, In: Neuropharmacology. 197, 15 p., 108722.

    Research output: Contribution to journalJournal articlepeer-review

  23. 2020
  24. Published

    Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing

    Khoo, K. K., Galleano, I., Gasparri, F., Wieneke, R., Harms, Hendrik, Poulsen, Mette Homann, Chua, H. C., Wulf, M., Tampé, R. & Pless, Stephan, 1 Dec 2020, In: Nature Communications. 11, 1, 10 p., 2284.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium

    Chua, H. C., Wulf, M., wbv551, wbv551, Rasmussen, L. P. & Pless, Stephan, Apr 2020, In: Science Advances. 6, 17, 11 p., aaz3154.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedstrom, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 7 Feb 2020, In: Biophysical Journal. 118, 3, supplement 1, p. 582A-582A

    Research output: Contribution to journalConference abstract in journalpeer-review

  27. Published

    The Sodium Leak Channel Complex is Modulated by Voltage and Extracellular Calcium

    Chua, H. C., Wulf, M., wbv551, wbv551, Rasmussen, L. P. & Pless, Stephan, 7 Feb 2020, p. 499A-499A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  28. Published

    Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels

    Lynagh, T., Flood, E., Boiteux, C., Sheikh, Zeshan Pervez, Allen, T. W. & Pless, Stephan, 3 Feb 2020, In: The Journal of general physiology. 152, 2

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels

    Kasimova, M. A., Lynagh, T., Sheikh, Zeshan Pervez, Granata, D., Borg, C. B., Carnevale, V. & Pless, Stephan, 2020, In: Biophysical Journal. 118, 4, p. 861-872 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Mechanism and site of action of big dynorphin on ASIC1a

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedström, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 13, p. 7447-7454

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

    Lynagh, T., Kiontke, S., Meyhoff-Madsen, M., Gless, B. H., Johannesen, J., Kattelmann, S., Christiansen, A., Dufva, M., Laustsen, A. H., Devkota, K., Olsen, Christian Adam, Kuemmel, D., Pless, Stephan & Lohse, B., 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13709-13718 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Structure of the human sodium leak channel NALCN

    Kschonsak, M., Chua, H. C., Noland, C. L., wbv551, wbv551, Clairfeuille, T., Bahlke, O. Ø., Ameen, A. O., Li, Z. R., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2020, In: Nature. 587, p. 313-318

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    The current chemical biology tool box for studying ion channels

    Braun, N., Sheikh, Zeshan Pervez & Pless, Stephan, 2020, In: The Journal of Physiology. 598, 20, p. 4455-4471 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. 2019
  35. Published

    Molecular determinants for agonist recognition and discrimination in P2X2 receptors

    Gasparri, F., Wengel, J., Grutter, T. & Pless, Stephan, 24 May 2019, In: Journal of General Physiology. 151, 7, p. 898–911

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    A Semi-Synthetic Approach to Engineer Ligand- and Voltage-Gated Ion Channels in Live Cells

    Khoo, K. K., Galleano, I. & Pless, Stephan, 2019, p. 274A-274A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  37. Published

    Elucidating the Function and Cell-Specific Interactions of P2X7 Receptor Variants Linked to Mental Disorders

    Poulsen, Mette Homann, Fang, J. & Pless, Stephan, 2019, p. 109A-110A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  38. Published

    Indirect Determinants of Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels

    Sheikh, Zeshan Pervez, Lynagh, T., Kristensen, Anders Skov & Pless, Stephan, 2019, p. 110A-110A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  39. 2018
  40. Published

    Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations

    Sereikaité, Vita, Jensen, T. M. T., Bartling, Christian Reinhard Otto, Jemth, P., Pless, Stephan & Strømgaard, Kristian, 18 Oct 2018, In: ChemBioChem. 19, 20, p. 2136-2145

    Research output: Contribution to journalReviewpeer-review

  41. Published

    One drug-sensitive subunit is sufficient for a nearmaximal retigabine effect in KCNQ channels

    Yau, M. C., Kim, R. Y., Wang, C. K., Li, J., Ammar, T., Yang, R. Y., Pless, Stephan & Kurata, H. T., 1 Oct 2018, In: Journal of General Physiology. 215, 10, p. 1421-1431 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener

    Wang, A. W., Yau, M. C., Wang, C. K., Sharmin, N., Yang, R. Y., Pless, Stephan & Kurata, H. T., 30 Aug 2018, In: Journal of General Physiology. 150, 10, p. 1432-1443 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes

    Lynagh, T., Mikhaleva, Y., Colding, J. M., Glover, J. C. & Pless, Stephan, 14 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. 8430-8435

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results

    Chua, H. C., Servatius, H., Asatryan, B., Schaller, A., Rieubland, C., Noti, F., Seiler, J., Roten, L., Baldinger, S. H., Tanner, H., Fuhrer, J., Haeberlin, A., Lam, A., Pless, Stephan & Medeiros-Domingo, A., 1 Aug 2018, In: Clinical Research in Cardiology. 107, 8, p. 670-678 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins

    Pless, Stephan & Sivilotti, L. G., 1 Apr 2018, In: Current Opinion in Physiology. 2, p. 19-26 8 p.

    Research output: Contribution to journalReviewpeer-review

  46. Published

    How an intrinsic ligand tunes the activity of a potassium channel

    Khoo, K. K. & Pless, Stephan, 22 Mar 2018, In: Journal of General Physiology. 150, 4, p. 517-520

    Research output: Contribution to journalComment/debatepeer-review

  47. Published

    High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics

    Wulf, M. & Pless, Stephan, 6 Feb 2018, In: Cell Reports. 22, 6, p. 1615-1626 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Inhibitor-Induced Conformational Changes in ASIC1A

    Lund, Camilla, Borg, C. B., Lynagh, T. & Pless, Stephan, 2 Feb 2018, p. 130A-130A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  49. Published

    Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels

    Sheikh, Zeshan Pervez, Lynagh, T. P. & Pless, Stephan, 2 Feb 2018, p. 24A-24A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  50. Published

    Peptide Modulation of Acid-Sensing Ion Channels

    Borg, C. B., Haugaard-Kedstrom, L. M., Lynagh, T., Strømgaard, Kristian & Pless, Stephan, 2 Feb 2018, p. 130A-130A.

    Research output: Contribution to conferencePosterResearch

  51. Published

    Phenotypic Spectrum of HCN4 Mutations: A Clinical Case

    Servatius, H., Porro, A., Pless, Stephan, Schaller, A., Asatryan, B., Tanner, H., de Marchi, S. F., Roten, L., Seiler, J., Haeberlin, A., Baldinger, S. H., Noti, F., Lam, A., Fuhrer, J., Moroni, A. & Medeiros-Domingo, A., Feb 2018, In: Circulation. Genomic and precision medicine. 11, 2, e002033.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel

    Callau-Vázquez, D., Pless, Stephan & Lynagh, T., 2018, In: Biochemistry. 57, 8, p. 1360-1368

    Research output: Contribution to journalJournal articlepeer-review

  53. 2017
  54. Published

    PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

    Kim, R. Y., Pless, Stephan & Kurata, H. T., 23 Oct 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. E9702–E9711

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen

    Lynagh, T., Romero-Rojo, J. L., Lund, Camilla & Pless, Stephan, 12 Oct 2017, In: Journal of Medicinal Chemistry. 60, 19, p. 8192-8200 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    A selectivity filter at the intracellular end of the acid-sensing ion channel pore

    Lynagh, T., Flood, E., Boiteux, C., Wulf, M., Komnatnyy, V. V., Colding, J. M., Allen, T. W. & Pless, Stephan, 12 May 2017, In: eLife. 6, 21 p., 24630.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    A New Method to Detect Intra- and Extracellular Conformational Changes in Ion Channels with High Temporal Resolution

    Wulf, M. & Pless, Stephan, 3 Feb 2017, In: Biophysical Journal. 12, 3, p. 285A-285A

    Research output: Contribution to journalConference abstract in journalpeer-review

  58. Published

    Effects of Ligand Conformations and Hetero-Liganded States on P2X2 Receptors

    Gasparri, F., Wengel, J., Grutter, T. & Pless, Stephan, 3 Feb 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 421A-421A 2069-Pos.

    Research output: Contribution to journalConference abstract in journalpeer-review

Previous 1 2 Next

ID: 93715174