Stephanie Heusser

Stephanie Heusser

Assistant Professor


Publication year:
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1 - 15 out of 15Page size: 100
  1. 2024
  2. Accepted/In press

    Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels

    Sarkar, Debayan, Galleano, I., Heusser, Stephanie, Ou, S. Y., Uzun, G. R., Khoo, K. K., van der Heden van Noort, G. J., Harrison, J. S. & Pless, Stephan, 2024, (Accepted/In press) In: Cell Chemical Biology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2022
  4. Published

    Conformational decoupling in acidsensing ion channels uncovers mechanism and stoichiometry of PcTx1mediated inhibition

    Heusser, Stephanie, Borg, C. B., Colding, J. M. & Pless, Stephan, 2022, In: eLife. 11, 20 p., e73384.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

    Noland, C. L., Chua, H. C., Kschonsak, M., Heusser, Stephanie, Braun, N., Chang, T., Tam, C., Tang, J., Arthur, C. P., Ciferri, C., Pless, Stephan & Payandeh, J., 2022, In: Nature Communications. 13, 1, 10 p., 1416.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2021
  7. Published

    Acid-sensing ion channels as potential therapeutic targets

    Heusser, Stephanie & Pless, Stephan, 2021, In: Trends in Pharmacological Sciences. 42, 12, p. 1035-1050

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Characterizing Conformational Changes of ASIC1a During Gating and Peptide Modulation

    Heusser, Stephanie, Sheikh, Zeshan Pervez, Borg, C. B., Galleano, I. & Pless, Stephan, 2021, p. 337A-337A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  9. Published

    Conformational Landscapes of Ligand-Gated Ion Channel GLIC from Markov State Modeling

    Bergh, C., Heusser, Stephanie, Howard, R. J. & Lindahl, E. R., 2021, p. 58A-58A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  10. Published

    Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

    Bergh, C., Heusser, Stephanie, Howard, R. & Lindahl, E., 2021, In: eLife. 10, 23 p., 68369.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Probing Allosteric Networks in Ligand-Gated Ion Channel Gating by Electrophysiology and Molecular Dynamics in the Model Receptor GLIC

    Howard, R. J., Zhuang, Y., Gutheim, S., Zeckey, L., Heusser, Stephanie & Lindahl, E. R., 2021, p. 58A-58A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  12. 2020
  13. Published

    Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedstrom, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 7 Feb 2020, In: Biophysical Journal. 118, 3, supplement 1, p. 582A-582A

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  14. Published

    Allosteric Gating Determinants in the Transmembrane Domain of Pentameric Ligand-Gated Ion Channels

    Howard, R. J., Zhuang, Y., Heusser, Stephanie, Bergh, C. C., Rovsnik, U., Orellana, L. & Lindahl, E., 2020, p. 584A-584A.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  15. Published

    Mechanism and site of action of big dynorphin on ASIC1a

    Borg, C. B., Braun, N., Heusser, Stephanie, Bay, Y., Weis, D., Galleano, I., Lund, Camilla, Tian, W., Haugaard-Kedström, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 13, p. 7447-7454

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2018

  17. Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity

    Heusser, Stephanie, Lycksell, M., Wang, X., McComas, S. E., Howard, R. J. & Lindahl, E., 1 Oct 2018, (E-pub ahead of print) In: Proceedings of the National Academy of Sciences of the United States of America. 115, 42, p. 10672-10677

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

    Fourati, Z., Howard, R. J., Heusser, Stephanie, Hu, H., Ruza, R. R., Sauguet, L., Lindahl, E. & Delarue, M., 24 Apr 2018, In: Cell Reports. 23, 4, p. 993-1004 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2016
  20. Published

    Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel

    Heusser, Stephanie, Yoluk, Ö., Klement, G., Riederer, E. A., Lindahl, E. & Howard, R. J., Jul 2016, In: Journal of Neurochemistry. 138, 2, p. 243-53 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. 2013
  22. Published

    Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels

    Heusser, Stephanie, Howard, R. J., Borghese, C. M., Cullins, M. A., Broemstrup, T., Lee, U. S., Lindahl, E., Carlsson, J. & Harris, R. A., Nov 2013, In: Molecular Pharmacology. 84, 5, p. 670-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 203075805