Trine Meldgaard Lund

Trine Meldgaard Lund

Associate Professor

ORCID: 0000-0001-8598-2880

Publication year:
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  1. 2024
  2. Published

    Dose safety and pharmacodynamics of subcutaneous bupivacaine in a novel extended-release microparticle formulation: A phase 1, dose-ascending study in male volunteers

    Jensen, E. K., Bøgevig, S., Balchen, T., Springborg, A. H., Royal, M. A., Storgaard, Ida Klitzing, Lund, Trine Meldgaard, Møller, Kirsten & Werner, M. U., 2024, In: Basic & clinical pharmacology & toxicology. 134, 5, p. 657-675

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Evaluation of Multi-Frequency Bioelectrical Impedance Analysis against Dual-Energy X-ray Absorptiometry for Estimation of Low Muscle Mass in Older Hospitalized Patients

    Nielsen, R. L., Andersen, A. L., Kallemose, T., Damgaard, Morten, Bornæs, O., Juul-Larsen, H. G., Strejby Christensen, L. W., Jawad, B. N., Andersen, Ove, Rasmussen, H. H., Munk, T., Lund, Trine Meldgaard & Houlind, Morten Baltzer, 2024, In: Journal of Clinical Medicine. 13, 1, 15 p., 196.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Population pharmacokinetic-pharmacodynamic model of subcutaneous bupivacaine in a novel extended-release microparticle formulation

    Storgaard, Ida Klitzing, Jensen, E. K., Bøgevig, S., Balchen, T., Springborg, A. H., Royal, M. A., Møller, Kirsten, Werner, M. U. & Lund, Trine Meldgaard, 2024, In: Basic & clinical pharmacology & toxicology. 134, 5, p. 676-685

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2023
  6. Published

    Appetite stimulation with cannabis-based medicine and methods for assessment of glomerular filtration in older patients with medical illness: A study protocol

    Nielsen, R. L., Bornæs, O., Storgaard, I. K., Kallemose, T., Jørgensen, L. M., Jawad, B. N., Altintas, I., Juul-larsen, H. G., Tavenier, J., Durhuus, J. A., Bengaard, A. K. P., Holst, J. J., Kolko, M., Sonne, D. P., Breindahl, T., Damgaard, M., Porrini, E., Hornum, M., Andersen, O., Pedersen, M. M. & 6 others, Rasmussen, H. H., Munk, T., Lund, Trine Meldgaard, Jensen, A. P. S. L., Andersen, A. L. & Houlind, Morten Baltzer, 2023, In: Basic & Clinical Pharmacology & Toxicology. 133, 3, p. 237-253 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Performance of the 2009 CKDEPI, 2021 CKDEPI, and EKFC equations among high-risk patients in Denmark

    Houlind, Morten Baltzer, Iversen, E., Curovic, V. R., Jørgensen, M. B., Andersen, A., Gustafsson, Finn, Nelson, L. M. S., Perch, Michael, Damgaard, Morten, Persson, F., Feldt-Rasmussen, Bo, Andersen, Ove, Lund, Trine Meldgaard & Hornum, Mads, 2023, In: Clinical Chemistry and Laboratory Medicine. 61, 10, p. e192-e195

    Research output: Contribution to journal › Letter › Research › peer-review

  8. 2022
  9. Published

    Artificial neural network vs pharmacometric model for population prediction of plasma concentration in real-world data: a case study on valproic acid

    Soeorg, H., Sverrisdóttir, E., Andersen, Morten, Lund, Trine Meldgaard & Sessa, Maurizio, 2022, In: Clinical Pharmacology and Therapeutics. 111, 6, p. 1278-1285

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Comment on Delanaye et al: Future perspectives regarding kidney function estimates and dose adjustments

    Iversen, E., Hornum, Mads, Lund, Trine Meldgaard & Houlind, Morten Baltzer, 2022, In: British Journal of Clinical Pharmacology. 88, 6, p. 2998-2999

    Research output: Contribution to journal › Letter › Research › peer-review

  11. Published

    Pharmacom-epi: A framework for integrating pharmacometric modeling into Pharmacoepidemiological research using real-world data

    Soeorg, H., Sverrisdottir, E., Andersen, Morten, Lund, Trine Meldgaard & Sessa, Maurizio, 2022, In: Pharmacoepidemiology and Drug Safety. 31, S2, p. 568-569

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  12. Published

    The PHARMACOM-EPI framework for integrating pharmacometric modelling into pharmacoepidemiological research using real-world data: application to assess death associated with valproate

    Soeorg, H., Sverrisdóttir, E., Andersen, Morten, Lund, Trine Meldgaard & Sessa, Maurizio, 2022, In: Clinical Pharmacology and Therapeutics. 111, 4, p. 840-856

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2021
  14. Published

    Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

    Lyauk, Y. K., Jonker, D. M., Hooker, A., Lund, Trine Meldgaard & Karlsson, M. O., 2021, In: The AAPS journal. 23, 2, 14 p., 33.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2020
  16. Published

    Demonstrating Contribution of Components of Fixed-Dose Drug Combinations Through Longitudinal Exposure-Response Analysis

    Nøhr-Nielsen, A., Lange, Theis, Forman, Julie Lyng, Papathanasiou, T., Foster, D. J. R., Upton, R. N., Bjerrum, Ole Jannik & Lund, Trine Meldgaard, 2020, In: The AAPS Journal. 22, 2, 32.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design

    Springborg, A. D., Jensen, E. K., Kreilgaard, M., Petersen, M. A., Papathanasiou, T., Lund, Trine Meldgaard, Taylor, B. K. & Werner, M. U., 2020, In: PLoS ONE. 15, 11, 22 p., e0242169.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Impact of dose-escalation schemes and drug discontinuation on weight loss outcomes with liraglutide 3.0 mg: A model-based approach

    Papathanasiou, T., Strathe, A., Agersø, H., Lund, Trine Meldgaard & Overgaard, R. V., 2020, In: Diabetes, Obesity and Metabolism. 22, 6, p. 969-977 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Integrated Item Response Theory Modeling of Multiple Patient-Reported Outcomes Assessing Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

    Lyauk, Y. K., Lund, Trine Meldgaard, Hooker, A. C., Karlsson, M. O. & Jonker, D. M., 2020, In: The AAPS Journal. 22, 5, 13 p., 98.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

    Lyauk, Y. K., Jonker, D. M., Lund, Trine Meldgaard, Hooker, A. C. & Karlsson, M. O., 2020, In: The AAPS Journal. 22, 5, 15 p., 115.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents

    Gade, C., Sverrisdóttir, E., Dalhoff, Kim, Sonne, J., Johansen, M. Ø., Christensen, H. R., Burhenne, J., Mikus, G., Holm, Jens-Christian, Lund, Trine Meldgaard & Holst, H., 2020, In: Clinical Pharmacokinetics. 59, p. 643-654

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Pharmacodynamic modelling reveals synergistic interaction between docetaxel and SCO-101 in a docetaxel-resistant triple negative breast cancer cell line

    Nøhr-Nielsen, A., Bagger, Sofie Morsing, Brünner, N., Stenvang, Jan & Lund, Trine Meldgaard, 2020, In: European Journal of Pharmaceutical Sciences. 148, 10 p., 105315.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2019
  24. Published

    Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models

    Papathanasiou, T., Strathe, A., Overgaard, R. V., Lund, Trine Meldgaard & Hooker, A. C., 29 Jul 2019, In: The AAPS Journal. 21, 5, 95.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Body of evidence and approaches applied in the clinical development programme of fixed-dose combinations in the European Union from 2010 to 2016

    Nøhr-Nielsen, A., De Bruin, M. L., Thomsen, M., Pipper, C. B., Lange, Theis, Bjerrum, Ole Jannik & Lund, Trine Meldgaard, 2019, In: British Journal of Clinical Pharmacology. 85, 8, p. 1829-1840 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Dose Finding in the Clinical Development of 60 US Food and Drug Administration-Approved Drugs Compared With Learning vs. Confirming Recommendations

    Lyauk, Y. K., Jonker, D. M. & Lund, Trine Meldgaard, 2019, In: Clinical and Translational Science. 12, 5, p. 481-489

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.

    Papathanasiou, T., Springborg, A., Kongstad, Kenneth Thermann, Stærk, Dan, Møller, Kirsten, Taylor, B. K., Lund, Trine Meldgaard & Werner, M. U., 2019, In: British Journal of Anaesthesia. 123, 2, p. e204-e214

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Simultaneous quantification of high-dose naloxone and naloxone-3-β-D-glucuronide in human plasma by UHPLC-MS/MS

    Kongstad, Kenneth Thermann, Papathanasiou, T., Springborg, A., Lund, Trine Meldgaard, Werner, M. U. & Stærk, Dan, 2019, In: Bioanalysis. 11, 03, p. 165-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. 2018
  30. Published

    Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations

    Papathanasiou, T., Strathe, A., Hooker, A. C., Lund, Trine Meldgaard & Overgaard, R. V., May 2018, In: The AAPS Journal. 20, 13 p., 64.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2017
  32. Published

    Quantification of the Pharmacodynamic Interaction of Morphine and Gabapentin Using a Response Surface Approach

    Papathanasiou, T., Juul, R. V., Gabel-Jensen, C., Kreilgaard, M., Heegaard, Anne-Marie & Lund, Trine Meldgaard, 1 Nov 2017, In: AAPS Journal. 19, 6, p. 1804–1813 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches

    Juul, R. V., Nyberg, J., Kreilgaard, M., Christrup, Lona Louring, Simonsson, U. S. H. & Lund, Trine Meldgaard, Aug 2017, In: Journal of Pharmacokinetics and Pharmacodynamics. 44, 4, p. 325-333 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2016
  35. Published

    A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

    Juul, R. V., Knøsgaard, K. R., Olesen, A. E., Pedersen, K. V., Kreilgaard, M., Christrup, Lona Louring, Osther, P. J., Drewes, A. M. & Lund, Trine Meldgaard, Jul 2016, In: A A P S Journal. 18, 4, p. 1013-1022 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

    Knøsgaard, K., Juul, R. V., Olesen, A. E., Pedersen, K. V., Kreilgaard, M., Christrup, Lona Louring, Osther, P. J. S., Drewes, A. M. & Lund, Trine Meldgaard, Jun 2016.

    Research output: Contribution to conference › Poster › Research

  37. Published

    Pharmacokinetic Metamodel of Morphine and Morphine-6-Glucuronide in Neonates and Adults

    Sverrisdóttir, E., Foster, D. J. R., Olesen, A. E., Lund, Trine Meldgaard, Drewes, A. M., Christrup, Lona Louring, Kreilgaard, M. & Upton, R. N., Jun 2016.

    Research output: Contribution to conference › Poster › Research

  38. Published

    A pharmacokinetic-pharmacodynamic model of morphine exposure and subsequent morphine consumption in postoperative pain

    Juul, R. V., Nyberg, J., Lund, Trine Meldgaard, Rasmussen, S., Kreilgaard, M., Christrup, Lona Louring & Simonsson, U. S. H., 2016, In: Pharmaceutical Research. 33, 5, p. 1093–1103 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain

    Papathanasiou, T., Juul, R. V., Heegaard, Anne-Marie, Kreilgaard, M. & Lund, Trine Meldgaard, 2016, In: European Journal of Pharmaceutical Sciences. 82, p. 97–105 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Population pharmacokinetic modelling of morphine, gabapentin and their combination in the rat

    Papathanasiou, T., Juul, R. V., Gabel-Jensen, C., Kreilgaard, M. & Lund, Trine Meldgaard, 2016, In: Pharmaceutical Research. 33, 11, p. 2630–2643 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. 2015
  42. Published

    Response surface analysis of synergistic interactions of morphine and gabapentin in a rat model of postoperative pain.

    Papathanasiou, T., Juul, R. V., Heegaard, Anne-Marie, Kreilgaard, M. & Lund, Trine Meldgaard, 19 Oct 2015.

    Research output: Contribution to conference › Poster › Research

  43. Published

    Exploring the relationship between analgesic event rate and pain intensity in kidney stone surgery: A Repeated Time to Event Pilot Study

    Juul, R. V., Pedersen, K. V., Christrup, Lona Louring, Olesen, A. E., Drewes, A., Osther, P. J. S. & Lund, Trine Meldgaard, Jun 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  44. Published

    A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain

    Sverrisdóttir, E., Lund, Trine Meldgaard, Olesen, A. E., Drewes, A. M., Christrup, Lona Louring & Kreilgaard, M., 7 Apr 2015, In: European Journal of Pharmaceutical Sciences. 74, p. 45–62 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Carnitine Levels in Skeletal Muscle, Blood, and Urine in Patients with Primary Carnitine Deficiency During Intermission of L-Carnitine Supplementation

    Rasmussen, J., Thomsen, J. A., Olesen, J. H., Lund, Trine Meldgaard, Mohr, M., Clementsen, J., Nielsen, Olav Wendelboe & Lund, A. M., 10 Feb 2015, JIMD Reports. Zschocke, J., Baumgartner, M., Morava, E., Patterson, M., Rahman, S. & Peters, V. (eds.). Berlin: Springer, Vol. 20. p. 103-111 9 p. (JIMD Reports).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  46. Published

    Modelling concentration-analgesia relationships for morphine to evaluate experimental pain models

    Sverrisdóttir, E., Foster, D. J. R., Upton, R. N., Olesen, A. E., Lund, Trine Meldgaard, Gabel-Jensen, C., Drewes, A. M., Christrup, Lona Louring & Kreilgaard, M., 23 Jan 2015, In: European Journal of Pharmaceutical Sciences. 66, p. 50-58 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    COMBINATION OF MORPHINE AND GABAPENTIN LEADS TO SYNERGISTIC EFFECTS IN A RAT MODEL OF POSTOPERATIVE PAIN

    Papathanasiou, T., Juul, R. V., Heegaard, Anne-Marie, Kreilgaard, M. & Lund, Trine Meldgaard, 14 Jan 2015.

    Research output: Contribution to conference › Poster › Research

  48. Published

    Determination of gastric emptying and small intestine transit time in dogs by paracetamol and sulfapyridine absorption modelling using nonlinear mixed-effects pharmacokinetics

    Hadji-Popovski, K., Skyggebjerg, R., Ynddal, L., Lund, Trine Meldgaard & Kristensen, K., 14 Jan 2015.

    Research output: Contribution to conference › Poster › Research

  49. Published

    Determination of gastric emptying in dogs by paracetamol absorption test using nonlinear mixed-effects pharmacokinetics

    Hadji-Popovski, K., Vegge, A., Olsen, J., Lund, Trine Meldgaard & Kristensen, K., 14 Jan 2015.

    Research output: Contribution to conference › Poster › Research

  50. Published

    Repeated Time-to-event Analysis of Consecutive Analgesic Events in Postoperative Pain

    Juul, R. V., Rasmussen, S., Kreilgaard, M., Christrup, Lona Louring, Simonsson, U. S. H. & Lund, Trine Meldgaard, 2015, In: Anesthesiology. 123, 12, p. 1411-1419 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    The metabolic impact of β-hydroxybutyrate on neurotransmission: Reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity

    Lund, Trine Meldgaard, Ploug, K. B., Iversen, A., Jensen, Anders A. & Jansen-Olesen, I., 2015, In: Journal of Neurochemistry. 132, 5, p. 520-531 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. 2014
  53. Published

    How Repeated Time To Event (RTTE) modelling of opioid requests after surgery may improve future post-operative pain management

    Juul, R. V., Rasmussen, S., Kreilgaard, M., simonsson, U., Christrup, Lona Louring & Lund, Trine Meldgaard, 11 Jul 2014.

    Research output: Contribution to conference › Poster › Research

  54. 2013
  55. Published

    How Repeated Time To Event (RTTE) modelling of opioid requests after surgery may improve future post-operative pain management

    Juul, R. V., Rasmussen, S., Kreilgaard, M., Simonsson, U., Christrup, Lona Louring & Lund, Trine Meldgaard, 5 Aug 2013.

    Research output: Contribution to conference › Poster › Research

  56. Published

    Modelling analgesia-concentration relationships for morphine to evaluate experimental pain models

    Sverrisdóttir, E., Foster, D., Upton, R., Olesen, A. E., Lund, Trine Meldgaard, Christrup, Lona Louring & Kreilgaard, M., Jun 2013.

    Research output: Contribution to conference › Poster › Research

  57. Published

    Modelling analgesia-concentration relationships for morphine to evaluate experimental pain models

    Sverrisdóttir, E., Foster, D., Upton, R., Olesen, A. E., Lund, Trine Meldgaard, Christrup, Lona Louring & Kreilgaard, M., 2013, Population Approach Group in Europe.

    Research output: Other contribution › Research

  58. 2012
  59. Published

    KATP channel openers in the trigeminalvascular system

    Ploug, K. B., Amrutkar, D. V., Baun, M., Ramachandran, R., Iversen, A., Lund, Trine Meldgaard, Gupta, S., Hay-Schmidt, A., Olesen, J. & Jansen-Olesen, I., 2012, In: Cephalagia. 32, 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. 2011
  61. Published

    ß-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons

    Lund, Trine Meldgaard, Obel, L. F., Risa, Ø. & Sonnewald, U., 1 Aug 2011, In: Neurochemistry International. 59, 2, p. 309-18 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Development of quantitative pharmacology-pharmacometrics in Denmark

    Honoré, P. G. H., Bjerrum, Ole Jannik, Lund, Trine Meldgaard, Angelo, H., Ingwersen, S. H., Thygesen, P., Kristensen, K. & Larsen, F., 2011.

    Research output: Contribution to conference › Poster › Research

  63. 2009
  64. Published

    Aspartate-glutamate homeostasis in cerebellar neurons changes when shifting from glucose to beta-hydroxybutyrate as substrate

    Lund, Trine Meldgaard, Clausen, M., Risa, Ø., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. s1, p. 291-291

    Research output: Contribution to journal › Conference abstract in journal › Research

  65. Published

    Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons

    Lund, Trine Meldgaard, Risa, Ø., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 2009, In: Journal of Neurochemistry. 110, 1, p. 80-91 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1303792