Trond Ulven

Trond Ulven

Professor

Member of:


    1. 2024
    2. Published

      Drug Repurposing in Crohn's Disease Using Danish Real-World Data

      Shakibfar, Saeed, Allin, K. H., Jess, T., Barbieri, M. A., Battini, V., Simoncic, E., Kirchgesner, J., Ulven, Trond & Sessa, Maurizio, 2024, In: Pragmatic and observational research. 15, p. 17-29

      Research output: Contribution to journalJournal articlepeer-review

    3. Published

      Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

      Dragano, N. R. V., Milbank, E., Haddad-Tóvolli, R., Garrido-Gil, P., Nóvoa, E., Fondevilla, M. F., Capelli, V., Zanesco, A. M., Solon, C., Morari, J., Pires, L., Estevez-Salguero, Á., Beiroa, D., González-García, I., Barca-Mayo, O., Diéguez, C., Nogueiras, R., Labandeira-García, J. L., Rexen Ulven, E., Ulven, T. & 3 others, Claret, M., Velloso, L. A. & López, M., 2024, In: Molecular Metabolism. 79, 13 p., 101840.

      Research output: Contribution to journalJournal articlepeer-review

    4. 2023
    5. Published

      Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists

      Valentini, Alice, Schultz-Knudsen, Katrine, Hansen, A. H., Tsakoumagkou, A., Jenkins, L., Christensen, H. B., Manandhar, Asmita, Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2023, In: Journal of Medicinal Chemistry. 66, 9, p. 6105–6121

      Research output: Contribution to journalJournal articlepeer-review

    6. Published

      Functional-Group-Tolerant Pd-Catalyzed Carbonylative Negishi Coupling with Aryl Iodides

      Kalinin, D. V. & Ulven, Trond, 2023, In: Journal of Organic Chemistry. 88, 23, p. 16633-16638

      Research output: Contribution to journalJournal articlepeer-review

    7. Published

      Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets

      Lorza-Gil, E., Kaiser, G., Carlein, C., Hoffmann, M. D. A., König, G. M., Haug, S., Prates Roma, L., Ulven, Elisabeth Rexen, Ulven, Trond, Kostenis, E., Birkenfeld, A. L., Häring, H. U., Ullrich, S. & Gerst, F., 2023, In: Diabetologia. 66, p. 1501–1515

      Research output: Contribution to journalJournal articlepeer-review

    8. Published

      Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library

      Yao, R., Jensen, Anders A., Bryce-Rogers, H. P., Schultz-Knudsen, Katrine, Zhou, L., Hovendal, N. P., Pedersen, H., Kubus, M., Ulven, Trond & Laraia, L., 2023, In: Journal of Medicinal Chemistry. 66, 16, p. 11536-11554

      Research output: Contribution to journalJournal articlepeer-review

    9. Published
    10. Published

      Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization

      Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.

      Research output: Contribution to journalJournal articlepeer-review

    11. Published

      Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

      Deng, Y., Perez Almeria, C. V., van Gijzel, L., Schaller, Kay, Vedel, L., Gloriam, David E., Ulven, Trond & Bräuner, Hans, 2023, In: Basic and Clinical Pharmacology and Toxicology. 132, 6, p. 459-471

      Research output: Contribution to journalJournal articlepeer-review

    12. 2022
    13. Published

      Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

      Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, Trond, Hudson, B. D., Ulven, Elisabeth Rexen, Dekker, N., Tobin, A. B. & Milligan, G., 2022, In: eLife. 11, 23 p., e73777.

      Research output: Contribution to journalJournal articlepeer-review

    14. Published

      FFA1/Gq - Gi interaction determines glucose-induced insulin secretion of neonatal beta cells

      Gerst, F., Lorza-Gil, E., Kaiser, G., Ulven, Trond, Kostenis, E., Haring, H. -., Birkenfeld, A. L. & Ullrich, S., 2022, In: Diabetologia. 65, Suppl 1, p. S109-S109

      Research output: Contribution to journalConference abstract in journalpeer-review

    15. Published

      Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls

      Morozzi, C., Sauerland, M., Gamon, Luke Francis, Manandhar, Asmita, Ulven, Trond & Davies, Michael J., 2022, In: Redox Biology. 52, 8 p., 102299.

      Research output: Contribution to journalJournal articlepeer-review

    16. Published

      Synthesis of Lysophosphatidylcholine and Mixed Phosphatidylcholine

      Papangelis, N. & Ulven, Trond, 2022, In: The Journal of Organic Chemistry. 87, 12, p. 8194–8197

      Research output: Contribution to journalJournal articlepeer-review

    17. 2021
    18. Published

      Acute effects of delayed-release hydrolyzed pine nut oil on glucose tolerance, incretins, ghrelin and appetite in healthy humans

      Sørensen, K. V., Korfitzen, S. S., Kaspersen, M. H., Ulven, Elisabeth Rexen, Ekberg, J. H., Bauer-Brandl, A., Ulven, Trond & Højlund, K., 2021, In: Clinical Nutrition. 40, 4, p. 2169-2179

      Research output: Contribution to journalJournal articlepeer-review

    19. Published

      Discovery of GPR183 Agonists Based on an Antagonist Scaffold

      Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627

      Research output: Contribution to journalJournal articlepeer-review

    20. Published

      Effects of delayed-release olive oil and hydrolyzed pine nut oil on glucose tolerance, incretin secretion and appetite in humans

      Sørensen, K. V., Kaspersen, M. H., Ekberg, J. H., Bauer-Brandl, A., Ulven, Trond & Højlund, K., 2021, In: Nutrients. 13, 10, 13 p., 3407.

      Research output: Contribution to journalJournal articlepeer-review

    21. Published

      G protein-coupled receptor modulators and a pharmaceutical composition

      Ulven, Trond & Ieremias, L., 2021, IPC No. A61K31/44, A61P25/00, A61P29/00, C07D213/69, C07D405/12, Patent No. WO 2021/123394 A1, 18 Dec 2020, Priority date 20 Dec 2019, Priority No. EP20150090A

      Research output: Patent

    22. Published

      One-Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction

      Loureiro, D. R. P., Soares, J. X., Maia, A., Silva, A. M. N., Rangel, M., Azevedo, C. M. G., Hansen, S., Ulven, Trond, Pinto, M. M. M., Reis, S. & Afonso, C. M. M., 2021, In: ChemistrySelect. 6, 18, p. 4511-4514 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    23. Published

      Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2

      Hansen, A. H., Christensen, H. B., Pandey, S. K., Sergeev, E., Valentini, Alice, Dunlop, J., Dedeo, D., Fratta, S., Hudson, B. D., Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2021, In: ChemMedChem. 16, 21, p. 3326-3341

      Research output: Contribution to journalJournal articlepeer-review

    24. Published

      The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

      Mårtensson, J., Sundqvist, M., Manandhar, Asmita, Ieremias, L., Zhang, L., Ulven, Trond, Xie, X., Björkman, L. & Forsman, H., 2021, In: Journal of Innate Immunity. 13, p. 242–256

      Research output: Contribution to journalJournal articlepeer-review

    25. Published

      USE OF FFAR2 AGONISTS FOR THE TREATMENT OF BACTERIAL SUPERINFECTIONS POST-VIRAL INFECTION

      Trottein, F., Ulven, Trond & Sencio, V., 2021, Patent No. WO2021018786, 4 Feb 2021, Priority date 24 Jul 2019, Priority No. EP20190188615 20190726

      Research output: Patent

    26. 2020
    27. Published

      Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators

      Ulven, Elisabeth Rexen, Quon, T., Sergeev, E., Barki, N., Brvar, M., Hudson, B. D., Dutta, P., Hansen, A. H., Bielefeldt, L. Ø., Tobin, A. B., McKenzie, C. J., Milligan, G. & Ulven, Trond, 9 Apr 2020, In: Journal of Medicinal Chemistry. 63, 7, p. 3577-3595 19 p.

      Research output: Contribution to journalJournal articlepeer-review

    28. Published

      An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights

      Köse, M., Pillaiyar, T., Namasivayam, V., De Filippo, E., Sylvester, K., Ulven, Trond, Von Kügelgen, I. & Müller, C. E., 12 Mar 2020, In: Journal of Medicinal Chemistry. 63, 5, p. 2391-2410 20 p.

      Research output: Contribution to journalJournal articlepeer-review

    29. Published

      Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

      Sencio, V., Barthelemy, A., Tavares, L. P., Machado, M. G., Soulard, D., Cuinat, C., Queiroz-Junior, C. M., Noordine, M. L., Salomé-Desnoulez, S., Deryuter, L., Foligné, B., Wahl, C., Frisch, B., Vieira, A. T., Paget, C., Milligan, G., Ulven, T., Wolowczuk, I., Faveeuw, C., Le Goffic, R. & 4 others, Thomas, M., Ferreira, S., Teixeira, M. M. & Trottein, F., 3 Mar 2020, In: Cell Reports. 30, 9, p. 2934-2947.e6

      Research output: Contribution to journalJournal articlepeer-review

    30. Published

      Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms

      Engel, D. F., Bobbo, V. C. D., Solon, C. S., Nogueira, G. A., Moura-Assis, A., Mendes, N. F., Zanesco, A. M., Papangelis, A., Ulven, Trond & Velloso, L. A., 2020, In: Scientific Reports. 10, 1, 12 p., 11047.

      Research output: Contribution to journalJournal articlepeer-review

    31. Published

      Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

      Husted, Anna Sofie, Ekberg, J. H., Tripp, E., Nissen, T. A. D., Meijnikman, S., O'Brien, S. L., Ulven, Trond, Acherman, Y., Bruin, S. C., Nieuwdorp, M., Gerhart-Hines, Zach, Calebiro, D., Dragsted, Lars Ove & Schwartz, Thue W., 2020, In: Molecular Metabolism. 42, 10 p., 101103.

      Research output: Contribution to journalJournal articlepeer-review

    32. Published

      FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

      Lorza-Gil, E., Kaiser, G., Ulven, Elisabeth Rexen, Koenig, G. M., Gerst, F., Oquendo, M. B., Birkenfeld, A. L., Haering, H., Kostenis, E., Ulven, Trond & Ullrich, S., 2020, In: Scientific Reports. 10, 1, 11 p., 16497.

      Research output: Contribution to journalJournal articlepeer-review

    33. Published

      Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice

      Murtaza, B., Hichami, A., Khan, A. S., Shimpukade, B., Ulven, Trond, Ozdener, M. H. & Khan, N. A., 2020, In: Journal of Lipid Research. 61, 2, p. 133-142 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    34. Published

      Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

      Prihandoko, R., Kaur, D., Wiegman, C. H., Alvarez-Curto, E., Donovan, C., Chachi, L., Ulven, Trond, Tyas, M. R., Euston, E., Dong, Z., Alharbi, A. G. M., Kim, R. Y., Lowe, J. G., Hansbro, P. M., Chung, K. F., Brightling, C. E., Milligan, G. & Tobin, A. B., 2020, In: Science Translational Medicine. 12, 557, 13 p., 9009.

      Research output: Contribution to journalJournal articlepeer-review

    35. 2019
    36. Published

      Preparation of substituted pyrrolo[2,3-c]pyridine-2-carboxamides and thieno[2,3-c]pyridine-2-carboxamides as AMPK inhibitors.

      Lanz, J. & Ulven, Trond, 6 Jun 2019, WIPO. World Intellectual Property Organisation, Patent No. WO2019106087A1

      Research output: Patent

    37. Published

      Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

      Theiler, A., Bärnthaler, T., Platzer, W., Richtig, G., Peinhaupt, M., Rittchen, S., Kargl, J., Ulven, Trond, Marsh, L. M., Marsche, G., Schuligoi, R., Sturm, E. M. & Heinemann, A., 2019, In: The Journal of allergy and clinical immunology. 144, 3, p. 764-776

      Research output: Contribution to journalJournal articlepeer-review

    38. Published

      Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1

      Larsen, Olav, Lückmann, Michael, van der Velden, W. J. C., Oliva-Santiago, M., Brvar, M., Ulven, Trond, Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 2019, In: ACS Pharmacology & Translational Science. 2, 6, p. 429-441 13 p.

      Research output: Contribution to journalLetterpeer-review

    39. 2018
    40. Published

      Preparation of tetrahydroisoquinoline and tetrahydrobenzoazepine derivatives for use as GPR120 modulators.

      Brown, J., Connolly, S., Hansen, S. V. F., Milne, G., Shimpukade, B., Smyth, D., Thomas, G., Ulven, Trond, Brvar, M. & Rigby, A., 27 Sep 2018, Caldan Therapeutics Limited, UK ., Patent No. WO2018172727A1

      Research output: Patent

    41. Published

      Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum

      Domljanovic, I., Ulven, Elisabeth Rexen, Ulven, Trond, Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 31 Jul 2018, In: ACS Omega. 3, 7, p. 7580-7586 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    42. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

      Schilperoort, M., van Dam, A. D., Hoeke, G., Shabalina, I. G., Okolo, A., Hanyaloglu, A. C., Dib, L. H., Mol, I. M., Caengprasath, N., Chan, Y., Damak, S., Miller, A. R., Coskun, T., Shimpukade, B., Ulven, Trond, Kooijman, S., Rensen, P. C. & Christian, M., 17 Jan 2018, In: E M B O Molecular Medicine. 10, 3, 18 p., e8047.

      Research output: Contribution to journalJournal articlepeer-review

    43. Published

      Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties

      Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550 17 p.

      Research output: Contribution to journalJournal articlepeer-review

    44. 2017
    45. Complex Pharmacology of Free Fatty Acid Receptors

      Milligan, G., Shimpukade, B., Ulven, Trond & Hudson, B. D., 11 Jan 2017, In: Chemical Reviews. 117, 1, p. 67-110 44 p.

      Research output: Contribution to journalJournal articlepeer-review

    46. A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

      Sergeev, E., Hansen, A. H., Bolognini, D., Kawakami, K., Kishi, T., Aoki, J., Ulven, Trond, Inoue, A., Hudson, B. D. & Milligan, G., 2017, In: Scientific Reports. 7, 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    47. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

      Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2017, In: Journal of Medicinal Chemistry. 60, 13, p. 5638-5645 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    48. Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

      Houthuijzen, J. M., Oosterom, I., Hudson, B. D., Hirasawa, A., Daenen, L. G. M., McLean, C. M., Hansen, S. V. F., van Jaarsveld, M. T. M., Peeper, D. S., Jafari Sadatmand, S., Roodhart, J. M. L., van de Lest, C. H. A., Ulven, Trond, Ishihara, K., Milligan, G. & Voest, E., 2017, In: F A S E B Journal. 31, 5, p. 2195-2209 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    49. Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)

      Hansen, S. V. F. & Ulven, Trond, 2017, Free Fatty Acid Receptors. Springer Science+Business Media, p. 33-56 24 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    50. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

      Dragano, N. R. V., Solon, C., Ramalho, A. F., de Moura, R. F., Razolli, D. S., Ulven, Elisabeth Rexen, Goncalves de Azavedo, C. M. B. P., Ulven, Trond & Velloso, L. A., 2017, In: Journal of Neuroinflammation. 14, 91, 16 p.

      Research output: Contribution to journalJournal articlepeer-review

    51. Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4

      Watterson, K. R., Hansen, S. V. F., Hudson, B. D., Alvarez-Curto, E., Raihan, S. Z., Goncalves de Azavedo, C. M. B. P., Martin, G., Dunlop, J., Yarwood, S. J., Ulven, Trond & Milligan, G., 2017, In: Molecular Pharmacology. 91, 6, p. 630-641 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    52. Succinct synthesis of saturated hydroxy fatty acids and

      Kaspersen, M. H., Jenkins, L., Dunlop, J., Milligan, G. & Ulven, Trond, 2017, In: MedChemComm. 8, 6, p. 1360-1365 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    53. Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

      Mahmud, Z. A., Jenkins, L., Ulven, Trond, Labéguère, F., Gosmini, R., De Vos, S., Hudson, B. D., Tikhonova, I. G. & Milligan, G., 2017, In: Scientific Reports. 7, 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    54. 2016
    55. Published

      Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

      Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874

      Research output: Contribution to journalJournal articlepeer-review

    56. A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

      Grundmann, M., Tikhonova, I. G., Hudson, B. D., Smith, N. J., Mohr, K., Ulven, Trond, Milligan, G., Kenakin, T. & Kostenis, E., 17 Mar 2016, In: Cell Chemical Biology. 23, 3, p. 392-403 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    57. Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy

      Hansen, S. V. F., Ulven, Elisabeth Rexen, Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, Trond, 1 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2841-2846 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    58. A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

      Due-Hansen, M. E., Pandey, S. K., Ulven, Elisabeth Rexen, Andersen, R., Hansen, S. V. F. & Ulven, Trond, 2016, In: Organic & Biomolecular Chemistry. 14, 2, p. 430-433 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    59. Controlled generation and use of CO in flow

      Hansen, S. V. F., Wilson, Z. E., Ulven, Trond & Ley, S. V., 2016, In: Reaction Chemistry & Engineering. 1, 3, p. 280-287 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    60. Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

      Ulven, Elisabeth Rexen, Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4849-4858 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    61. Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120

      Prihandoko, R., Alvarez-Curto, E., Hudson, B. D., Butcher, A. J., Ulven, Trond, Miller, A. M., Tobin, A. B. & Milligan, G., 2016, In: Molecular Pharmacology. 89, 5, p. 505-520 16 p.

      Research output: Contribution to journalJournal articlepeer-review

    62. Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

      Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Ulven, Elisabeth Rexen, Milligan, G., Stocker, C. J. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8868-8878 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    63. Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands

      Sergeev, E., Hojgaard Hansen, A., Pandey, S. K., Mackenzie, A. E., Hudson, B. D., Ulven, Trond & Milligan, G., 2016, In: Journal of Biological Chemistry. 291, p. 303-317 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    64. The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

      Björkman, L., Mårtensson, J., Winther, M., Gabl, M., Holdfeldt, A., Uhrbom, M., Bylund, J., Højgaard Hansen, A., Pandey, S. K., Ulven, Trond, Forsman, H. & Dahlgren, C., 2016, In: Molecular and Cellular Biology. 36, 20, p. 2583-2595 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    65. Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice

      Gozal, D., Qiao, Z., Almendros, I., Zheng, J., Khalyfa, A., Shimpukade, B. & Ulven, Trond, 2016, In: International Journal of Obesity. 40, 7, p. 1143-1149 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    66. 2015
    67. Published

      Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120

      Ulven, Trond & Ulven, Elisabeth Rexen, 17 Jul 2015, In: Annual Review of Nutrition. 35, p. 239-263 25 p.

      Research output: Contribution to journalJournal articlepeer-review

    68. Published

      Oxalyl chloride as a practical carbon monoxide source for carbonylation reactions

      Hansen, S. V. F. & Ulven, Trond, 5 Jun 2015, In: Organic Letters. 17, 11, p. 2832-2835 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    69. Published

      Characterising pharmacological ligands to study the long chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4

      Milligan, G., Alvarez-Curto, E., Watterson, K. R., Ulven, Trond & Hudson, B. D., 2015, In: British Journal of Pharmacology. 172, 13, p. 3254-3265 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    70. Published

      Comprehensive and quantitative profiling of lipid species in human milk, cow milk and a phospholipid-enriched milk formula by GC and MS/MSALL

      Sokol, O., Ulven, Trond, Færgeman, N. J. & Ejsing, C. S., 2015, In: European Journal of Lipid Science and Technology. 117, 6, p. 751-759 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    71. 2014
    72. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

      Hudson, B. D., Ulven, Elisabeth Rexen, Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, Trond & Milligan, G., Aug 2014, In: Molecular Pharmacology. 86, 2, p. 200-210 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    73. The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120)

      Hudson, B. D., Shimpukade, B., Milligan, G. & Ulven, Trond, 18 Jul 2014, In: Journal of Biological Chemistry. 289, 29, p. 20345-20358 14 p.

      Research output: Contribution to journalJournal articlepeer-review

    74. Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

      Butcher, A. J., Hudson, B. D., Shimpukade, B., Alvarez-Curto, E., Prihandoko, R., Ulven, Trond, Milligan, G. & Tobin, A. B., 27 Jun 2014, In: Journal of Biological Chemistry. 289, 26, p. 18451-18465 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    75. Direct N9-arylation of purines with aryl halides

      Larsen, A. F. & Ulven, Trond, 21 May 2014, In: Chemical Communications. 50, 39, p. 4997-4999 3 p.

      Research output: Contribution to journalJournal articlepeer-review

    76. G-protein-coupled receptors for free fatty acids

      Milligan, G., Ulven, Trond, Murdoch, H. & Hudson, B. D., 2 Jan 2014, In: British Journal of Nutrition. 111, Supplement S1, p. S3-S7

      Research output: Contribution to journalJournal articlepeer-review

    77. Phenanthroline-2,9-bistriazoles as selective G-quadruplex ligands

      Nielsen, M. C., Larsen, A. F., Abdikadir, F. H. & Ulven, Trond, 2014, In: European Journal of Medicinal Chemistry. 72, p. 119-126 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    78. Published

      Treatment of type 2 diabetes by free Fatty Acid receptor agonists

      Watterson, K. R., Hudson, B. D., Ulven, Trond & Milligan, G., 2014, In: Frontiers in Endocrinology. 5

      Research output: Contribution to journalJournal articlepeer-review

    79. 2013
    80. Published

      GPR120 receptor modulators

      Ulven, Trond & Shimpukade, B., 19 Dec 2013, Patent No. WO 2013/185766 A1

      Research output: Patent

    81. Published

      Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

      Chalikiopoulos, A., Thiele, S., Malmgaard-Clausen, M., Rydberg, P., Isberg, V., Ulven, Trond, Frimurer, Thomas Michael, Rosenkilde, Mette & Gloriam, David E., 25 Nov 2013, In: Journal of Chemical Information and Modeling. 53, 11, p. 2863-73 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    82. Published

      GPR120 receptor modulators

      Ulven, Trond & Shimpukade, B., 26 Sep 2013, Patent No. WO 2013/139341 A1

      Research output: Patent

    83. In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469

      Urban, C., Hamacher, A., Partke, H. J., Roden, M., Schinner, S., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Gohlke, H. & Kassack, M. U., 17 Jul 2013, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1021-2030 1010 p.

      Research output: Contribution to journalJournal articlepeer-review

    84. Published

      Multistep Continuous-Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure-Activity Relationships of CCR8 Ligands

      Petersen, T. P., Mirsharghi, S., Rummel, P. C., Thiele, S., Rosenkilde, Mette, Ritzén, A. & Ulven, Trond, 8 Jul 2013, In: Chemistry: A European Journal. 19, 28, p. 9343-50 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    85. Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

      Hudson, B. D., Due-Hansen, M. E., Ulven, Elisabeth Rexen, Hansen, A., Mackenzie, A. E., Murdoch, H., Pandey, S. K., Ward, R. J., Marquez, R., Tikhonova, I. G., Ulven, Trond & Milligan, G., 14 Jun 2013, In: Journal of Biological Chemistry. 288, p. 17296-17312 17 p.

      Research output: Contribution to journalJournal articlepeer-review

    86. Discovery of TUG-770

      Ulven, Elisabeth Rexen, Hansen, S. V. F., Urban, C., Hudson, B. D., Wargent, E. T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C. J., Ullrich, S., Kostenis, E., Kassack, M. U., Milligan, G., Cawthorne, M. A. & Ulven, Trond, 9 May 2013, In: A C S Medicinal Chemistry Letters. 4, 5, p. 441-445 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    87. Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schmidt, J., Hansen, S. V. F., Hudson, B. D., Zaibi, M., Markussen, S. B., Hagesaether, E., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 982-992 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    88. Reevaluation of Fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans

      Wagner, R., Kaiser, G., Gerst, F., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Grundmann, M., Machicao, F., Peter, A., Kostenis, E., Ulven, Trond, Fritsche, A., Häring, H. & Ullrich, S., 1 Feb 2013, In: Diabetes. 62, 6, p. 2106-2111 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    89. Published

      The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs

      Hudson, B. D., Ulven, Trond & Milligan, G., 1 Jan 2013, In: Current Topics in Medicinal Chemistry. 13, 1, p. 14-25 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    90. Published

      Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

      Petersen, T. P., Larsen, A. F., Ritzén, A. & Ulven, Trond, 2013, In: Journal of Organic Chemistry. 78, 8, p. 4190-4195 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    91. Mucus can change the permeation rank order of drug candidates

      Hagesaether, E., Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 2013, In: International Journal of Pharmaceutics. 452, 1-2, p. 276-282 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    92. Published

      Selective copper catalysed aromatic N-arylation in water

      Engel-Andreasen, J., Shimpukade, B. & Ulven, Trond, 2013, In: Green Chemistry. 15, 2, p. 336-340 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    93. The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

      Hudson, B. D., Shimpukade, B., Mackenzie, A. E., Butcher, A. J., Pediani, J. D., Ulven, Elisabeth Rexen, Heathcote, H., Tobin, A. B., Ulven, Trond & Milligan, G., 2013, In: Molecular Pharmacology. 84, 5, p. 710-725 16 p.

      Research output: Contribution to journalJournal articlepeer-review

    94. 2012
    95. Published

      Preparation of ortho-fluoro substituted compounds for the treatment of metabolic diseases.

      Ulven, Trond & Christiansen, E., 11 Oct 2012, Patent No. WO 2012/136221A1

      Research output: Patent

    96. Published

      Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

      Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.

      Research output: Contribution to journalJournal articlepeer-review

    97. Published

      Antidiabetic enolic glucoside of phenylpyruvic acid.

      Joubert, E., Fey, S. J., Louw, J., Ulven, Trond & Tyagi, R., 12 Apr 2012, Patent No. WO 2012/045363A1

      Research output: Patent

    98. Published

      A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

      Blättermann, S., Peters, L., Ottersbach, P. A., Bock, A., Konya, V., Weaver, C. D., Gonzalez, A., Schröder, R., Tyagi, R., Luschnig, P., Gäb, J., Hennen, S., Ulven, Trond, Pardo, L., Mohr, K., Gütschow, M., Heinemann, A. & Kostenis, E., 2012, In: Nature Chemical Biology. 8, 7, p. 631-638 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    99. Published

      A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

      Tyagi, R., Shimpukade, B., Blättermann, S., Kostenis, E. & Ulven, Trond, 2012, In: MedChemComm. 3, p. 195-198 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    100. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

      Hudson, B. D., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, Trond & Milligan, G., 2012, In: F A S E B Journal. 26, 12, p. 4951-4965 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    101. Published

      Discovery of a potent and selective GPR120 agonist

      Shimpukade, B., Hudson, B. D., Hovgaard, C. K., Milligan, G. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 9, p. 4511-4515 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    102. Published

      Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3

      Hudson, B. D., Tikhonova, I. G., Pandey, S. K., Ulven, Trond & Milligan, G., 2012, In: Journal of Biological Chemistry. 287, 49, p. 41195-41209 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    103. Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 14, p. 6624-6628 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    104. Published

      PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2

      Schröder, R., Xue, L., Konya, V., Martini, L., Kampitsch, N., Whistler, J. L., Ulven, Trond, Heinemann, A., Pettipher, R. & Kostenis, E., 2012, In: P L o S One. 7, 3, p. e33329

      Research output: Contribution to journalJournal articlepeer-review

    105. Published

      Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

      Ulven, Trond, 2012, In: Frontiers in Endocrinology. 3

      Research output: Contribution to journalJournal articlepeer-review

    106. Published

      Tetrasubstituted phenanthrolines as highly potent, water-soluble, and selective g-quadruplex ligands

      Larsen, A. F., Nielsen, M. C. & Ulven, Trond, 2012, In: Chemistry: A European Journal. 18, 35, p. 10892-10902 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    107. Published

      The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow

      Petersen, T. P., Polyzos, A., O'Brien, M., Ulven, Trond, Baxendale, I. R. & Ley, S. V., 2012, In: ChemSusChem (Print). 5, 2, p. 274-277 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    108. 2011
    109. Published

      Method of synthesizing a 5-oxo-conjugated fatty acid

      Ulven, Trond & Tyagi, R., 27 Oct 2011, Patent No. WO 2011/131619 A1

      Research output: Patent

    110. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

      Schmidt, J., Smith, N. J., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Hudson, B. D., Ward, R. J., Drewke, C., Milligan, G., Kostenis, E. & Ulven, Trond, 10 Jan 2011, In: Journal of Biological Chemistry. 286, 12, p. 10628-10640 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    111. Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40

      Schmidt, J., Liebscher, K., Merten, N., Grundmann, M., Mielenz, M., Sauerwein, H., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Ullrich, S., Gomeza, J., Drewke, C. & Kostenis, E., 2011, In: Journal of Biological Chemistry. 286, 14, p. 11890-11894 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    112. Published

      Efficient Synthesis of 4,7-Diamino Substituted 1,10-Phenanthroline-2,9-dicarboxamides

      Larsen, A. F. & Ulven, Trond, 2011, In: Organic Letters. 13, 13, p. 3546-3548 3 p.

      Research output: Contribution to journalJournal articlepeer-review

    113. Published

      Extracellular loop 2 of the free Fatty Acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator

      Smith, N. J., Ward, R. J., Stoddart, L. A., Hudson, B. D., Kostenis, E., Ulven, Trond, Morris, J. C., Tränkle, C., Tikhonova, I. G., Adams, D. R. & Milligan, G., 2011, In: Molecular Pharmacology. 80, 1, p. 163-173 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    114. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties

      Ulven, Elisabeth Rexen, Urban, C., Grundmann, M., Due-Hansen, M. E., Hagesaether, E., Schmidt, J., Pardo, L., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2011, In: Journal of Medicinal Chemistry. 54, 19, p. 6691-6703 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    115. 2010
    116. Published

      Novel CRTH2 antagonists: a review of patents from 2006 to 2009

      Ulven, Trond & Kostenis, E., 1 Nov 2010, In: Expert Opinion on Therapeutic Patents. 20, 11, p. 1505-1530 26 p.

      Research output: Contribution to journalJournal articlepeer-review

    117. A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

      Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 19 Feb 2010, In: Journal of Organic Chemistry. 75, 4, p. 1301-1304 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    118. Published

      Compounds for the treatment of metabolic diseases

      Ulven, Trond & Christiansen, E., 4 Feb 2010, Patent No. WO 2010/012650

      Research output: Patent

    119. Published

      Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2

      Grimstrup, M., Rist, Ø., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Mathiesen, Jesper M., Kostenis, E. & Högberg, T., 1 Feb 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1181-1185 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    120. Published

      Macrocyclic G-quadruplex ligands

      Nielsen, M. C. & Ulven, Trond, 1 Jan 2010, In: Current Medicinal Chemistry. 17, 29, p. 3438-3448 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    121. Published

      Structure-activity study of dihydrocinnamic acids and discovery of the potent FFA1 (GPR40) agonist TUG-469

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Merten, N., Pfleiderer, M., Karlsen, K. K., Rasmussen, S. S., Steensgaard, M., Hamacher, A., Schmidt, J., Drewke, C., Petersen, R. K., Kristiansen, Karsten, Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2010, In: ACS Medicinal Chemistry Letters. 1, 7, p. 345-349 5 p.

      Research output: Contribution to journalLetterpeer-review

    122. Published

      Targeting the prostaglandin D2 receptors DP1 and CRTH2 for treatment of inflammation

      Ulven, Trond & Kostenis, E., 2010, Frontiers in Medicinal Chemistry. Bentham Science Publishers, Vol. 5.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    123. 2009
    124. Published

      Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands

      Nielsen, M. C., Borch, J. & Ulven, Trond, 15 Dec 2009, In: Bioorganic & Medicinal Chemistry. 17, 24, p. 8241-8246 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    125. Published

      Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

      Rist, O., Grimstrup, M., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Kostenis, E. & Högberg, T., 4 Dec 2009, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1177-1180 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    126. Published

      A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

      Petersen, T. P., Ritzén, A. & Ulven, Trond, 19 Nov 2009, In: Organic Letters. 11, 22, p. 5134-5137 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    127. Published

      1,2-Dihydrospiro[carbazole-3(4H),2'-[1,3]dioxolane]

      Bjerrum, J. V., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o579

      Research output: Contribution to journalJournal articlepeer-review

    128. Published

      4-Fluoro-N-methyl-N-(1,2,3,4-tetrahydrocarbazol-3-yl)benzenesulfonamide

      Rasmussen, K. G., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o742

      Research output: Contribution to journalJournal articlepeer-review

    129. Published

      Cyclopropyl and cyclobutyl epothilone analogs

      Nicolaou, K. C., Namoto, K., Ritzén, A., Ulven, Trond, Shoji, M. & Altmann, K., 2009, Patent No. EP 1,420,780 B1

      Research output: Patent

    130. Published

      Discovery and structure-activity relationship investigations of 4-arylethynyldihydrocinnamic acid agonists of the antidiabetic target free fatty acid receptor 1

      Christiansen, E., Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 2009.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    131. Published

      Ethyl 2-(1,2,3,4-tetrahydrospiro[carbazole-3,2'- [1,3]dioxolan]-9-yl)acetate

      Loffler, P., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, Section E, p. o685

      Research output: Contribution to journalJournal articlepeer-review

    132. Published

      Extraction of G-quadruplex ligands from disulfide-based dynamic combinatorial libraries

      Nielsen, Mads & Ulven, Trond, 2009, p. ORGN-345.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    133. Published

      Flow chemistry methods for the synthesis chemokine receptor ligands

      Petersen, T. P., Ritzén, A. & Ulven, Trond, 2009, p. ORGN-570.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    134. Published

      The C-terminal tail of CRTH2 is a key molecular determinant that constrains GalphaI- and downstream-signaling cascade activation

      Schroeder, R., Merten, N., Mathiesen, Jesper M., Martini, L., Letunic, A. K., Krop, F., Blaukat, A., Fang, Y., Tran, E., Ulven, Trond, Drewke, C., Whistler, J., Pardo, L., Gomeza, J. & Kostenis, E., 2009, In: Journal of Biological Chemistry. 284, 2, p. 1324-1336 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    135. 2008
    136. Published

      Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes

      Ulven, Elisabeth Rexen, Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A. D., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 27 Nov 2008, In: Journal of Medicinal Chemistry. 51, 22, p. 7061-4 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    137. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    138. Published

      Selective extraction of G-quadruplex ligands from a rationally designed scaffold-based dynamic combinatorial library

      Nielsen, M. C. & Ulven, Trond, 1 Jan 2008, In: Chemistry: A European Journal. 14, 31, p. 9487-9490 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    139. 2007
    140. Published

      A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst

      Royer, J. F., Schratl, P., Lorenz, S., Kostenis, E., Ulven, Trond, Schuligoi, R., Peskar, B. A. & Heinemann, A., 1 Dec 2007, In: Allergy. 62, 12, p. 1401-1409 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    141. Published

      Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2

      Ulven, Trond, Gallen, M. J., Nielsen, M. C., Merten, N., Schmidt, C., Mohr, K., Tränkle, C. & Kostenis, E., 1 Nov 2007, In: Bioorganic & Medicinal Chemistry Letters. 17, 21, p. 5924-5927 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    142. Published

      The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking

      Schratl, P., Royer, J. F., Kostenis, E., Ulven, Trond, Sturm, E. M., Waldhoer, M., Hoefler, G., Schuligoi, R., Lippe, I. T., Peskar, B. A. & Heinemann, A., 1 Oct 2007, In: Journal of Immunology. 179, 7, p. 4792-4799 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    143. Published

      Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

      Uller, L., Mathiesen, Jesper M., Alenmyr, L., Korsgren, M., Ulven, Trond, Högberg, T., Andersson, G., Persson, C. G. A. & Kostenis, E., 1 Feb 2007, In: Respiratory Research. 8, 16

      Research output: Contribution to journalJournal articlepeer-review

    144. Published

      Phenoxyacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2007, Patent No. WO 2007/062678 A1

      Research output: Patent

    145. Published

      Thiazole- and pyrimidineacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2007, Patent No. WO 2007/062677 A1

      Research output: Patent

    146. 2006
    147. Published

      6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists

      Ulven, Trond, Little, P. B., Receveur, J., Frimurer, Thomas Michael, Rist, Ø., Nørregaard, P. K., Mathiesen, Jesper M. & Högberg, T., 2006, In: Bioorganic & Medicinal Chemistry Letters. 16, 4, p. 1070-1075 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    148. Published

      Emerging roles of DP and CRTH2 in allergic inflammation

      Kostenis, E. & Ulven, Trond, 2006, In: Trends in Molecular Medicine. 12, 4, p. 148-158 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    149. Published

      Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

      Ulven, Trond, Receveur, J., Grimstrup, M., Rist, Ø., Frimurer, Thomas Michael, Gerlach, L., Mathiesen, Jesper M., Kostenis, E., Uller, L. & Högberg, T., 2006, In: Journal of Medicinal Chemistry. 49, 23, p. 6638-6641 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    150. Published

      On the mechanism of interaction of potent, surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

      Mathiesen, Jesper M., Christopoulos, A., Ulven, Trond, Royer, J. F., Campillo, M., Heinemann, A., Pardo, L. & Kostenis, E., 2006, In: Molecular Pharmacology. 69, 4, p. 1441-1453 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    151. Published

      Targeting G protein-coupled 7TM receptors in treatment of inflammation

      Ulven, Trond, 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1317-1318 2 p.

      Research output: Contribution to journalJournal article

    152. Published

      Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation

      Ulven, Trond & Kostenis, E., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1427-1444 18 p.

      Research output: Contribution to journalJournal articlepeer-review

    153. 2005
    154. Published

      6-Acylamino-2-aminoquinolines as Potent Melanin-Concentrating Hormone 1 Receptor Antagonists

      Ulven, Trond, Frimurer, Thomas Michael, Receveur, J., Little, P. B., Rist, Ø., Nørregaard, P. K. & Högberg, T., 2005, In: Journal of Medicinal Chemistry. 48, 18, p. 5684-5697 14 p.

      Research output: Contribution to journalJournal articlepeer-review

    155. Published

      A physicogenetic method to assign ligand-binding relationships between 7TM receptors

      Frimurer, Thomas Michael, Ulven, Trond, Elling, T. C. E., Gerlach, L. O., Kostenis, E. & Högberg, T., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 16, p. 3707-3712 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    156. Published

      CRTH2 receptor ligands for therapeutic use

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/115382 A1

      Research output: Patent

    157. Published

      CRTH2 receptor ligands for therapeutic use - B-series

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E. & Högberg, T., 2005, Patent No. WO 2005/115374 A1

      Research output: Patent

    158. Published

      Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2

      Mathiesen, Jesper M., Ulven, Trond, Martin, L., Gerlach, L., Heinemann, A. & Kostenis, E., 2005, In: Molecular Pharmacology. 68, 2, p. 393-402 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    159. Published

      Minor Structural Modifications Convert the Dual TP/CRTH2 Antagonist Ramatroban into a Highly Selective and Potent CRTH2 Antagonist

      Ulven, Trond & Kostenis, E., 2005, In: Journal of Medicinal Chemistry. 48, 4, p. 897-900 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    160. Published

      Preparation of phenyl benzoyl pyrazoles as CRTH2 receptor ligands

      Ulven, Trond, Frimurer, Thomas Michael, Rist, O., Kostenis, E., Hoegberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/115382 A1

      Research output: Patent

    161. Published

      Preparation of substituted thiazoleacetic acids as CRTH2 receptor ligands

      Ulven, Trond, Frimurer, Thomas Michael, Rist, O., Kostenis, E., Hoegberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/116001 A1

      Research output: Patent

    162. Published

      Quinazoline compounds and their use in MCH-related disease

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/123714

      Research output: Patent

    163. Published

      Substituted thiazoleacetic acids as CRTH2 receptor ligands

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/116001 A1

      Research output: Patent

    164. 2004
    165. Published

      4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

      Receveur, J., Bjurling, E., Ulven, Trond, Little, P. B., Nørregaard, P. K. & Högberg, T., 18 Oct 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 20, p. 5075-5080 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    166. Published
    167. Published

      Cyclic Quinoline compounds for use in MCH receptor related disorders

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052371

      Research output: Patent

    168. Published

      Novel benzamide compounds for use in MCH receptor related disorders

      Högberg, T., Bjurling, A. E., Receveur, J., Ulven, Trond, Elling, C. E. & Nørregaard, P. K., 2004, Patent No. WO 2004/048319

      Research output: Patent

    169. Published

      Quinoline compounds for use in MCH receptor related disorders

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052370

      Research output: Patent

    170. 2002
    171. Published

      Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries

      Nicolaou, K. C., Montagnon, T., Ulven, Trond, Baran, P. S., Zhong, Y. & Sarabia, F., 22 May 2002, In: American Chemical Society. Journal. 124, 20, p. 5718-5728 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    172. 2001
    173. Published

      Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues

      Nicolaou, K. C., Namoto, K., Ritzén, A., Ulven, Trond, Shoji, M., Li, J., D'Amico, G., Liotta, D., French, C. T., Wartmann, M., Altmann, K. H. & Giannakakou, P., 26 Sep 2001, In: American Chemical Society. Journal. 123, 38, p. 9313-9323 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    174. Published

      Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

      Nicolaou, K. C., Namoto, K., Li, J., Ritzén, A., Ulven, Trond, Shoji, M., Zaharevitz, D., Gussio, R., Sackett, D. L., Ward, R. D., Hensler, A., Fojo, T. & Giannakakou, P., 8 Jan 2001, In: ChemBioChem. 2, 1, p. 69-75 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    175. Published

      Synthesis of all diastereomers of the 2-deoxypentoses and 2,6-dideoxyhexoses from 2-phenyl-1,3-dioxan-5-one hydrate

      Ulven, Trond & Carlsen, P. H. J., 2001, In: European Journal of Organic Chemistry. 17, p. 3367-3374 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    176. 2000
    177. Published

      A method for the selective hydrolysis of ketone hydrazones in the presence of acetals

      Ulven, Trond & Carlsen, P. H. J., 2000, In: European Journal of Organic Chemistry. 2000, 21, p. 3971-3972 2 p.

      Research output: Contribution to journalJournal articlepeer-review

    178. Published

      Synthesis of 1,3-O-benzylidene-2-deoxy-L-riboaldose from 2-phenyl-1,3-dioxan-5-one

      Ulven, Trond & Carlsen, P. H. J., 2000, In: Synthetic Communications. 30, 13, p. 2275-2280 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    179. 1997
    180. Published

      Synthesis of racemic 3,5-O-benzylidene-2-deoxypentoses from 2-phenyl-1,3-dioxan-5-one hydrate

      Ulven, Trond, Sørbye, K. A. & Carlsen, P. H. J., 1997, In: Acta Chemica Scandinavica. 51, 10, p. 1041-1044 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    181. 1996
    182. Published

      Synthesis of benzylidene-protected dihydroxyacetone

      Carlsen, P. H. J., Sørbye, K. A., Ulven, Trond & Aasbø, K., 1996, In: Acta Chemica Scandinavica. 50, 2, p. 185-187 3 p.

      Research output: Contribution to journalJournal articlepeer-review

    ID: 187375453