Ulf Madsen

Ulf Madsen

Associate Professor emeritus


  1. 2014
  2. Published
  3. Published
  4. 2012
  5. Published

    Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice

    Rytter, Hana Malá, Chen, Y., Worm, V. H., Kure, J., Kaae, B. H., Madsen, Ulf, Badolo, L., Pickering, Darryl S & Mogensen, J., 2012, In: Behavioural Brain Research. 226, 1, p. 18-25

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

    Mølck, C., Harpsøe, Kasper, Gloriam, David E., Clausen, Rasmus Prætorius, Madsen, Ulf, Pedersen, L., Jimenez, H. N., Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, 2012, In: Molecular Pharmacology. 82, 5, p. 929-37 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators

    Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451

    Research output: Contribution to journalJournal articlepeer-review

  8. 2011
  9. Published

    Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene

    Molck, C., Harpsøe, Kasper, Gloriam, David E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, Rasmus Prætorius, Madsen, Ulf, Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, Sep 2011, In: Current Neuropharmacology. 9, p. 43-43

    Research output: Contribution to journalConference abstract in journal

  10. Published

    Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

    Pinto, A., Conti, P., Grazioso, G., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte & De Micheli, C., 1 Feb 2011, In: European Journal of Medicinal Chemistry. 46, 2, p. 787-793

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

    Pøhlsgaard, J., Frydenvang, Karla Andrea, Madsen, Ulf & Kastrup, Jette Sandholm Jensen, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 135-150

    Research output: Contribution to journalReviewpeer-review

  12. 2010
  13. Published

    GABA and glutamic acid receptor ligands

    Frølund, Bente & Madsen, Ulf, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 239-262

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  14. Published

    Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: Design, synthesis, and pharmacological characterization

    Conti, P., Pinto, A., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Hansen, K. B., Landucci, E., Pellegrini-Giampietro, D. E., De Sarro, G., Donato Di Paola, E. & De Micheli, C., 2010, In: ChemMedChem. 5, 9, p. 1465-1475

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Textbook of drug design and discovery

    Krogsgaard-Larsen, Povl, Strømgaard, Kristian & Madsen, Ulf, 2010, 4 ed. Boca Raton: CRC Press. 460 p.

    Research output: Book/ReportBook

  16. 2008
  17. Published

    Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid

    Pinto, A., Conti, P., De Amici, M., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Christesen, T., Bräuner, Hans & De Micheli, C., 2008, In: Journal of Medicinal Chemistry. 51, 7, p. 2311-2315

    Research output: Contribution to journalJournal articlepeer-review

  18. 2007
  19. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites

    Kaae, B. H., Harpsøe, Kasper, Sanz, A. C., Pickering, Darryl S, Sauerberg, P., Clausen, Rasmus Prætorius, Kastrup, Jette Sandholm Jensen, Liljefors, T. & Madsen, Ulf, 19 Aug 2007, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 234

    Research output: Contribution to journalConference abstract in journal

  20. Published

    Erratum: Synthesis and pharmacology of glutamate receptor ligands: New isothiazole analogues of ibotenic acid (Organic and Biomolecular Chemistry (2007) 5 DOI:10.1039/b615162k)

    Jørgensen, C. G., Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic and Biomolecular Chemistry. 5, 5, p. 848 1 p.

    Research output: Contribution to journalComment/debatepeer-review

  21. Published

    Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors

    Jørgensen, C. G., Bräuner, Hans, Nielsen, Birgitte, Kehler, J., Clausen, Rasmus Prætorius, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Bioorganic & Medicinal Chemistry. 15, 10, p. 3524-3538

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

    Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Journal of Biological Chemistry. 282, 35, p. 25726-25736

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Pharmacological characterisation of biarylisopropylalsulphonamide AMPA-R potentiators

    Pickering, Darryl S, Sanz, C., Harpsøe, Kasper, Clausen, Rasmus Prætorius, Sauerberg, P., Liljefors, T., Madsen, Ulf & Kaae, B. H., 2007, In: Journal of Neurochemistry. 102 (suppl. 1), 41

    Research output: Contribution to journalConference abstract in journal

  24. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

    Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In: Chemistry & Biology. 14, 11, p. 1294-303 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof

    Conti, P., De Amici, M., Roda, G., Pinto, A., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans & De Micheli, C., 2007, In: Tetrahedron. 63, 10, p. 2249-2256

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid

    Conti, P., Caligiuri, A., Pinto, A., Roda, G., Tamborini, L., Nielsen, Birgitte, Madsen, Ulf, Frydenvang, Karla Andrea, Colombo, A. & De Micheli, C., 2007, In: European Journal of Medicinal Chemistry. 42, 8, p. 1059-1068

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid

    Jørgensen, C. G., Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic & Biomolecular Chemistry. 5, 3, p. 463-471

    Research output: Contribution to journalJournal articlepeer-review

  28. 2005
  29. Published

    Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids

    Conti, P., De Amici, M., Grazioso, G., Roda, G., Pinto, A., Hansen, K. B., Nielsen, Birgitte, Madsen, Ulf, Bräuner, Hans, Egebjerg, J., Vestri, V., Pellegrini-Giampietro, D. E., Sibille, P., Acher, F. C. & De Micheli, C., 6 Oct 2005, In: Journal of Medicinal Chemistry. 48, 20, p. 6315-25

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology

    Frølund, Bente, Greenwood, J. R., Holm, M. M., Egebjerg, J., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Stensbøl, T. B. & Krogsgaard-Larsen, Povl, 15 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 18, p. 5391-8

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Synthesis of novel N1-substituted bicyclic pyrazole amino acids and evaluation of their interaction with glutamate receptors

    Conti, P., Grazioso, G., di Ventimiglia, S. J., Pinto, A., Roda, G., Madsen, Ulf, Bräuner, Hans, Nielsen, Birgitte, Costagli, C. & Galli, A., Jun 2005, In: Chemistry & Biodiversity. 2, 6, p. 748-57

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids

    Meyer, U., Bisel, P., Bräuner, Hans, Madsen, Ulf, Höfner, G., Wanner, K. T. & Frahm, A. W., Feb 2005, In: Chirality. 17, 2, p. 99-107

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders

    Madsen, Ulf, Bräuner, Hans, Greenwood, J. R., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 27 Jan 2005, Drug Discovery Handbook. John Wiley & Sons, Inc., p. 797-907 111 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  34. Published
  35. Published

    GABA and Glutamate Receptor Ligands and Therapeutic Potential in CNS Disorders

    Madsen, Ulf, Greenwood, J., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 2005, Drug Discovery Handbook. Wiley, p. 797–907

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  36. 2004
  37. Published

    Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5

    Valgeirsson, J., Nielsen, E. O., Peters, D., Mathiesen, C., Kristensen, Anders Skov & Madsen, Ulf, 30 Dec 2004, In: Journal of Medicinal Chemistry. 47, 27, p. 6948-57 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

    Conti, P., De Amici, M., Grazioso, G., Roda, G., Barberis Negra, F. F., Nielsen, Birgitte, Stensbøl, T. B., Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, De Sarro, G., Toma, L. & De Micheli, C., 30 Dec 2004, In: Journal of Medicinal Chemistry. 47, 27, p. 6740-8 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors

    Hermit, M. B., Greenwood, J. R., Nielsen, Birgitte, Bunch, Lennart, Jørgensen, C. G., Vestergaard, H. T., Stensbøl, T. B., Sanchez, C., Krogsgaard-Larsen, Povl, Madsen, Ulf & Bräuner, Hans, 23 Feb 2004, In: European Journal of Pharmacology. 486, 3, p. 241-50

    Research output: Contribution to journalJournal articlepeer-review

  40. 2003
  41. Published

    2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5

    Valgeirsson, J., Nielsen, E. Ø., Peters, D., Varming, T., Mathiesen, C., Kristensen, Anders Skov & Madsen, Ulf, 18 Dec 2003, In: Journal of Medicinal Chemistry. 46, 26, p. 5834-43 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors

    Conti, P., De Amici, M., Grazioso, G., Roda, G., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., 14 Nov 2003, In: European Journal of Organic Chemistry. 22, p. 4455-4461 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids

    Conti, P., De Amici, M., Joppolo Di Ventimiglia, S., Stensbøl, T. B., Madsen, Ulf, Bräuner, Hans, Russo, E., De Sarro, G., Bruno, G. & De Micheli, C., 3 Jul 2003, In: Journal of Medicinal Chemistry. 46, 14, p. 3102-8

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Design of novel conformationally restricted analogues of glutamic acid

    Conti, P., De Amici, M., Roda, G., Vistoli, G., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., 24 Feb 2003, In: Tetrahedron. 59, 9, p. 1443-1452 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO)

    Bjerrum, E. J., Kristensen, Anders Skov, Pickering, D. S., Greenwood, J. R., Nielsen, Birgitte, Liljefors, T., Schousboe, Arne, Bräuner, Hans, Madsen, Ulf & Pickering, Darryl S, 2003, In: Journal of Medicinal Chemistry. 46, 11, p. 2246-9 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue

    Bunch, Lennart, Liljefors, T., Greenwood, J. R., Frydenvang, Karla Andrea, Bräuner, Hans, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2003, In: Journal of Organic Chemistry. 68, 4, p. 1489-95 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors

    Johansen, Tommy Nørskov, Greenwood, J. R., Frydenvang, Karla Andrea, Madsen, Ulf & Krogsgaard-Larsen, Povl, 2003, In: Chirality. 15, 2, p. 167-79 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  48. 2002
  49. Published

    Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid

    Conti, P., De Amici, M., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., Nov 2002, In: Farmaco. 57, 11, p. 889-95

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: Application to the synthesis of thioibotenic acid

    Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, 5 Apr 2002, In: Journal of Organic Chemistry. 67, 7, p. 2375-2377

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids

    Kromann, H., Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf & Krogsgaard-Larsen, Povl, 14 Feb 2002, In: Journal of Medicinal Chemistry. 45, 4, p. 988-91

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology

    Stensbøl, T. B., Uhlmann, P., Morel, S., Eriksen, B. L., Felding, J., Kromann, H., Hermit, M. B., Greenwood, J. R., Braüner-Osborne, H., Madsen, Ulf, Junager, F., Krogsgaard-Larsen, Povl, Begtrup, M., Vedsø, P. & Bräuner, Hans, 3 Jan 2002, In: Journal of Medicinal Chemistry. 45, 1, p. 19-31

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    Mixed cyano-gilman cuprates - Advances in conjugate addition to alpha,beta-unsaturated pyroglutaminol

    Bunch, Lennart, Krogsgaard-Larsen, Povl & Madsen, Ulf, Jan 2002, In: Synthesis. 1, p. 31-33

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

    Johansen, Tommy Nørskov, Janin, Y. L., Nielsen, Birgitte, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Vogensen, S. B., Madsen, Ulf & Krogsgaard-Larsen, Povl, 2002, In: Bioorganic & Medicinal Chemistry. 10, 7, p. 2259-66 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

    Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In: Chirality. 14, 4, p. 351-63 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. 2001
  57. Published

    Synthesis and receptor binding affinity of new selective GluR5 ligands

    Bunch, Lennart, Johansen, T. H., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl & Madsen, Ulf, Apr 2001, In: Bioorganic & Medicinal Chemistry. 9, 4, p. 875-9

    Research output: Contribution to journalJournal articlepeer-review

  58. Published
  59. Published

    Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors

    Sløk, F. A., Bräuner, Hans, Stensbøl, T. B., Johansen, Tommy Nørskov, Ebert, B., Mortensen, M., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E. & Krogsgaard-Larsen, Povl, 2001, Medicinal Chemistry into the Millenium. Campbell, M. M. & Blagbrough, I. S. (eds.). UK: Royal Society of Chemistry, p. 52-64 13 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  60. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors

    Madsen, Ulf, Bräuner, Hans, Frydenvang, Karla Andrea, Hvene, L., Johansen, Tommy Nørskov, Nielsen, Birgitte, Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, Povl, 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  61. Published

    Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol

    Bunch, Lennart, Norrby, P., Frydenvang, Karla Andrea, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2001, In: Organic Letters. 3, 3, p. 433-5 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. 2000
  63. Published

    Ligands for glutamate receptors: design and therapeutic prospects

    Bräuner, Hans, Egebjerg, J., Nielsen, E. O., Madsen, Ulf & Krogsgaard-Larsen, Povl, 13 Jul 2000, In: Journal of Medicinal Chemistry. 43, 14, p. 2609-45

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist

    Madsen, Ulf, Sløk, F. A., Stensbøl, T. B., Bräuner, Hans, Lützhøft, H. H., Poulsen, M. V., Eriksen, L. & Krogsgaard-Larsen, Povl, Jan 2000, In: European Journal of Medicinal Chemistry. 35, 1, p. 69-76

    Research output: Contribution to journalJournal articlepeer-review

  65. 1999
  66. Published

    3-pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing

    Zimmermann, D., Janin, Y. L., Brehm, L., Bräuner, Hans, Ebert, B., Johansen, Tommy Nørskov, Madsen, Ulf & Krogsgaard-Larsen, Povl, 1 Nov 1999, In: European Journal of Medicinal Chemistry. 34, 11, p. 967-976

    Research output: Contribution to journalJournal articlepeer-review

  67. Published

    Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists

    Conti, P., De Amici, M., De Sarro, G., Rizzo, M., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf, Toma, L. & De Micheli, C., 7 Oct 1999, In: Journal of Medicinal Chemistry. 42, 20, p. 4099-107

    Research output: Contribution to journalJournal articlepeer-review

  68. 1998
  69. Published

    Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity

    Conti, P., De Amici, M., De Sarro, G., Stensbøl, T. B., Bräuner, Hans, Madsen, Ulf & De Micheli, C., 24 Sep 1998, In: Journal of Medicinal Chemistry. 41, 20, p. 3759-62

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid

    Madsen, Ulf, Dumpis, M. A., Bräuner, Hans & Piotrovsky, L. B., 16 Jun 1998, In: Bioorganic & Medicinal Chemistry Letters. 8, 12, p. 1563-8

    Research output: Contribution to journalJournal articlepeer-review

  71. Published

    Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid

    Johansen, Tommy Nørskov, Ebert, B., Bräuner, Hans, Didriksen, M., Christensen, I. T., Søby, K. K., Madsen, Ulf, Krogsgaard-Larsen, Povl & Brehm, L., 12 Mar 1998, In: Journal of Medicinal Chemistry. 41, 6, p. 930-9

    Research output: Contribution to journalJournal articlepeer-review

  72. 1997
  73. Published

    (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors

    Ahmadian, H., Nielsen, Birgitte, Bräuner, Hans, Johansen, Tommy Nørskov, Stensbøl, T. B., Sløk, F. A., Sekiyama, N., Nakanishi, S., Krogsgaard-Larsen, Povl & Madsen, Ulf, 24 Oct 1997, In: Journal of Medicinal Chemistry. 40, 22, p. 3700-5

    Research output: Contribution to journalJournal articlepeer-review

  74. Published

    New analogues of ACPD with selective activity for group II metabotropic glutamate receptors

    Bräuner, Hans, Madsen, Ulf, Mikiciuk-Olasik, E. & Curry, K., 13 Aug 1997, In: European Journal of Pharmacology. 332, 3, p. 327-31 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  75. Published
  76. 1996
  77. Published

    Design of excitatory amino acid receptor agonists, partial agonists and antagonists: Ibotenic acid as a key lead structure

    Krogsgaard-Larsen, Povl, Ebert, B., Lund, Trine Meldgaard, Bräuner, Hans, Sloøk, F. A., Johansen, Tommy Nørskov, Brehm, L. & Madsen, Ulf, 10 Sep 1996, In: European Journal of Medicinal Chemistry. 31, 7-8, p. 515-537 23 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Published
  79. 1994
  80. Published

    Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA

    Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Lenz, S. M. & Krogsgaard-Larsen, Povl, Jun 1994, In: Neurochemistry International. 24, 6, p. 507-15 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands

    Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Ebert, B., Krogsgaard-Larsen, Povl & Madsen, Ulf, 1994, In: Journal of Medicinal Chemistry. 37, 20, p. 3252-62 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. 1993
  83. Published

    Design, synthesis and pharmacology of model compounds for indirect elucidation of the topography of AMPA receptor sites

    Madsen, Ulf, Frølund, Bente, Lund, Trine Meldgaard, Ebert, B. & Krogsgaard-Larsen, Povl, 1993, In: European Journal of Medicinal Chemistry. 28, p. 791–800

    Research output: Contribution to journalJournal articlepeer-review

  84. Published

    Enzymatic resolution of AMPA by use of alpha-chymotrypsin

    Nielsen, Birgitte, Fisker, H., Ebert, B., Madsen, Ulf, Curtis, D. R., Krogsgaard-Larsen, Povl & Hansen, J. J., 1993, In: Bioorganic & Medicinal Chemistry Letters. 3, 1, p. 107–114 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  85. 1992
  86. Published

    Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid

    Christensen, I. T., Ebert, B., Madsen, Ulf, Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 18 Sep 1992, In: Journal of Medicinal Chemistry. 35, 19, p. 3512-3519 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  87. Published

    Molecular pharmacology of cortical and spinal AMPA receptors

    Ebert, B., Madsen, Ulf, Lund, Trine Meldgaard, Holm, T. & Krogsgaard-Larsen, Povl, 1 Jan 1992, In: Molecular Neuropharmacology. 2, 1, p. 47-49 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    Subtype-selective excitatory amino acid receptor agonists and antagonists derived from ibotenic acid

    Ebert, B., Lund, Trine Meldgaard, Madsen, Ulf, Brehm, L. & Krogsgaard-Larsen, Povl, 1992, New leads and targets in drug research: Alfred Benzon Symposium 33. Krogsgaard-Larsen, P., Christensen, S. B. & Kofod, H. (eds.). Copenhagen, p. 340-351 11 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  89. 1991
  90. Published
  91. 1990
  92. Published

    AMPA receptor agonists, design, synthesis and molecular pharmacology

    Lund, Trine Meldgaard, Christensen, I. T., Madsen, Ulf, Ebert, B., Brehm, L. & Krogsgaard-Larsen, Povl, 1990, In: Neurochemistry International. 16 suppl 1, 51, p. 51 1 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  93. Published

    Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors

    Madsen, Ulf, Brehm, L., Schaumburg, K., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1990, In: Journal of Medicinal Chemistry. 33, 1, p. 374-80 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  94. Published

    Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors

    Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  95. Published

    Structural, stereochemical and conformational requirements for activation and blockade of central glutamic acid receptors

    Krogsgaard-Larsen, Povl, Madsen, Ulf, Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B. & Hansen, J. J., 1990, Problems and Wonders of Chirale Molecules. Simonyi, M. (ed.). Budapest: Akadémiai Kiadó, p. 205-225 21 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  96. 1989
  97. Published

    Excitatory Amino acid agonists and parital agonists

    Christensen, I. T., Reinhardt, A., Nielsen, Birgitte, Ebert, B., Madsen, Ulf, Nielsen, E. Ø., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: drug design and delivery. 5, p. 57-71 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  98. Published

    Excitatory amino acid agonists and partial agonists

    Christensen, I. T., Reinhardt, A., Nielsen, B., Ebert, B., Madsen, Ulf, Nielsen, E. O., Brehm, L. & Krogsgaard-Larsen, Povl, 1989, In: Drug Design and Delivery. 5, 1, p. 57-71 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. Published

    Isoxazole amino acids as glutamic acid receptor agonists: conformational and stereochemical aspects

    Hansen, J. J., Madsen, Ulf, Nielsen, E. Ø., Nielsen, Birgitte, Brehm, L. & Krogsgaard-Larsen, Povl, 1989, New Methods in Drug Research. Makriayannis, A. (ed.). Barcelona: Prous Scientific Publishers, Vol. 3. p. 73-101 29 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  100. Published

    Medicinal chemical and pharmacological focus on GABA and glutamic acid receptors in neurodegenerative disorders

    Krogsgaard-Larsen, Povl, Hedegaard, A., Nielsen, L., Nielsen, Birgitte, Madsen, Ulf, Brehm, L., Falch, E., Hjeds, H. & Hansen, J. J., 1989, Trends in Medicinal Chemistry '88. van der Goot, H., Domány, G., Pallos, L. & Timmerman, H. (eds.). Elsevier, Amsterdam, p. 429-452 24 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  101. 1987
  102. Published

    Molecular pharmacology of excitatory amino acid receptors: conformational and stereochemical requirements

    Krogsgaard-Larsen, Povl, Madsen, Ulf, Nielsen, Birgitte, Hansen, J. J., Nielsen, E. Ø., Brehm, L. & Curtis, D. R., 1987, Proceedings of the X'th International Congress of Pharmacology. Rand, M. J. & Raper, C. (eds.). Elsevier, p. 113-116 4 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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