Anthelmintic properties of traditional African and Caribbean medicinal plants: identification of extracts with potent activity against Ascaris suum in vitro
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Anthelmintic properties of traditional African and Caribbean medicinal plants : identification of extracts with potent activity against Ascaris suum in vitro. / Williams, Andrew R.; Soelberg, Jens; Jäger, Anna.
In: Parasite, Vol. 23, 24, 14.06.2016.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Anthelmintic properties of traditional African and Caribbean medicinal plants
T2 - identification of extracts with potent activity against Ascaris suum in vitro
AU - Williams, Andrew R.
AU - Soelberg, Jens
AU - Jäger, Anna
PY - 2016/6/14
Y1 - 2016/6/14
N2 - Ascariasis affects more than 1 billion people worldwide, mainly in developing countries, causing substantial morbidity. Current treatments for Ascaris infection are based on mass drug administration (MDA) with synthetic anthelmintic drugs such as albendazole, however continual re-infection and the threat of drug resistance mean that complementary treatment options would be highly valuable. Here, we screened ethanolic extracts from 29 medicinal plants used in Africa (Ghana) and the Caribbean (US Virgin Islands) for in vitro anthelmintic properties against Ascaris suum, a swine parasite that is very closely related to the human A. lumbricoides. A wide variety of activities were seen in the extracts, from negligible to potent. Extracts from Clausena anisata, Zanthoxylum zanthoxyloides and Punica granatum were identified as the most potent with EC50 values of 74, 97 and 164 mu g/mL, respectively. Our results encourage further investigation of their use as complementary treatment options for ascariasis, alongside MDA.
AB - Ascariasis affects more than 1 billion people worldwide, mainly in developing countries, causing substantial morbidity. Current treatments for Ascaris infection are based on mass drug administration (MDA) with synthetic anthelmintic drugs such as albendazole, however continual re-infection and the threat of drug resistance mean that complementary treatment options would be highly valuable. Here, we screened ethanolic extracts from 29 medicinal plants used in Africa (Ghana) and the Caribbean (US Virgin Islands) for in vitro anthelmintic properties against Ascaris suum, a swine parasite that is very closely related to the human A. lumbricoides. A wide variety of activities were seen in the extracts, from negligible to potent. Extracts from Clausena anisata, Zanthoxylum zanthoxyloides and Punica granatum were identified as the most potent with EC50 values of 74, 97 and 164 mu g/mL, respectively. Our results encourage further investigation of their use as complementary treatment options for ascariasis, alongside MDA.
KW - Ascaris suum
KW - Anthelmintic
KW - Clausena anisata
KW - Zanthoxylum zanthoxyloides
KW - Punica granatum
U2 - 10.1051/parasite/2016024
DO - 10.1051/parasite/2016024
M3 - Journal article
C2 - 27301442
VL - 23
JO - Parasite
JF - Parasite
SN - 1252-607X
M1 - 24
ER -
ID: 165745965