Anthelmintic properties of traditional African and Caribbean medicinal plants: identification of extracts with potent activity against Ascaris suum in vitro

Research output: Contribution to journalJournal articlepeer-review

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Anthelmintic properties of traditional African and Caribbean medicinal plants : identification of extracts with potent activity against Ascaris suum in vitro. / Williams, Andrew R.; Soelberg, Jens; Jäger, Anna.

In: Parasite, Vol. 23, 24, 14.06.2016.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Williams, AR, Soelberg, J & Jäger, A 2016, 'Anthelmintic properties of traditional African and Caribbean medicinal plants: identification of extracts with potent activity against Ascaris suum in vitro', Parasite, vol. 23, 24. https://doi.org/10.1051/parasite/2016024

APA

Williams, A. R., Soelberg, J., & Jäger, A. (2016). Anthelmintic properties of traditional African and Caribbean medicinal plants: identification of extracts with potent activity against Ascaris suum in vitro. Parasite, 23, [24]. https://doi.org/10.1051/parasite/2016024

Vancouver

Williams AR, Soelberg J, Jäger A. Anthelmintic properties of traditional African and Caribbean medicinal plants: identification of extracts with potent activity against Ascaris suum in vitro. Parasite. 2016 Jun 14;23. 24. https://doi.org/10.1051/parasite/2016024

Author

Williams, Andrew R. ; Soelberg, Jens ; Jäger, Anna. / Anthelmintic properties of traditional African and Caribbean medicinal plants : identification of extracts with potent activity against Ascaris suum in vitro. In: Parasite. 2016 ; Vol. 23.

Bibtex

@article{7a880e0366f044f5aaf27ac264338a76,
title = "Anthelmintic properties of traditional African and Caribbean medicinal plants: identification of extracts with potent activity against Ascaris suum in vitro",
abstract = "Ascariasis affects more than 1 billion people worldwide, mainly in developing countries, causing substantial morbidity. Current treatments for Ascaris infection are based on mass drug administration (MDA) with synthetic anthelmintic drugs such as albendazole, however continual re-infection and the threat of drug resistance mean that complementary treatment options would be highly valuable. Here, we screened ethanolic extracts from 29 medicinal plants used in Africa (Ghana) and the Caribbean (US Virgin Islands) for in vitro anthelmintic properties against Ascaris suum, a swine parasite that is very closely related to the human A. lumbricoides. A wide variety of activities were seen in the extracts, from negligible to potent. Extracts from Clausena anisata, Zanthoxylum zanthoxyloides and Punica granatum were identified as the most potent with EC50 values of 74, 97 and 164 mu g/mL, respectively. Our results encourage further investigation of their use as complementary treatment options for ascariasis, alongside MDA.",
keywords = "Ascaris suum, Anthelmintic, Clausena anisata, Zanthoxylum zanthoxyloides, Punica granatum",
author = "Williams, {Andrew R.} and Jens Soelberg and Anna J{\"a}ger",
year = "2016",
month = jun,
day = "14",
doi = "10.1051/parasite/2016024",
language = "English",
volume = "23",
journal = "Parasite",
issn = "1252-607X",
publisher = "E D P Sciences",

}

RIS

TY - JOUR

T1 - Anthelmintic properties of traditional African and Caribbean medicinal plants

T2 - identification of extracts with potent activity against Ascaris suum in vitro

AU - Williams, Andrew R.

AU - Soelberg, Jens

AU - Jäger, Anna

PY - 2016/6/14

Y1 - 2016/6/14

N2 - Ascariasis affects more than 1 billion people worldwide, mainly in developing countries, causing substantial morbidity. Current treatments for Ascaris infection are based on mass drug administration (MDA) with synthetic anthelmintic drugs such as albendazole, however continual re-infection and the threat of drug resistance mean that complementary treatment options would be highly valuable. Here, we screened ethanolic extracts from 29 medicinal plants used in Africa (Ghana) and the Caribbean (US Virgin Islands) for in vitro anthelmintic properties against Ascaris suum, a swine parasite that is very closely related to the human A. lumbricoides. A wide variety of activities were seen in the extracts, from negligible to potent. Extracts from Clausena anisata, Zanthoxylum zanthoxyloides and Punica granatum were identified as the most potent with EC50 values of 74, 97 and 164 mu g/mL, respectively. Our results encourage further investigation of their use as complementary treatment options for ascariasis, alongside MDA.

AB - Ascariasis affects more than 1 billion people worldwide, mainly in developing countries, causing substantial morbidity. Current treatments for Ascaris infection are based on mass drug administration (MDA) with synthetic anthelmintic drugs such as albendazole, however continual re-infection and the threat of drug resistance mean that complementary treatment options would be highly valuable. Here, we screened ethanolic extracts from 29 medicinal plants used in Africa (Ghana) and the Caribbean (US Virgin Islands) for in vitro anthelmintic properties against Ascaris suum, a swine parasite that is very closely related to the human A. lumbricoides. A wide variety of activities were seen in the extracts, from negligible to potent. Extracts from Clausena anisata, Zanthoxylum zanthoxyloides and Punica granatum were identified as the most potent with EC50 values of 74, 97 and 164 mu g/mL, respectively. Our results encourage further investigation of their use as complementary treatment options for ascariasis, alongside MDA.

KW - Ascaris suum

KW - Anthelmintic

KW - Clausena anisata

KW - Zanthoxylum zanthoxyloides

KW - Punica granatum

U2 - 10.1051/parasite/2016024

DO - 10.1051/parasite/2016024

M3 - Journal article

C2 - 27301442

VL - 23

JO - Parasite

JF - Parasite

SN - 1252-607X

M1 - 24

ER -

ID: 165745965