Astrocytic pyruvate carboxylation: Status after 35 years

Research output: Contribution to journal › Review › Research › peer-review

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Astrocytic pyruvate carboxylation : Status after 35 years. / Schousboe, Arne; Waagepetersen, Helle S.; Sonnewald, Ursula.

In: Journal of Neuroscience Research, Vol. 97, 01.01.2019, p. 890-896.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Schousboe, A, Waagepetersen, HS & Sonnewald, U 2019, 'Astrocytic pyruvate carboxylation: Status after 35 years', Journal of Neuroscience Research, vol. 97, pp. 890-896. https://doi.org/10.1002/jnr.24402

APA

Schousboe, A., Waagepetersen, H. S., & Sonnewald, U. (2019). Astrocytic pyruvate carboxylation: Status after 35 years. Journal of Neuroscience Research, 97, 890-896. https://doi.org/10.1002/jnr.24402

Vancouver

Schousboe A, Waagepetersen HS, Sonnewald U. Astrocytic pyruvate carboxylation: Status after 35 years. Journal of Neuroscience Research. 2019 Jan 1;97:890-896. https://doi.org/10.1002/jnr.24402

Author

Schousboe, Arne ; Waagepetersen, Helle S. ; Sonnewald, Ursula. / Astrocytic pyruvate carboxylation : Status after 35 years. In: Journal of Neuroscience Research. 2019 ; Vol. 97. pp. 890-896.

Bibtex

@article{738199d7cbc143ae8e1251f3bbc8c43a,
title = "Astrocytic pyruvate carboxylation: Status after 35 years",
abstract = "The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.",
keywords = "anaplerosis, astrocytes, cataplerosis, glutamate, glutamine, neurons",
author = "Arne Schousboe and Waagepetersen, {Helle S.} and Ursula Sonnewald",
year = "2019",
month = jan,
day = "1",
doi = "10.1002/jnr.24402",
language = "English",
volume = "97",
pages = "890--896",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "JohnWiley & Sons, Inc.",

}

RIS

TY - JOUR

T1 - Astrocytic pyruvate carboxylation

T2 - Status after 35 years

AU - Schousboe, Arne

AU - Waagepetersen, Helle S.

AU - Sonnewald, Ursula

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.

AB - The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.

KW - anaplerosis

KW - astrocytes

KW - cataplerosis

KW - glutamate

KW - glutamine

KW - neurons

UR - http://www.scopus.com/inward/record.url?scp=85061987603&partnerID=8YFLogxK

U2 - 10.1002/jnr.24402

DO - 10.1002/jnr.24402

M3 - Review

C2 - 30801795

AN - SCOPUS:85061987603

VL - 97

SP - 890

EP - 896

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

ER -

ID: 222390875