Dark Classics in Chemical Neuroscience: NBOMes

Research output: Contribution to journalJournal articlepeer-review

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Dark Classics in Chemical Neuroscience : NBOMes. / Poulie, Christian Bernard Matthijs; Jensen, Anders A; Halberstadt, Adam; Kristensen, Jesper L.

In: ACS Chemical Neuroscience, 2020, p. 3860–3869.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Poulie, CBM, Jensen, AA, Halberstadt, A & Kristensen, JL 2020, 'Dark Classics in Chemical Neuroscience: NBOMes', ACS Chemical Neuroscience, pp. 3860–3869. https://doi.org/10.1021/acschemneuro.9b00528

APA

Poulie, C. B. M., Jensen, A. A., Halberstadt, A., & Kristensen, J. L. (2020). Dark Classics in Chemical Neuroscience: NBOMes. ACS Chemical Neuroscience, 3860–3869. https://doi.org/10.1021/acschemneuro.9b00528

Vancouver

Poulie CBM, Jensen AA, Halberstadt A, Kristensen JL. Dark Classics in Chemical Neuroscience: NBOMes. ACS Chemical Neuroscience. 2020;3860–3869. https://doi.org/10.1021/acschemneuro.9b00528

Author

Poulie, Christian Bernard Matthijs ; Jensen, Anders A ; Halberstadt, Adam ; Kristensen, Jesper L. / Dark Classics in Chemical Neuroscience : NBOMes. In: ACS Chemical Neuroscience. 2020 ; pp. 3860–3869.

Bibtex

@article{2ce4a2352721448788c35f954cab17e0,
title = "Dark Classics in Chemical Neuroscience: NBOMes",
abstract = "N-Benzylphenethylamines, commonly known as NBOMes, are synthetic psychedelic compounds derived from the phenethylamine class of psychedelics (2C-X compounds), which originally have been derived from the naturally occurring alkaloid mescaline. Analogously to their parent compounds and other classical psychedelics, such as psilocybin and LSD, NBOMes are believed to exert their main pharmacological effects through activation of serotonin 2A (5-HT2A) receptors. Since their introduction as New Psychoactive Substances (NPSs) in 2010, NBOMes have been widely used for recreational purposes; this has resulted in numerous cases of acute toxicity, sometimes with lethal outcomes, leadingto the classification of several NBOMes as Schedule I substances, in 2013. However, in addition to their recreational use, the NBOMe class has yielded several important biochemical tools, including [11C]Cimbi-36, which is now being used in positron emission tomography (PET) studies of the 5-HT2A and 5-HT2C receptors in the mammalian brain, and 25CN-NBOH, one of the most selective 5-HT2A receptor agonists developed to date. In this review, the history, chemistry and structure-activity relationships, ADME properties and safety profiles of NBOMes will be outlined and discussed.",
author = "Poulie, {Christian Bernard Matthijs} and Jensen, {Anders A} and Adam Halberstadt and Kristensen, {Jesper L}",
year = "2020",
doi = "10.1021/acschemneuro.9b00528",
language = "English",
pages = "3860–3869",
journal = "ACS Chemical Neuroscience",
issn = "1948-7193",
publisher = "American Chemical Society",

}

RIS

TY - JOUR

T1 - Dark Classics in Chemical Neuroscience

T2 - NBOMes

AU - Poulie, Christian Bernard Matthijs

AU - Jensen, Anders A

AU - Halberstadt, Adam

AU - Kristensen, Jesper L

PY - 2020

Y1 - 2020

N2 - N-Benzylphenethylamines, commonly known as NBOMes, are synthetic psychedelic compounds derived from the phenethylamine class of psychedelics (2C-X compounds), which originally have been derived from the naturally occurring alkaloid mescaline. Analogously to their parent compounds and other classical psychedelics, such as psilocybin and LSD, NBOMes are believed to exert their main pharmacological effects through activation of serotonin 2A (5-HT2A) receptors. Since their introduction as New Psychoactive Substances (NPSs) in 2010, NBOMes have been widely used for recreational purposes; this has resulted in numerous cases of acute toxicity, sometimes with lethal outcomes, leadingto the classification of several NBOMes as Schedule I substances, in 2013. However, in addition to their recreational use, the NBOMe class has yielded several important biochemical tools, including [11C]Cimbi-36, which is now being used in positron emission tomography (PET) studies of the 5-HT2A and 5-HT2C receptors in the mammalian brain, and 25CN-NBOH, one of the most selective 5-HT2A receptor agonists developed to date. In this review, the history, chemistry and structure-activity relationships, ADME properties and safety profiles of NBOMes will be outlined and discussed.

AB - N-Benzylphenethylamines, commonly known as NBOMes, are synthetic psychedelic compounds derived from the phenethylamine class of psychedelics (2C-X compounds), which originally have been derived from the naturally occurring alkaloid mescaline. Analogously to their parent compounds and other classical psychedelics, such as psilocybin and LSD, NBOMes are believed to exert their main pharmacological effects through activation of serotonin 2A (5-HT2A) receptors. Since their introduction as New Psychoactive Substances (NPSs) in 2010, NBOMes have been widely used for recreational purposes; this has resulted in numerous cases of acute toxicity, sometimes with lethal outcomes, leadingto the classification of several NBOMes as Schedule I substances, in 2013. However, in addition to their recreational use, the NBOMe class has yielded several important biochemical tools, including [11C]Cimbi-36, which is now being used in positron emission tomography (PET) studies of the 5-HT2A and 5-HT2C receptors in the mammalian brain, and 25CN-NBOH, one of the most selective 5-HT2A receptor agonists developed to date. In this review, the history, chemistry and structure-activity relationships, ADME properties and safety profiles of NBOMes will be outlined and discussed.

U2 - 10.1021/acschemneuro.9b00528

DO - 10.1021/acschemneuro.9b00528

M3 - Journal article

C2 - 31657895

SP - 3860

EP - 3869

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

SN - 1948-7193

ER -

ID: 229337199