Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds
Research output: Contribution to journal › Journal article › Research › peer-review
A technically simple procedure for direct C-H difluoromethylation of heteroaromatic compounds using off-the-shelf difluoroacetic acid as the difluoromethylating reagent has been developed. Mono-difluoromethylation versus bis-difluoromethylation is controlled as the result of the reaction temperature. The reactions described here enable access to the late-stage C-H mono- and bis-difluoromethylation for preparation of tool compounds for chemical biology and provide access to this hitherto untapped substituent for drug discovery.
Original language | English |
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Journal | Chemistry: A European Journal |
Volume | 23 |
Pages (from-to) | 18125-18128 |
ISSN | 0947-6539 |
DOIs | |
Publication status | Published - 11 Oct 2017 |
- Journal Article
Research areas
ID: 183760324