Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers
Research output: Contribution to journal › Journal article › Research › peer-review
In this work, a fragment-based labeling procedure was developed based on condensation reactions. Six F-18-labeled (arylpiperazinyl-butyl)oxindole derivatives were synthesized. These structures are interesting lead compounds with respect to development of a 5-HT7R PET tracer. They were radiolabeled in sufficient radiochemical yields, purities and molar activities for future in vivo evaluation in rodents.
Original language | English |
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Journal | Journal of Radioanalytical and Nuclear Chemistry |
Volume | 326 |
Pages (from-to) | 1749-1762 |
Number of pages | 14 |
ISSN | 0236-5731 |
DOIs | |
Publication status | Published - 2020 |
- Arylpiperazines, Alkylation, Fluorine-18, Carbon-11, Screening, Positron emission tomography, POSITRON-EMISSION-TOMOGRAPHY, IN-VITRO EVALUATION, NO-CARRIER, MEDIATED F-18-FLUORINATION, RECEPTOR ANTAGONIST, F-18, RADIOFLUORINATION, DERIVATIVES, DISCOVERY, LIGANDS
Research areas
ID: 252554329