GPCRdb: an information system for G protein-coupled receptors
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
GPCRdb : an information system for G protein-coupled receptors. / Isberg, Vignir; Mordalski, Stefan; Munk, Christian; Rataj, Krzysztof; Harpsøe, Kasper; Hauser, Alexander S; Vroling, Bas; Bojarski, Andrzej J; Vriend, Gert; Gloriam, David E.
In: Nucleic Acids Research, Vol. 44, No. D1, 04.01.2016, p. D356-64.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - GPCRdb
T2 - an information system for G protein-coupled receptors
AU - Isberg, Vignir
AU - Mordalski, Stefan
AU - Munk, Christian
AU - Rataj, Krzysztof
AU - Harpsøe, Kasper
AU - Hauser, Alexander S
AU - Vroling, Bas
AU - Bojarski, Andrzej J
AU - Vriend, Gert
AU - Gloriam, David E
N1 - FUNDING: European Research Council [639125 to D.E.G]; Lundbeck Foundation [R163-2013-16327 to D.E.G]; Danish Council for Independent Research [1331-00180 to D.E.G]; Polish National Science Centre [DEC-2014/12/T/NZ2/00529 to S.M.]. Funding for open access charge: European Research Council [639125 to D.E.G].
PY - 2016/1/4
Y1 - 2016/1/4
N2 - Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.
AB - Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.
KW - Development of new medicine
U2 - 10.1093/nar/gkv1178
DO - 10.1093/nar/gkv1178
M3 - Journal article
C2 - 26582914
VL - 44
SP - D356-64
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - D1
ER -
ID: 153606474