GPCRdb in 2021: integrating GPCR sequence, structure and function
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GPCRdb in 2021 : integrating GPCR sequence, structure and function. / Kooistra, Albert J; Mordalski, Stefan; Pándy-Szekeres, Gáspár; Esguerra, Mauricio; Mamyrbekov, Alibek; Munk, Christian; Keserű, György M; Gloriam, David E.
In: Nucleic Acids Research, Vol. 49, No. D1, 2021, p. D335-D343.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - GPCRdb in 2021
T2 - integrating GPCR sequence, structure and function
AU - Kooistra, Albert J
AU - Mordalski, Stefan
AU - Pándy-Szekeres, Gáspár
AU - Esguerra, Mauricio
AU - Mamyrbekov, Alibek
AU - Munk, Christian
AU - Keserű, György M
AU - Gloriam, David E
N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.
PY - 2021
Y1 - 2021
N2 - G protein-coupled receptors (GPCRs) form both the largest family of membrane proteins and drug targets, mediating the action of one-third of medicines. The GPCR database, GPCRdb serves >4 000 researchers every month and offers reference data, analysis of own or literature data, experiment design and dissemination of published datasets. Here, we describe new and updated GPCRdb resources with a particular focus on integration of sequence, structure and function. GPCRdb contains all human non-olfactory GPCRs (and >27 000 orthologs), G-proteins and arrestins. It includes over 2 000 drug and in-trial agents and nearly 200 000 ligands with activity and availability data. GPCRdb annotates all published GPCR structures (updated monthly), which are also offered in a refined version (with re-modeled missing/distorted regions and reverted mutations) and provides structure models of all human non-olfactory receptors in inactive, intermediate and active states. Mutagenesis data in the GPCRdb spans natural genetic variants, GPCR-G protein interfaces, ligand sites and thermostabilising mutations. A new sequence signature tool for identification of functional residue determinants has been added and two data driven tools to design ligand site mutations and constructs for structure determination have been updated extending their coverage of receptors and modifications. The GPCRdb is available at https://gpcrdb.org.
AB - G protein-coupled receptors (GPCRs) form both the largest family of membrane proteins and drug targets, mediating the action of one-third of medicines. The GPCR database, GPCRdb serves >4 000 researchers every month and offers reference data, analysis of own or literature data, experiment design and dissemination of published datasets. Here, we describe new and updated GPCRdb resources with a particular focus on integration of sequence, structure and function. GPCRdb contains all human non-olfactory GPCRs (and >27 000 orthologs), G-proteins and arrestins. It includes over 2 000 drug and in-trial agents and nearly 200 000 ligands with activity and availability data. GPCRdb annotates all published GPCR structures (updated monthly), which are also offered in a refined version (with re-modeled missing/distorted regions and reverted mutations) and provides structure models of all human non-olfactory receptors in inactive, intermediate and active states. Mutagenesis data in the GPCRdb spans natural genetic variants, GPCR-G protein interfaces, ligand sites and thermostabilising mutations. A new sequence signature tool for identification of functional residue determinants has been added and two data driven tools to design ligand site mutations and constructs for structure determination have been updated extending their coverage of receptors and modifications. The GPCRdb is available at https://gpcrdb.org.
U2 - 10.1093/nar/gkaa1080
DO - 10.1093/nar/gkaa1080
M3 - Journal article
C2 - 33270898
VL - 49
SP - D335-D343
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - D1
ER -
ID: 255109445