MicroRNAs, epigenetics and disease
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MicroRNAs, epigenetics and disease. / Silahtaroglu, Asli; Stenvang, Jan.
In: Essays in Biochemistry, Vol. 48, No. 1, 2010, p. 165-185.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - MicroRNAs, epigenetics and disease
AU - Silahtaroglu, Asli
AU - Stenvang, Jan
PY - 2010
Y1 - 2010
N2 - Epigenetics is defined as the heritable chances that affect gene expression without changing the DNA sequence. Epigenetic regulation of gene expression can be through different mechanisms such as DNA methylation, histone modifications and nucleosome positioning. MicroRNAs are short RNA molecules which do not code for a protein but have a role in post-transcriptional silencing of multiple target genes by binding to their 3' UTRs (untranslated regions). Both epigenetic mechanisms, such as DNA methylation and histone modifications, and the microRNAs are crucial for normal differentiation, development and maintenance of tissue-specific gene expression. These mechanisms also explain how cells with the same DNA content can differentiate into cells with different functions. Changes in epigenetic processes can lead to changes in gene function, cancer formation and progression, as well as other diseases. In the present chapter we will mainly focus on microRNAs and methylation and their implications in human disease, mainly in cancer.
AB - Epigenetics is defined as the heritable chances that affect gene expression without changing the DNA sequence. Epigenetic regulation of gene expression can be through different mechanisms such as DNA methylation, histone modifications and nucleosome positioning. MicroRNAs are short RNA molecules which do not code for a protein but have a role in post-transcriptional silencing of multiple target genes by binding to their 3' UTRs (untranslated regions). Both epigenetic mechanisms, such as DNA methylation and histone modifications, and the microRNAs are crucial for normal differentiation, development and maintenance of tissue-specific gene expression. These mechanisms also explain how cells with the same DNA content can differentiate into cells with different functions. Changes in epigenetic processes can lead to changes in gene function, cancer formation and progression, as well as other diseases. In the present chapter we will mainly focus on microRNAs and methylation and their implications in human disease, mainly in cancer.
KW - Disease
KW - Epigenesis, Genetic
KW - Humans
KW - MicroRNAs
U2 - 10.1042/bse0480165
DO - 10.1042/bse0480165
M3 - Journal article
C2 - 20822493
VL - 48
SP - 165
EP - 185
JO - Essays in Biochemistry
JF - Essays in Biochemistry
SN - 0071-1365
IS - 1
ER -
ID: 32137033