Structural dynamics bridge the gap between the genetic and functional levels of GPCRs

Research output: Contribution to journalReviewpeer-review

G protein–coupled receptors (GPCRs) are implicated in nearly all physiological processes in the human body and represent an important drug targeting class. The genes encoding the different GPCR (sub)types determine their specific functionality, which can be altered by natural genetic variants and isoforms. Deciphering the molecular link between sequence diversity and its functional consequences is a current challenge and critical for the comprehension of the physiological response of GPCRs. It requires a global understanding of how protein sequence translates into protein structure, how this impacts the structural motions of the protein, and, finally, how all these factors determine the receptor functionality. Here, we discuss available resources and state-of-the-art computational approaches to address this question.

Original languageEnglish
JournalCurrent Opinion in Structural Biology
Volume69
Pages (from-to)150-159
Number of pages10
ISSN0959-440X
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

    Research areas

  • Computational biology, GPCRs, Receptor signaling, Structural dynamics, Web resources

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