Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils
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Oligomeric and protofibrillar aggregates that are populated along the pathway of amyloid fibril formation appear generally to be more toxic than the mature fibrillar state. In particular, α-synuclein, the protein associated with Parkinson's disease, forms kinetically trapped protofibrils in the presence of lipid vesicles. Here, we show that lipid-induced α-synuclein protofibrils can convert rapidly to mature fibrils at higher temperatures. Furthermore, we find that β-synuclein, generally considered less aggregation prone than α-synuclein, forms protofibrils at higher temperatures. These findings highlight the importance of energy barriers in controlling the de novo formation and conversion of amyloid fibrils.
Original language | English |
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Journal | Chemical communications (Cambridge, England) |
Volume | 54 |
Issue number | 56 |
Pages (from-to) | 7854-7857 |
Number of pages | 4 |
ISSN | 1359-7345 |
DOIs | |
Publication status | Published - 10 Jul 2018 |
Externally published | Yes |
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