- Radioactive labeling strategies, especially for the PET nuclides carbon-11 and fluorine-18; combinatorial-like PET tracer development
- Tool development to study CNS related pharmacological targets as GPCR´s, ion channels and enzymes (Neuroimaging)
- Bioorthogonal chemistry: Applied radioactive, organic chemistry in living organisms
- Functional selective PET imaging: Is conformational selection the key to biased agonism?
- Nanoparticle imaging
- Neuroimaging aims to image the structure or pharmacology of the nervous system. In my group, we develop new molecular probes to image in vivo and non-invasively brain function.
- Pretargeted chemistry has the potential to revolutionize nuclear molecular imaging and therapy of antibodies. It increases target accumulation and thus efficiency.
- Current labeling strategies usually apply last-step labeling. Combinatorial like approaches increase throughput and thus result in higher tracer development success rates.
Radioactive materials are used to study reaction mechanisms, physiological and pathophysiological processes.