José Moreira
Professor
Translational and Clinical Pharmacology
Jagtvej 160
2100 København Ø
- 2024
- Published
Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2
Mohamed, M. M. M., Abboud, M. M., Maleckis, M., De Oliveira Souza, Luciano, Moreira, José, Gotfredsen, C. H., Weber, T. & Ding, L., 2024, In: Journal of Natural Products. 87, 4, p. 1075–1083Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Proteomic Profiling of Colorectal Adenomas Identifies a Predictive Risk Signature for Development of Metachronous Advanced Colorectal Neoplasia
Bech, J. M., Terkelsen, Thilde Bagger, Bartels, Annette Snejbjerg, Coscia, F., Doll, S., Zhao, S., Zhang, Z., Brünner, N., Lindebjerg, J., Madsen, G. I., Fang, X., Mann, Matthias & Moreira, José, 2023, In: Gastroenterology. 165, 1, p. 121-132.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation
Ebert, S., Zang, L., Ismail, N., Otabil, M., Fröhlich, A., Egea, V., Ács, S., Hoeberg, M., Berres, M. L., Weber, C., Moreira, José, Ries, C., Bernhagen, J. & El Bounkari, O., 2023, In: Cells. 12, 14, 24 p., 1899.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The invariant chain CD74 protein is a cell surface binding partner of TIMP-1 in breast cancer cells
Høeberg, M., Noer, Julie Boertmann, Vistesen, M. V., Bartels, Annette Snejbjerg, Bech, E. M., Nygård, S. B., Lademann, U., Stenvang, Jan, Liu, S., Fuglsang, Anja Thoe, Brünner, N. & Moreira, José, 2023, In: Molecular Oncology. 17, 8, p. 1595-1612Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Itraconazole Reverts ABCB1-Mediated Docetaxel Resistance in Prostate Cancer
Lima, T. S., De Oliveira Souza, Luciano, Iglesias Gato, Diego, Elversang, J., Jørgensen, Flemming Steen, Kallunki, Tuula Anneli, Røder, Andreas, Brasso, K. & Moreira, José, 2022, In: Frontiers in Pharmacology. 13, 13 p., 869461.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Functional proteomic profiling of triple-negative breast cancer
Gromova, I., Espinoza, J. A., Grauslund, M., Santoni Rugiu, Eric, Talman, M. L. M., van Oostrum, J. & Moreira, José, 2021, In: Cells. 10, 10, 14 p., 2768.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Profiling of Docetaxel-Resistant Prostate Cancer Cells Identifies Multiple Mechanisms of Therapeutic Resistance
Lima, T. S., Iglesias Gato, Diego, De Oliveira Souza, Luciano, Stenvang, Jan, Lima, D. S., Røder, Andreas, Brasso, K. & Moreira, José, 2021, In: Cancers. 13, 19 p.Research output: Contribution to journal › Journal article › Research
- Published
HLA Class II Histocompatibility Antigen gamma Chain (CD74) Expression Is Associated with Immune Cell Infiltration and Favorable Outcome in Breast Cancer
Noer, Julie Boertmann, Talman, M. M. & Moreira, José, 2021, In: Cancers. 13, 24, 16 p., 6179.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging
Wohlwend, M., Laurila, P., William, K., Romani, M., Lima, T., Pattawaran, P., Benegiamo, G., Salonen, M., Schneider, B. L., Lahti, J., Eriksson, J. G., Barrès, Romain, Wisloff, U., Moreira, José & Auwerx, J., 2021, In: Science Translational Medicine. 13, 623, 14 p., eabc7367.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
A streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis
Coscia, F., Doll, S., Bech, J. M., Schweizer, L., Mund, Andreas, Lengyel, E., Lindebjerg, J., Madsen, G. I., Moreira, José & Mann, Matthias, 2020, In: Journal of Pathology. 251, p. 110-112Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion
Brix, D. M., Tvingsholm, S. A., Hansen, M. B., Clemmensen, K. B., Ohman, T., Siino, V., Lambrughi, M., Hansen, K., Puustinen, P., Gromova, I., James, P., Papaleo, E., Varjosalo, M., Moreira, José, Jäättelä, M. & Kallunki, Tuula Anneli, 2019, In: Oncogene. 38, p. 3170-3184Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteogenomic characterization of patient-derived xenografts highlights the role of REST in neuroendocrine differentiation of castration-resistant prostate cancer
Flores-Morales, A., Bergmann, T. B., Lavallee, C., Batth, T. S., Lin, D., Lerdrup, M., Friis, S., Bartels, A., Kristensen, G., Krzyzanowska, A., Xue, H., Fazli, L., Hansen, K., Røder, M. A., Brasso, K., Moreira, J. M., Bjartell, A., Wang, Y., Olsen, J. V., Collins, C. C. & 1 others, , 2019, In: Clinical Cancer Research. 25, 2, p. 1-15Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs
Matos, A. L. D. S. A., Oakhill, J. S., Moreira, José, Loh, K., Galic, S. & Scott, J. W., 30 Apr 2019, In: Biochemical Society Transactions. 47, p. 733-741Research output: Contribution to journal › Review › Research › peer-review
- Published
Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer
Nordgaard, C., Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer
Thorsen, S. F., Gromova, I., Christensen, I. J., Fredriksson, S., Andersen, C. L., Nielsen, H. J., Stenvang, Jan & Moreira, José, Dec 2019, In: International Journal of Molecular Sciences (Online). 20, 19 p., 6082.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas
Aaberg-Jessen, C., Sørensen, M. D., Matos, A. L. S. A., Moreira, José, Brünner, N., Møldrup Knudsen, A. & Kristensen, B. W., 9 Mar 2018, In: BMC Cancer. 18, 16 p., 270.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms
Andersen, Anne Poder, Samsøe-Petersen, Jacob, Ørnbo, E. K., Bødtkjer, E., Moreira, José, Kveiborg, Marie & Pedersen, Stine Helene Falsig, 2018, In: International Journal of Cancer. 142, 12, p. 2529-2542 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predictive value of combined analysis of pro-NPY and ERG in localized prostate cancer
Kristensen, G., Røder, Andreas, Berg, K. D., Elversang, J., Iglesias Gato, Diego, Moreira, José, Toft, B. G. & Brasso, K., 2018, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 126, 10, p. 804-813Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Let-7 microRNA controls invasion-promoting lysosomal changes via the oncogenic transcription factor myeloid zinc finger-1
Tvingsholm, S. A., Hansen, M. B., Clemmensen, K. K. B., Brix, D. M., Rafn, B., Frankel, Lisa, Louhimo, R., Moreira, José, Hautaniemi, S., Gromova, I., Jäättelä, M. & Kallunki, Tuula Anneli, 2018, In: Oncogene. 7, 2, p. 1-15 15 p., 14.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Molecular Oncology journal has moved to open access
Celis, J. E. & Moreira, José, 1 Feb 2017, In: Molecular Oncology. 11, 2, 1 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Elucidation of Altered Pathways in Tumor-Initiating Cells of Triple-Negative Breast Cancer: A Useful Cell Model System for Drug Screening
Christensen, A. G., Ehmsen, S., Terp, M. G., Batra, R., Alcaraz, N., Baumbach, J., Noer, Julie Boertmann, Moreira, José, Leth-Larsen, R., Larsen, M. R. & Ditzel, H. J., 2017, In: Stem Cells. 35, 8, p. 1898-1912Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of BLCAP as a novel STAT3 interaction partner in bladder cancer
Gromova, I., Svensson, S., Gromov, P. & Moreira, José, 2017, In: PloS one. 12, 11, 18 p., e0188827.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells
Hansen, S. N., Ehlers, Natasja Spring, Zhu, S., Thomsen, M. B. H., Nielsen, R. L., Liu, D., Wang, G., Hou, Y., Zhang, X., Xu, X., Bolund, L., Yang, H., Wang, J., Moreira, José, Ditzel, H. J., Brünner, N., Rasmussen, A. S., Stenvang, Jan & Gupta, R., 9 Jun 2016, In: B M C Genomics. 17, 15 p., 442.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines
Jandu, H., Aluzaité, K., Fogh, L., Thrane, S. W., Noer, J. B., Proszek, J., Nguyen Do, K., Hansen, S. N., Damsgaard-Hansen, B., Nielsen, S. L., Stougaard, M., Knudsen, B. R., Moreira, J., Hamerlik, P., Gajjar, M., Smid, M., Martens, J., Foekens, J., Pommier, Y., Brünner, N. & 2 others, , 22 Jan 2016, In: B M C Cancer. 16, 13 p., 34.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: A potential novel approach to the treatment of metastatic colorectal cancer
Tarpgaard, L. S., Ørum-Madsen, M. S., Christensen, I. J., Nordgaard, C., Noer, Julie Boertmann, Guren, T. K., Glimelius, B., Sorbye, H., Ikdahl, T., Kure, E. H., Tveit, K. M., phw435, P., Pfeiffer, P., Brünner, N. & Moreira, José, 8 Aug 2016, In: OncoTarget. 7, 37, p. 59441-59457 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy
Gromova, I., Gromov, P., Honma, N., Kumar, S., Rimm, D., Talman, M. M., Wielenga, V. T. & Moreira, José, 2015, In: Molecular Oncology. 9, 8, p. 1636-1654 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways
Hansen, S. N., Westergaard, David, Thomsen, M. B. H., Vistesen, M. V., Do, K. N., Fogh, L., Belling, K. G., Wang, J., Yang, H., Gupta, R., Ditzel, H. J., Moreira, José, Brünner, N., Stenvang, Jan & Rasmussen, A. S., 2015, In: Tumor Biology. 36, 6, p. 4327-4338 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Establishment and characterization of models of chemotherapy resistance in colorectal cancer: towards a predictive signature of chemoresistance
Jensen, N. F., Stenvang, J., Beck, M. K., Hanáková, B., Belling, K. C., Do, K. N., Viuff, B. M., Nygård, S. B., Gupta, R., Rasmussen, M. H., Tarpgaard, L. S., Hansen, T. P., Budinská, E., Pfeiffer, P., Bosman, F., Tejpar, S., Roth, A., Delorenzi, M., Andersen, C. L., Rømer, M. U. K. & 2 others, , 24 Feb 2015, In: Molecular Oncology. 9, 6, p. 1169-1185 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug transporters in breast cancer: response to anthracyclines and taxanes
Kümler, I., Stenvang, Jan, Moreira, José, Brünner, N. & Nielsen, Dorte Lisbet, Sep 2015, In: Expert Review of Anticancer Therapy. 15, 9, p. 1075-1092 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Topoisomerase-1 gene copy aberrations are frequent in patients with breast cancer
Kümler, I., Balslev, E., Poulsen, T. S., Nielsen, Signe Lykke, Nygård, S. B., Rømer, M. U., Christensen, I. J., Høgdall, E., Moreira, José, Nielsen, Dorte Lisbet, Brünner, N. & Stenvang, Jan, 8 Apr 2015, In: International Journal of Cancer. 137, 8, p. 2000-2006 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and characterization of a new TIMP-1 binding protein
Moreira, José, Høeberg, M., Lademann, U. A., Viuff, B. M., Jensen, L. V., Stenvang, Jan, Nygård, S. B., Ørum-Madsen, M. S., Vistesen, M. V., Fuglsang, Anja Thoe, Liu, S. & Brünner, N., 2015, In: Cancer Research. 75, 9 suppl., 1 p., Abstract P5-07-08.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Intact and cleaved plasma soluble urokinase receptor in patients with metastatic colorectal cancer treated with oxaliplatin with or without cetuximab
Tarpgaard, L. S., Christensen, I. J., Høyer-Hansen, G., Lund, I. K., Guren, T. K., Glimelius, B., Sorbye, H., Tveit, K. M., Nielsen, H. J., Moreira, José, Pfeiffer, P. & Brünner, N., 15 Nov 2015, In: International Journal of Cancer. 137, 10, p. 2470-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment
Andersen, Anne Poder, Moreira, José & Pedersen, Stine Helene Falsig, 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1638, 11 p., 20130098.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative analysis of evolutionarily conserved motifs of epidermal growth factor receptor 2 (HER2) predicts novel potential therapeutic epitopes
Deng, X., Zheng, X., Yang, H., Moreira, José, Brünner, N. & Christensen, Henrik, 2014, In: PLOS ONE. 9, 9, 9 p., e106448.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast
Gromov, P., Espinoza, J. A., Talman, M., Honma, N., Kroman, N., Wielenga, V. T., Moreira, José & Gromova, I., 2014, In: P L o S One. 9, 11, 14 p., e112024.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic analysis of tissue samples in translational breast cancer research
Gromov, P., Moreira, José & Gromova, I., 2014, In: Expert Review of Proteomics. 11, 3, p. 285-302 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Purification and characterization of bioactive his6-tagged recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1) protein expressed at high yields in mammalian cells
Jensen, L. V., Lademann, U. A., Andersen, E. V., Højrup, P., Thaysen-Andersen, M., Krogh, B. O., Viuff, B. M., Brünner, N., Stenvang, Jan & Moreira, José, 2014, In: Protein Expression and Purification. 101, p. 157-164 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Looking back, to go forward
Moreira, José, 1 Jan 2014, In: Molecular Oncology. 8, 3, p. 445-446 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation: CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation
Puustinen, P., Rytter, A., Mortensen, M., Kohonen, P., Moreira, José & Jäättelä, M., 2014, In: Journal of Cell Biology. 204, 5, p. 713-727 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Contribution of Na+,HCO3--cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7)
Bødtkjer, E., Moreira, José, Mele, M., Vahl, P., Wielenga, V. T., Christiansen, P. M., Jensen, V. E. D., Pedersen, Stine Helene Falsig & Aalkjær, C., 2013, In: International Journal of Cancer. 132, 6, p. 1288-1299 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic profiling of triple-negative breast carcinomas in combination with a three-tier orthogonal technology approach identifies Mage-A4 as potential therapeutic target in estrogen receptor negative breast cancer
Cabezón, T., Gromova, I., Gromov, P., Serizawa, R. R., Wielenga, V. T., Kroman, Niels Thorndahl, Celis, J. E. & Moreira, José, 2013, In: Molecular & Cellular Proteomics. 12, 2, p. 381-394 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumor interstitial fluid: a treasure trove of cancer biomarkers
Gromov, P., Gromova, I., Olsen, C. J., Timmermans-Wielenga, V., Talman, M., Serizawa, R. R. & Moreira, José, 2013, In: B B A - Proteins and Proteomics. 1834, 11, p. 2259-2270 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells
Hekmat, O., Munk, S., Fogh, L., Yadav, R., Francavilla, C., Horn, H., Würtz, S. Ø., Schrohl, A-S., Damsgaard, B., Romer, M. U., Belling, K., Jensen, N. F., Gromova, I., Bekker-Jensen, D. B., Moreira, J., Jensen, L. J., Gupta, R., Lademann, U. A., Brünner, N., Olsen, J. V. & 1 others, , 5 Aug 2013, In: Journal of Proteome Research. 12, 9, p. 4136-4151 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proximity probing assays for simultaneous visualization of protein complexes in situ
Moreira, José, Thorsen, S. B., Brünner, N. & Stenvang, Jan, 2013, In: Expert Review of Proteomics. 10, 3, p. 219-221 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy: a novel strategy in drug development
Stenvang, Jan, Kümler, I., Nygård, S. B., Smith, D. H., Nielsen, D., Brünner, N. & Moreira, José, 2013, In: Frontiers in Oncology. 3, 9 p., 313.Research output: Contribution to journal › Review › Research › peer-review
- 2012
- Published
Immunoexpression analysis and prognostic value of BLCAP in breast cancer
Gromova, I., Gromov, P., Kroman, N., Wielenga, V. T., Simon, R., Sauter, G. & Moreira, José, 2012, In: P L o S One. 7, 9, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression
Rafn, B., Nielsen, C. F., Andersen, S. H., Szyniarowski, P., Corcelle-Termeau, E., Valo, E., Fehrenbacher, N., Olsen, C. J., Daugaard, M., Egebjerg, C., Bøttzauw, T., Kohonen, P., Nylandsted, J., Hautaniemi, S., Moreira, José, Jaattela, M. & Kallunki, T., 2012, In: Molecular Cell. 45, 6, p. 764-776 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Challenges and Opportunities in Oncoproteomics
Celis, J. E. & Moreira, José, 1 Jan 2010, In: Molecular Oncology. 4, 6, p. 459-460 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
Bladder cancer-associated protein, a potential prognostic biomarker in human bladder cancer
Moreira, José, Ohlsson, G., Gromov, P., Simon, R., Sauter, G., Celis, J. E. & Gromova, I., 2010, In: Molecular & Cellular Proteomics. 9, 1, p. 161-77 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tissue proteomics of the human mammary gland: towards an abridged definition of the molecular phenotypes underlying epithelial normalcy
Moreira, José, Cabezón, T., Gromova, I., Gromov, P., Timmermans, V. J. M., Machado, I., Llombart-Bosch, A., Kroman, Niels Thorndahl, Rank, F. & Celis, J. E., 2010, In: Molecular Oncology. 4, 6, p. 539-561 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 37757167
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Comparative analysis of evolutionarily conserved motifs of epidermal growth factor receptor 2 (HER2) predicts novel potential therapeutic epitopes
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
367
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FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast
Research output: Contribution to journal › Journal article › Research › peer-review
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230
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The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published