Kristian Strømgaard
Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- 1999
- Published
Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor
Strømgaard, Kristian, Brierley, M. J., Andersen, K., Sløk, F. A., Mellor, I. R., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Dec 1999, In: Journal of Medicinal Chemistry. 42, 25, p. 5224-5234 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12
Strømgaard, Kristian, Bjørnsdottir, I., Andersen, K., Brierley, M. J., Rizoli, S., Eldursi, N., Mellor, I. R., Usherwood, P. N., Hansen, S. H., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Feb 2000, In: Chirality. 12, 2, p. 93-102 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues
Strømgaard, Kristian, Brier, T. J., Andersen, K., Mellor, I. R., Saghyan, A., Tikhonov, D., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Nov 2000, In: Journal of Medicinal Chemistry. 43, 23, p. 4526-4533 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
A versatile method for solid phase synthesis of polyamines: neuroactive polyamine toxins as example
Strømgaard, Kristian, Andersen, K., Ruhland, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 2001, In: Synthesis. 6, p. 877-884 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recent advances in the medicinal chemistry of polyamine toxins
Strømgaard, Kristian, Andersen, K., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., Nov 2001, In: Mini - Reviews in Medicinal Chemistry. 1, 4, p. 317-338 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist
Strømgaard, Kristian, Mellor, I. R., Andersen, K., Neagoe, I., Pluteanu, F., Usherwood, P. N. R., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 22 Apr 2002, In: Bioorganic & Medicinal Chemistry Letters. 12, 8, p. 1159-1162 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ginkgolides: selective acetylations, translactonization, and biological evaluation
Jaracz, S., Strømgaard, Kristian & Nakanishi, K., 28 Jun 2002, In: Journal of Organic Chemistry. 67, 13, p. 4623-4626 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation
Strømgaard, Kristian, Saito, D. R., Shindou, H., Ishii, S., Shimizu, T. & Nakanishi, K., 29 Aug 2002, In: Journal of Medicinal Chemistry. 45, 18, p. 4038-4046 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors
Kromann, H., Krikstolaityte, S., Andersen, A. J., Andersen, K., Krogsgaard-Larsen, Povl, Jaroszewski, J. W., Egebjerg, J. & Strømgaard, Kristian, 19 Dec 2002, In: Journal of Medicinal Chemistry. 45, 26, p. 5745-5754 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors
Mellor, I. R., Brier, T. J., Pluteanu, F., Strømgaard, Kristian, Saghyan, A., Eldursi, N., Brierley, M. J., Andersen, K., Jaroszewski, J. W., Krogsgaard-Larsen, Povl & Usherwood, P. N. R., Jan 2003, In: Neuropharmacology. 44, 1, p. 70-80 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists
Vogensen, S. B., Strømgaard, Kristian, Shindou, H., Jaracz, S., Suehiro, M., Ishii, S., Shimizu, T. & Nakanishi, K., 13 Feb 2003, In: Journal of Medicinal Chemistry. 46, 4, p. 601-608 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors
Brier, T. J., Mellor, I. R., Tikhonov, D. B., Neagoe, I., Shao, Z., Brierley, M. J., Strømgaard, Kristian, Jaroszewski, J. W., Krogsgaard-Larsen, Povl & Usherwood, P. N. R., Oct 2003, In: Molecular Pharmacology. 64, 4, p. 954-964 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors
Ivic, L., Sands, T. T. J., Fishkin, N., Nakanishi, K., Kriegstein, A. R. & Strømgaard, Kristian, 5 Dec 2003, In: Journal of Biological Chemistry. 278, 49, p. 49279-49285 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Ginkgolides and glycine receptors: a structure-activity relationship study
Jaracz, S., Nakanishi, K., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: Chemistry: A European Journal. 10, 6, p. 1507-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-specific incorporation of unnatural amino acids into proteins
Strømgaard, A., Jensen, Anders A. & Strømgaard, Kristian, 2004, In: ChemBioChem. 5, 7, p. 909-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of polyamines and polyamine toxins. An improved alkylation procedure
Strømgaard, Kristian & Andersen, T., 2004, In: Tetrahedron Letters. 45, p. 7929-7933Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemistry and biology of terpene trilactones from Ginkgo biloba
Strømgaard, Kristian & Nakanishi, K., 19 Mar 2004, In: Angewandte Chemie International Edition. 43, 13, p. 1640-1658 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins
Strømgaard, Kristian & Mellor, I., Sep 2004, In: Medicinal Research Reviews. 24, 5, p. 589-620 32 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of a tritiated ginkgolide
Strømgaard, Kristian, Suehiro, M. & Nakanishi, K., 15 Nov 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 22, p. 5673-5675 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Natural products as tools for studies of ligand-gated ion channels
Strømgaard, Kristian, 2005, In: Chemical Record. 5, 4, p. 229-239 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polyamine toxins: development of selective ligands for ionotropic receptors
Strømgaard, Kristian, Jensen, L. S. & Vogensen, S. B., 1 Mar 2005, In: Toxicon. 45, 3, p. 249-254 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist
Andersen, T. F., Vogensen, S. B., Jensen, L. S., Knapp, K. M. & Strømgaard, Kristian, 1 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 17, p. 5104-5112 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy
Strømgaard, Kristian, Piazzi, L., Olsen, Christian Adam, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, 11, p. 1013-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stoffer fra Tempeltæet (Ginkgo biloba) som redskaber for studier af hjernens funktion
Jensen, Anders A. & Strømgaard, Kristian, 2006, In: Dansk Kemi 83. 87, 1, p. 16-18Research output: Contribution to journal › Journal article › Communication
- Published
Unaturlige aminosyrer skaber ny viden om proteiner
Rannes, J., Andersen, J., Jensen, Anders A., Christensen, L. & Strømgaard, Kristian, 2006, In: Lægemiddelforskning. p. 28-29Research output: Contribution to journal › Journal article › Communication
- Published
Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors
Jensen, L. S., Bølcho, U., Egebjerg, J. & Strømgaard, Kristian, Apr 2006, In: ChemMedChem. 1, 4, p. 419-428 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives
Andersen, T. F., Tikhonov, D. B., Bølcho, U., Bolshakov, K., Nelson, J. K., Pluteanu, F., Mellor, I. R., Egebjerg, J. & Strømgaard, Kristian, 7 Sep 2006, In: Journal of Medicinal Chemistry. 49, 18, p. 5414-5423 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Expressed protein ligation of ionotropic glutamate receptors
Jensen, M. S., Kristensen, Anders Skov & Strømgaard, Kristian, 2007, In: Biopolymers. 88, 4, p. 602Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Probing the pharmacophore of ginkgolides as glycine receptor antagonists
Jensen, Anders A., Begum, N., Vogensen, S. B., Knapp, K. M., Gundertofte, K., Dzyuba, S. V., Ishii, H., Nakanishi, K., Kristiansen, Uffe & Strømgaard, Kristian, 2007, In: Journal of Medicinal Chemistry. 50, 7, p. 1610-1617Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors
Frølund, S. U., Ziegler, H. L., Franzyk, Henrik, Strømgaard, Kristian, Kristensen, Anders Skov & Jaroszewski, J. W., 2008.Research output: Contribution to conference › Poster › Research
- Published
From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies
Eildal, J. N. N., Andersen, J., Kristensen, Anders Skov, Jørgensen, A. M., Bang-Andersen, B., Jørgensen, M. & Strømgaard, Kristian, 2008, In: Journal of Medicinal Chemistry. 51, 10, p. 3045-3048Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Giftstoffer fra hvepse og edderkopper i forskning og lægemiddeludvikling
Strømgaard, Kristian, 2008, In: Carlsbergfondet. Aarsskrift. p. 42-47Research output: Contribution to journal › Journal article › Communication
- Published
Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction
Bach, Anders, Chi, C. N., Olsen, T. B., Pedersen, S. W., Røder, M. U., Pang, G. F., Clausen, Rasmus Prætorius, Jemth, P. & Strømgaard, Kristian, 2008, In: Journal of Medicinal Chemistry. 51, 20, p. 6450-6459Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein-protein interaktion: et nyt mål for udvikling af lægemidler
Bach, Anders, Gottschalk, M., Kristensen, Anders Skov & Strømgaard, Kristian, 2008, In: Lægemiddelforskning. p. 10-12Research output: Contribution to journal › Journal article › Communication
- 2009
- Published
A sequential binding mechanism in a PDZ domain
Chi, C. N., Bach, Anders, Engström, Å., Wang, H., Strømgaard, Kristian, Gianni, S. & Jemth, P., 2009, In: Biochemistry. 48, 30, p. 7089-7097Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction
Bach, Anders, Chi, C. N., Pang, G. F., Olsen, L., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2009, In: Angewandte Chemie - International Edition. 48, 51, p. 9685-9689Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction
Gottschalk, M., Bach, Anders, Hansen, J. L., Krogsgaard-Larsen, Povl, Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Neurochemical Research. 34, 10, p. 1729-1737Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Location of the antidepressant binding site in the serotonin transporter: importance of SER-438 in recognition of citalopram and tricyclic antidepressants
Andersen, J., Taboureau, O., Hansen, K. B., Olsen, L., Egebjerg, J., Strømgaard, Kristian & Kristensen, Anders Skov, 2009, In: Journal of Biological Chemistry. 284, 15, p. 10276-10284Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rational design of a-conotoxin analogues targeting a7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives
Armishaw, C., Jensen, Anders A., Balle, T., Clark, R. J., Harpsøe, Kasper, Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, In: Journal of Biological Chemistry. 284, 14, p. 9498-9512Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters
Andersen, J., Kristensen, Anders Skov, Bang-Andersen, B. & Strømgaard, Kristian, 2009, In: Chemical Communications. 25, p. 3677-3692Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Skræddersyede proteiner: uden naturens begrænsninger
Strømgaard, Kristian, Jensen, M. S. & Kristensen, Anders Skov, 2009, In: Lægemiddelforskning. p. 10-12Research output: Contribution to journal › Journal article › Communication
- Published
Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors
Nelson, J. K., Frølund, S. U., Tikhonov, D. B., Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Angewandte Chemie - International Edition. 48, 17, p. 3087-3091Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological activity of novel a-conotoxin analogues incorporating substituted proline derivatives
Armishaw, C., Jensen, Anders A., Skonberg, C., Liljefors, T. & Strømgaard, Kristian, 2009, Peptides for youth: The proceedings of the 20th American peptide symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). Springer, Vol. 611. p. 179-180 (Advances in Experimental Medicine and Biology, Vol. 611).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- 2010
- Published
Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: Discovery of nanomolar, nonselective, and use-dependent antagonists
Frølund, S., Bella, A., Kristensen, Anders Skov, Ziegler, H. L., Witt, M., Olsen, C. A., Strømgaard, Kristian, Franzyk, Henrik & Jaroszewski, J. W., 2010, In: Journal of Medicinal Chemistry. 53, 20, p. 7441-7451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemical biology
Strømgaard, Kristian, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 59-74Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example
Chi, C. N., Bach, Anders, Gottschalk, M., Kristensen, Anders Skov, Strømgaard, Kristian & Jemth, P., 2010, In: Journal of Biological Chemistry. 285, 36, p. 28252-28260Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter
Andersen, J., Olsen, L., Hansen, K. B., Taboureau, O., Jørgensen, Flemming Steen, Jørgensen, A. M., Bang-Andersen, B., Egebjerg, J., Strømgaard, Kristian & Kristensen, Anders Skov, 2010, In: Journal of Biological Chemistry. 285, 3, p. 2051-2063Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure and absolute configuration of ginkgolide B characterized by IR- and VCD spectroscopy
Andersen, N. H., Christensen, Niels Johan, Lassen, P. R., Freedman, T. B. N., Nafie, L. A., Strømgaard, Kristian & Hemmingsen, Lars Bo Stegeager, 2010, In: Chirality. 22, 2, p. 217-223 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Textbook of drug design and discovery
Krogsgaard-Larsen, Povl, Strømgaard, Kristian & Madsen, Ulf, 2010, 4 ed. Boca Raton: CRC Press. 460 p.Research output: Book/Report › Book › Education
- Published
Modified peptides as potent inhibitors of the PSD-95/NMDA receptor interaction
Bach, Anders & Strømgaard, Kristian, 14 Jan 2010, Patent No. WO2010/004003 (Granted: EP2320927B1; US9241967B2)Research output: Patent
- Published
Antidepressive lægemidler: nu i 3D
Andersen, J., Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, Dec 2010, In: Lægemiddelforskning. 2010, p. 25-27Research output: Contribution to journal › Journal article › Communication
- 2011
- Published
Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization: The effect of linker length on stability and activity at nicotinic acetylcholine receptors
Armishaw, C. J., Jensen, Anders A., Balle, L. D., Scott, K. C. M., Sørensen, L. & Strømgaard, Kristian, 2011, In: Antioxidants & Redox Signaling. 14, 1, p. 65-76Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata
Barslund, A. F., Poulsen, Mette Homann, Bach, T. B., Lucas, S., Kristensen, Anders Skov & Strømgaard, Kristian, 2011, In: Journal of Natural Products. 74, 3, p. 483-486Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97
Chi, C. N., Bach, Anders, Engström, Å., Strømgaard, Kristian, Lundström, P., Ferguson, N. & Jemth, P., 4 Feb 2011, In: Journal of Biological Chemistry. 286, 5, p. 3597-3606Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expedient synthesis of 1,3-substituted benzene peptidomimetics
Bach, Anders & Strømgaard, Kristian, 8 Feb 2011, In: Synthesis. 2011, 5, p. 807-815Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction
Bach, Anders, Eildal, J. N. N., Stuhr-Hansen, N., Deeskamp, R., Gottschalk, M., Pedersen, S. W., Kristensen, Anders Skov & Strømgaard, Kristian, 10 Mar 2011, In: Journal of Medicinal Chemistry. 54, 5, p. 1333-1346Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters
Andersen, J., Stuhr-Hansen, N., Zachariassen, L., Toubro, S., Hansen, S. M. R., Eildal, J. N. N., Bond, A. D., Bøgesø, K. P., Bang-Andersen, B., Kristensen, Anders Skov & Strømgaard, Kristian, 19 Jul 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 29, p. 12137-12142Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain
Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small molecules from spiders used as chemical probes
Olsen, C. A., Kristensen, Anders Skov & Strømgaard, Kristian, 25 Nov 2011, In: Angewandte Chemie International Edition. 50, 48, p. 11296-11311Research output: Contribution to journal › Review › Research › peer-review
- 2012
- Submitted
High-affinity, dimeric inhibitors of PSD-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain
Bach, Anders & Strømgaard, Kristian, 2012, (Submitted) Patent No. WO2012/156308 (Granted: EP2707014B1; US9139615B2)Research output: Patent
- Published
Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket
Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: The Journal of Biological Chemistry. 287, 52, p. 43694-43707 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket
Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, Albin Gustav, Strømgaard, Kristian & Kristensen, Anders Skov, 2012, In: Journal of Biological Chemistry. 287, p. 43694-43707 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand binding by PDZ domains
Chi, C. N., Bach, Anders, Strømgaard, Kristian, Gianni, S. & Jemth, P., 2012, In: BioFactors. 38, 5, p. 338-348 (Review) 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains
Haq, S. R., Chi, C. N., Bach, Anders, Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O. A., Lundström, P., Montemiglio, L. C., Strømgaard, Kristian, Gianni, S. & Jemth, P., Jan 2012, In: Journal of the American Chemical Society. 134, 1, p. 599-605Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A heteromeric snake toxin and the molecular details of pain perception
Strømgaard, Kristian & Kristensen, Anders Skov, 23 Apr 2012, In: Angewandte Chemie International Edition. 51, 17, p. 4009-4011Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An expanded view of the protein folding landscape of PDZ domains
Hultqvist, G., Pedersen, S. W., Chi, C. N., Strømgaard, Kristian, Gianni, S. & Jemth, P., 11 May 2012, In: Biochemical and Biophysical Research Communications. 421, 3, p. 550-553 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors
Lucas, S., Poulsen, Mette Homann, Nørager, N. G., Barslund, A. F., Bach, T. B., Kristensen, Anders Skov & Strømgaard, Kristian, 26 Nov 2012, In: Journal of Medicinal Chemistry. 55, 22, p. 10297-10301 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Møller, T. C., Wirth, V. F., Roberts, N. I., Bender, J., Bach, Anders, Jacky, B. P. S., Strømgaard, Kristian, Deussing, J. M., Schwartz, Thue W. & Martinez, Karen Laurence, 2013, In: PLOS ONE. 8, 5, e63352.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group
Pedersen, S. W., Armishaw, C. J. & Strømgaard, Kristian, 2013, Peptide synthesis and applications. Humana Press, Vol. 1047. p. 65-80 16 p. (Methods in Molecular Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors
Poulsen, Mette Homann, Lucas, S., Bach, T. B., Barslund, A. F., Wenzler, C., Jensen, C. B., Kristensen, Anders Skov & Strømgaard, Kristian, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1171-1181 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy
Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.Research output: Contribution to journal › Journal article › Research
- Published
UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801
Andreasen T., Jesper, Bach, Anders, Gynther, M., Nasser, A., Mogensen, J., Strømgaard, Kristian & Pickering, Darryl S, Apr 2013, In: Neuropharmacology. 67, p. 193-200 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthetic and mechanistic insight into nosylation of glycine residues
Stuhr-Hansen, N., Sølling, Theis Ivan & Strømgaard, Kristian, 14 Apr 2013, In: Organic & Biomolecular Chemistry. 11, 14, p. 2288-2293 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Energetic pathway sampling in a protein interaction domain
Hultqvist, G., Haq, S. R., Punekar, A. S., Chi, C. N., Engström, A., Bach, Anders, Strømgaard, Kristian, Selmer, M., Gianni, S. & Jemth, P., 25 Jun 2013, In: Structure. 21, 7, p. 1193-1202Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of peptide thioesters through fmoc-based solid-phase peptide synthesis by using amino thioesters
Stuhr-Hansen, N., Wilbek, T. S. & Strømgaard, Kristian, 1 Aug 2013, In: European Journal of Organic Chemistry. 2013, 24, p. 5290-5294 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A parallel semisynthetic approach for structure-activity relationship studies of peptide YY
Albertsen, L., Østergaard, S., Paulsson, J. F., Norrild, J. C. & Strømgaard, Kristian, Sep 2013, In: ChemMedChem. 8, 9, p. 1505-13Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations
Eildal, J. N. N., Hultqvist, G., Balle, T., Stuhr-Hansen, N., Padrah, S., Gianni, S., Strømgaard, Kristian & Jemth, P., 4 Sep 2013, In: Journal of the American Chemical Society. 135, 35, p. 12998-3007 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons
Nørager, N. G., Jensen, C. B., Rathje, Mette, Andersen, J., Madsen, Kenneth Lindegaard, Kristensen, Anders Skov & Strømgaard, Kristian, 20 Sep 2013, In: A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recombinant production of peptide C-terminal α-amides using an engineered intein
Albertsen, L., Shaw, A. C., Norrild, J. C. & Strømgaard, Kristian, 20 Nov 2013, In: Bioconjugate Chemistry. 24, 11, p. 1883-94 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications
Albertsen, L., Andersen, J. J., Paulsson, J. F., Thomsen, J. K., Norrild, J. C. & Strømgaard, Kristian, 12 Dec 2013, In: A C S Medicinal Chemistry Letters. 4, 12, p. 1228-1232 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids
Stuhr-Hansen, N., Padrah, S. & Strømgaard, Kristian, 2014, In: Tetrahedron Letters. 55, 30, p. 4149-4151 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations
Pedersen, S. W., Pedersen, S. B., Anker, L., Hultqvist, G., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2014, In: Nature Communications. 5, p. 1-11 11 p., 3215.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain
Pedersen, S. W., Hultqvist, G., Strømgaard, Kristian & Jemth, P., 2014, In: PLOS ONE. 9, 4, p. 1-7 7 p., e95619.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins
Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.Research output: Contribution to journal › Journal article › Research
- Published
Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors
Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, Feb 2014, In: Molecular Pharmacology. 85, 2, p. 261-268 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin
Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, 22 Feb 2014, In: Neurochemical Research. 39, 10, p. 1906-1913 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites
Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, 18 Apr 2014, In: ACS chemical biology. 9, 4, p. 935-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (prozac)
Andersen, J., Stuhr-Hansen, N., Zachariassen, L. G., Koldsø, H., Schiøtt, B., Strømgaard, Kristian & Kristensen, Anders Skov, May 2014, In: Molecular Pharmacology. 85, 5, p. 703-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors
Nørager, N. G., Poulsen, Mette Homann, Jensen, A. G., Jeppesen, N. S., Kristensen, Anders Skov & Strømgaard, Kristian, 12 Jun 2014, In: Journal of Medicinal Chemistry. 57, 11, p. 4940-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines
Stuhr-Hansen, N., Bork, N. & Strømgaard, Kristian, 14 Aug 2014, In: Organic & Biomolecular Chemistry. 12, 30, p. 5745-51 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
THE DEVELOPMENT AND CHARACTERIZATION OF A PEPTIDE-BASED SYNTENIN INHIBITOR - IMPLACATIONS FOR CANCER METASTASIS
Haugaard-Kedstrom, L. M., Albertsen, L., Gil, F. A., Ivarsson, Y., Strømgaard, Kristian & Kedström, L. M. H., Sep 2014, In: Journal of Peptide Science. 20, Suppl. 1, p. s39 1 p., YO11.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Structure–Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors
Xiong, X., Poulsen, Mette Homann, Hussein, R. A., Nørager, N. G. & Strømgaard, Kristian, Dec 2014, In: ChemMedChem. 9, 12, p. 2661-70 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin
Maric, H., Kasaragod, V. B., Hausrat, T. J., Kneussel, M., Tretter, V., Strømgaard, Kristian & Schindelin, H., 22 Dec 2014, In: Nature Communications. 5, p. 1-11 11 p., 5767.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter
Andersen, J., Ringsted, K. B., Bang-Andersen, B., Strømgaard, Kristian & Kristensen, Anders Skov, 2015, In: Scientific Reports. 5, p. 1-12 12 p., 15650.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor
Nissen, K. B., Andersen, J. J., Haugaard-Kedström, L. M., Bach, Anders & Strømgaard, Kristian, 2015, In: Journal of Medicinal Chemistry. 58, p. 1575-1580 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polyamine toxins from spiders and wasps: Polyamine toxins from spiders and wasps
Xiong, X. & Strømgaard, Kristian, 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer, Japan, p. 201-214 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Research output: Contribution to journal › Journal article › Research › peer-review
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