Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications. / Albertsen, Louise; Andersen, J.J.; Paulsson, J.F.; Thomsen, J.K.; Norrild, Jens Chr.; Strømgaard, K.

In: A C S Medicinal Chemistry Letters, Vol. 4, No. 12, 12.12.2013, p. 1228-1232.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Albertsen, L, Andersen, JJ, Paulsson, JF, Thomsen, JK, Norrild, JC & Strømgaard, K 2013, 'Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications', A C S Medicinal Chemistry Letters, vol. 4, no. 12, pp. 1228-1232. https://doi.org/10.1021/ml400335g

APA

Albertsen, L., Andersen, J. J., Paulsson, J. F., Thomsen, J. K., Norrild, J. C., & Strømgaard, K. (2013). Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications. A C S Medicinal Chemistry Letters, 4(12), 1228-1232. https://doi.org/10.1021/ml400335g

Vancouver

Albertsen L, Andersen JJ, Paulsson JF, Thomsen JK, Norrild JC, Strømgaard K. Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications. A C S Medicinal Chemistry Letters. 2013 Dec 12;4(12):1228-1232. https://doi.org/10.1021/ml400335g

Author

Albertsen, Louise ; Andersen, J.J. ; Paulsson, J.F. ; Thomsen, J.K. ; Norrild, Jens Chr. ; Strømgaard, K. / Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications. In: A C S Medicinal Chemistry Letters. 2013 ; Vol. 4, No. 12. pp. 1228-1232.

Bibtex

@article{664ed291b9324b20803e7e714682f153,
title = "Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications",
abstract = "Peptide YY (PYY) is a gut hormone that activates the G protein-coupled neuropeptide Y (NPY) receptors, and because of its appetite reducing actions, it is evaluated as an antiobesity drug candidate. The C-terminal tail of PYY is crucial for activation of the NPY receptors. Here, we describe the design and preparation of a series of PYY(3-36) depsipeptide analogues, in which backbone amide-to-ester modifications were systematically introduced in the C-terminal. Functional NPY receptor assays and circular dichroism revealed that the ψ(CONH) bonds at positions 30-31 and 33-34 are particularly important for receptor interaction and that the latter is implicated in Y receptor selectivity.",
author = "Louise Albertsen and J.J. Andersen and J.F. Paulsson and J.K. Thomsen and Norrild, {Jens Chr.} and K. Str{\o}mgaard",
year = "2013",
month = dec,
day = "12",
doi = "10.1021/ml400335g",
language = "English",
volume = "4",
pages = "1228--1232",
journal = "ACS Medicinal Chemistry Letters",
issn = "1948-5875",
publisher = "American Chemical Society",
number = "12",

}

RIS

TY - JOUR

T1 - Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications

AU - Albertsen, Louise

AU - Andersen, J.J.

AU - Paulsson, J.F.

AU - Thomsen, J.K.

AU - Norrild, Jens Chr.

AU - Strømgaard, K.

PY - 2013/12/12

Y1 - 2013/12/12

N2 - Peptide YY (PYY) is a gut hormone that activates the G protein-coupled neuropeptide Y (NPY) receptors, and because of its appetite reducing actions, it is evaluated as an antiobesity drug candidate. The C-terminal tail of PYY is crucial for activation of the NPY receptors. Here, we describe the design and preparation of a series of PYY(3-36) depsipeptide analogues, in which backbone amide-to-ester modifications were systematically introduced in the C-terminal. Functional NPY receptor assays and circular dichroism revealed that the ψ(CONH) bonds at positions 30-31 and 33-34 are particularly important for receptor interaction and that the latter is implicated in Y receptor selectivity.

AB - Peptide YY (PYY) is a gut hormone that activates the G protein-coupled neuropeptide Y (NPY) receptors, and because of its appetite reducing actions, it is evaluated as an antiobesity drug candidate. The C-terminal tail of PYY is crucial for activation of the NPY receptors. Here, we describe the design and preparation of a series of PYY(3-36) depsipeptide analogues, in which backbone amide-to-ester modifications were systematically introduced in the C-terminal. Functional NPY receptor assays and circular dichroism revealed that the ψ(CONH) bonds at positions 30-31 and 33-34 are particularly important for receptor interaction and that the latter is implicated in Y receptor selectivity.

UR - http://www.scopus.com/inward/record.url?scp=84890450993&partnerID=8YFLogxK

U2 - 10.1021/ml400335g

DO - 10.1021/ml400335g

M3 - Journal article

AN - SCOPUS:84890450993

VL - 4

SP - 1228

EP - 1232

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

SN - 1948-5875

IS - 12

ER -

ID: 96081753