Standard
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy. / Hansen, Steffen Vissing Fahnøe; Christiansen, Elisabeth; Urban, Christian; Hudson, Brian D; Stocker, Claire J; Due-Hansen, Maria E; Wargent, Ed T; Shimpukade, Bharat; Almeida, Reinaldo; Ejsing, Christer S; Cawthorne, Michael A; Kassack, Matthias U; Milligan, Graeme; Ulven, Trond.
In:
Journal of Medicinal Chemistry, Vol. 59, No. 6, 01.03.2016, p. 2841-2846.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Hansen, SVF
, Christiansen, E, Urban, C, Hudson, BD, Stocker, CJ, Due-Hansen, ME, Wargent, ET, Shimpukade, B, Almeida, R, Ejsing, CS, Cawthorne, MA, Kassack, MU, Milligan, G
& Ulven, T 2016, '
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy',
Journal of Medicinal Chemistry, vol. 59, no. 6, pp. 2841-2846.
https://doi.org/10.1021/acs.jmedchem.5b01962APA
Hansen, S. V. F.
, Christiansen, E., Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G.
, & Ulven, T. (2016).
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy.
Journal of Medicinal Chemistry,
59(6), 2841-2846.
https://doi.org/10.1021/acs.jmedchem.5b01962Vancouver
Hansen SVF
, Christiansen E, Urban C, Hudson BD, Stocker CJ, Due-Hansen ME et al.
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy.
Journal of Medicinal Chemistry. 2016 Mar 1;59(6):2841-2846.
https://doi.org/10.1021/acs.jmedchem.5b01962Author
Hansen, Steffen Vissing Fahnøe ; Christiansen, Elisabeth ; Urban, Christian ; Hudson, Brian D ; Stocker, Claire J ; Due-Hansen, Maria E ; Wargent, Ed T ; Shimpukade, Bharat ; Almeida, Reinaldo ; Ejsing, Christer S ; Cawthorne, Michael A ; Kassack, Matthias U ; Milligan, Graeme ; Ulven, Trond. / Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy. In: Journal of Medicinal Chemistry. 2016 ; Vol. 59, No. 6. pp. 2841-2846.
Bibtex
@article{334346ded34740af91e1f2a2eddad331,
title = "Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy",
abstract = "The free fatty acid receptor 1 (FFA1 or GPR40) is established as an interesting potential target for treatment of type 2 diabetes. However, to obtain optimal ligands, it may be necessary to limit both lipophilicity and polar surface area, translating to a need for small compounds. We here describe the identification of 24, a potent FFA1 agonist with low lipophilicity and very high ligand efficiency that exhibit robust glucose lowering effect.",
author = "Hansen, {Steffen Vissing Fahn{\o}e} and Elisabeth Christiansen and Christian Urban and Hudson, {Brian D} and Stocker, {Claire J} and Due-Hansen, {Maria E} and Wargent, {Ed T} and Bharat Shimpukade and Reinaldo Almeida and Ejsing, {Christer S} and Cawthorne, {Michael A} and Kassack, {Matthias U} and Graeme Milligan and Trond Ulven",
year = "2016",
month = mar,
day = "1",
doi = "10.1021/acs.jmedchem.5b01962",
language = "English",
volume = "59",
pages = "2841--2846",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "6",
}
RIS
TY - JOUR
T1 - Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy
AU - Hansen, Steffen Vissing Fahnøe
AU - Christiansen, Elisabeth
AU - Urban, Christian
AU - Hudson, Brian D
AU - Stocker, Claire J
AU - Due-Hansen, Maria E
AU - Wargent, Ed T
AU - Shimpukade, Bharat
AU - Almeida, Reinaldo
AU - Ejsing, Christer S
AU - Cawthorne, Michael A
AU - Kassack, Matthias U
AU - Milligan, Graeme
AU - Ulven, Trond
PY - 2016/3/1
Y1 - 2016/3/1
N2 - The free fatty acid receptor 1 (FFA1 or GPR40) is established as an interesting potential target for treatment of type 2 diabetes. However, to obtain optimal ligands, it may be necessary to limit both lipophilicity and polar surface area, translating to a need for small compounds. We here describe the identification of 24, a potent FFA1 agonist with low lipophilicity and very high ligand efficiency that exhibit robust glucose lowering effect.
AB - The free fatty acid receptor 1 (FFA1 or GPR40) is established as an interesting potential target for treatment of type 2 diabetes. However, to obtain optimal ligands, it may be necessary to limit both lipophilicity and polar surface area, translating to a need for small compounds. We here describe the identification of 24, a potent FFA1 agonist with low lipophilicity and very high ligand efficiency that exhibit robust glucose lowering effect.
U2 - 10.1021/acs.jmedchem.5b01962
DO - 10.1021/acs.jmedchem.5b01962
M3 - Journal article
VL - 59
SP - 2841
EP - 2846
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 6
ER -
