Cyclic peptide drug discovery in the Rogers Group

Cyclic peptides excel at binding. They can tightly and specifically interact with proteins that are reluctant to bind traditional small molecule drugs. In the Rogers lab, we use a mixture of chemistry and molecular biology to isolate such cyclic peptides de novo. We ‘reprogram’ nature’s peptide synthesis machinery - the ribosome - to synthesize and screen trillions of unique cyclic peptides to discover promising drug-like biopharmaceuticals.

We thank the following foundations for their generous support of our research:

•  Novo Nordisk Fonden