Computational Receptor Biology – Gloriam Group

David Gloriam’s group identifies mechanisms, structures and ligands of G protein-coupled receptors (GPCRs) – the main mediators of human signalling and drug responses – and develop the field’s main online database, GPCRdb (see video and






































































































GPCR activation mechanisms across classes and macro/microscales
Nature Structural & Molecular Biology. Accepted

GPCRdb in 2021: Integrating GPCR sequence, structure and function
Nucleic Acids Research. 2021

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.
Cell. 2019

An online resource for GPCR structure determination and analysis.
Nature Methods. 2019

Trends in GPCR drug discovery: new agents, targets and indications
Nature Reviews Drug Discovery. 2017 [Citations: 1,065]

From collaborations
Structural insights into the lipid and ligand regulation of serotonin receptors
Nature. 2021

Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
Nature. 2020

Combinatorial expression of functionally distinct GPCR isoforms can diversify receptor signalling
Nature. 2020

Pharmacogenomics of GPCR drug targets
Cell. 2018 [Citations: 329]

Selectivity determinants of GPCR–G-protein binding
T Flock, AS Hauser, N Lund, DE Gloriam, S Balaji, MM Babu
Nature. 2017 [Citations: 217]





















Our group is mainly funded by grants from external foundations and councils. In recent years we have obtained major grants (> 0.3 million DKK) from Alfred Benzon Foundation, European Research Council, Independent Research Fund Denmark, Lundbeck Foundation, Novo Nordisk Foundation and Stiftelsen Olle Engkvist Byggmästare.

Lundbeck Foundation Personalised Medicine grant

Hans Bräuner-Osborne (main applicant), David Gloriam and Alexander Hauser have received a DKK 10 million Personalised Medicine grant from the Lundbeck Foundation for the project: Advancing personalised medicine for psychiatric diseases through integrative GPCR PharmacogenomicsThe project aims to find out how genetic variants in GPCRs affect the usage of drugs treating psychiatric disorders.

logo gor Lundbeck Foundation

Novo Nordisk Foundation Ascending Investigator

Major grant on GPCR biased signalling.
David Gloriam has received DKK 10 million (€ ~1,3 M) Hallas-Møller Ascending Investigator grant from the Novo Nordisk Foundation (an ERC Consolidator-like Danish grant) for the project: GPCR Biased Signalling: Illuminating the Pathways to Function and DiseaseThe project aims to find out how just one cell-surface receptor can elicit vastly different biological, therapeutic or adverse effects when activated by natural, medicinal or abused substances. The Gloriam group will develop a new database resource to consolidate this new research field and conduct molecular modelling to select receptor targets and identify molecular mechanisms and substances.

logo for Novo Nordisk Foundation

EU PhD training network

Towards biased ligands for the serotonin 5-HT2A receptors - a target of CNS drugs and hallucinogens,

SAFER is the first European research platform to gain a molecular understanding and improve selectivity in the stimulation of the serotonin 5-HT2A receptor – the primary target for many CNS-related disorders and hallucinogens. SAFER will design and prepare ligands for the receptor, generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases.

The SAFER network comprises five PhD students in pharmacology, chemistry, crystallography, computational drug design and scientific database development; first receiving 1-1,5 years joint training at the University of Copenhagen (Denmark) followed by industrial research at Enamine (Kiev, Ukraine) or SARomics (Lund, Sweden).

SAFER is coordinated by Jesper Kristensen at the University of Copenhagen who leads a chemistry group that has developed serotonin 5-HT2A receptor ligands being used as tracers for human brain imaging for diagnosis and evaluation of treatments.

PhD to Christian Munk

PhD fellowship to GPCRdb lead developer.
GPCRdb lead developer Christian Munk received a PhD grant from the Lundbeck Foundation for the project:  GPCR-G protein complex conformations – Structural stabilisation in selective signalling 

Scholarship to Anders Nielsen

12-month research scholarship.
Anders Nielsen got a 12-month research scholarship from The Danish Council for Independent Research | Medical Sciences to identify orphan receptor tool compounds. 

GPCR Consortium grant

Towards tools for structure determination. 
The group became a funded member of the GPCR Consortium headed by Ray Stevens, and will develop a GPCR crystallisation construct design tool in GPCRdb.

Group picture GCPR Consortium grant

Mutation annotation grant

Towards database of ligand-affecting GPCR mutations. 
365,000 SEK received from Stiftelsen Olle Engkvist Byggmästare to annotate mutant data for the GPCRdb.

Logo Olle Engkvist Byggemästare

Lundbeck Foundation Fellow

Orphan receptor ligand identification.
David Gloriam received a 10 million DKK Lundbeck Foundation Fellowship for the project "Orphan Receptor Ligands And Signals - Keys to Physiological Functions And Drug Discovery.

logo Lundbeck Foundation

ERC Starting Grant

Orphan receptor ligand identification.
David Gloriam received a 1.5 million EUR ERC Starting Grant for the project "DE-ORPHAN - Determination of Orphan Receptor Physiological Agonists and sigNals"

logo European Research Council











Albert J. Kooistra receives the MGMS Frank Blaney Award


portrait Albert Kooistra

David Gloriam receives big data prize from the Danish Royal Academy of Sciences and Letters



Alexander S. Hauser receives Bachem Award for Peptide Science


portrait of award winner Alexander Hauser

Alexander Hauser receives HC Ørsted research talent prize


portrait Alexander Hauser

Professor inauguration

Inauguration of David Gloriam as Professor. … »

David Gloriam at a reception

Crystal refinement bronze

Bronze prize in crystal structure refinement.
Louise Nikolajsen got bronze prize (diploma and money) in a GPCR crystal refinement competition at the 4th Annual Shanghai iHuman Forum.

Portrait of Louise Nikolajsen holding her diploma

Wikipedia gold

Gold prize in Wikipedia competition. 
The International Society for Computational Biology (ISCB) announces competitions to improve the coverage on Wikipedia of any aspect of computational biology. In the last WikiProject competition PhD student Alexander S. Hauser has been awarded 1st and 2nd prize awards with an in-depth update of the molecular docking Wikipedia page as well as Wikidata entry. 

Portrait of Alexander Hauser

Oral & poster awards

2nd Central European Biomedical Congress. 
Stefan Mordalski and Gáspár Pándy-Szekeres received awards for their oral and poster presentations, respectively, at the 2nd Central European Biomedical Congress, in Krakow, Poland.

group portrait of Stefan Mordalski and Gáspár Pándy-Szekeres

GPCR modelling gold

Best 5-HT1B model in global competition. 
1st and 3rd places in the GPCR  Dock competition for structure modeling of the serotonin 5-HT1B receptor and receptor-ligand complex, respectively. GPCR Dock is a highly competitive competition and involved 44 international groups, including leading GPCR modelers and software developers.









GPCRdb accelerates data-driven receptor research

2021 01 18
GPCRdb accelerates data-driven receptor research

Discovery of new hormone-receptor signalling systems

Press release and video

Ultra-large virtual screening for drugs

News & views article and podcast

Press release: GPCR structure determination resource

Online tools to determine GPCR 3D structures.
The first web-based tool to determine GPCR 3D structures (Nature Methods) - Eng

Press release: 5-HT2C structure

Shedding insight on GPCR-ligand polypharmacology.
Polypharmacology and 3D structure of the serotonin 5-HT2C receptor (Cell) - Eng 

Video on GPCR pharmacogenomics

From the Cell article on pharmacogenomics of GPCR drug targets. … »

Press release: GPCR pharmacogenomics

Genetic variation in GPCR drug targets.
Pharmacogenomics of GPCR drug targets (Cell) - Eng1Eng2 & Dan 

Press release: GPCR drug discovery

Trends for drugs, clinical trials and indications.
Trends in GPCR drug discovery (Nat Rev Drug Discov) - Eng & Dan 

Press release: G protein selectivity

Determinants of GPCR-G protein coupling.
Receptor signalling: GPCR - G protein selectivity (Nature) - Eng & Dan 

Intro to the GPCRdb database

Popular scientific article about the GPCRdb database.  

Video on orphan receptor ligand identification

Video made in relation to the award of the Lundbeck Foundation Fellowship to David Gloriam. English: … »


































































































































Group leader

Group Leader

David Gloriam

Phone +45 3533 6162

Group members

Name Title Image
Andreassen, Søren Norge Academic Research Staff Billede af Andreassen, Søren Norge
Caroli, Jimmy Postdoc Billede af Caroli, Jimmy
Henseler, Jascha PhD Fellow Billede af Henseler, Jascha
Kastrup, Jette Sandholm Jensen Professor Billede af Kastrup, Jette Sandholm Jensen
Kulkarni, Yashraj Postdoc Billede af Kulkarni, Yashraj
Pacalon, Jody Sullivan Postdoc Billede af Pacalon, Jody Sullivan
Pedersen, Eva-Marie Lucin Mokdasi A Laboratory Technician Billede af Pedersen, Eva-Marie Lucin Mokdasi A
Pándy-Szekeres, Gáspár Academic Research Staff Billede af Pándy-Szekeres, Gáspár
Rodriguez Espigares, Ismael Academic Research Staff Billede af Rodriguez Espigares, Ismael
Simonyan, Arman PhD Fellow Billede af Simonyan, Arman
Sánchez Lorente, Javier Research Assistant Billede af Sánchez Lorente, Javier
Taracena Herrera, Luis Pablo Academic Research Staff Billede af Taracena Herrera, Luis Pablo
Weckerle, Felix Anton Research Fellow Billede af Weckerle, Felix Anton
Xiao, Binghan PhD Fellow Billede af Xiao, Binghan