Association between atopic disease and vaccination granulomas: A nested case–control study
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Association between atopic disease and vaccination granulomas : A nested case–control study. / Hoffmann, Stine Skovbo; Thiesson, Emilia Myrup; Johansen, Jeanne Duus; Hviid, Anders.
In: Contact Dermatitis, Vol. 90, No. 4, 2024, p. 411-419.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association between atopic disease and vaccination granulomas
T2 - A nested case–control study
AU - Hoffmann, Stine Skovbo
AU - Thiesson, Emilia Myrup
AU - Johansen, Jeanne Duus
AU - Hviid, Anders
N1 - Publisher Copyright: © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2024
Y1 - 2024
N2 - Background: Vaccination granulomas are observed in 1% of all children vaccinated with an aluminium-adsorbed vaccine. Most children with granulomas also have aluminium contact allergy (CA). CA and atopic diseases are both highly prevalent among children and may be associated. Objective: To investigate the association between vaccination granulomas and atopic dermatitis (AD), asthma and rhinitis in children. Methods: We sourced a cohort of all Danish children born from 2009 to 2017 and conducted a nested case–control study, with cases defined as children with vaccination granulomas, matched to controls 1:10 on sex, socioeconomic class, gestational age and season of birth. All cases and controls were vaccinated with aluminium-adsorbed vaccines and followed until their second birthday. We used conditional logistic regression to estimate the odds ratios (ORs). Results: The study included 2171 cases with vaccination granulomas, and 21 710 controls. Children with a diagnosis of AD had a significantly higher risk of a vaccination granuloma (OR 1.50, 95% confidence intervals [CI] 1.25–1.80). No significant association was found between granulomas and asthma or rhinitis. The association between granulomas and AD was even higher in an additional sensitivity-analysis, following the children until their fourth birthday (OR 2.71, 95% CI 2.36–3.11). Conclusion: AD was significantly associated with vaccination granulomas, but not with other atopic diseases, within both the first 2 and 4 years of life.
AB - Background: Vaccination granulomas are observed in 1% of all children vaccinated with an aluminium-adsorbed vaccine. Most children with granulomas also have aluminium contact allergy (CA). CA and atopic diseases are both highly prevalent among children and may be associated. Objective: To investigate the association between vaccination granulomas and atopic dermatitis (AD), asthma and rhinitis in children. Methods: We sourced a cohort of all Danish children born from 2009 to 2017 and conducted a nested case–control study, with cases defined as children with vaccination granulomas, matched to controls 1:10 on sex, socioeconomic class, gestational age and season of birth. All cases and controls were vaccinated with aluminium-adsorbed vaccines and followed until their second birthday. We used conditional logistic regression to estimate the odds ratios (ORs). Results: The study included 2171 cases with vaccination granulomas, and 21 710 controls. Children with a diagnosis of AD had a significantly higher risk of a vaccination granuloma (OR 1.50, 95% confidence intervals [CI] 1.25–1.80). No significant association was found between granulomas and asthma or rhinitis. The association between granulomas and AD was even higher in an additional sensitivity-analysis, following the children until their fourth birthday (OR 2.71, 95% CI 2.36–3.11). Conclusion: AD was significantly associated with vaccination granulomas, but not with other atopic diseases, within both the first 2 and 4 years of life.
KW - aluminium
KW - atopic dermatitis
KW - atopic disease
KW - contact allergy
KW - vaccination granulomas
U2 - 10.1111/cod.14472
DO - 10.1111/cod.14472
M3 - Journal article
C2 - 38059542
AN - SCOPUS:85178871187
VL - 90
SP - 411
EP - 419
JO - Contact Dermatitis. Supplement
JF - Contact Dermatitis. Supplement
SN - 1396-6669
IS - 4
ER -
ID: 380201561