Chewing gum and lozenges as delivery systems for noscapine

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Chewing gum and lozenges as delivery systems for noscapine. / Norgaard Jensen, L.; Christrup, Lona Louring; Menger, N.; Bundgaard, H.

In: Acta Pharmaceutica Nordica, Vol. 3, No. 4, 01.01.1991, p. 219-222.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Norgaard Jensen, L, Christrup, LL, Menger, N & Bundgaard, H 1991, 'Chewing gum and lozenges as delivery systems for noscapine', Acta Pharmaceutica Nordica, vol. 3, no. 4, pp. 219-222.

APA

Norgaard Jensen, L., Christrup, L. L., Menger, N., & Bundgaard, H. (1991). Chewing gum and lozenges as delivery systems for noscapine. Acta Pharmaceutica Nordica, 3(4), 219-222.

Vancouver

Norgaard Jensen L, Christrup LL, Menger N, Bundgaard H. Chewing gum and lozenges as delivery systems for noscapine. Acta Pharmaceutica Nordica. 1991 Jan 1;3(4):219-222.

Author

Norgaard Jensen, L. ; Christrup, Lona Louring ; Menger, N. ; Bundgaard, H. / Chewing gum and lozenges as delivery systems for noscapine. In: Acta Pharmaceutica Nordica. 1991 ; Vol. 3, No. 4. pp. 219-222.

Bibtex

@article{6306ae14100b4aa0a2cfd1661b704ec4,
title = "Chewing gum and lozenges as delivery systems for noscapine",
abstract = "Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.",
author = "{Norgaard Jensen}, L. and Christrup, {Lona Louring} and N. Menger and H. Bundgaard",
year = "1991",
month = jan,
day = "1",
language = "English",
volume = "3",
pages = "219--222",
journal = "Acta Pharmaceutica Nordica",
issn = "1100-1801",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Chewing gum and lozenges as delivery systems for noscapine

AU - Norgaard Jensen, L.

AU - Christrup, Lona Louring

AU - Menger, N.

AU - Bundgaard, H.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.

AB - Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.

UR - http://www.scopus.com/inward/record.url?scp=0026343463&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0026343463

VL - 3

SP - 219

EP - 222

JO - Acta Pharmaceutica Nordica

JF - Acta Pharmaceutica Nordica

SN - 1100-1801

IS - 4

ER -

ID: 46100651