Our primary focus is on proton-coupled secondary active transporters that beside playing a major role in physiology, influence uptake and distribution of drugs. Understanding their structural dynamics, how they recognize substrates, interact with inhibitors, and perform the transport cycle and are energized by the electrochemical proton-gradient. Secondly, we are interested in enzymes involved in castration resistant prostate cancer and are prime therapeutic targets. We collaborate with medicinal chemists to provide 3D structures of the enzymes in complex with promising drug-candidates. Our key experimental techniques are recombinant protein protduction, X-ray crystallography and CryoEM, but also functional assays combined with mutational studies.