Protein-membrane interactions in health and disease in the Galvagnion Group
Our research aims at understanding how changes in protein-lipid interactions can lead to the loss of function and/or the gain of toxicity of proteins in the context of disease.
In particular, we aim at providing mechanistic insights into the interplay between disruptions in lipid homeostasis and neurodegenerative disorders, such as Parkinson's Disease. In order to address this question, we use a multidisciplinary approach at the interface between biology and biophysics including the study of different disease cellular models and the characterization of protein-membrane interactions and aggregation at the molecular level.
1. Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation (Galvagnion C, et al, Brain, 2022)
2. Short chain negatively charged phospholipids initiate α-synuclein aggregation (Galvagnion C, et al, Nat Chem Biol. 2015; Galvagnion C, et al, PNAS 2016)
3. Lipid molecules co-assemble with α-synuclein into amyloid fibrils (Galvagnion C, et al, J Phys Chem Lett. 2019)
2022
- Innovation fund Denmark’s Industrial PhD Fellowship
We are pleased to welcome Josephine Fussing Tengberg in the group for the PhD project “LRRK2 modulation of lysosomal function and α-synuclein homeostasis – investigation of how LRRK2 mutations lead to Parkinson’s disease” in collaboration with Lundbeck and funded by the Innovation Fund Denmark.
2021
- DKK 145,000 grant from Parkinsonforeningen
We are grateful to the Danish Parkinson’s disease foundation (Parkinsonforeningen) for a DKK 145,000 grant to continue our work on investigating lipid changes associated with decreases in GCase protein and activity levels in differentiated SH-SY5Y cells.
2020
- DKK 9,978,812 Novo-Nordisk Foundation Hallas-Møller Emerging Investigator grant
Céline Galvagnion has been awarded a Hallas-Møller Emerging Investigator grant of DKK DKK 9,978,812 for the project “Brain lipid ageing and selective neuronal vulnerability in the context of Parkinson’s Disease”. More information can be found here.
2019
- DKK 4,499,587 Carlsberg Foundation Young Researcher Fellowship grant
Céline Galvagnion has been awarded a Carlsberg Foundation Young Researcher Fellowship grant of DKK 4,499,587 as a contribution for the project “Establishing the role of Glucocerebrosidase mutations and associated changes in lipid metabolism in the emergence of alpha-synuclein and Parkinson Disease pathology”. More information can be found here.
- DKK 100,000 grant from Parkinsonforeningen
We are grateful to the Danish Parkinson’s disease foundation (Parkinsonforeningen) for a DKK 100,000 grant to start our work on investigating lipid changes associated with decreases in GCase protein and activity levels in differentiated SH-SY5Y cells.
Group members
| Name | Title | Phone | |
|---|---|---|---|
| Dreier, Jesper Elmsted | PhD Fellow | +4535322043 | |
| Galvagnion-Büll, Céline | Associate Professor | +4535337828 | |
| Marlet, Frederik Ravnkilde | Postdoc | +4535334982 | |
| Marlet, Frederik Ravnkilde | Visiting Student | +4535334982 | |
| Sanz Muñoz, Sonia | Postdoc | +4535321119 |