Patrick Ryan Gentry

Patrick Ryan Gentry

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ORCID: 0000-0003-0670-6648

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1 - 10 out of 26Page size: 10
  1. 2019
  2. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist

    Nøhr, A. C., Shehata, Mohamed A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, Patrick Ryan, Gloriam, David E. & Bräuner-Osborne, Hans, 7 Mar 2019, In : Scientific Reports. 9, 1, 10 p., 3802.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2018

  4. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

    Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, Patrick Ryan, Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2016

  6. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators

    Berizzi, A. E., Gentry, Patrick Ryan, Rueda, P., Den Hoedt, S., Sexton, P. M., Langmead, C. J. & Christopoulos, A., Oct 2016, In : Molecular Pharmacology. 90, 4, p. 427-36 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

    Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, Patrick Ryan, Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., 15 Jun 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. 2015

  9. Novel Allosteric Modulators of G Protein-coupled Receptors

    Gentry, Patrick Ryan, Sexton, P. M. & Christopoulos, A., 7 Aug 2015, In : The Journal of Biological Chemistry. 290, 32, p. 19478-88 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges

    Kurata, H., Gentry, Patrick Ryan, Kokubo, M., Cho, H. P., Bridges, T. M., Niswender, C. M., Byers, F. W., Wood, M. R., Daniels, J. S., Conn, P. J. & Lindsley, C. W., 1 Feb 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 3, p. 690-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2014

  12. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)

    Morris, L. C., Nance, K. D., Gentry, Patrick Ryan, Days, E. L., Weaver, C. D., Niswender, C. M., Thompson, A. D., Jones, C. K., Locuson, C. W., Morrison, R. D., Daniels, J. S., Niswender, K. D. & Lindsley, C. W., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 10192-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Lindsley, C. W. & Wood, M. R., 25 Sep 2014, In : Journal of Medicinal Chemistry. 57, 18, p. 7804-10 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Discovery, optimization, and characterization of novel subtype-selective M5 muscarinic acetylcholine receptor ligands

    Gentry, Patrick Ryan, Aug 2014

    Research output: Book/Report › Ph.D. thesis › Research

  15. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Utley, T. J., Rajapakse, A., Byers, F., Niswender, C. M., Morrison, R. D., Daniels, J. S., Wood, M. R., Conn, P. J. & Lindsley, C. W., Aug 2014, In : ChemMedChem. 9, 8, p. 1677-82 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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