Patrick Ryan Gentry
Visitor
Peptides and Proteins
Jagtvej 160, 2100 København Ø
- 2019
- Published
Identification of a novel scaffold for a small molecule GPR139 receptor agonist
Nøhr, A. C., Shehata, Mohamed A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, Patrick Ryan, Gloriam, David E. & Bräuner-Osborne, Hans, 7 Mar 2019, In : Scientific Reports. 9, 1, 10 p., 3802.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold
Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, Patrick Ryan, Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators
Berizzi, A. E., Gentry, Patrick Ryan, Rueda, P., Den Hoedt, S., Sexton, P. M., Langmead, C. J. & Christopoulos, A., Oct 2016, In : Molecular Pharmacology. 90, 4, p. 427-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy
Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, Patrick Ryan, Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., 15 Jun 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Novel Allosteric Modulators of G Protein-coupled Receptors
Gentry, Patrick Ryan, Sexton, P. M. & Christopoulos, A., 7 Aug 2015, In : The Journal of Biological Chemistry. 290, 32, p. 19478-88 11 p.Research output: Contribution to journal › Review › Research › peer-review
Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges
Kurata, H., Gentry, Patrick Ryan, Kokubo, M., Cho, H. P., Bridges, T. M., Niswender, C. M., Byers, F. W., Wood, M. R., Daniels, J. S., Conn, P. J. & Lindsley, C. W., 1 Feb 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 3, p. 690-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)
Morris, L. C., Nance, K. D., Gentry, Patrick Ryan, Days, E. L., Weaver, C. D., Niswender, C. M., Thompson, A. D., Jones, C. K., Locuson, C. W., Morrison, R. D., Daniels, J. S., Niswender, K. D. & Lindsley, C. W., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 10192-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)
Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Lindsley, C. W. & Wood, M. R., 25 Sep 2014, In : Journal of Medicinal Chemistry. 57, 18, p. 7804-10 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery, optimization, and characterization of novel subtype-selective M5 muscarinic acetylcholine receptor ligands
Gentry, Patrick Ryan, Aug 2014Research output: Book/Report › Ph.D. thesis › Research
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe
Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Utley, T. J., Rajapakse, A., Byers, F., Niswender, C. M., Morrison, R. D., Daniels, J. S., Wood, M. R., Conn, P. J. & Lindsley, C. W., Aug 2014, In : ChemMedChem. 9, 8, p. 1677-82 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 172786299
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Identification of a novel scaffold for a small molecule GPR139 receptor agonist
Research output: Contribution to journal › Journal article › Research › peer-review
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