Molecular Pharmacology Group
The aim of our research is to study the function of receptors and transporters at the molecular level, and to develop novel pharmacological tool compounds. Increasingly, we are also studying the function of selected ligands and targets ex vivo and in vivo using animal models and genetically modified mice.
Most of our projects are interdisciplinary, using computer modeling and medicinal chemistry in conjunction with molecular pharmacology:
- We use modeling of 3D structures to predict receptor/transporter interactions and to design selective ligands for chemical synthesis.
- For pharmacological assessment and delineation of the physiological function of the receptor/transporter in question, we use both our developed efficient pharmacological assays and phenotyping of genetically modified mice.
The projects build on collaborations with the Translational Neuropharmacology, Chemistry and Medicinal Chemistry, Computational Drug Design and Chemical Biology groups at the Department of Drug Design and Pharmacology, as well as many external academic and pharmaceutical industry collaborators in Denmark and abroad.