Vascular physiology and pharmacology
The purpose of our research is to unravel the mechanisms that are responsible for changes in function and expression of relevant ion channels and receptors during various pathological conditions such as ischemic heart disease, diabetes, and hypertension. This information will increase our knowledge of the complex regulation and adaptation of vascular structure and function in health and disease and may lead to better pharmacotherapy of cardiovascular diseases.
- The complex mechanism behind (auto-) regulatory control and adaptation of vascular tone (and morphology) in health and disease.
- Changes in receptor expression, innervation density (both sensory and sympathetic), intracellular signalling and calcium handling in healthy animals and animal models of disease (e.g. diabetes, hypertension, heart failure, ischemia and reperfusion).
- Consequences of changes in free energy flux and metabolism on vascular tone and reactivity.
- Wire- and pressurised myograph
- Langendorff heart perfusion system
- Organ bath Setups with Electric Field Stimulation (EFS)
- Measurement of physiological parameters (e.g. intracellular calcium, membrane
potential, pH, and redox status) using fluorescent microscopy technique.
- RT-PCR, Western blot, ELISA and immunohistochemistry.
- Professor Helle S. Waagepetersen
- Associate Professor Harrie C. M. Boonen
- Associate Professor Paul Robert Hansen
- Professor Christian Aalkjær
- Associate Professor Thomas Jespersen
- Professor Lars Edvinsson
- Professor Peter Møller
- Professor Steffen Loft
- Professor Jens Lykkesfeldt
- Chief Physician, MD Philip Hasbak
- Professor Jørgen Jeppesen
- Associate Professor, MD Inger Olesen
- Professor Ulf Simonsen
- Professor Gorm Greisen
- Consultant, PhD, Simon Trautner