Brain mechanisms of GHB and GABAergic signalling in the Wellendorph Lab 

Our lab is devoted to understanding brain mechanisms involving the inhibitory neurotransmitter GABA (γ-aminobutyric acid) and its metabolite GHB (γ-hydroxybutyric acid). We use biochemical and pharmacological analyses in cells, tissues and whole organisms to elucidate the role of GHB and GABA targets in brain dysfunction. 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  1. Identification of the ubiquitous neuronal signalling molecule CaMKIIα as the physiological target for GHB
  2. Identification and characterization of extrasynaptic GABAA receptors
  3. Drug discovery into and anti-ischemic effects of GABA transporter ligands

Linked articles:

  1. Leurs U, Klein AB, McSpadden ED, Griem-Krey N, Solbak SMØ, Houlton J, Villumsen IS, Vogensen SB, Hamborg, L, Gauger SJ, Palmelund LB, Larsen ASG, Shehata MA, Kelstrup CD, Olsen, JV, Bach A, Burnie RO, Kerr S, Gowing EK, Teurlings SMW, Chi CC, Gee CL, Frølund B, Kornum BR,  van Woerden GM, Clausen RP, Kuriyan J, Clarkson AN & Wellendorph P (2021). GHB confers neuroprotection through specific interaction with the CaMKIIα hub domain. Proc. Natl. Acad. Sci USA 118 No 31 e2108079118. https://doi.org/10.1073/pnas.2108079118 

  2. Falk-Petersen CB, Rostrup F, Löffler R, Buchleihtner S, Harpsøe K, Gloriam D, Frølund B, Wellendorph P (2021). Molecular determinants underlying delta selective compound 2 activity at d-containing GABAA receptors. Mol. Pharmacol. 100, 46-56.

Free e-prints 

3. Dalby NO, Leurs U, Falk-Petersen C, Scholze P, Krall J, Frølund & Wellendorph P (2020). Silencing of spontaneous activity at α4β1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology. Br. J. Pharmacol. 2020 Jun 2. 177: 3975-3990

4. Falk-Petersen CB, Tsonkov T, Nielsen M, Harpsøe K, Bundgaard C, Frølund B, Kristiansen U, Gloriam D & Wellendorph P (2020). Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors. Sci. Rep. 10:10078

5. Lie MEK, Gowing  EK, Johansen  NB, Dalby NO, Thiesen L, Wellendorph P & Clarkson A (2018). The GAT3 selective substrate L-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. J. Cereb. Blood Flow Metab. 38: 166-173.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2022

Group picture Wellendorph groupTeam building

2021

Group event
Paddle tennis 

2019

Group event Escape Room Dec 2019

 

 

 

 

 

 

 

 

 

 

 

 

Group leader

Group Leader

Petrine Wellendorph
Professor

Phone +45 3533 6397
pw@sund.ku.dk

Group members

Name Title Phone E-mail
Jens Velde Andersen Postdoc +4535334853 E-mail
Jonas Sigurd Mortensen Postdoc +4535335369 E-mail
Kristine Sloth Wilhelmsen PhD Fellow   E-mail
Laura Mikél Mc Nair Assistant Professor +4535326132 E-mail
Nane Griem-Krey Postdoc +4591403792 E-mail
Sara Marie Øie Solbak Assistant Professor   E-mail
Stefanie Kickinger Postdoc +4535321722 E-mail
Stine Juul Gauger PhD Fellow +4535327111 E-mail

Navn Titel E-mail
Nane Griem-Krey PhD stud E-mail