Cyclic peptides excel at binding. They can tightly and specifically interact with proteins that are reluctant to bind traditional small molecule drugs. In the Rogers lab, we use a mixture of chemistry and molecular biology to isolate such cyclic peptides de novo. We ‘reprogram’ nature’s peptide synthesis machinery - the ribosome - to synthesize and screen trillions of unique cyclic peptides to discover promising drug-like biopharmaceuticals.
We thank the following foundations for their generous support of our research:
- Novo Nordisk Fonden