Peptide-based Drug Research Group

In a near future, infections caused by multidrug-resistant pathogenic bacteria are likely to become a major threat to public health. Cancer is a leading cause of death with high costs for medical treatment. Discovery of therapies that effectively combat these diseases is of high societal value.

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Chemotherapeutics comprise both antibiotics and anticancer drugs and common features are that their mode of action involves selective killing of cells (either microbial or cancerous) and severe problems with development of resistance mechanisms - either via bacterial selection processes or during cancer treatment of individual patients. To circumvent these issues, we design peptides and peptidomimetics capable of killing multidrug-resistant (MDR) bacteria as well as develop peptide-drug conjugates targeting cancer, MDR strains and circumvent drug-induced over-expression of efflux pumps.




  1. Identification of peptide-based antibacterial lead compounds
  2. Proof of concept for novel designs of antibacterial peptidomimetics
  3. Improved methods for on-resin peptide modification




































Collaborators - National

Prof. Claus E. Moser, Dept. Clinical Microbiology, Rigshospitalet (Copenhagen University Hospital)

Prof. Anders Løbner-Olesen, Dept. Biology, University of Copenhagen

Prof. Peter E. Nielsen, Dept. Cellular & Molecular Biology, University of Copenhagen

Prof. Hanne Ingmer, Dept. Veterinary & Animal Sciences, University of Copenhagen

Prof. Luca Guardabassi, Dept. Veterinary & Animal Sciences, University of Copenhagen

Prof. Camilla Foged, Dept. Pharmacy, University of Copenhagen

Prof. Niels Frimodt-Møller, Dept. Clinical Microbiology, Rigshospitalet (Copenhagen University Hospital)

Prof. Gunnar Houen, Rigshospitalet, Glostrup

Assoc. Prof. Peter Thulstrup, Dept. Chemistry, Science, University of Copenhagen

Assoc. Prof. Majid Sheykhzade, University of Copenhagen

Assoc. Prof. Peter Damborg, Dept. Veterinary & Animal Sciences, University of Copenhagen

Statens Serum Institut (several senior scientists), Denmark


Collaborators - International

Prof. Magnar Bjørås, Dept. Microbiology, Oslo University Hospital, Norway & Dept. Cancer Research & Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Prof. Fernando Rogério Pavan, Sao Paulo State University, Sao Paolo, Brazil.

Assoc. Prof. Liam Good, Pathobiology & Population Science, Royal Veterinary College, London, U.K.

Assoc. Prof. Lorenzo Stella, Dept. Chemical Science and Technologies, University of Rome Tor Vergata, Rome, Italy.

Prof. Maria Luisa Mangoni, Dept. Biochemical Sciences, Sapienza University of Rome, Rome, Italy.

Prof. Paolo Rovero, University of Florence, Italy.

Prof. Johan Svensson, Cawthron Institute, New Zealand.

Dr. Dorota Zabicka, National Microbiology Institute, Warzaw, Poland.

Director, O. Pugovics, Latvian Institute of Organic Synthesis, Riga, Latvia.

Dr. Ilona Domraceva, Latvian Institute of Organic Synthesis, Riga, Latvia.

Prof. Raivis Zalubovskis, Latvian Institute of Organic Synthesis, Riga, Latvia.

Prof. R. E. W. Hancock, University of British Columbia, Vancouver, Canada.

Assoc. Prof. Annelise Barron, Stanford Bioengineering, CA, USA.

Assoc. Prof. Reidar Lund, University of Oslo.

Dr. Jeff Watts, Zoetis, Kalamazoo, Michigan, USA .

Prof. Claes Dahlgren, Sahlgrenska Academy, University of Gothenburg, Sweden.

Assoc. Prof. Ian Mellor, School of Life Sciences, University of Nottingham, U.K.

Assoc. Prof. Izuddin Fahmy Abu, Institute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.



Henrik Franzyk:

Norwegian Research Council (Collaborative and Knowledge-building Project Collaborative Project; 2022-2024): A platform for development of peptide-based antimicrobials for treatment of infections with drug-resistant bacteria. Collaborator share: 4.04 mio NOK (1 PhD and part-time lab technicians).

Danish Technical Research Council (PhD project; 2022-2024): Exploration of efflux pump inhibitor conjugates via Trojan-horse and shuttle approaches. Grant: 2.88 mio DKK.

Novo Nordisk Foundation Challenge project (Center for Peptide-Based Antibiotics: CEPAN; 2017-2022); partner share: 14.9 mio DKK.

Partner in ENABLE (IMI: “New Drugs for Bad Bugs 4”; 2014-2021); share: 2.5 mio DKK.

Paul R. Hansen:

Partner in FP7-PEOPLE-2011-ITN TRAIN-ASAP, (2012-2017)

Partner in Antimicrobial peptides seen by neutrons (2016-2020) funded by Nordforsk.



Master students

If you are interested in carrying out your MSc project (specialeprojekt) in the group, please contact or for a discussion of available projects within solid-phase  synthesis, peptide chemistry of modification of drugs (e.g., antibiotics). Please provide a description of prior experience within practical organic and/or solid-phase synthesis together with a transcript of grades. Project duration is minimum 6 months (i.e., 30 ECTS), and preferably 12-months (i.e., 60 ECTS). International exchange students (e.g., with an ERASMUS grant) are welcome join, provided funding for travel and accomodation is already in place. Student research results typically become published in peer-reviewed journals when the overall research project is finalized.

PhD students

We do not currently have fully funded PhD fellowships available. Students with an EU scholarship (e.g. Marie Curie) or national grant are welcome to contact or

When available, fully funded PhD scholarships will be posted on Please apply only the online system, since e-mailed applications cannot be considered.

Also, visiting PhD students are welcome to contact or for a discussion of possibilities for a project within the group.

Postdoctoral fellows

We do not currently have fully funded postdoctoral fellowships available. Postdoctoral candidates with own fellowship are welcome to send their CV and letters of recommendation to or




Postdoctoral fellows/Assistant Professors

Nicki Frederiksen (2020-2022; supervisor: H. Franzyk )
Ashif Yasin Shaik (2018- 2022; supervisor: H. Franzyk)
Anita Wester (2017-2020; supervisor: H. Franzyk)
Anna Mette Hansen (2014-2018; supervisor: H. Franzyk)
Kolja M. Knapp  (2009-2011; supervisor: H. Franzyk)
Francois Crestey (2007-2009; supervisor: H. Franzyk)


Graduate students (= PhD students -2023 evt. incl. nuværende affiliation)

Nicki Frederiksen (2017-2020; main supervisor: H. Franzyk)
Malene Vinther Christensen (2015-2018; main supervisor: H. Franzyk)
Bala Krishna Prabhala (2014-2018; co-supervisor: P.R. Hansen)
Natalia Molchanova (2013-2016; main supervisor: H. Franzyk)
Alberto Oddo (2012-2015; main supervisor: P.R. Hansen)
Ines Greco (2012-2016; main supervisor: P.R. Hansen)
Sarah L. Skovbakke (2012-2016; main supervisor: H. Franzyk)
Gitte Bonke Seigan (2011-2014; main supervisor: H. Franzyk)
Christina Schjøt-Eskesen (2011-2015; co-supervisor: P.R. Hansen)
Rasmus D. Jahnsen (2010-2013; main supervisor: H. Franzyk)
Jens Kristian Munk (2010-2013; supervisor: P.R. Hansen)
Nicole Hartwig Trier (2009-2013; co-supervisor: P.R. Hansen)
Lars K. Ottesen (2007-2010; main supervisor: H. Franzyk)
Charlotte Lund Denholdt (2004-2008; co-supervisor: P.R. Hansen)
Dan Ifrah (2002-2006; co-supervisor: P.R. Hansen)
Trine S. Ryge (2001-2006; supervisor: P.R. Hansen)
Christian A. Olsen (2001-2004; main supervisor: H. Franzyk)
Malene R. Jørgensen (2001-2004; main supervisor: H. Franzyk)
Jacob A. D. Clausen (2009-2012; supervisor: H. Franzyk)
Jon H. Rasmussen (1995-1998; supervisor: H. Franzyk)
Signe M. Frederiksen (1995-1998; supervisor: H. Franzyk)


MSc, BSc, and visiting students

Julie Jin (2022-2023; PRH)
Lavan Sharif (2022-2023; PRH)
Murat Kalayci (2022-2023; PRH)
Serpil Ahmed (2022; PRH)
Anna Kristoffersen Foltmar (2021-2022; HF)
Abdullah Al-Awkati (2021-2022; PRH)
Nina Cecilie Lyck (2021-2022; HF)
Luise Pallasdies (2021-2022; HF)
Yunhao Duan (2021-2022; PRH)
Oguzhan Saglam (2021-2022; PRH)
Teodor Olejko (2021-2022; PRH)
Mohammad Firoznezhad  (2021; PRH)
Ilaria Fanelli (2021; PRH)
Malak A. Suleiman (2020-2021; HF)
Farah Mughal (2020-2021; PRH)
Sannie Rafique (2020-2021; PRH)
Thomas Bobak (2020; PRH)
Stavroula Louka (2019-2020; HF)
Sahar Hashim Ali Hussein (2019-2020; HF)
Sarah Benali (2019-2020; PRH)
Azra Kapicic (2019-2020; PRH)
Maria Prokou (2019-2020; PRH)
Mahdieh Dagina Pedersen (2019; PRH)
Chirag Mudaliar (2018-2019; HF)
Rajan Ali (2018-2019; PRH)
Jasmina Rashid (2018-2019; PRH)
Nikoline Nielsen (2018-2019; PRH)
Georgia Karathanasi (2018; PRH)
Lars Sørensen (2017-2018; HFD)
Signe Jensen (2017-2018; PRH)
Malene Pedersen (2017-2018; PRH)
Ida Andersen (2017-2018; PRH)
Kathleen Mary Coyle: (2017-2018; PRH)
Jing Zhou (2017-2018; PRH)
Catarina Freire (2017; PRH)
Catarina R. Coelho (2017; PRH)
Niccolo Valdarnini (2017; PRH)
Sabbah Ahmed (2016-2017; PRH)  
Wafaa Hamad Rissan Al-Mansour (2016-2017; PRH)
Christina Nielsen (2015-2016; HF)
Simon B. Christensen (2015-2016; HF)
Abdullah Lone (2015-2016; PRH)
KP Nandhini (2015; PRH)
Helen Mendel (2015; PRH)
Iris Perez-Gassol (2014-2015; HF)
Lena Münzker (2014-2015; PRH)
Johannes E. Hansen (2014-2015)
Marina Fuentes (2014; PRH)
Bardur Johannesen (2014; PRH)
Agnete Emborg (2013-2014; PRH)
Julie Harboe (2013-2014; PRH)
Ciara Gorey (2013; PRH)
Camilla J. Larsen (2012-2013; HF)
Paola Saporito (2012-2013; HF)
Maria Leth (2012; PRH)
Frederikke Fliedner (2012)
Paula Melo Paulon Hansen (2011-2012; PRH)
Simon Welner (2010-2011; PRH)
Surekha Dipak Amrutkar (2010-2011; PRH)
Tanja Poulsen (2009-2010; PRH)
Rasmus Jahnsen (2009-2010; HF)                                               
Jesper Søborg Bahnsen (2009-2010; HF)
Christian Hougaard (2008-2009; HF)
Arham Isa (2007-2008; HF)                               
Angelo Bella (2007; HF)                                                                 
Maria Buccolo (2007; HF)
Sandra Lerche Nielsen (2005-2006; PRH)
Karin Jørgensen (2005; PRH)
Susanne Ladefoged Nielsen (2003-2004; PRH)
Ole Weltz (2001-2002; PRH)
Charlotte Lund Hansen (2001-2002; PRH)
Petrine Wellendorph (2000-2001¸HF)







































Research areas

Group leader

Group Leader

Henrik Franzyk
Associate Professor

Phone: +45 35 33 62 55

Group members

Name Title Phone E-mail
Adamsen (Wan), Uraiwan Ngamrabiab Laboratory Technician +4535336685 E-mail
Franzyk, Henrik Associate Professor +4535336255 E-mail
Hansen, Paul Robert Associate Professor +4535336625 E-mail
Jensen, Emma Dyhr PhD Fellow +4535325774 E-mail
Jørgensen, Johan Storm PhD Student +4535321488 E-mail
Madsen, Mikkel Stampe PhD Fellow +4535336283 E-mail
Simonsen, Birgitte Laboratory Technician. +4535336148 E-mail