Strømgaard Lab

In the Strømgaard lab, we combine tools from chemistry and biology, and apply these in peptide and protein engineering. Our aims are to develop modulators for protein-protein interactions and to provide molecular-level insight herein. We are interested in protein-protein interactions that are therapeutically relevant, in particular between integral membrane proteins and their intracellular protein partners, also known as receptor-complexes.

Group picture of Strømgaard Lab























C. R. O. Bartling, T. M. T. Jensen, S. M. Henry, A. L. Colliander, V. Sereikaitė, M. Wenzler, P. Jain, H. M. Maric, K. Harpsøe, S. W. Pedersen, L. S. Clemmensen, L. M. Haugaard-Kedström, D. E. Gloriam, A. Ho, K. Strømgaard, Targeting the APP-Mint2 protein-protein interaction with a peptide based-inhibitor reduces amyloid-β formation, J. Am. Chem. Soc. 2021, 143, 891−901

L. Haugaard-Kedström, L. S. Clemmensen, V. Sereikaite, Z. Jin, E. F. A. Fernandes, B. Wind, F. Abalde-Gil, J. Daberger, M. Vistrup-Parry, D. Aguilar-Morante, R. Leblanc, A. L. Egea Jimenez, M. Albrigtsen, K. Jensen, T. M. T. Jensen, Y. Ivarsson, R. Vincentelli, P. Hamerlik, J. Andersen, P. Zimmermann, W. Lee, K. Strømgaard, A high-affinity peptide ligand targeting syntenin inhibits glioblastoma, J. Med. Chem. 2021, 64, 1423-1434.

M. Vistrup-Parry, W. B. Sneddon, S. Bach, K. Strømgaard, P. A. Friedman,T. Mamonova, Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport, J. Biol. Chem. 2021, 296, 100473.

D. J. Essig, J. R. Balboa, K. Strømgaard, Development of peptide-based PDZ domain inhibitors, Methods Mol. Biol. 2021, 2256, 157-177.

C. Kossmann, S. Ma, L. S. Clemmensen, K. Strømgaard, Chemical synthesis of PDZ domains, Methods Mol. Biol. 2021, 2256, 193-216.

T. M. T. Jensen, C. R. O. Bartling, O. A. Karlsson, E. Åberg, L. Haugaard-Kedström, K. Strømgaard, P. Jemth, Molecular details of a coupled binding and folding reaction between the amyloid precursor protein and a folded domain, ACS Chem. Biol. 2021, 16, 1191-1200.

Z. Najarzadeh, J. Nielsen, A. Farzadfard, V. Sereikaite, K. Strømgaard, R. Meyer, D. E. Otzen, Daniel, Human Fibrinogen inhibits amyloid assembly of most Phenol Soluble Modulins (PSM) from Staphylococcus aureus, ACS Omega 2021, 6, 21960-21970.

Z. Najarzadeh, M. Zaman, V. Sereikaite, K. Strømgaard, M. Andreasen, D. E. Otzen, Daniel, Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus, J. Biol. Chem. 2021, 297, 100953.

M. Vistrup-Parry, X. Chen, T. L. Johansen, S. Bach, S. C. Buch-Larsen, C. R. O. Bartling, C. Ma, L. S. Clemmensen, M. L. Nielsen, M. Zhang, K. Strømgaard, Site-specific phosphorylation of PSD-95 dynamically regulates the post-synaptic density as observed by phase separation, iScience, 2021, 24, 103268.


H. Zhang, A. L. Nielsen, K. Strømgaard, Recent achievements in developing selective Gq inhibitors. Med. Res. Rev. 2020, 40, 135-157.

S. Ma, K. Strømgaard, L. S. Clemmensen, Site-specific phosphorylation of PDZ domains, Methods Mol. Biol. 2020, 2133, 235-261.

E. F. A. Fernandes, L. M. Haugaard-Kedström, K. Strømgaard, Effects of a combination of lipidation and cell-penetrating peptide on a peptide dimeric inhibitor of PSD-95, Austr. J. Chem. 2020, 73, 307-311.

C. B. Borg, N. Braun, S. A. Heusser, Y. Bay, D. Weis, I. Galleano, C. Lund, W. Tian, L. M. Haugaard-Kedström, E. P. Bennett, T. Lynagh, K. Strømgaard, J. Andersen, S. A. Pless, Mechanism and site of action of big dynorphin on ASIC1a, Proc. Natl. Acad. Sci. USA 2020, 117, 7447-7454.

N. R. Christensen, M. De Luca, M. B. Lever, M. Richner, A. B. Hansen, K. L. Jensen, M. Rathje, G. Noes-Holt, D. B. Jensen, S. Erlendsson, C. R. O. Bartling, I. Ammendrup-Johnsen, S. E. Pedersen, M. Schönauer, K. B. Nissen, S. R. Midtgaard, K. Teilum, L. Arleth, A. T. Sørensen, A. Bach, K. Strømgaard, C. F. Meehan, C. B. Vægter, U. Gether, K. L. Madsen, A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain, EMBO Mol. Med. 2020, 12, e11248.

J. Li, Y. Ge, J. X. Huang, K. Strømgaard, X. Zhang, X. F. Xiong, Heterotrimeric G proteins as therapeutic targets in drug discovery, J. Med. Chem. 2020, 63, 5013-5030.

G. Langlhofer, N. Schaefer, H. Maric, A. Keramidas, Y. Zhang, P. Baumann, R. Blum, U. Breitinger, K. Strømgaard, A. Schlosser, M. Kessels, D. Koch, B. Qualmann, H.-G. Breitinger, J. Lynch, C. Villmann, A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibition, J. Neurosci. 2020, 40, 4954-4969.

A. Toto, S. Ma, F. Malagrinò, L. Visconti, L. Pagano, K. Strømgaard, S. Gianni, Comparing the binding properties of peptides mimicking the envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein. Protein Sci. 2020, 29, 2038-2042.

M. Kristensen, K. Kucharz, E. F. A. Fernandes, K. Strømgaard, M. S. Nielsen, H. C. C. Helms, A. Bach, M. U. Tofte-Hansen, B. I. A. Garcia, M. Lauritzen, B. Brodin, Conjugation of therapeutic PSD-95 inhibitors to the cell-penetrating peptide Tat affects blood-brain barrier adherence, uptake, and permeation. Pharmaceutics 2020, 12, E661.

M. I. Rosenbaum, L.S. Clemmensen, D. S. Bredt, B. Bettler, K. Strømgaard, Targeting receptor complexes: A new dimension in drug discovery, Nature Rev. Drug Discov. 2020, 19, 884–901.


X-F. Xiong, H. Zhang, M. W. Boesgaard, C. R. Underwood, H. Bräuner-Osborne, K. Strømgaard, Structure-activity relationship studies of the natural product Gq/11 protein inhibitor YM-254890, Chemmedchem, 2019, 14, 865-870.

D. Malfacini, J. Patt, S. Annala, K. Harpsøe, F. Eryilmaz, R. Reher, M. Crüsemann, W. Hanke, H. Zhang, D. Tietze, D. E. Gloriam, H. Bräuner-Osborne, K. Strømgaard, G. M. König, A. Inoue, J. Gomeza, E. Kostenis, Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity. J. Biol. Chem. 2019, 294, 5747-5758.

A. Bach, B. H. Clausen, L. K. Kristensen, M. G. Andersen, D. G. Ellman, P. B. L. Hansen, H. Hasseldam, M. Heitz, D. Özcelik, E. J. Tuck, M. V. Kopanitsa, S. G. N. Grant, K. Lykke-Hartmann, F. F. Johansen, K. L. Lambertsen, K. Strømgaard, Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor. Neuropharmacology, 2019, 150, 100-111.

N. R. Christensen, J. Čalyševa, E. F. A. Fernandes, S. Lüchow, L: S. Clemmensen, L. M. Haugaard-Kedström, K. Strømgaard, PDZ domains as drug targets. Adv. Ther. 2019, 2, 1800143.

J. Petersen, K. Strømgaard, B. Frølund, C. Clemmensen, Designing poly-agonists for treatment of metabolic diseases: Challenges and opportunities, Drugs, 2019, 79, 1187-1197.

V. Sereikaite, T. Fritzius, V. B. Kasaragod, N. Bader, H. M. Maric, H. Schindelin, B. Bettler, K. Strømgaard, Targeting the γ-aminobutyric acid type B (GABAB) receptor complex: Development of inhibitors targeting the K+ channel tetramerization domain (KCTD) containing proteins/GABAB receptor protein-protein interaction, J. Med. Chem. 2019, 62, 8819-8830.

Z. Najarzadeh, H. Mohammad-Beigi, J. N. Pedersen, G. Christiansen, T. V. Sønderby, S. A. Shojaosadati, D. Morshedi, K. Strømgaard, G. Meisl, D. Sutherland, J. S. Pedersen, D. E. Otzen, Plant polyphenols inhibit functional amyloid and biofilm formation in Pseudomonas strains by directing monomers to off-pathway oligomers, Biomolecules, 2019, 9, E659.


N. G. Nørager, M. H. Poulsen, K. Strømgaard, Controlling Ca2+ permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors with photochromic ion channel blockers, J. Med. Chem. 2018, 61, 8048-8053.

V. Sereikaitė, T. M. T. Jensen, C. R. O. Bartling, P. Jemth, S. A. Pless, K. Strømgaard, Probing backbone hydrogen bonds in proteins by amide-to-ester mutations. Chembiochem, 2018, 19, 2136-2145.

T. M. T. Jensen, L. Albertsen, C. R. O. Bartling, L. M. Haugaard-Kedström, K. Strømgaard, Probing the Mint2 protein-protein interaction network relevant to the pathophysiology of Alzheimer's disease. Chembiochem, 201819, 1119-1122.

A. Bleem, G. Christiansen, D. J. Madsen, H. Maric, K. Strømgaard, J. D. Bryers, V. Daggett, R. L. Meyer, D. E. Otzen, Protein engineering reveals mechanisms of functional amyloid formation in Pseudomonas aeruginosa biofilms. J. Mol. Biol. 2018, 430, 3751-3763.

H. Zhang H, A. L Nielsen, M. W. Boesgaard, K. Harpsøe, N. L. Daly, X. F. Xiong, C. R. Underwood, L. M. Haugaard-Kedström, H. Bräuner-Osborne, D. E. Gloriam, K. Strømgaard, Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. Eur. J. Med. Chem. 2018156, 847-860.